BREAST CANCER

This study is testing whether a personalized treatment approach can lead to long-term remission or cure for people with advanced HER2-positive breast cancer. Researchers will use regular blood tests to guide treatment decisions, adjusting therapies based on cancer activity while …

This study is testing whether adding a new drug called inavolisib to two standard breast cancer medications works better than the standard two-drug combination alone. It's for people with advanced breast cancer that has a specific genetic change (PIK3CA mutation) and is sensitive…

This study is for people with a high-risk type of breast cancer who have had surgery but still have some cancer cells left. Researchers want to see if a special blood test can find signs that the cancer is coming back before it shows up on standard scans. If the blood test is pos…

This study is testing a new, faster type of radiation therapy for women who have had surgery for breast cancer. It uses artificial intelligence to quickly adjust the radiation plan right before each treatment, aiming to target the cancer more precisely while better protecting hea…

This early-phase study is testing a new type of cell therapy for people with advanced solid tumors, including melanoma, that have spread and are not responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack c…

This large international study is testing whether a new drug called palazestrant works better than the current standard treatment when combined with another cancer drug called ribociclib. The trial will involve about 1,000 adults with advanced breast cancer that hasn't been treat…

This is the first human study of an experimental drug called BL-M17D1 for people with advanced breast cancer and other solid tumors. The main goals are to find the safest dose and see how the body processes the drug. Researchers will also look for early signs that the drug might …

This large study is testing whether a new drug called HRS-8080 works better than standard hormone therapy at preventing breast cancer from returning. It involves 4,800 women with high-risk early breast cancer who have already completed 2-5 years of initial hormone treatment. The …

This study is testing whether a new drug called NBQ72S can help control breast cancer that has spread to the lining of the brain and spinal cord, a serious complication. About 10 patients will receive the drug through an IV every 28 days until their cancer worsens or side effects…

This early-stage study is checking if it's safe to give radiation therapy along with two oral cancer drugs (abemaciclib and letrozole) before surgery for a common type of breast cancer. It will involve about 15 post-menopausal women with early-stage, hormone-positive breast cance…

This study looks back at medical records to compare two types of minimally invasive breast cancer surgeries: robot-assisted and endoscopic approaches. Researchers will examine 200 women with early-stage breast cancer who had one of these procedures. The goal is to understand whic…

This study is observing patients in Russia to see if adding the drug ribociclib to standard hormone therapy is better at preventing breast cancer from coming back after initial treatment. It will follow over 2,700 patients with stage II or III breast cancer who have had surgery. …

This study is testing a three-part treatment for breast cancer that has spread to the brain. First, patients receive a precise, focused radiation treatment (radiosurgery) along with a daily pill called olaparib. After that, they receive an immunotherapy drug (durvalumab) plus a s…

This early-stage study is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—for people with metastatic triple negative breast cancer that has spread and is no longer responding to standard treatments. The main goal is to find the safest and m…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This study is testing two different combinations of oral medications given before surgery (neoadjuvant therapy) for early-stage breast cancer that is hormone-sensitive. It aims to see if adding a third drug (entinostat) to a standard two-drug combo (dalpiciclib and letrozole) is …

This early-stage trial is testing a new oral drug called KESONOTIDE in people with advanced solid tumors that have spread. The main goal is to find a safe dose and see how well the body handles the medicine. About 80 adults with cancers like prostate, breast, lung, ovarian, and o…

This early-stage study is testing a new drug called IDE161, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have spread. The main goals are to find safe doses and see if the treatment shows early signs of shrinkin…

This study is testing a new device that uses heat to try to destroy any leftover cancer cells right after a tumor is removed during breast-conserving surgery. The device is placed in the space where the tumor was and uses radio waves to heat and treat the surrounding tissue. Rese…

This study is for people with a high-risk type of breast cancer who are already on standard hormone-blocking pills. It first uses a special blood test to look for tiny signs of cancer that might be returning. If the test turns positive but a scan shows no visible spread, patients…

This is a first-in-human study testing a new experimental drug called 212Pb-DOTAM-GRPR1 in adults with advanced cancers that have returned or spread. The main goal is to find a safe and tolerable dose. Researchers will also check if the drug, which delivers radiation directly to …

This study is testing whether women with low-risk breast cancer can safely skip radiation to the lymph node areas. Researchers want to know if avoiding this radiation works just as well at preventing cancer from returning while reducing treatment side effects. The trial will comp…

This study is testing a new type of cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors will analyze a patient's tumor to select a specific target, then infuse specially engineered immune cells (CAR-NK cells) from a heal…

This study is testing a minimally invasive treatment that uses extreme cold and heat to destroy breast cancer tumors. It is for patients who cannot have or choose not to have standard surgery. Researchers will follow 200 participants for over 5 years to see how safe the treatment…

This study is testing whether cancer survivors who get a personalized referral to a nutrition and exercise program will adopt healthier habits. It's enrolling 306 people who have finished treatment for breast, prostate, or colorectal cancer but aren't currently meeting standard d…

This study is testing whether giving chemotherapy more frequently before surgery helps control a specific type of aggressive breast cancer. It will involve 64 women with hormone-positive, HER2-negative breast cancer that is growing quickly. Researchers will measure how much cance…

This study is testing whether different antibody-drug conjugate (ADC) medications can help control advanced breast cancer in patients whose cancer has progressed despite previous ADC treatment. The trial will enroll 160 adults with metastatic breast cancer who have already receiv…

This study is testing whether adding an experimental drug called zanidatamab to standard chemotherapy helps eliminate HER2-positive breast cancer before surgery. Researchers will enroll 125 people with early-stage breast cancer to see if this combination leads to better outcomes.…

This early-phase trial is testing a new treatment strategy for metastatic triple-negative breast cancer that has stopped responding to standard chemotherapy. Researchers want to see if giving the drug bortezomib first can make the cancer more vulnerable to a later combination of …

This study is testing whether freezing small breast tumors (cryoablation) works as well as standard surgery (lumpectomy) for early-stage breast cancer. Researchers will compare both treatments in 120 women aged 50+ with low-risk tumors to see which has fewer complications, better…

This study is testing whether giving radiation treatment a second time is safe for women whose breast cancer has returned in the same breast. Researchers want to understand both the benefits and risks of this approach for patients who have already had radiation therapy. The study…

This is the first study in people to test a new drug called HMBD-501 for advanced cancers that have a specific marker called HER3 and have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help shrink or control tumors in pa…

This study is testing a 12-week video coaching program called WeCan-Rural, designed to help breast cancer survivors in rural areas build healthy habits. The program teaches nutrition, exercise, and symptom management skills to potentially reduce future heart disease risk. Researc…

This study is testing whether a genetic test called RecurIndex can help doctors decide which breast cancer patients need radiation to their lymph nodes after surgery. It aims to see if patients with a low-risk genetic score can safely skip this radiation, potentially reducing sid…

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This program provides access to the breast cancer drug ribociclib for patients who have exhausted standard treatments or need it as additional therapy after surgery. It's designed for people with advanced cancer that has stopped responding to available options, or for early-stage…

This study is testing whether combining two drugs, tinengotinib and fulvestrant, can help control advanced breast cancer that has stopped responding to standard hormone therapies. It will involve about 94 people with HR-positive, HER2-negative or low-expressing breast cancer that…

This study aims to understand how well the drug trastuzumab deruxtecan works and what side effects patients experience in real-world medical settings in China. It will follow 800 adults with advanced breast cancer that has spread and is difficult to remove surgically. Researchers…

This trial is testing whether a new oral medication called OP-1250 works better than current standard hormone therapies for people with advanced breast cancer that has continued to grow despite previous hormone treatments. The study will enroll about 510 adults whose cancer is ho…

This study is testing whether a combination of two targeted drugs (pertuzumab and trastuzumab) plus hormone therapy, given after surgery, can help prevent cancer from returning in people with early-stage, hormone-positive, HER2-positive breast cancer. About 375 participants will …

This registry study follows 500 women with early-stage breast cancer who choose single-dose radiation during their lumpectomy surgery. Researchers will track whether cancer returns and monitor side effects over 5 years of follow-up visits. The goal is to better understand the lon…

This study is testing whether adding targeted radiation to standard hormone therapy drugs helps control advanced breast cancer that has spread. It will enroll 102 women with hormone-positive breast cancer that has metastasized to up to five sites. Researchers want to see if this …

This trial is for people with advanced breast cancer that has stopped responding to a common first-line treatment. Researchers will use a simple blood test to look for genetic clues in the cancer. Based on those clues, patients will be matched with one of several new experimental…

This Canadian study is testing whether a personalized approach to cancer treatment works. It gives the immunotherapy drug atezolizumab to about 200 patients with advanced breast, lung, or other cancers, but only if their tumor's genetic analysis suggests they might respond. The g…

This study aims to understand if a major surgery to remove breast cancer that has grown into the chest wall improves patients' quality of life and controls the disease. It will follow 104 patients who undergo this surgery, tracking their pain, daily function, and whether the canc…

This study is comparing two ways to give radiation during breast-conserving surgery for early breast cancer. It will follow 620 women aged 55+ to see which method better prevents cancer from returning locally and causes fewer complications. One group gets a single dose of radiati…

This study is testing whether a new combination of three drugs can safely shrink tumors in people with HER2-positive breast cancer before they have surgery. The treatment aims to eliminate all cancer cells from the breast and lymph nodes by the time of surgery. Researchers will e…

This early-stage trial is testing a new oral medication called MOMA-313, given alone or with an existing cancer drug (olaparib), in people with advanced solid tumors that have stopped responding to other treatments. The main goal is to find safe dose levels and see how the body p…

This study is testing whether a drug called zanidatamab can eliminate early-stage HER2-positive breast cancer before surgery. It will involve about 20 patients who haven't had any prior cancer treatment. Researchers will check if the cancer completely disappears after taking the …

This study aims to find the best breast reconstruction approach for women who have had a mastectomy and need radiotherapy. It will follow 750 patients to compare different reconstruction types and timings, focusing on patient satisfaction, complications, safety, and costs. The go…

This study is testing whether combining three existing cancer drugs works better to control advanced breast cancer that has spread. It's for people whose cancer is fueled by hormones and has either just been diagnosed as advanced or returned after more than a year. The main goal …

This study is testing whether giving radiation therapy before mastectomy surgery allows for immediate breast reconstruction using the patient's own tissue. It compares this approach to the standard method where reconstruction happens months later. The research aims to see if this…

This study is testing whether combining two drugs, tucatinib and Doxil, is safe and effective for treating advanced HER2-positive breast cancer that has spread or returned after prior treatment. It will involve about 36 patients who have already had at least one other HER2-target…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a new approach for early-stage, hormone-positive breast cancer. It gives patients a single, high-dose radiation treatment before surgery to try to shrink or eliminate the tumor. The trial also explores using a special ultrasound instead of surgery to check l…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This early-stage trial is testing a new drug called AZD8205, both by itself and combined with other cancer drugs, for people with advanced solid tumors that have spread or returned. The main goals are to find safe doses and see if the treatments can shrink tumors. It is enrolling…

This study is testing a more personalized approach to radiotherapy for breast cancer patients at high risk of both side effects and the cancer returning. It uses a new blood test to identify patients who are especially sensitive to radiation, then gives them a more precise, adapt…

This early-stage study is testing the safety and best dose of a two-drug combination (alpelisib and pembrolizumab) for patients with advanced breast cancer or melanoma that has spread. It aims to see if this combo can help control the disease, including in cases where cancer has …

This study is testing whether an online portal can help connect patients with support services. It's for people who speak English, Chinese, or Spanish and have been diagnosed with breast cancer or cardiovascular disease. The goal is to see if virtual patient navigation is a usefu…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This large study is testing if a targeted pill called ribociclib can safely replace chemotherapy for certain patients with early-stage, hormone-sensitive breast cancer. It will enroll nearly 4,000 women who would typically be offered chemotherapy after surgery. The goal is to see…

This early-stage trial is testing a new targeted cancer drug called IKS014 in people with advanced HER2-positive solid tumors, including breast and stomach cancers. The main goals are to find the highest safe dose and see if the drug can shrink tumors. The study will enroll about…

This large trial is testing if adding a targeted local treatment to standard drug therapy helps people with advanced breast cancer that has spread to only a few spots in the body. After 12 weeks of initial drug treatment, 340 participants will be randomly assigned to either conti…

This is the first human study of LNCB74, a new targeted cancer drug designed to deliver chemotherapy directly to cancer cells. Researchers will test different doses in 145 adults with advanced solid tumors (including ovarian, breast, lung, and other cancers) to find the safest an…

This study is testing whether restricting eating to a 10-hour daily window during cancer treatment can reduce side effects and improve tumor response. Researchers are enrolling 175 adults with breast or colorectal cancer who are receiving chemotherapy with curative intent. The go…

This study is testing a new two-part treatment for advanced breast cancer that has spread and stopped responding to standard hormone therapies. It combines a radioactive drug designed to find and attack cancer cells with a common chemotherapy pill. The goal is to find the safest …

This study is testing a two-step treatment for women aged 51+ whose breast cancer has returned in the same breast. Instead of removing the entire breast, doctors first give five quick, targeted radiation treatments to the small area of recurrence. One to two weeks later, surgeons…

This early-stage study is testing the safety and initial effects of a new drug called SYN818 when given with an existing cancer drug, olaparib. It is for adults with advanced or metastatic solid tumors (like ovarian or breast cancer) that have specific genetic changes (BRCA mutat…

