BREAST CANCER

This study tests a personalized approach for people with HER2+ metastatic breast cancer. Doctors use a blood test (ctDNA) and scans to decide when to increase or decrease treatments, combined with local therapies and brain-sparing prevention. The goal is to achieve long-lasting r…

This early-phase trial tests an investigational vaccine designed to teach the immune system to recognize and attack HER2-positive breast cancer cells. The study includes 36 adults with locally advanced HER2-positive breast cancer. The main goals are to check the vaccine's safety …

This early-phase trial tests a personalized vaccine made from a patient's own tumor DNA. The goal is to train the immune system to recognize and attack any remaining cancer cells after standard chemotherapy and surgery. The study enrolls 16 adults with high-risk triple negative b…

This study is for people with breast cancer that has spread to only a few places in the body (oligometastasis). It tests whether adding targeted treatments like radiation or surgery to standard therapy can help people live longer. About 340 participants will first receive 12 week…

This study tests a program to help Black women with breast cancer follow their prescribed treatment plan, including chemotherapy and hormone therapy. Researchers will compare the program to standard care in 250 participants to see if it improves treatment start, reduces delays, a…

This study is for people with metastatic breast cancer (cancer that has spread). It aims to see if choosing treatments based on specific tumor markers (biomarkers) can help control the disease longer. About 700 participants will receive standard therapies matched to their biomark…

This study tests the drug atezolizumab in about 200 adults with different incurable solid tumors. Researchers use each person's tumor DNA and RNA to see if their cancer might respond to the drug. Participants receive the same dose every 3 weeks, and the study checks if the geneti…

This study tests whether women with certain aggressive breast cancers (triple negative or HR-/HER2+) who have a complete response to chemotherapy and radiation can safely avoid breast surgery. About 200 participants will receive the combined treatment and be monitored for 5 years…

This study tests a treatment called TIL therapy for people with advanced breast cancer who have run out of standard options. Doctors take immune cells from a patient's tumor, grow them in a lab, and put them back into the body after a short chemotherapy. The goal is to shrink tum…

This study tests whether a simple blood test that finds tumor DNA can help doctors decide when to give extra treatment to women with a high-risk type of breast cancer (ER+/HER2-). About 70 women who have finished initial hormone therapy but are still at risk will be monitored. If…

This study tests whether adding doxycycline, a cheap and safe antibiotic, to standard chemotherapy can better target cancer stem cells in early-stage breast cancer. These stem cells are thought to resist treatment and cause cancer to return. About 50 women with ER+/HER2- breast c…

This study tests a new drug, KESONOTIDE™, in people with advanced solid tumors like prostate, breast, lung, ovarian, pancreatic, skin cancer, or glioblastoma. The main goal is to check if the drug is safe and tolerable, and to find the right dose. About 80 adults will take part i…

This early-phase trial tests whether the drug bortezomib can make metastatic triple-negative breast cancer more sensitive to the immunotherapy pembrolizumab and chemotherapy cisplatin. About 20 women with advanced disease who have already received standard chemotherapy will recei…

This study tests a completely oral (pill-based) chemotherapy combination called CMC for people with early-stage breast cancer who have had surgery. The goal is to see if this all-oral regimen is as effective and safer than standard IV chemo. About 25 adults will take three differ…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (including breast and endometrial cancers) have a specific AKT1 E17K gene mutation. The main goals are to check the drug's safety and find the right dose. Participant…

This study tests an experimental drug called YL202 in about 200 people with advanced solid tumors, including lung, breast, and head & neck cancers. The goal is to see if the drug can shrink tumors and how safe it is. Participants must be between 18 and 75 years old and have tried…

This study tests whether adding two targeted drugs (entinostat and anlotinib) to the standard hormone therapy fulvestrant can shrink tumors or slow cancer growth in people with a common type of advanced breast cancer (HR+/HER2-). About 118 adults whose cancer returned or worsened…

This study tests whether shorter courses of radiation to the lymph nodes are safe and effective for people with breast cancer who have had surgery. About 768 participants will receive either standard or shorter radiation schedules. The goal is to reduce side effects while still p…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This early-stage study tests a new treatment for triple negative breast cancer that has come back or not responded to other therapies. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goal is to che…

This study looks at how well a drug called Trop-2 ADC (sacituzumab govitecan) works for breast cancer patients whose cancer has spread to the brain. Researchers will track 100 patients from multiple hospitals to see if the drug shrinks brain tumors and how safe it is. The goal is…

This study tests whether adding a vitamin A-like drug (ATRA) to a platelet-boosting medication (romiplostim N01) works better than the platelet drug alone for cancer survivors whose platelet counts stay low after chemotherapy. About 220 adults with gynecologic, breast, or lung ca…

This study looks at whether women with early-stage breast cancer who have a complete response to chemotherapy can safely avoid radiation after lumpectomy. About 352 women whose cancer has not spread to lymph nodes will be enrolled. The goal is to see if skipping radiation keeps t…

This study tests a new drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and shrinks tu…

This study tests whether adding a new drug called inavolisib to standard hormone therapy and a CDK4/6 inhibitor can help people with a specific type of advanced breast cancer (PIK3CA-mutated, HR+, HER2-). About 450 adults whose cancer has not been treated for advanced disease wil…