This study is testing whether switching between two newer cancer drugs can help control advanced breast cancer that has spread and stopped responding to a similar prior treatment. It will involve about 357 people with HER2-negative metastatic breast cancer. The main goal is to se…

This study is testing whether adding a new drug called patritumab deruxtecan to standard chemotherapy and immunotherapy before surgery works better for certain aggressive breast cancers. Researchers want to see if this combination helps eliminate more cancer cells before surgery …

This study is testing a new three-step approach to breast reconstruction for women who have had breast cancer surgery or have Poland syndrome. First, a temporary tissue expander stretches the skin, then the patient's own fat is injected, and finally a permanent implant is placed.…

This study is testing whether a new digital care system can improve quality of life for older adults who have cancer along with other health conditions. It will involve 720 patients aged 70+ with breast, lung, colorectal, or prostate cancer across eight hospitals in France. The m…

This study is testing whether a specific type of exercise can help protect the heart health of breast cancer survivors who have finished chemotherapy. Researchers are comparing high-intensity interval training (short bursts of very hard effort) to traditional moderate exercise to…

This is the first human study of an experimental drug called OCT-598 for people with advanced solid tumors that have stopped responding to standard treatments. Researchers will test increasing doses to find the safest and most effective amount, both when given alone and when comb…

This study is testing if using highly focused radiation on a single tumor that has started growing again can help people with metastatic breast cancer stay on their current effective drug treatments longer. Participants will receive this targeted radiation while continuing their …

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This early-stage study aims to find safe and effective doses for a new breast cancer drug, palazestrant, when combined with four different existing cancer drugs. It will enroll about 190 adults with advanced or metastatic ER-positive, HER2-negative breast cancer who have had limi…

This study aims to understand if receiving therapy before breast cancer surgery improves treatment response and long-term survival. It will enroll 488 women with early or advanced breast cancer who plan to get pre-operative treatment. Researchers will compare different treatment …

This study is testing whether a newer targeted drug combination (T-DM1 followed by Herceptin Hylecta) causes fewer side effects than the standard treatment (paclitaxel with Herceptin Hylecta) for people with early-stage HER2-positive breast cancer after surgery. About 500 partici…

This study is testing a new, less invasive robotic surgery technique for removing breast tissue in people with breast cancer or a high risk of developing it. The goal is to see if this single-port robotic surgery is as safe and effective as traditional open surgery, while potenti…

This study is testing whether adding a targeted drug (sacituzumab govitecan) and an immunotherapy drug (zimberelimab) to precise brain radiation works better and is safe for people with triple negative breast cancer that has spread to the brain. It will involve about 31 participa…

This study is testing a new drug, elacestrant, combined with other cancer medicines to see if they can better control advanced breast cancer that has spread. It will involve about 435 adults whose cancer has worsened despite prior hormone therapy. The first part finds safe doses,…

This early-stage study is testing a new targeted cancer drug called STX-478, both alone and in combination with other approved cancer therapies. It aims to find a safe dose and see if it can help control advanced solid tumors, particularly breast cancer, that have a specific gene…

This study is testing whether the drug sacituzumab govitecan can help control metastatic breast cancer in people who have already received another targeted treatment called trastuzumab deruxtecan. The trial will enroll 75 adults with hormone receptor-positive, HER2-low breast can…

This is the first study in people to test a new drug called RLY-2608, which is designed to target a specific genetic mutation (PIK3CA) found in many advanced solid tumors and breast cancers. The main goals are to find the safest and most effective dose, check for side effects, an…

This large international study is testing whether new drug combinations work better than current standard treatments for advanced triple-negative breast cancer. Researchers will compare two experimental treatments against standard chemotherapy in 625 patients whose cancer has ret…

This study is testing whether adding an experimental drug called afuresertib to the standard hormone therapy fulvestrant can better control advanced breast cancer that has grown despite prior treatments. It is for adults with a specific type of breast cancer (HR+/HER2-) that has …

This study is testing a new drug called HRS-6209, given in combination with other treatments, for women with breast cancer. The main goals are to find a safe dose and see if the drug combination shows early signs of helping to control the cancer. The study will enroll about 80 wo…

This early study is testing if a simple, at-home device that gently stimulates a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. The goal is to see if this stimulation improves heart function and reduces inflammation. Ab…

This study looks at a scarless surgical technique for breast cancer that uses the patient's own chest wall tissue to fill the space where the tumor was removed. Researchers will follow 250 patients who had this surgery over the past 10 years to see if it leads to better cancer co…

This study is testing a new drug called patritumab deruxtecan for people with advanced HER2-positive breast cancer that has spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the treatment can shrink or eliminate the cancer. It is for people…

This early-stage study aims to find the safest and most effective dose of the drug abemaciclib when given at the same time as targeted radiation therapy. It is for people with advanced, hormone-sensitive breast cancer that has spread to the bones. The goal is to see if this combi…

This study aims to personalize treatment for triple-negative breast cancer before surgery. It will test if the number of immune cells in a patient's tumor and how well the tumor shrinks on MRI scans can help doctors decide the best type and amount of chemo-immunotherapy. The goal…

This study is testing whether short, frequent bursts of physical activity (like walking breaks after meals) are as good as a standard 30-minute workout for controlling blood sugar in breast cancer survivors taking hormone therapy. It will involve 24 sedentary, postmenopausal wome…

This study is testing a personalized treatment approach for breast cancer that has spread to nearby lymph nodes. Researchers want to see if adjusting radiation, surgery, and drug therapy based on how well a patient's tumor responds to initial chemotherapy can help keep the cancer…

This study is testing whether a shorter, once-daily radiation schedule works as well as the current standard treatment for breast cancer that returns in the same breast. The goal is to provide a more convenient option that helps participants keep their breast while controlling th…

This study aims to find out if a shorter, more intense course of radiation before breast cancer surgery works as well as the standard, longer course. It will involve 126 women who plan to have a mastectomy followed by tissue-based breast reconstruction. Researchers will compare p…

This study is testing a new, less invasive way to perform a mastectomy for breast cancer. It uses a small camera and tools inserted through a single cut in the armpit to remove breast tissue, aiming to hide the scar and preserve the nipple. The goal is to see if this endoscopic t…

This study is testing a new, shorter radiation schedule for women whose breast cancer has returned in a previously treated breast. Instead of the standard 3-5 weeks of treatment, participants receive radiation focused only on the tumor area over just 5 days (one week). The main g…

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This study is testing whether adding a supervised exercise program to standard chemotherapy before breast cancer surgery can help eliminate tumors more completely. It will involve 712 patients who will either follow a high-intensity exercise plan during their chemo or receive usu…

This study monitors the safety and effectiveness of the already-approved breast cancer drug Capivasertib as it is used in everyday medical practice in South Korea. It aims to track any side effects and see how well the drug works for about 130 patients who are prescribed it accor…

This study is testing whether a shorter, 5-day course of radiation is a safe and effective alternative to the standard longer treatment for women with early-stage breast cancer who have had a lumpectomy. It aims to see if this approach causes few or mild side effects while still …

This study is testing if adding the weight loss medication tirzepatide to standard hormone therapy can help prevent breast cancer from spreading in overweight patients. It focuses on people with early-stage, hormone-positive breast cancer who have a high risk of recurrence, as sh…

This study is testing a combination of three drugs given to patients before breast cancer surgery. The goal is to see if this treatment can shrink tumors and potentially eliminate all detectable cancer by the time of surgery. It is for postmenopausal women with a specific type of…

This study is testing whether giving hormone therapy before surgery helps women with a specific type of breast cancer have more successful operations. It focuses on postmenopausal women with hormone-sensitive, lobular breast cancer who plan to have breast-conserving surgery. The …

This study is testing whether proton radiation therapy can effectively control early-stage breast cancer while causing fewer side effects than traditional radiation. It focuses radiation only on the area where the tumor was removed, potentially sparing healthy breast tissue. The …

This study is observing whether women with specific types of early-stage breast cancer can safely avoid radiation to their lymph nodes after surgery. Researchers are following 635 patients who have hormone-sensitive, HER2-negative tumors with 1-3 positive lymph nodes and a specia…

This study is testing whether combining radiation with immunotherapy drugs can turn a patient's own breast cancer into a personalized vaccine. It involves 100 post-menopausal women with a specific type of breast cancer. The goal is to see if this combination is safe and can help …

This study observes how well the drug dalpiciclib works for people with advanced hormone-positive breast cancer in real-world settings. Researchers will follow 420 patients whose doctors have chosen to use dalpiciclib as part of their treatment. The study tracks how long the canc…

This study is testing an investigational drug called Dato-DXd for people with a specific type of advanced breast cancer that has spread and no longer responds to standard hormone treatments. The goal is to see if this drug, given as an IV infusion every 3 weeks, can effectively c…

This study is testing whether a shorter 3-week course of proton radiation therapy is as safe as the standard 5-week course for women with breast cancer who need radiation to the breast/chest wall and nearby lymph nodes. Researchers want to see if the shorter treatment causes simi…

This is the first study in people testing a new cancer drug called AGX101. It aims to find a safe and effective dose for patients with advanced solid tumors that have spread or cannot be removed by surgery, and who have no other standard treatment options left. The drug is given …

This study is testing whether adding an immunotherapy drug (pembrolizumab) to a targeted chemotherapy drug (sacituzumab govitecan) works better than the chemotherapy drug alone. It is for people with a specific, hard-to-treat type of advanced breast cancer (triple-negative and PD…

This study is testing whether combining three existing drugs—tucatinib, trastuzumab, and eribulin—is safe and effective for people with advanced HER2+ breast cancer that has continued to grow despite previous treatments. It will enroll about 30 adults to see if this combination c…

This early-stage study is testing FT836, a new type of 'off-the-shelf' CAR T-cell therapy, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates FT836, which is given al…

This study is testing a new drug, SI-B003, given alone or combined with another drug called BL-B01D1, for people with advanced HER2-negative breast cancer that has spread or come back and cannot be removed by surgery. The main goals are to see if the treatment shrinks tumors and …

This study is testing an experimental drug called zelenectide pevedotin for people with advanced breast cancer that has a specific genetic feature called NECTIN4 amplification. It is for patients whose cancer has returned, cannot be surgically removed, or has spread, and who have…

This study is testing whether a new drug combination (dalpiciclib plus hormone therapy) works as well as standard chemotherapy for shrinking certain breast cancers before surgery. It will involve 144 postmenopausal women with ER-positive, HER2-negative breast cancer. The main goa…

This study is testing if adding a common antibiotic called doxycycline to standard chemotherapy can improve treatment for early-stage breast cancer. The goal is to see if doxycycline can target stubborn 'cancer stem cells' that are thought to survive chemo and cause the cancer to…

This study is testing a new treatment called VSV-02 for people with advanced solid tumors who have few or no other treatment options left. VSV-02 is a specially engineered virus designed to both kill cancer cells directly and boost the body's immune system to fight the cancer. Th…

This early-stage trial is testing a new oral drug called ALTA2618 for people with advanced cancers that have a specific genetic mutation called AKT1 E17K. The study aims to find the safest and most effective dose and see how well the drug works against cancers like breast and end…

This study is testing whether adding a liver-supporting drug (L-Ornithine L-Aspartate) to two standard breast cancer medications can help control advanced breast cancer that has continued to grow despite previous treatment. It will involve 20 women whose cancer is hormone-sensiti…

This is an early-stage study to test the safety and initial effects of a new experimental drug called GNC-077 in people with advanced breast cancer and other solid tumors. Researchers will give increasing doses to small groups of patients to find the highest safe amount. The main…

This study is testing whether a combination of two drugs, neratinib and capecitabine, can help control breast cancer that has spread to the brain. It is for patients whose cancer is officially classified as HER2-negative but shows signs of abnormal HER2 activity on a special test…

This study is testing if a special arm and leg exercise program can help protect the heart and blood vessels in women undergoing chemotherapy for breast cancer. Researchers will compare this new exercise approach to traditional treadmill walking to see which is more feasible and …

This study is testing whether women with early-stage breast cancer who have no cancer left after chemotherapy can safely skip radiation therapy after breast-conserving surgery. It will follow 352 women aged 50+ who had a complete response to chemo to see if their cancer returns w…

This is a very early study to test the safety and find the right dose of a new drug called BL-B01D1. It is for adults with advanced breast cancer or other solid tumors that have spread or cannot be removed by surgery and have few treatment options left. The main goals are to see …

This study is testing a new way to mark the area where a breast tumor was removed during surgery. The goal is to help doctors more accurately target radiation therapy afterward and to better identify if any additional tissue needs to be removed. It involves 50 adults with early-s…

This study is observing how well an existing drug called Trop-2 ADC (sacituzumab govitecan) works for breast cancer patients whose cancer has spread to the brain. Researchers will collect data from about 100 patients already receiving this drug in their normal care at multiple ho…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study aims to find out if a precise, high-dose radiation treatment called SBRT can help control breast cancer that has spread to only a few other places in the body. Researchers will look back at the medical records of 300 patients who received this treatment to see if it im…

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This study is testing whether targeted radiation therapy can safely give breast cancer patients a second chance to keep their breast when cancer returns after previous lumpectomy and radiation. The research involves 120 patients who will receive carefully planned radiation to spe…

This early-stage study is testing a new type of personalized cell therapy called GC203 TIL in adults with advanced solid tumors that have stopped responding to standard treatments. Doctors take a patient's own immune cells from a tumor, modify them in a lab to potentially fight c…

This study tests whether using patients' genetic information helps doctors personalize chemotherapy doses to reduce side effects while maintaining effectiveness. Researchers will randomly assign 860 cancer patients to either receive genetic-guided dosing or standard care. The goa…

This study is testing a new drug called YL202, given alongside other cancer treatments, to see if it is safe and effective for people with advanced solid tumors like breast or lung cancer. The main goals are to find the safest dose and see if the treatment helps shrink tumors. It…

This is the first study in people for a new drug called OKI-219, designed to target a specific genetic mutation (PI3KαH1047R) found in some advanced cancers. The main goals are to find a safe dose and see how the body handles the drug, both alone and combined with other cancer tr…

This study aims to find the best way to prevent wound complications in women who need repeat breast cancer surgery after previous radiation treatment. Researchers will compare three approaches: a week of antibiotics, a special wound vacuum dressing, or no extra treatment. The goa…

This study is testing whether a specialized radiation treatment can help control breast cancer in patients who cannot or choose not to have surgery. It aims to see if this approach safely prevents cancer from worsening while maintaining quality of life. The research focuses on pa…

This study is testing a new, non-heat-based electrical treatment called irreversible electroporation (IRE) for early-stage breast cancer. It aims to see if using IRE to destroy the tumor right before standard surgical removal is safe and effective. The research will involve 24 pa…

This study is testing a new drug called JSKN003 against standard chemotherapy for people with advanced HER2-low breast cancer that has spread or returned. It is for adults whose cancer has worsened after trying 1 or 2 prior chemotherapy treatments. The goal is to see if JSKN003 c…

This study tests an existing cancer drug called T-DXd in people with advanced breast cancer that has low levels of a protein called HER2. It aims to see how well the drug controls the cancer and improves quality of life for up to 250 participants whose cancer has spread and canno…

This international trial is comparing two different approaches for treating breast cancer that has spread to the lymph nodes under the arm. It will test whether a less extensive surgery followed by radiation leads to better quality of life and less arm swelling than the standard,…

This study is testing whether exercise can help protect the hearts of older breast cancer survivors. Many survivors face increased risk of heart problems after chemotherapy. Researchers will compare a 12-week exercise program to a gentle stretching program in 60 survivors over ag…

This study is testing whether it's safe to skip additional armpit surgery or radiation for certain breast cancer patients. It focuses on people whose initial cancer had spread to armpit lymph nodes but who show no remaining cancer there after chemotherapy. The main goal is to see…

This study is testing whether a new drug (PF-07220060) combined with letrozole works better than current standard treatments for advanced breast cancer. It's for adults with a specific type of breast cancer that has spread and who haven't had any prior treatment for their advance…

This study is testing a special breathing technique to protect the heart during radiation treatment for breast cancer. It involves holding a deep breath while radiation is delivered, which moves the heart slightly away from the treatment area. Researchers are observing 400 patien…

This study is testing two different doses of a new drug, inavolisib, when given with an existing hormone therapy (fulvestrant) for people with a specific type of advanced breast cancer. It aims to see which dose is more effective and safer for patients whose cancer has a PIK3CA m…

This study is testing an experimental drug called disitamab vedotin for people with advanced breast cancer that has spread and has a protein called HER2 on the tumor cells. It is for patients whose cancer has continued to grow despite receiving standard treatments, including othe…

This study is testing whether a combination of two drugs, trastuzumab deruxtecan and durvalumab, can effectively shrink tumors before surgery in people with stage III inflammatory breast cancer that expresses the HER2 protein. The goal is to see if this pre-surgery treatment can …

This study is testing whether a new immunotherapy combination can help people with advanced metastatic breast cancer live longer when standard treatments have stopped working. The trial will compare the experimental treatment against whatever therapy a doctor would normally choos…

This study is looking at whether adding a type of drug called a CDK4/6 inhibitor to standard hormone therapy helps prevent breast cancer from returning after surgery. It will involve about 229 adults with a specific type of breast cancer (HR+/HER2-) that has not spread. The main …

This large, late-stage trial is testing whether adding an experimental drug called gedatolisib to two standard breast cancer medications works better than the standard two-drug combination alone. It's for people with advanced HR-positive, HER2-negative breast cancer that has wors…

This study is testing a new drug combination called inavolisib for people with early-stage breast cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if giving these drugs before surgery can safely shrink or eliminate the tumor. The study will enroll a…

This study is testing a new treatment sequence for high-risk breast cancer. It aims to see if giving a short, targeted radiation treatment along with an immune-boosting drug directly into the tumor can better prepare the body's immune system before starting standard chemotherapy.…

This study is testing whether patients and surgeons are comfortable with a random assignment to either biological (animal tissue) or synthetic (man-made) mesh during breast reconstruction after cancer surgery. The research involves 60 women who will be randomly assigned to receiv…

This study is testing a new oral drug called ACE-86225106 to see if it is safe and can help control advanced solid tumors in adults. It is for people with cancers like ovarian, breast, or prostate cancer that have not responded well to standard treatments. The main goals are to f…

This study is testing whether a much faster radiation treatment schedule is safe and effective for certain breast cancer patients. Instead of weeks of daily treatments, participants receive three radiation sessions over about two days. Researchers will track side effects, cancer …

This is a first-in-human study testing a new cancer drug called AVA6000 in patients with advanced solid tumors that have spread or cannot be removed by surgery. The drug is a modified version of a common chemotherapy (doxorubicin) designed to be activated only inside tumors, pote…

This large study aims to find out if adding chemotherapy is better than not using it for young, premenopausal women with early-stage, hormone-sensitive breast cancer that has a low-to-intermediate risk of returning. All participants will receive standard hormone-blocking treatmen…

This study is testing whether freezing small, early-stage breast tumors is as effective as surgery. It's for women aged 50+ with specific low-risk cancers. The goal is to see if this less invasive procedure leads to better quality of life and cosmetic results while still controll…

This study is testing a much shorter radiation schedule for women with early-stage breast cancer. After a lumpectomy, participants receive just 5 concentrated radiation treatments instead of the standard longer course. The main goal is to see if this shorter approach is safe and …

This study is testing whether a more targeted radiation treatment is just as good as the standard, broader radiation at keeping breast cancer from coming back. It involves over 1,600 women with early-stage breast cancer who have had surgery and have a small amount of cancer in 1-…

This is a first-in-human study to test a new investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard therapies. The main goals are to find a safe dose, understand the drug's side effects, and see how…

This study is testing whether adding a new drug called inavolisib to two existing breast cancer drugs works better than the standard two-drug combination. It is for people whose advanced breast cancer has stopped responding to hormone therapy and who have a specific genetic patte…

This study is testing whether slowly increasing the dose of the breast cancer drug abemaciclib over 2-3 weeks can help patients better tolerate the treatment. The goal is to reduce severe diarrhea, a common side effect, so more people can stay on the full, recommended dose. The t…

This study is testing a new cancer vaccine made from a patient's own or donated tumor cells. The cells are modified in a lab to train the patient's immune system to attack the cancer, then injected back into the patient. The goal is to see if this approach can help people with ad…

This study is for women with a specific, hard-to-treat type of triple-negative breast cancer who have already had surgery. It aims to see if adding a drug called 'antivascular therapy' to standard chemotherapy is better at preventing the cancer from returning than chemotherapy al…

This study aims to see if having patient navigators—guides who help patients through the healthcare system—improves completion rates of radiation therapy for breast and prostate cancer. It focuses on African American, Native American, and Hispanic/Latino patients. Researchers wil…

This study is for people with breast cancer that has spread to underarm lymph nodes, even after receiving chemotherapy or hormone therapy before surgery. It aims to find out if treating these lymph nodes with radiation is as good at controlling cancer as surgery, but with less ri…

This study observes how well the drug Disitamab vedotin (RC48-ADC) works and what side effects it causes for people with breast cancer in real-world settings. It will follow 45 patients who are already taking or have taken this medication. The main goal is to see how long patient…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This study is testing whether a special web application can help breast cancer patients better follow their prescribed hormone therapy after initial treatment. Researchers will compare patients using the app to those receiving standard care to see if it improves how consistently …

This study is testing whether a 12-week Pilates exercise program can help strengthen bones in breast cancer survivors who are taking hormonal therapy. Hormonal therapy can weaken bones, increasing the risk of osteoporosis. Researchers will measure changes in bone density and qual…

This study is testing a new, all-oral (pill-only) chemotherapy combination for people with early-stage breast cancer who need treatment after surgery. The goal is to see if taking these pills at home is as effective and manageable as traditional IV chemotherapy given in a clinic.…

This large Phase 3 trial is testing whether an immunotherapy called GLSI-100 can prevent breast cancer from returning in patients at high risk for recurrence. The study involves 750 people who have already finished their standard breast cancer treatments but still have a high cha…

This study is testing whether a new daily pill (PF-07248144) combined with a standard hormone injection (fulvestrant) works better than current standard treatments for advanced breast cancer. It is for people whose cancer has continued to grow despite prior hormone-based therapy.…

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This study is testing whether giving higher doses of radiation before surgery can better shrink early-stage breast tumors. Researchers will give increasing radiation doses to 21 women with favorable breast cancer types to find the highest safe dose. The goal is to see if this app…

This study tests a program designed to help Black women with breast cancer better follow their medication and treatment plans. It compares a special support program led by fellow survivors against standard care materials. The goal is to see if better communication with doctors le…

This early-stage study is testing a new drug combination called BMS-986507 in adults with advanced lung or breast cancer that has spread. The main goals are to find a safe dose and see how the body processes the drug, while also looking for early signs that it might help control …

This study is testing a new way to coordinate care for cancer patients who also have other ongoing health problems like diabetes or high blood pressure. It will involve 340 patients with breast, gastrointestinal, or blood cancers. The goal is to see if better teamwork between can…

This study is testing if adding the drug capivasertib to standard hormone therapy can help people with a specific type of advanced breast cancer stay on their treatment longer and maintain their quality of life. It is for adults whose cancer has continued to grow despite prior ho…

This large study is testing whether women with breast cancer who have no signs of cancer in their armpit lymph nodes on an ultrasound after chemotherapy can safely skip having those lymph nodes surgically removed. The goal is to see if avoiding this surgery leads to similar long-…

This study is testing the safety and effectiveness of a new drug, VS-6766, when combined with two existing breast cancer drugs (abemaciclib and fulvestrant). It is for people with advanced HR+/HER2- breast cancer that has worsened despite prior standard treatments. The goal is to…

This study is testing a new approach to see if many women with early breast cancer can safely skip radiotherapy after surgery. Researchers will use a special MRI scan and detailed tissue analysis to identify patients with a very low risk of the cancer returning. If successful, th…

This study is testing whether adding one or two new drugs to standard hormone therapy can help control advanced breast cancer that has stopped responding to previous treatments. It will enroll 118 women whose cancer is hormone-receptor positive and HER2-negative, and has grown de…

This study is comparing a newer drug, trastuzumab deruxtecan (T-DXd), to the standard pre-surgery treatment for people with non-metastatic HER2-positive breast cancer. About 370 participants will be randomly assigned to receive either the new drug or the standard treatment for th…

This study is testing if adding a new drug called JS105 to two standard breast cancer medications works better than the standard two-drug combination alone. It is for adults with a specific type of advanced breast cancer that has returned or spread and has a PIK3CA gene mutation.…

This early-stage study is testing a personalized treatment for advanced breast cancer. Doctors take a patient's own immune cells from a tumor sample, grow large numbers of them in a lab, and then infuse them back into the patient. The goal is to see if this 'TIL therapy' is safe …

This study is testing if adding an existing antifungal drug, posaconazole, to standard chemotherapy and immunotherapy can improve treatment results for patients with triple-negative breast cancer before surgery. Researchers aim to see if this combination helps more patients achie…

This early-stage study is testing a new drug called GDC-0587, both alone and combined with another cancer drug, for people with advanced breast cancer. It is specifically for patients whose cancer has continued to grow despite treatment with a common class of drugs called CDK4/6 …

This study is testing if a technique called 'systematic shaving' during breast-conserving surgery can help surgeons remove all the cancer in one operation. It compares the new shaving method to standard surgery in 234 patients to see if it leads to fewer cases where cancer cells …

This study is testing a new, less invasive treatment for early-stage breast cancer. It compares a technique that freezes and heats the tumor (cryo-thermal ablation) against standard breast-conserving surgery. The main goal is to see if the new method is as effective at preventing…

This study is testing if a drug called dapagliflozin can protect the heart from damage caused by a common and powerful type of breast cancer chemotherapy. It will involve 40 breast cancer patients who are scheduled to receive anthracycline chemotherapy. The goal is to see if taki…

This study is testing if a 16-week supervised exercise and lifestyle program can improve heart health and fitness in women who have had early-stage breast cancer. It will enroll 100 survivors to see if the program helps their heart function, reduces body fat, and improves their q…

This study is testing if giving a standard cancer drug (paclitaxel) over a longer time to patients with low muscle mass results in drug levels similar to those seen in patients with normal muscle mass. The goal is to see if this personalized timing approach could make the treatme…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This study is testing whether older women with early-stage, low-risk breast cancer can safely skip hormone therapy (endocrine therapy) after surgery and radiation. It aims to see if radiation alone can effectively control the cancer while improving quality of life by avoiding the…

This study aims to see if switching between two different targeted drug combinations helps control advanced HER2-positive breast cancer for a longer time after the first treatment stops working. It will involve 600 women whose cancer has spread and who have already tried one of t…

This study is for people whose hormone-positive, HER2-negative breast cancer has returned in the breast or nearby lymph nodes after initial treatment. It tests if adding a drug called abemaciclib to standard hormone therapy is better at preventing the cancer from coming back or s…

This study is testing if freezing a tumor (cryoablation) followed by an immunotherapy drug (pembrolizumab) before surgery can help prevent cancer from coming back in women with a hard-to-treat type called triple-negative breast cancer. It's for women who still have cancer after i…

This is a first-in-human study to test the safety and side effects of a new drug called BL-B16D1. It will involve adults with advanced breast cancer or other solid tumors that have spread and cannot be removed by surgery, and who have run out of standard treatment options. The ma…

This study is testing which of two chemotherapy combinations works better to shrink tumors before surgery for triple-negative breast cancer, an aggressive type. Researchers will compare nab-paclitaxel with carboplatin versus nab-paclitaxel with epirubicin in 520 women. The goal i…

This study is testing whether a mobile app can help people with a specific type of breast cancer stay on their prescribed medication. It will compare 240 patients who use the app with those who don't, tracking who continues their treatment over a year. The app provides informatio…

This study aims to monitor the safety of an already-approved breast cancer drug, trastuzumab deruxtecan, specifically in Indian patients. It will enroll 100 adults with advanced, HER2-positive breast cancer that has spread and who have already tried other HER2-targeted treatments…

This study is testing whether a new drug called elacestrant works as well alone as it does combined with standard ovarian suppression therapy in premenopausal women with early-stage breast cancer. Researchers will give 140 participants either the single drug or the combination fo…

This study is testing whether cancer patients can safely receive more of their routine care through video visits from home instead of traveling to the clinic. It involves 1,750 people with breast or prostate cancer who have already had several clinic visits. The goal is to see if…

This study is testing a new approach for early-stage, low-risk breast cancer. It compares a single dose of radiation given right during surgery to the standard treatment of weeks of daily radiation afterward. The main goal is to see if the one-time treatment causes less fatigue w…

This study compares two different drug combinations given before surgery for HER2-positive breast cancer. Researchers want to see if a newer drug (pyrotinib) works as well as the current standard drug (pertuzumab) when combined with two other medications. The study will measure h…

This early-stage trial is testing a personalized vaccine for people with high-risk triple-negative breast cancer who still have cancer cells after standard chemotherapy and surgery. Doctors create a custom vaccine from the patient's own tumor and immune cells, aiming to train the…

This large study is testing whether adding a CDK4/6 inhibitor drug to standard hormone therapy helps prevent breast cancer from coming back in high-risk patients. It involves about 1,900 women with a specific type of early-stage breast cancer (HR+/HER2+) who have already complete…

This early-stage study is testing a new radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head/neck, and other solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose, see how the body process…

This study is testing whether treating insomnia first helps breast cancer survivors lose weight more effectively. Researchers will compare two approaches: one group receives insomnia treatment before weight loss coaching, while the other gets basic sleep education first. The stud…

This study is testing an experimental drug called YL202 in people with advanced solid tumors that have spread or can't be removed by surgery. The trial aims to see if YL202 can shrink tumors and control cancer growth while monitoring side effects. It will enroll 200 adults in Chi…

This early-stage study is testing the safety of a new type of treatment called CAR-T cell therapy for adults with triple negative breast cancer that has returned or stopped responding to other treatments. Doctors will collect a patient's own immune cells, modify them in a lab to …

This study aims to personalize radiation therapy for breast cancer patients based on their individual risk of the cancer returning and their personal likelihood of experiencing side effects. Researchers will use a blood test to predict a patient's sensitivity to radiation and gro…

This study aims to find the best way to treat breast cancer that has returned in the breast or nearby lymph nodes after initial treatment. It will follow 500 patients who receive standard repeat radiation, with or without added heat therapy (hyperthermia), to see which approach b…

This study is testing if combining two drugs, capecitabine and elacestrant, works better than just capecitabine alone for people with advanced, hormone-sensitive breast cancer. It's for patients whose cancer has stopped responding to a common class of prior medications. The main …

This early-stage trial is testing the safety and effectiveness of combining two drugs, neratinib and ruxolitinib, for a difficult-to-treat form of breast cancer. It is for people whose triple-negative breast cancer has spread and returned to the chest wall after previous chemothe…

This study aims to see if adding a low-dose, continuous chemotherapy pill (capecitabine) to a standard two-drug treatment works better for controlling advanced breast cancer that has spread to internal organs like the liver or lungs. It will involve 258 women whose cancer is horm…

This study is testing if it is safe for some breast cancer patients to skip surgery. It is for women with triple negative or HER2+ breast cancer who have no visible cancer left after completing chemotherapy and radiation. The main goal is to see if these patients can have the sam…

This early-stage study is testing a new oral medication called INX-315 in people with advanced cancers that have spread or stopped responding to standard treatments. It aims to find a safe dose and see if the drug can help control cancers like certain types of breast and ovarian …

This study is testing whether an artificial intelligence (AI) model can help doctors choose the next treatment for people with advanced breast cancer. It focuses on patients whose cancer has started growing again after their first targeted therapy. The AI will analyze tumor data …

This study is for people with a common type of early-stage breast cancer who are at higher risk of the cancer coming back. The main goal is to see if a special blood test can find tiny traces of cancer (called ctDNA) before a person feels sick or a scan shows anything. If the blo…

This study is testing whether a targeted surgical approach to remove cancerous lymph nodes in early-stage breast cancer patients can effectively control the disease and prevent it from returning. The trial will follow 45 women with hormone-positive breast cancer who have small am…

This trial aims to find the best drug combinations for different types of breast cancer before surgery. It tests new drugs alongside standard chemotherapy in 5,000 women with early-stage or locally advanced breast cancer. The study uses tumor analysis and MRI scans to match treat…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This study is testing a personalized cell therapy for people with metastatic cancer that has not responded to standard treatments. Doctors take a patient's own white blood cells, genetically modify them in a lab to better recognize and attack their specific cancer, and then infus…

This is the first study in people to test a new drug called XMT-1660 for several types of advanced solid tumors that have returned or spread. The main goals are to find a safe dose and see what side effects it causes. Researchers will also look for early signs that the drug can s…

This study compares two surgical approaches for removing early-stage breast cancer while preserving healthy breast tissue. Researchers are testing whether using a special localization device called Savi Scout® can help surgeons remove less healthy tissue during surgery without le…

This early-stage study is testing a new type of cancer drug called MBRC-201 in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe and effective dose and to see how the body processes the drug. The study will en…

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This study is testing a new decision-making tool for women aged 70 and older who have a common, low-risk type of early breast cancer. The goal is to see if giving patients a detailed guide and training their surgeons in shared decision-making leads to fewer aggressive treatments …

This early-stage study is testing a new drug called CLR 125 in people with advanced triple-negative breast cancer that has come back or stopped responding to other treatments. The main goals are to find the safest and most effective dose for future studies and to understand what …

This study is testing whether a shorter 5-day radiation schedule works as well as the standard 9-day schedule for early-stage breast cancer. Researchers want to see if patients report similar satisfaction with their breast appearance and experience similar side effects. The trial…

This early-stage study is testing a new drug called BL-M07D1 for people with advanced cancers that have a specific marker called HER2. The trial aims to find the safest dose and see if the drug helps control cancer growth in patients who have already tried standard treatments. Re…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is testing if a single, high-precision dose of radiation is as effective and safe as the standard 5-dose treatment for certain early-stage breast cancers. It aims to see if the one-time treatment can control the cancer just as well while potentially being more convenie…

This trial is testing several new drug combinations for people with early-stage breast cancer who are scheduled for chemotherapy before surgery. It compares these new treatments to the current standard of care to see which works better. The study is designed to be flexible, allow…

This study is testing a new drug called TER-2013 in people with advanced solid tumors that have specific genetic changes. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients who have run out of standard treatment options.

This study is testing whether shorter courses of radiation therapy are as safe and effective as standard, longer courses for breast cancer patients who have had surgery. It will enroll about 768 men and women at higher risk of their cancer returning. The main goal is to see if th…

This study is for people with advanced triple-negative breast cancer whose disease is stable or shrinking after initial treatment. It aims to see if continuing immunotherapy with longer time between doses works as well as the standard schedule at keeping the cancer under control.…

This study is testing whether a handheld robotic device called HandX can help surgeons safely perform a type of mastectomy that uses a small side incision. The goal is to remove breast tissue while preserving the nipple and skin, aiming for less scarring and better cosmetic resul…

This study is testing whether adding an experimental drug called evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better for people with advanced triple-negative breast cancer who also have metabolic issues like high blood sugar or obesity. About 55 participants w…

This is the first study in people for a new drug called BL0175. It aims to find a safe dose and see if it can help control advanced breast, ovarian, or endometrial cancers that have stopped responding to standard hormone therapies in postmenopausal women. The study will closely m…

This early-stage trial is testing a two-part personalized treatment for adults with advanced solid cancers that have spread and contain specific KRAS gene mutations. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells w…

This study is testing whether adding a drug called ribociclib to standard radiation therapy is safe for women with high-risk, hormone-positive breast cancer. The goal is to see if this combination can better control the cancer and prevent it from coming back after surgery. Resear…

This study is testing whether a single, highly focused dose of radiation given before breast cancer surgery is safe and effective. It uses a special machine called GammaPod that targets only the tumor area to spare healthy tissue. Researchers want to find the best dose that minim…

This early-stage study is testing a new type of personalized immune cell therapy called CAR-T for people with advanced lung or breast cancer that has stopped responding to standard treatments. The therapy involves collecting a patient's own immune cells, modifying them in a lab t…

This study is testing a targeted cancer treatment approach for Nigerian women with HER2-positive breast cancer. Participants receive a combination of targeted drugs and chemotherapy both before and after surgery. The research aims to see how effective and safe this treatment is f…

This is an early-stage study testing a new drug called BL-M07D1 for people with advanced breast cancer and other solid tumors that have spread or cannot be removed by surgery. The main goal is to find a safe dose and check for side effects in a small group of patients whose cance…

This study is testing whether keeping blood pressure extra low during breast cancer chemotherapy is safer and more effective at preventing heart damage than standard blood pressure care. Researchers will compare two different blood pressure targets in 130 women receiving chemothe…

This is the first study in people testing a new oral drug called BBI-940 for advanced or metastatic breast cancer. The main goal is to find a safe and tolerable dose, either alone or combined with another cancer drug. Researchers will enroll about 96 adults whose cancer has progr…

This is an early-stage study testing a new vaccine designed to teach the body's immune system to recognize and attack HER2-positive breast cancer cells. It is for people with high-risk, locally advanced breast cancer who have already completed standard HER2-targeted therapy. The …

This study is testing whether a computer algorithm called ENLIGHT can find better treatment options for people with aggressive, metastatic breast cancer that has stopped responding to standard therapies. Researchers will analyze a tumor sample from each participant using the algo…

This global Phase 3 trial is testing which of two drug combinations works better to control advanced breast cancer that has a specific genetic change (PIK3CA mutation) and has worsened after standard hormone therapy. It will enroll about 540 adults whose cancer has returned or sp…

This small pilot study is testing a new, highly personalized approach to treating advanced breast or stomach cancer. For each of the 10 participants, scientists will first use lab tests on their own tumor cells to find the best drug combination. Then, an artificial intelligence (…

This large, global study is testing whether a new drug called elacestrant works better than standard hormone therapy at keeping breast cancer from returning. It will involve over 4,200 people with a specific type of early-stage breast cancer that has spread to lymph nodes and has…

This study is testing a new type of personalized cancer treatment called CAR-T cell therapy. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer cells that have a specific marker called CD70, and then infuse them back …

This study is testing a new drug called GDC-4198 for people with advanced breast cancer that has stopped responding to standard treatments. Researchers will compare GDC-4198 alone and combined with another drug against the current standard treatment to see which works better and …

This study is testing whether adding an experimental drug called QL1706 to standard chemotherapy works better than chemotherapy alone when given before surgery for a common type of breast cancer (HR+/HER2-). It will involve 238 women to see if the combination helps eliminate all …

This is an early-stage study to test the safety and initial effectiveness of a new oral drug called BG-75202. It will be given to people with advanced breast cancer and other solid tumors who have run out of standard treatment options. The study will first test the drug alone to …

This study is testing a combination of two drugs, Sac-TMT and KL-A167, as a treatment given before surgery for triple-negative breast cancer. The goal is to see if this combination can effectively shrink or eliminate the tumor and is safe for patients. The trial will enroll about…

This study is testing whether adding immunotherapy drugs (pembrolizumab with or without olaparib) to standard radiation therapy is safe and more effective at controlling metastatic breast cancer than radiation alone. It is for adults with specific types of breast cancer (triple-n…

This study is testing two new imaging agents for PET/CT scans to see if they can better detect and characterize breast cancer tumors. The goal is to see if these new scans can more accurately show where cancer is located and how much of certain proteins the tumors have. This coul…

This study is testing whether a newer type of PET scan (using a tracer called 68Ga-FAPI-46) is better at finding where estrogen-positive breast cancer has spread compared to the standard scan (18F-FDG). Researchers will enroll 20 women with this type of breast cancer to see if th…

This study aims to find out how often breast cancer spreads to the brain without causing symptoms in patients with aggressive forms of the disease. Researchers will use MRI brain scans, blood tests, and questionnaires with 100 participants who have specific types of stage IIb or …

This study is testing whether a safe fluorescent dye called indocyanine green (ICG) can help surgeons find lymph nodes during mastectomy surgery for breast cancer. Researchers want to see if this dye works as well as the standard radioactive tracer method when surgeons use the sa…

This study is testing if a specialized type of PET scan, called an FES PET/CT, can help doctors better see and plan radiation treatment for breast cancer that has spread to the brain. The scan will be given to 20 patients before their standard radiation treatment. Researchers wil…

This study aims to develop an artificial intelligence (AI) tool that can predict whether breast cancer will spread to other parts of the body. Researchers will analyze existing tissue samples from 400 patients who had breast cancer surgery between 2015 and 2025. The AI will exami…

This study is testing a new blood test designed to detect five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will analyze tiny particles in the blood using a special light-based technique and artificial intelligence. The goal is t…

This study is testing a new, detailed ultrasound imaging technique to see if it can better spot and identify cancerous tumors in the breast, liver, and kidney. It will involve 40 people, including 30 patients with known growths and 10 healthy volunteers. The main goal is to see i…

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing whether a new type of mammogram, called Contrast-Enhanced Mammography (CEM), is better than standard mammograms at finding breast cancer in women with dense breast tissue. It will enroll 1,000 women with dense breasts to compare the two methods. The goal is …

This study is testing whether adding a new blood test called DiviTum® TKa to standard monitoring helps doctors make better decisions about when to schedule imaging scans for patients with advanced breast cancer. The goal is to see if this test can reduce the burden of frequent sc…

This study aims to see if a newer type of scan called Molecular Breast Imaging (MBI) works as well as the standard MRI for detecting breast cancer in women at high risk. It will enroll 300 women who will get both scans to compare their accuracy. The goal is to find out if MBI cou…

This study is testing a magnetic liquid called Magtrace that helps surgeons find lymph nodes during breast cancer surgery. Researchers want to see how well it works at finding the right nodes and how often it causes temporary skin discoloration. They will also ask patients how an…

This early-stage study is testing a new imaging tracer to see if it can help doctors better tell the difference between cancer and normal tissue on a PET/CT scan. Researchers will give the tracer to 24 adults with specific cancers, including brain, breast, and rectal tumors, to s…

This study is testing a new device that uses light and artificial intelligence to help surgeons check if all cancer has been removed during breast-conserving surgery. The device scans the removed tissue during the operation and quickly identifies areas where cancer cells might re…

This study is testing a new method to detect breast cancer using a simple blood test. Researchers want to see if this new test is accurate and reliable for finding cancer signals. The trial is recruiting 100 healthy volunteers to help validate the test's performance.

This study is testing a new device called ARTIDIS that measures the physical stiffness of breast tissue from a biopsy. The goal is to see if this 'nanomechanical' measurement can help doctors better identify cancer type, predict how aggressive it might be, and forecast how well a…

This small pilot study aims to see if a newer type of 3D X-ray scan (called CE-DBT) can give doctors the same level of confidence as a standard MRI when looking at known suspicious areas in the breast. Researchers will recruit 20 women who are already scheduled for or have recent…

This study is testing a new type of breast scan that uses a special tracer to light up estrogen-positive breast cancer. The goal is to see if this scan can create a clearer, more detailed picture of the cancer's size and location within the breast than standard imaging. About 20 …

This study is testing a new type of MRI scan designed to see inside breast tumors in a special way. The scan looks for 'leaky' areas where cancer cells might escape into the bloodstream and spread. Researchers want to see if this scan can help doctors identify which patients have…

This study aims to develop a new blood test using artificial intelligence to help doctors better treat triple-negative breast cancer. Researchers will analyze tiny particles in the blood and tumor tissue from 130 patients to create a test that can predict how well chemotherapy is…

This large study aims to find out if a robotic ultrasound system can find breast cancer as effectively as a human sonographer. It will involve 70,000 women aged 35-64 who have no history of breast cancer. Participants will be randomly assigned to receive their screening ultrasoun…

This study is testing a new type of imaging scan (called 18F-FFNP PET/MRI) to see if it can predict how well a patient's breast cancer will respond to hormone therapy given before surgery. Researchers want to know if this scan, performed early in treatment, can reliably show whet…

This study is testing a new device designed to find and analyze individual cancer cells in the blood of people with breast cancer. The goal is to see if this 'liquid biopsy' can help doctors better understand a patient's cancer and guide treatment decisions. The study will enroll…

This study is testing a new type of imaging scan called PYLARIFY PET-CT. The goal is to see if it can more accurately detect when cancer has spread (metastasized) in patients with pancreatic, liver, or breast cancer. Researchers will compare the new scan's results to current stan…

This study is testing a personalized blood test to see if it can predict whether high-risk early breast cancer will come back after chemotherapy. It will enroll 1,800 patients who are about to start chemo and follow them for over 5 years. The goal is to see if tiny traces of canc…

This study is testing whether a new 3D imaging system used right in the operating room helps surgeons better see if they've removed all the cancer during breast-conserving surgery. 314 patients will be randomly assigned to have their removed tissue checked with either the standar…

This study is observing whether a new, high-resolution PET-CT scan of a tumor immediately after it's removed can help surgeons and doctors. The goal is to see if the scan's images match the lab results and if using this information during surgery leads to better long-term outcome…

This study is testing a small marker device called OneMark to see if it helps doctors better locate breast cancer. It will be compared to a standard marker during surgery and checked over time in patients being monitored. The goal is to see if OneMark is easier for surgeons and r…

This study is testing a new two-part imaging method to help surgeons see breast cancer tumors more clearly. First, participants get a special MRI scan before surgery. Then, they receive an experimental fluorescent dye (pHLIP ICG) that makes cancer cells glow under a special camer…

This study is testing a new method to detect breast, lung, and pancreatic cancers through a blood test. Researchers will measure specific enzyme levels in blood samples from 220 participants, including cancer patients and healthy volunteers. The goal is to see if this test can di…

This pilot study is testing whether a fluorescent green dye can help surgeons find the first lymph nodes where breast cancer might spread. Researchers will compare this new method to the current standard radioactive tracer technique. The study involves training surgeons and then …

This study is testing if a newer type of mammogram that uses a safe contrast dye is better at finding breast cancer than the current standard 3D mammogram for women with dense breast tissue. It will involve over 2,000 women aged 45-74 who have dense breasts. Participants will get…

This study is testing if a simple, handheld ultrasound machine can help sort breast lumps found during a physical exam. The goal is to quickly identify lumps that are likely harmless, so those women can avoid unnecessary mammograms and biopsies. This could reduce wait times at bu…

This small, early-stage study is testing a new type of PET scan to see if it can predict which patients with a specific type of breast cancer (HER2-positive) will respond well to targeted therapy drugs. Researchers will give participants a special imaging tracer and use a combine…

This study is testing whether a new artificial intelligence (AI) tool called Mirai can better identify women at high risk for breast cancer compared to current standard methods. Researchers will invite about 200 women identified as high-risk by either method to receive an MRI sca…

This study is testing whether regular MRI brain scans can help find breast cancer that has spread to the brain earlier than usual. It involves patients with certain aggressive or metastatic breast cancer types where brain screening is not currently standard. The goal is to see if…

This study aims to help doctors choose better treatments for breast cancer patients by analyzing the genetic makeup of their tumors. Researchers will test tumor tissue from 1,600 participants to identify specific genetic changes that might respond to targeted therapies. The goal …

This study is testing a new type of PET/CT scan to see if it can accurately check whether breast cancer has been cleared from underarm lymph nodes after a patient completes pre-surgery drug treatment. The goal is to find a better, non-invasive way to assess treatment success befo…

This study is testing whether a special type of mammogram called contrast-enhanced mammography (CEM) can help doctors better decide which suspicious breast findings need a biopsy. The research involves 2,100 women who have been told they need a biopsy for a suspicious breast find…

This study is testing whether a special green dye that glows under a camera can find lymph nodes as accurately as the current standard method in breast cancer patients who have had chemotherapy first. During surgery, doctors will use both the new glowing dye and the standard meth…

This study is testing a new method to check if breast cancer has spread to lymph nodes after chemotherapy. Researchers will mark a cancerous lymph node before treatment, then remove it along with a few others after chemotherapy to see if this smaller procedure is as accurate as r…

This study is testing if a special type of mammogram that uses a contrast dye can work as well as a breast MRI to see if chemotherapy successfully shrank a breast tumor before surgery. It involves about 30 people with locally advanced breast cancer who are getting chemotherapy be…

This study is testing if adding a special type of mammogram that uses contrast dye every two years helps find returning breast cancer more effectively in women with a personal history of the disease. It will involve 1,500 women who get their regular annual mammogram plus this ext…

This study is testing a new method to help surgeons find the most important lymph nodes during breast cancer surgery after chemotherapy. Researchers inject a safe magnetic tracer before chemotherapy starts, aiming to 'mark' key lymph nodes so they can be accurately found and remo…

This large study is testing whether using artificial intelligence (AI) to help radiologists read mammograms is as good at finding breast cancer as the current standard method, which uses two radiologists. It aims to see if AI can save time for doctors while keeping screening just…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study aims to improve breast cancer diagnosis in Nigeria by training local radiologists. Using tablet-based mobile health devices, researchers will teach doctors how to perform ultrasound-guided breast biopsies, a more precise method than current options. The goal is to crea…

This study is testing a new, non-radioactive method to find the first lymph nodes where cancer might spread. It compares a special contrast-enhanced ultrasound to the current standard method that uses a radioactive dye. The goal is to see if the ultrasound method works just as we…

This study is testing a new device called SPCTRone that helps surgeons check if they've removed all the cancer during breast-conserving surgery. The device uses light patterns and artificial intelligence to analyze tissue right in the operating room. Researchers will compare the …

This study is testing a new type of imaging that combines a standard MRI scan with a special light-based scan. It aims to see if this combined approach can better detect breast cancer. The trial will involve 20 women who have recently been diagnosed with breast cancer. The goal i…

This study aims to help hospitals switch to a new method for finding the first lymph node where breast cancer might spread. The new method uses a safe green dye and a special camera during surgery, instead of a radioactive tracer that requires an extra hospital visit. Researchers…

This study is testing whether a drug called dapagliflozin can protect the heart from damage caused by a common type of breast cancer chemotherapy. About 100 women receiving anthracycline chemotherapy will take either dapagliflozin or a placebo pill daily during treatment. Researc…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and education through mobile mammography units. It will enroll 1,000 underserved women in Texas who are already scheduled for a mammogram. The goal is to…

This study aims to find better ways to catch breast cancer early in women who are at high genetic risk. Researchers will test whether shorter, faster MRI scans work as well as traditional full-length MRIs for regular monitoring. The study will create a registry of 400 high-risk w…

This study is testing whether a comprehensive prevention program can help drain fluid from the arm and stop lymphedema (chronic arm swelling) from developing. It involves 285 women with breast cancer who are having surgery to remove lymph nodes under their arm. The main goal is t…

This study is testing a community outreach program to help more people get screened for breast, lung, and prostate cancer. It aims to connect 200 underserved adults at community spots to screening services and help them navigate follow-up care if needed. The goal is to see if thi…

This large international study is testing if giving patients a lidocaine (a common numbing medicine) infusion during and for 24 hours after breast cancer surgery can prevent them from developing moderate or severe chronic pain one year later. It will enroll 4,300 women and compar…

This study is testing a phone-based coaching program designed to help Latina women who are at high risk for breast cancer. The goal is to see if this support helps more women get recommended cancer screenings and genetic services. The program involves three weekly phone sessions …

This study is testing if a short educational video can help patients use fewer opioid painkillers after breast reconstruction surgery. Researchers will compare opioid use in patients who watch the video to those who receive standard care. The goal is to prevent long-term opioid d…

This study is testing whether very low doses of two existing breast cancer drugs, exemestane and tamoxifen, can help prevent breast cancer in postmenopausal women at high risk for the disease. The main goal is to see which low-dose option has a better impact on women's quality of…

This study is testing a program designed to help more Native American women get breast cancer screening mammograms. It will involve 200 women from the Navajo Nation who are overdue for a mammogram. The program uses a tablet-based education tool and may also include one-on-one sup…

This study is testing whether placing small antibiotic beads near breast tissue expanders during reconstruction surgery can prevent infections. Researchers want to see if this local antibiotic delivery reduces the risk of surgical site infections and fluid buildup (seroma) in the…

This study is testing if a digital chatbot can help women, especially from underserved communities, follow through with recommended breast cancer screening and follow-up care. It will enroll 2,700 women who recently had a mammogram. Half will receive usual care, and the other hal…

This study is testing an online program designed to help women at high risk for breast cancer lower their risk through lifestyle changes. The program includes a webinar and a personalized virtual visit to create a prevention plan. Researchers want to see if women find the program…

This study is testing if a special wound dressing that applies gentle suction (negative pressure therapy) can prevent infections and poor healing after complex breast cancer surgery. It will involve 254 women at high risk for healing problems, such as those who smoke, have diabet…

This large international study is testing if giving an intravenous drug called lidocaine during breast cancer surgery can prevent patients from developing long-lasting pain months later. Over 1,600 patients will be randomly assigned to receive either the lidocaine infusion or a p…

This study is testing whether two non-drug methods—acupuncture and compression sleeves—can prevent nerve damage, a common and painful side effect of breast cancer chemotherapy. Researchers will compare using acupuncture alone, compression sleeves alone, both together, or standard…

This study is testing whether arm-based aerobic exercise can improve artery health and reduce heart disease risk in women who have completed breast cancer treatment. Researchers will measure artery stiffness and exercise capacity in 18 participants before and after an exercise tr…

This study is testing a peer-led support course designed specifically for Black women who have survived breast cancer. Researchers want to see if this community-based program improves participants' quality of life by addressing social and environmental challenges. The study invol…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study compares two exercise programs to help women recover after breast cancer surgery. Researchers want to see if 12 weeks of supervised dragon boat racing with a coach works better than following exercise videos at home alone. They will measure changes in body composition,…

This study is testing two different group exercise programs to see which one better helps breast cancer survivors build muscle mass. The research involves 30 women who have completed breast cancer treatment (except for ongoing hormone therapy). Participants will attend supervised…

This study aims to help breast cancer survivors who experience pelvic discomfort, dryness, and pain—common side effects of cancer treatments. Researchers are comparing three approaches: pelvic floor muscle exercises, a gentle radiofrequency treatment, and a combination of both. T…

This study is testing a self-help stress management program designed to help breast and gynecologic cancer patients in Vietnam cope with their diagnosis and treatment. About 285 patients will be randomly assigned to either try the new program or receive standard care. Researchers…

This study is testing a new version of a smartphone app called iCareBreast+ to see if it's helpful for women undergoing chemotherapy for breast cancer. The app provides self-care support and information. Researchers want to see if using the app for two months can improve patients…

This study is testing whether taking a creatine supplement while doing exercise helps breast cancer survivors regain strength, endurance, and muscle mass more quickly after finishing chemotherapy. Researchers will compare 60 breast cancer survivors doing exercise with or without …

This study is testing two different walking exercise programs for women receiving chemotherapy for breast cancer. It aims to see which approach is better at improving fitness and reducing cancer-related fatigue. The study will enroll 140 participants to compare a fixed weekly wal…

This study aims to see if a non-invasive light therapy called photobiomodulation can improve sexual quality of life for women with breast cancer. It focuses on 25 women who continue to experience vaginal dryness and pain despite using standard moisturizers. Researchers will measu…

This study is testing whether wearing a special headband with embedded semiconductors can help reduce memory and thinking problems, often called 'chemo brain' or brain fog, in people with breast or gynecological cancers. Researchers will enroll 50 participants who have recently f…

This study is testing if giving a steroid medication (dexamethasone) can reduce painful skin reactions on the hands and feet caused by a chemotherapy drug called liposomal doxorubicin. It will enroll 182 adults with breast cancer who are scheduled to receive this specific chemo r…

This study is testing a special pain management program designed to help breast cancer survivors who experience joint and muscle pain as a side effect of their hormone-blocking medication. The program uses counseling and coping techniques to reduce pain, improve mood and thinking…

This small pilot study is testing whether a session of Medical Reiki, a gentle hands-on energy therapy, given right before breast cancer surgery can help improve recovery and well-being. It will involve 32 women undergoing mastectomy, comparing real Reiki to a sham (pretend) vers…

This study is testing whether a simple arm-strengthening exercise program done at home can help manage lymphedema, a common and often painful swelling that can occur after breast cancer treatment. Researchers will compare two groups of 50 female participants: one doing the exerci…

This study is testing whether a 3-month strength training program is a practical way to help breast cancer survivors in Appalachia manage their fatigue. Researchers want to see if people with different income levels can stick with the program. The main goal is to understand what …

This study is testing two different arm exercise programs to help breast cancer survivors. Researchers want to see if using resistance bands and aerobic arm exercises can improve arm strength, function, and quality of life while reducing side effects like swelling and weakness. T…

This study is preparing to test a virtual mindfulness program designed to help breast and gynecologic cancer survivors address sexual health and body image concerns. Researchers will enroll 60 participants to evaluate how well the program can be delivered and studied across multi…

This study is testing whether adding vaginal radiofrequency therapy to standard moisturizer treatment can better relieve vaginal dryness and discomfort in women taking hormone therapy for breast cancer. It will compare two groups of 75 patients over six months: one using a standa…

This study is testing whether taking a specific probiotic powder for six months can help reduce the common and difficult side effects of chemotherapy in people with breast cancer. It will involve 100 participants who are receiving standard chemotherapy drugs. Researchers will tra…

This study is testing whether a single 60-minute counseling session can help reduce anxiety and depression in breast cancer patients who are waiting to start regular therapy. Researchers want to see if this brief session is helpful and practical for patients to complete. The stud…

This study is testing whether combining electroacupuncture with self-applied acupressure can help improve the day-to-day life of people with early-stage breast cancer who are going through chemotherapy. Researchers will compare the real treatments to fake versions to see if they …

This study is testing a two-part surgical technique for women who have had a mastectomy for breast cancer. It combines fat grafting (moving a patient's own fat) with a latissimus dorsi muscle flap to rebuild the breast. The main goal is to see how well this combination works and …

This study is testing whether mindfulness-based breathing exercises can help breast cancer patients better manage the symptoms and stress caused by chemotherapy. It will involve 72 patients who are receiving chemotherapy for the first time. Researchers will measure changes in sym…

This study is testing a digital health program called AYA STEPS that helps young adult cancer survivors manage symptoms like pain, fatigue, and emotional distress. The program teaches skills to improve communication with healthcare providers and engagement with recommended follow…

This study is testing whether a smartphone app can help people with early-stage breast cancer feel better while taking hormone therapy. The app provides education and self-care tips to help manage common side effects like fatigue, pain, and sleep problems. Researchers will compar…

This study is testing whether a nasal spray given before surgery can help patients feel calmer and more comfortable during breast-conserving cancer surgery. Researchers will compare the spray to a placebo (saltwater spray) in about 394 women to see if it reduces anxiety, improves…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study aims to see if a medication called solifenacin works better than clonidine to reduce hot flashes in breast cancer patients taking hormone therapy drugs like tamoxifen. It will involve 110 women who experience frequent hot flashes. Researchers will compare how well each…

This study is testing whether online group discussions can improve the well-being of Black American women diagnosed with breast cancer. Researchers want to see if these sessions help reduce feelings of depression and fatigue. The trial will compare women who participate in four o…

This study aims to find the best way to manage pain after breast cancer surgery. It will compare two different nerve-block techniques, given via ultrasound, to see which one provides better pain relief and reduces the need for opioid painkillers. The trial involves 40 women under…

This study compares two standard methods for delivering numbing medicine to breast cancer patients having a total mastectomy. Researchers want to see which approach—giving the numbing medicine before surgery versus during surgery—better controls pain and reduces the need for opio…

This study is testing whether a gentle radiofrequency treatment combined with pelvic floor exercises can help reduce vaginal dryness, pain during sex, and other menopause symptoms in women who have survived breast cancer. Researchers will compare the real treatment to a sham (fak…

This study is testing short, easy-to-use digital activities delivered via a smartphone app to help breast cancer survivors manage distress and improve their wellbeing. It will involve 120 women who are within five years of their diagnosis and are experiencing elevated anxiety or …

This study is testing a new web application designed to help cancer patients report side effects from radiation therapy. Patients with breast, gynecologic, or urologic cancers will use the app weekly to log symptoms, which are sent securely to their doctors. The system uses a red…

This study is testing whether a 16-week virtual exercise program can improve fitness, strength, and quality of life for people with stable metastatic breast cancer. Researchers will compare 100 participants who either follow the exercise plan or receive their usual care. The goal…

This study is testing whether a special computer-based brain training program can help breast cancer survivors who are struggling with memory and thinking problems, often called 'chemo brain.' Researchers will compare the brain training to a simpler computer activity in nearly 40…

This study is testing whether a vaginal suppository called Revaree Plus can improve vaginal health for women experiencing dryness and discomfort during breast cancer treatment. Researchers will enroll 60 women with hormone-receptor positive breast cancer who have completed primar…

This study is testing whether a 12-week, completely remote exercise program can help reduce the severe fatigue that often follows cancer treatment. It is designed specifically for breast and prostate cancer survivors living in rural areas who have finished their main treatment. R…

This study is testing if a specific exercise and nutrition plan can help women with breast cancer feel better during chemotherapy. Researchers want to see if supervised weight training sessions, combined with a high-protein drink after each workout, can help patients keep their m…

This study is testing whether a mobile app can help reduce cancer-related distress in young women with breast cancer. It will enroll 120 women aged 18-45 who are experiencing significant distress. The research will see if using the app for connection and education makes a measura…

This study aims to find the best way to manage pain after breast cancer surgery. Researchers are comparing two different nerve-blocking injections given before surgery to see which one better controls pain and reduces the need for strong opioid painkillers like morphine. The tria…

This study is testing if a drug called memantine, combined with a supervised exercise program, can help reduce memory and thinking problems ('chemo brain') during breast cancer chemotherapy. It will involve 90 women with early-stage breast cancer who are already reporting mild co…

This study is testing whether the medication gabapentin should be a standard part of pain management for patients having breast removal surgery (mastectomy). It involves nearly 1,900 patients at a major cancer center. The main goal is to see if using gabapentin around the time of…

This study is testing whether a special diet that mimics fasting can help reduce high cholesterol, a common side effect of certain breast cancer medications. It will involve 60 post-menopausal women with early-stage breast cancer who are already taking aromatase inhibitors and ha…

This study is testing a mobile app called TEAMWork, designed to help breast cancer patients keep their jobs during and after treatment. The app provides advice for having conversations about cancer with employers and doctors. Researchers are asking about 546 breast cancer patient…

This small study is testing whether a supervised exercise program can help reduce pain sensitivity in breast cancer survivors who have persistent pain after treatment. Researchers will work with 10 women who have completed their cancer treatment at least 6 months ago but still ex…

This study is testing a free, personalized exercise program designed to help women with breast cancer during and after treatment. The program offers flexible options including in-person, online, or home-based workouts tailored to each person's needs and treatment stage. Researche…

This study is testing whether having a nurse use hypnosis before and during breast cancer surgery can help patients need less opioid pain medication afterward. Researchers are comparing three approaches: hypnosis with local anesthesia, hypnosis before standard anesthesia, and sta…

This study is testing if a simple coloring activity can help breast cancer patients feel less anxious and distressed during chemotherapy. Researchers will have 60 patients either color mandala patterns for 30 minutes during their treatment or receive their usual care. They will m…

This study is testing whether a special breathing muscle training program can help obese breast cancer survivors exercise for longer periods and feel less tired. Researchers will compare a real breathing training program to a fake one, followed by exercise for all participants. T…

This study is testing whether a special pre-treatment program helps cancer patients feel better physically and emotionally. The program includes guided exercise and psychological support before patients undergo surgery or radiation. Researchers will compare 125 patients who recei…

This study aims to help breast cancer patients stay on their hormone therapy by better managing its side effects. Researchers will compare two approaches for women who develop bothersome symptoms: switching to a different medication versus following standard treatment guidelines.…

This study is testing whether a free, 16-week exercise program can help people with metastatic breast cancer feel better and be more active. Researchers want to see if participating in the 'Get Real and Heel' program improves quality of life, reduces fatigue, and decreases feelin…

This study is testing whether following a specific diet can help protect memory and thinking skills in women undergoing treatment for breast cancer. Researchers want to see if the MIND diet, which focuses on brain-healthy foods, can reduce the 'chemo brain' side effects that many…

This study is testing whether a 6-week online support program can help breast cancer survivors feel better mentally and emotionally after finishing their main cancer treatments. The program teaches coping skills and provides support through weekly video sessions. Researchers want…

This study is testing whether a digital support tool can help people with breast, prostate, or colorectal cancer sit less during their treatment. The goal is to see if reducing long periods of sitting improves their well-being, reduces side effects, and lowers future health risks…

This study is testing whether an artificial intelligence (AI) tool can help doctors better manage the difficult side effects of chemotherapy. Adults with breast or colorectal cancer will be randomly assigned to receive either standard care or care where doctors use AI-generated s…

This study is testing whether drinking tart cherry juice can prevent nerve pain (neuropathy) caused by a common chemotherapy drug called paclitaxel. It will enroll 86 people with breast or ovarian cancer who are starting this type of chemo. Participants will be randomly assigned …

This study is testing if a weekly cycling exercise program can help breast cancer patients better maintain their physical fitness and strength during chemotherapy. Researchers will compare a group doing 15 weeks of supervised cycling to a group receiving standard care. The goal i…

This study is testing whether using anesthesia without opioids during breast reconstruction surgery leads to less need for morphine pain medication afterward. Researchers will compare two groups of patients: one receiving traditional opioid-based anesthesia and one receiving opio…

This study is testing a 7-day wellness retreat designed for women who have finished treatment for breast or gynecological cancers. It aims to see if the retreat is practical to study and if it helps improve survivors' quality of life, reduce stress, and ease symptoms like fatigue…

This small pilot study is testing whether breast cancer patients can consistently use a topical cream called azelaic acid during their radiation therapy. The main goal is to see if using it at least twice a day is practical and tolerable. Researchers want to learn if this approac…

This study aims to improve sexual quality of life for breast cancer survivors by comparing two support approaches. Researchers will follow 264 patients who recently completed cancer treatment, offering either regular personalized sexual health support or support only when request…

This study is testing a program that combines physical therapy and yoga to help reduce pain in breast cancer patients who experience joint and muscle pain as a side effect of their hormone therapy. The program includes education so patients can practice yoga at home. Researchers …

This study is testing whether a specific nutritional supplement, called APPORTAL®, can help reduce severe fatigue in people with breast cancer who are undergoing chemotherapy. Researchers will enroll 92 female participants who are experiencing moderate to severe fatigue. They wil…

This study is testing whether a walking program can help reduce severe fatigue in older women who have finished breast cancer treatment. Researchers will compare a supervised group walking program to a home-based walking plan over 8 weeks. The goal is to see if regular walking ca…

This study is testing two different ways to deliver mindfulness training to help younger breast cancer survivors who are feeling depressed or fatigued after finishing their main cancer treatments. It will compare a live, instructor-led class over Zoom with a self-paced smartphone…

This study is testing whether following the MIND diet can help improve memory, focus, and thinking problems (often called 'chemo brain') in breast cancer survivors. It will involve 200 women who have finished their main cancer treatment but still report cognitive issues. Particip…

This study compares two anesthesia methods during breast cancer surgery to see which better prevents long-term pain. Researchers will follow 230 patients for one year after mastectomy, measuring pain levels and psychological factors. One group receives traditional opioid-based an…

This study is testing whether listening to brief guided meditation sessions during radiation therapy can help reduce anxiety for people with breast or gynecological cancers. It will compare the anxiety levels of patients who receive the meditation sessions to those who receive st…

This study is testing whether a 16-week high-intensity interval training (HIIT) exercise program can help improve memory, focus, and thinking skills in women undergoing chemotherapy for breast cancer. Researchers will compare the exercise group to a control group doing gentle str…

This study is testing a new, personalized way to perform a special arm massage (manual lymphatic drainage) to prevent painful swelling (lymphedema) after breast cancer surgery. Researchers will compare this new method, which uses a safe dye to map a patient's unique lymph system,…

This study is testing a new, custom-made mesh that dissolves over time to see if it improves the cosmetic results and safety of breast reconstruction right after a mastectomy. It is for women with breast cancer who are having their breast removed and an implant placed immediately…

This study is testing whether a group exercise program called Strength After Breast Cancer can be successfully offered in a physical therapy clinic. The program aims to help women who have finished breast cancer treatment improve their physical function and quality of life. Resea…

This study is testing whether taking tart cherry concentrate and fish oil (omega-3) supplements together for 12 weeks can reduce joint pain and stiffness in breast cancer patients. These side effects are common from a type of hormone therapy called aromatase inhibitors. Researche…

This study is testing a new remote therapy program called Nite2Day. It aims to help women with breast cancer in rural areas manage common and difficult symptoms like insomnia, fatigue, stress, and pain. Participants will have six video or phone sessions with a therapist to learn …

This study is testing whether a 12-week virtual dance program can help breast cancer survivors who have persistent pain after surgery. Researchers want to see if dancing improves pain, fatigue, body image, and overall quality of life. About 30 participants will take part in the o…

This study is testing a nutritional supplement called Epidiferphane in people with breast cancer who are receiving taxane chemotherapy. The goal is to see if the supplement can reduce common and often severe side effects like nerve pain and anemia, which frequently force patients…

This study is testing whether a 6-week online mindfulness course can help reduce stress and other treatment-related symptoms for women with breast cancer who are receiving chemotherapy. Researchers will compare 200 participants who either take the course or receive no interventio…

This study is testing if an online brain exercise program works better when a trained coach supervises it remotely. It's for people with breast cancer who have finished chemotherapy and are struggling with memory and thinking problems, often called 'chemo fog.' Researchers want t…

This study is testing four different group exercise programs to see which ones best help women recover after breast cancer treatment. It will measure improvements in fitness, muscle mass, and body fat. The goal is to find the most effective workout plans to help survivors feel st…

This study is testing whether adding acupuncture to standard anti-nausea medicine helps reduce nausea better for cancer patients undergoing chemotherapy. It will involve 90 patients who are already experiencing nausea despite taking their prescribed anti-sickness drugs. Participa…

This study is testing whether an exercise program focused on enjoyment helps breast cancer survivors stay more active than traditional exercise programs. Researchers will compare two approaches: one based on how exercise makes you feel versus one based on how hard you work. The s…

This study aims to understand how exercise might help lower breast cancer risk in women with dense breast tissue. Researchers will compare 46 inactive women who either participate in a 16-week exercise program or wait without exercise. They'll measure changes in blood and breast …

This international study aims to understand how breast and prostate cancer develop differently in people of African ancestry. Researchers will collect genetic data and health information from 1,500 Black cancer patients across 10 countries. The goal is to identify genetic pattern…

This study is developing a computer tool to predict if and where breast cancer might spread in the body. Researchers will use artificial intelligence to analyze tissue samples from 2,000 women diagnosed with breast cancer. The goal is to create a more precise prediction system to…

This study aims to understand why breast cancer outcomes differ among women, especially focusing on Black and American Indian/Alaska Native women. It will enroll 3,300 women with invasive breast cancer in North Carolina to collect biological samples, health records, and survey da…

This study aims to understand how age influences the body's response to breast cancer treatment. Researchers will compare blood samples from younger and older patients with a specific type of early-stage breast cancer before and during their standard pre-surgery (neoadjuvant) the…

This study is testing a blood test that looks for tiny pieces of leftover cancer DNA after surgery for early-stage breast cancer. Researchers want to see if finding this DNA can predict which patients are at higher risk of their cancer coming back, which could help doctors decide…

This study aims to understand how standard chemotherapy affects the quality of life, side effects, and thinking skills of 100 Dutch patients with stage III triple-negative breast cancer. It does not test a new treatment but closely monitors patients during their usual care, using…

This study aims to understand how breast cancer treatments affect ovarian health and future fertility in premenopausal women with BRCA gene mutations. Researchers will track hormone levels in the blood before, during, and after treatment to see how chemotherapy and hormone therap…

This study is testing a new type of PET scan to see how breast cancer uses a nutrient called glutamine. Up to 40 adults with breast cancer will receive an injection of a special tracer and undergo scans to see where it goes in the body. The goal is to gather information to help d…

This study aims to test a simple method for understanding the daily lives of breast cancer survivors. Researchers want to see if a 14-day mobile phone diary is a practical way to track daily stress and thinking patterns. They will recruit 30 diverse survivors who are at least fiv…

This study is creating a large database of breast cancer patients treated at a single institute to better understand long-term survival. It will track outcomes like whether the cancer spreads over five years and analyze treatment patterns. The goal is to identify factors that pre…

This study aims to understand breast cancer screening experiences for people taking hormone therapy. Researchers will collect breast imaging data and interview participants about their screening experiences, feelings, and any barriers they face. The goal is to identify ways to im…

This study aims to collect detailed genetic information and health records from 25,000 adults who have cancer or are at risk of developing it. Researchers will analyze this data to better understand how cancer develops and to identify potential targets for future treatments. The …

This early-stage study is testing a new device that uses focused sound waves guided by an MRI to heat and destroy part of a breast cancer tumor. The main goal is to see if the procedure is safe and tolerable. All participants will still have their standard surgery to remove the t…

This early-stage study aims to see if taking cannabidiol (CBD) causes biological changes in breast cancer tumors before a patient's scheduled surgery. Researchers will enroll 60 people with breast cancer and randomly give them either CBD or a placebo pill for 5 to 56 days before …

This research aims to understand how a woman's immune system responds to breast cancer, and whether having been pregnant changes that response. The study will compare women with pregnancy-associated breast cancer to those whose cancer is not linked to pregnancy. Researchers will …

This study is testing whether new computer programs (AI algorithms) can help pathologists diagnose lung and breast cancer more quickly and accurately. Researchers will look back at samples from 600 patients in four countries to see how AI compares to standard lab methods. The goa…

This study aims to understand if breast cancers in women with BRCA2 gene mutations respond differently to hormone therapy before surgery compared to cancers in women without these mutations. Researchers will measure a specific protein (Ki67) in tumor samples before and after at l…

This French study aims to compare the costs and satisfaction levels between two methods used to mark breast tumors before surgery: a magnetic clip versus the traditional metal wire. It will follow 772 women undergoing breast-conserving surgery for up to six months, collecting dat…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to understand if a person's body weight and amount of body fat change how the breast cancer drug docetaxel is processed by the body. Researchers will measure drug levels in the blood of 48 women with early-stage breast cancer who are receiving the drug as part of …

This study aims to understand if the natural bacteria (microbiome) in a person's gut and breast tissue can predict who gets an infection after breast reconstruction surgery. Researchers will compare patients who receive antibiotics after surgery to those who do not, tracking them…

This study aims to map the genetic makeup of breast and prostate cancers in Brazilian patients. Researchers will analyze DNA from both tumors and blood to understand how genetic changes affect the disease and its treatment. The goal is to build a national database to help guide f…

This study is testing whether an animated educational video helps breast cancer patients better understand DIEP flap reconstruction surgery and reduces their anxiety. Researchers will survey 300 patients before and after they watch the video at their pre-surgery appointment, then…

This study aims to learn why some early-stage, hormone-sensitive breast cancers stop responding to standard hormone-blocking drugs. Researchers will give 100 patients hormone therapy for 4-12 weeks before their scheduled surgery and then analyze the removed tumor tissue. By compa…

This study aims to find out how often breast cancer spreads to other body parts after patients complete chemotherapy and surgery. Researchers will use CT scans to check 120 patients with node-positive breast cancer at the start and again 6 months later if the first scan is clear.…

This study aims to find the best remote language interpreter method for Spanish- and Mandarin-speaking breast cancer patients with limited English skills. Researchers will compare three different interpreting approaches during doctor visits to see which one makes the fewest trans…

This study is testing whether a new laboratory instrument called See.d can properly prepare blood samples for liquid biopsy analysis. Researchers will collect blood from 25 metastatic breast cancer patients and 20 healthy volunteers to see if the device can reliably prepare plasm…

This study is testing whether a detailed molecular analysis of breast cancer tumors helps doctors choose more effective treatments when the cancer has spread. Researchers will analyze tumor samples from 500 people with metastatic breast cancer and share the results with their doc…

This study aims to understand how a common breast cancer medication (an aromatase inhibitor) changes the bacteria in a patient's gut. Researchers will check stool and blood samples from 25 participants before starting the drug and again after 4 and 12 weeks of treatment. The goal…

This study aims to improve how we predict who might get cancer and detect its return very early, before symptoms or scans show it. Researchers will analyze blood and tissue samples from 850 people with or at risk for breast, ovarian, colon, lung, or skin cancer. The goal is to fi…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a decision-making toolkit designed to help women aged 80 and older who have survived breast cancer decide whether to continue getting regular mammograms. Researchers will compare the toolkit against usual care to see if it improves decision quality and chang…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to create a collection of breast cancer tissue samples from patients. Researchers will collect small pieces of tumor tissue to study its biology, genes, and proteins. The goal is to help scientists understand how breast cancer grows and responds to treatment, whic…

This study aims to understand how certain breast cancer drugs affect body composition—specifically fat and muscle mass. Researchers will follow 30 patients with advanced breast cancer who are starting standard treatment with CDK 4/6 inhibitor drugs. They will use scans and blood …

This study observes how patients with a common type of advanced breast cancer respond to standard first-line drug combinations and what treatments doctors choose next when those drugs stop working. It involves about 245 patients already receiving care, collecting their real-world…

This study is testing a simple weekly survey tool to see if patients can help identify when their cancer treatment is at risk of being delayed. It aims to understand why delays happen, especially looking at differences between racial groups, to help design better support systems …

This study aims to understand if the timing of a woman's menstrual cycle affects how well chemotherapy works against breast cancer. Researchers will follow 100 premenopausal women with triple-negative breast cancer who are starting chemotherapy before surgery. They will collect a…

This study aims to understand how specific changes in the CTNNA1 gene affect cancer risk in families. Researchers will collect family health histories from people who carry these gene changes and their close relatives. The goal is to better define cancer risks for gastric cancer,…

This study aims to understand what breast cancer survivors know about chemicals found in common personal care products like cosmetics and shampoos. Researchers will interview 30 survivors from a specific community program to learn about their interest in this topic. They will als…

This study aims to understand how a breast cancer treatment that nearly eliminates estrogen affects the heart. Researchers will compare heart function in 90 premenopausal women receiving this therapy to those receiving other treatments, using heart scans over two years. The goal …

This study aims to find better ways to predict which women at high risk for breast cancer are most likely to develop the disease. Researchers will collect blood and breast tissue samples, along with mammogram results, from 3,000 high-risk women. The goal is to combine this inform…

This study aims to build a collection of living breast cancer tissue samples, called a biobank, from 400 patients. Researchers will collect samples at key points in a patient's journey, like diagnosis and if the cancer returns. The goal is to study how the tumor, genes, and immun…

This study is testing whether a special blood test that looks for stray cancer cells can help predict if breast cancer might come back after surgery and chemotherapy. Researchers will follow 484 women who have already completed their main breast cancer treatments to see if the te…

This study aims to understand how common sleep problems affect memory, thinking skills, and overall well-being in people being treated for breast cancer. Researchers will observe 75 patients, using sleep trackers and questionnaires to measure sleep patterns and cognitive function…

This study is creating a registry to collect information from 1,500 people with triple negative breast cancer or inherited genetic mutations. Researchers want to understand how specific genetic changes affect cancer treatment responses and long-term survival. The registry will tr…

This study is testing a decision aid tool called MyMammogram to help women aged 40-49 in rural areas make informed choices about breast cancer screening. Researchers are working with patients and doctors to refine how the tool is delivered and whether adding doctor communication …

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study aims to understand if a person's life circumstances—like income, housing, and stress levels—are linked to inflammation in the body, which can affect breast cancer. Researchers will enroll 200 women with newly diagnosed breast cancer who haven't started treatment. Parti…

This study is testing how easy it is to use a mobile tool that helps breast cancer patients learn about breast reconstruction options after surgery. Twenty breast cancer patients will try the tool on their phones while researchers observe and ask questions about their experience.…

This study is testing new artificial intelligence (AI) tools designed to help doctors make better decisions for patients with heart conditions, breast cancer, or sepsis. It will use past patient records to see if the AI can provide safe, understandable recommendations. The goal i…

This study observes how patients with advanced breast cancer respond to an existing medication called trastuzumab deruxtecan in real-world settings. Researchers will track 800 patients in Germany to understand how long the treatment works before patients need new therapy and how …

This study aims to understand how chemotherapy for early-stage breast cancer might accelerate aging in specific organs like the heart and brain. Researchers will measure aging markers in blood samples from 60 women before and after chemotherapy treatment. The goal is to identify …

This study aims to see if cancer cells and DNA found in the blood can help predict how well treatment works for aggressive, high-risk early breast cancer. Researchers will enroll 130 patients with inflammatory or triple-negative/HER2+ breast cancer. They will use blood tests to t…

This study aims to find the best order to take mammogram pictures to make the process more comfortable for women who have had breast cancer. It will enroll 400 women who have finished treatment and are getting their yearly check-up mammogram. Researchers will test four different …

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study is collecting tissue, blood, and urine samples from people with and without breast cancer to create a large repository for research. The goal is to help scientists better understand how breast cancer develops and progresses by studying these samples. Participants' heal…

This study aims to better understand the experience of patients with advanced breast cancer who are receiving care at home through hospice. Researchers will use regular telehealth check-ins to connect patients and their caregivers with their cancer care team. The goal is to learn…

This study is testing whether a simple blood test can predict if breast cancer will return after initial treatment. It will follow 180 patients whose cancer did not completely disappear after chemotherapy, taking blood samples every 6 months for 5 years. The goal is to see if tin…

This study aims to understand what treatment options doctors choose for patients with high-risk early breast cancer in real-world settings. It will follow 100 patients who are already receiving standard medical care for five years, collecting data from their medical records and a…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This research program aims to learn how people understand and act on unexpected genetic findings that could impact their health, even if those findings weren't the original reason for their genetic test. Researchers are enrolling 5,000 people who have received such findings to co…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study is testing whether a new optical scanning device called NearWave can monitor how breast cancer responds to chemotherapy before surgery. Researchers will use the device on 15 patients receiving chemotherapy to see if it collects good enough data to predict treatment suc…

This study is testing a new, highly sensitive blood test method to detect tiny particles released by breast cancer cells. Researchers will compare blood samples from 105 women with early-stage breast cancer, metastatic breast cancer, and healthy volunteers. The goal is to see if …

This study aims to learn how well two newer breast cancer drugs, ribociclib and abemaciclib, work for people in everyday medical care, not just in controlled trials. It will follow 3,000 adults with a specific type of early-stage breast cancer to see how long they stay cancer-fre…

This project is building a large, diverse research registry for people who have had breast cancer. It aims to enroll 200,000 participants from across the United States, with a special focus on including people from communities that have been historically underrepresented in medic…

This study aims to understand how cancer treatments affect women's sexual function and ability to have children. Researchers will follow 475 women with breast cancer or lymphoma, collecting questionnaires and optional blood tests over time. The goal is to learn about these side e…

This study is testing a training program called 'Just ASK™' to see if it helps doctors and nurses talk more often with breast cancer patients about joining clinical trials. Researchers will work with four cancer clinics, training their staff at different times and recording patie…

This study aims to understand how certain natural fats produced by the body might be connected to breast cancer and obesity. Researchers will compare 60 postmenopausal women, some with breast cancer and some without, and look at their weight, diet, activity levels, and blood mark…

This study aims to understand how a cancer diagnosis impacts the health, needs, and quality of life of both patients and their family members over time. Researchers will follow 240 Danish patients with certain cancers and their caregivers for 18 months, using surveys and intervie…

This study aims to understand how breast cancer changes and becomes resistant to treatment by taking multiple tissue samples from different tumor sites over time. Researchers will collect biopsy samples from 200 people with metastatic breast cancer at diagnosis and when their can…

This study is creating a registry of fluid samples from around the lungs of patients with lung cancer or infections. Researchers will collect these samples during patients' normal medical procedures to build a database for future research. The goal is to help scientists develop b…

This study aims to collect real-world information on how cancer patients experience and report their symptoms from home during treatment. About 25 adults with breast, lung, ovarian, or blood cancers will use an online platform to complete weekly surveys for at least 12 weeks. The…

This French study observes breast cancer patients taking a medication called olaparib for 12 months in real-world settings. Researchers want to see how many patients complete the full treatment course and understand factors that might affect completion. The study collects informa…

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect surveys, blood, and tissue samples from 800 participants in South Florida to look for genetic and lifestyle factors. The goal is to gather knowledge that may he…

This study looks back at the medical records of 300 people with early-stage, HER2-positive breast cancer who received a standard two-drug targeted therapy. Researchers want to understand if having extremely high levels of the HER2 protein is linked to a higher chance of the cance…

This study aims to understand if younger women (45 and under) experience more or worse pain from a common white blood cell booster drug (pegfilgrastim) used during breast cancer chemotherapy compared to older women. Researchers will track pain levels and blood cell counts over a …

This study is testing a new type of CT scanner called HyperSight, which is built into a radiation therapy machine. Researchers want to see if the clearer pictures it takes can help doctors plan and deliver radiation treatment more accurately for various cancers. They will compare…

This study aims to understand how older women with breast cancer respond to CDK4/6 inhibitor drugs compared to younger patients. Researchers will observe 100 patients in real-world settings to track side effects and treatment effectiveness. The goal is to gather better informatio…

This study aims to understand why some breast cancers survive standard drug treatments before surgery. Researchers will collect leftover tissue and blood samples from about 1,000 patients whose cancer remained after initial therapy. They will use these samples to grow the cancer …

This study aims to understand the genetic makeup of a specific type of breast cancer called HER2-low. Researchers will observe 255 Chinese women with this cancer to see how often certain gene changes occur and if these changes are linked to how long patients live or if the cancer…

This study is testing whether a new decision-making tool is practical to use in a future, larger trial. The tool is designed to help breast cancer patients and their surgeons make shared, informed decisions about reconstruction surgery after a mastectomy. Researchers will enroll …

This study collects breast tissue samples from women undergoing surgery for breast cancer to create a research bank. The goal is to help scientists better understand breast cancer by studying these samples in future research projects. Participants contribute tissue that would oth…

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study aims to collect tumor and blood samples from 100 people with breast cancer. Researchers will use these samples to grow miniature 3D tumor models (organoids) in the lab. They will then test whether newly developed CAR-macrophages—a type of engineered immune cell—can eff…

This study aims to collect breast cancer tissue and blood samples from patients to build a research repository. The goal is to analyze these samples to better understand the disease, identify biomarkers, and study its genetic makeup. Participants will provide samples during their…

This study aims to improve how artificial intelligence (AI) reads mammograms by collecting a large, diverse set of images from 20,000 participants. The goal is to train AI models that work well for all women, reducing false alarms and missed cancers. Participants will also receiv…

This study aims to understand why breast cancer treatments sometimes stop working. Researchers will analyze tumor and blood samples from 320 people with different types of breast cancer whose disease has progressed despite treatment. By comparing samples before and after treatmen…

This study aims to see if tracking tiny pieces of tumor DNA and other markers in the blood can help doctors better understand and monitor breast, digestive, and gynecologic cancers. Researchers will follow 1,000 patients to see if these blood tests can predict how well treatments…

This study is testing if doctors can accurately find and test the first lymph nodes that drain from an inflammatory breast cancer tumor using a special imaging scan and dye. Researchers want to see if this less invasive procedure works for this aggressive cancer type, as it could…

This study aims to understand how chemotherapy affects thinking skills and brain health in older adults with breast cancer. Researchers will compare memory tests and brain scans from breast cancer patients receiving chemotherapy, those not receiving chemotherapy, and healthy volu…

This study aims to understand how well patients with advanced breast or prostate cancer take their prescribed oral medications and what factors might make it harder to follow their treatment plan. Researchers will enroll 200 patients to complete questionnaires and provide a blood…

This study aims to see if a simple blood test can find tiny bits of leftover cancer DNA after treatment. Researchers will track 900 patients with early-stage breast cancer to see if this 'liquid biopsy' can predict if their cancer will come back. The goal is to gather knowledge t…

This study aims to understand why some young women develop early menopause after chemotherapy for breast cancer or lymphoma, while others do not. Researchers will analyze stored ovarian tissue from 50 patients to look for genetic differences between the two groups. The goal is to…

This study is a long-term registry that will follow 2,000 people with a common type of early breast cancer for up to 10 years. It aims to understand how doctors and patients make decisions about treatments like chemotherapy and hormone therapy, especially when a specific gene tes…

This small pilot study is testing whether patients undergoing cancer treatment will consistently use a commercial fitness tracker to collect heart rate data. Researchers want to see if the devices are easy to use and if the collected data can help them learn more about cancer-rel…

This study aims to understand how a common type of breast cancer (HR+/HER2-) uses nutrients like sugar and fat to grow. During their scheduled cancer surgery, 16 participants will receive a special glucose infusion. Researchers will then collect small samples of their tumor and n…

This study aims to find out if simple blood tests can predict how well patients with advanced cancers respond to immunotherapy drugs. Researchers will track 50 patients with late-stage lung, breast, colorectal, liver, or stomach cancer who are starting immunotherapy. They will co…

This study aims to identify Black individuals and families in Houston, Texas who may be at increased risk for hereditary breast and colorectal cancers. Researchers will work with trusted community organizations to screen 1,000 participants using a simple questionnaire. Those iden…

This study aims to find out if certain substances in the blood can predict if and where breast cancer might spread. Researchers will compare blood samples from 160 women: some with metastatic breast cancer, some with early-stage cancer, and some who are healthy. The goal is to de…

This study aims to collect blood and other samples from adults with cancer to help scientists better understand how cancer affects the immune system and tumor biology. Participants provide samples for lab analysis, but this is not a treatment study. The goal is to gather knowledg…

This study aims to understand why some advanced breast cancers with BRCA gene mutations stop responding to a specific class of drugs called PARP inhibitors. Researchers will collect tumor and blood samples from 120 patients to look for specific biological markers linked to drug r…

This study aims to collect information from people with inflammatory breast cancer who have had a specific blood test to look for tiny amounts of leftover cancer cells. Researchers want to see if finding these cells before surgery can help predict if the cancer might come back. T…

This study is testing whether patients with early-stage breast cancer can follow a special diet for about 9 days before their surgery. Researchers want to see if patients can stick to either a ketogenic (very low carb) or a protein-restricted diet. The main goal is to check if th…

This study aims to understand how the cost of breast cancer treatment affects patients' financial well-being over time. Researchers will follow 864 people with early-stage breast cancer for one year after they start treatment. The study will track financial stress, quality of lif…

This study aims to understand whether certain proteins called selenoproteins could serve as markers for breast cancer progression or as targets for future treatments. Researchers will analyze tissue samples from past patients and collect blood samples from 300 breast cancer patie…

This study is creating a registry to collect information from breast MRI scans. Researchers want to learn if MRI is a better tool than mammograms for monitoring younger women (50 and under) with a history of breast cancer and dense breast tissue, which can hide cancer on a standa…

This large study aims to find out if a personalized breast cancer screening schedule is as safe and effective as the standard annual mammogram. It will enroll up to 100,000 women aged 30-74 across the U.S. Participants can choose to either follow a personalized screening plan bas…

This study is creating a Spanish-language version of a proven decision aid to help Latina breast cancer survivors understand their breast reconstruction options after mastectomy. Researchers are working with 50 Spanish-speaking Latina survivors to adapt the tool to be culturally …

This study aims to create better educational materials about genetic testing for cancer patients who speak different languages and come from diverse cultural backgrounds. Researchers will work with 445 patients who have breast, ovarian, prostate, pancreatic, or colorectal cancer …

This study aims to understand if hormone therapy for prostate or breast cancer affects sleep quality. Researchers will monitor 60 patients' sleep patterns before starting treatment and again at 6 and 12 months. The goal is to gather information to plan future studies on how to he…

This study is testing whether a special imaging scan, originally developed for prostate cancer, can detect a specific marker (PSMA) in certain types of advanced breast cancer. Researchers want to see if this marker can help predict which patients might not respond well to a commo…

This study aims to learn more about what factors influence breast cancer risk and how patients fare after diagnosis. Researchers will collect blood and tissue samples from 750 women and ask them to complete surveys during their regular medical care. The study does not provide any…

This study aims to understand what symptoms breast cancer patients experience that may be linked to the alcohol content in a specific chemotherapy drug. Researchers will observe over 1,000 patients receiving this drug either before or after surgery. The goal is to gather informat…

This online study aims to understand the perspectives of women who have completed treatment for early-stage breast cancer. Researchers want to know if these women are willing and able to make healthier food choices, particularly by reducing processed foods. Participants will comp…

This study is collecting information on a specific lymph node biopsy procedure used during breast cancer surgery. It involves 200 patients whose cancer has spread to a small number of underarm lymph nodes. The goal is to see how well this targeted procedure works and to track sid…

This online research study aims to better understand how genes affect a person's risk of developing breast cancer. Researchers are recruiting 25,000 adults living in the US to complete health surveys and provide a saliva sample by mail. The goal is to discover new genetic links t…

This study aims to understand how common and severe the fear of cancer returning is for people treated for breast or lung cancer. Researchers will survey 200 patients and conduct in-depth interviews to learn about their experiences and needs. The goal is to develop better tools t…