This study looks at whether radiation therapy to the underarm area is as effective as surgery to remove lymph nodes in breast cancer patients who still have cancer in their sentinel node after chemotherapy. The goal is to see if radiation causes less arm swelling (lymphedema) whi…

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This early-phase study tests a new drug called GNC-077 in 20 adults with advanced breast cancer or other solid tumors that have spread. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. Participants receive the drug by injection, …

This study compares a new drug, trastuzumab deruxtecan (T-DXd), with standard treatment given before surgery for HER2-positive breast cancer that has not spread. About 370 adults will receive either T-DXd or standard therapy for three cycles, then further treatment is chosen base…

This study tests whether adding ribociclib to standard hormone therapy (aromatase inhibitor) can prevent breast cancer from coming back in people with hormone receptor-positive, HER2-negative early breast cancer who still have cancer after initial chemotherapy. About 446 particip…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety and find the best dose. About 470 adults will take part to see if the drug can he…

This early-phase study is for people with metastatic HR+ HER2- breast cancer that has spread to the bone. Researchers want to find the best dose of the drug abemaciclib when given together with radiation and hormone therapy. The goal is to control the disease and manage side effe…

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in people with advanced HER2-negative breast cancer that has spread or cannot be removed. The goal is to see if these treatments can shrink tumors or slow the disease. About 58 adults who have not r…

This study tests if women who had a breast cancer return after previous lumpectomy and radiation can avoid mastectomy by getting a second, targeted radiation treatment. About 120 participants will receive either partial or whole breast radiation depending on their prior treatment…

This early-stage study tests a new oral drug, RGT-419B, in people with advanced hormone receptor-positive, HER2-negative breast cancer that has worsened after standard treatments. The goal is to find a safe dose and see if the drug, given alone or with hormone therapy, can help c…

This study is for people with early-stage ER+ breast cancer who still have dormant (sleeping) cancer cells in their bone marrow after surgery and standard therapy. Researchers will test two drugs—avelumab (an immunotherapy) and hydroxychloroquine—alone or combined with palbocicli…

This study follows 100 breast cancer patients who cannot have surgery to see if freezing the tumor (cryoablation) is safe and helps control the disease. Participants get an ultrasound-guided freeze treatment instead of an operation. The goal is to track complications and long-ter…

This study tests a new drug called MBRC-201 in people with advanced solid tumors (like prostate, breast, lung, colorectal, or pancreatic cancer) that have not responded to standard treatments. The goal is to find the best dose and see if it can shrink tumors or slow their growth.…

This early-stage study tests a new drug called BG-75202, alone or with other treatments, in people with advanced breast cancer or other solid tumors that have stopped responding to standard care. The main goals are to check safety, find the right dose, and see if the drug shrinks…

This study tests a new hormone therapy drug (elacestrant) given alone or with a drug that temporarily stops ovarian function in premenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if the drug alone works as well as the combination at slowing …

This early-phase study tests a new drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change called p53 R175H and a certain immune type (HLA-A*02:01). The goal is to find a safe dose and see if the drug can …

This trial tests a personalized cancer vaccine made from tumor cells grown in a lab. The cells are modified to boost the immune system, then killed and injected into the patient. The goal is to help people with metastatic melanoma, breast, ovarian, colorectal, gastric, lung, or k…

This study tests whether combining two drugs, sacituzumab govitecan and atezolizumab, can clear leftover cancer cells in the breast or lymph nodes after initial treatment. It includes 40 people with triple negative breast cancer who still have signs of cancer in their blood. The …

This study tests whether an artificial intelligence model can identify patients with advanced HR+ HER2- breast cancer who might benefit from a second CDK4/6 inhibitor after the first one stops working. About 105 participants will either receive a second CDK4/6 inhibitor plus fulv…

This early-stage study tests two drugs—alpelisib and pembrolizumab—together in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and watch for side effects. About 50 adults whose cancer has worsened after standard treatments wi…

This study looks at whether proton therapy can safely treat tumors that have come back after standard radiation. Proton beams are more precise than X-rays, so they may deliver a stronger dose to the tumor while sparing healthy tissue. The study will enroll 1,800 adults with vario…

This study tests a new drug called ACE-86225106 in adults with advanced solid tumors (like ovarian, breast, or prostate cancer) that are hard to treat or no longer respond to standard therapy. The goal is to see if the drug is safe, tolerable, and can shrink tumors. About 298 par…

This early-phase study tests a new combination treatment for people with a certain type of advanced breast cancer (ER+, HER2-, GRPR+) that has stopped responding to standard hormone therapy. The treatment adds a targeted radiation drug ([177Lu]Lu-NeoB) to two existing hormone-blo…

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing offers similar disease control with fewer complications and better quality of life. Participants will b…

This study is for women with a common type of advanced breast cancer (HR+ HER2-). It tests whether adding targeted radiation to each tumor site, along with standard hormone therapy and a targeted pill, can help keep the cancer from growing longer. About 102 participants will be r…

This study is for people with early-stage breast cancer that has spread to a few lymph nodes. Researchers want to see if a genetic test called RecurIndex can identify who can safely avoid radiation to the lymph nodes without increasing the chance of cancer coming back. About 540 …

This study tests if a new hormone therapy called elacestrant can better prevent breast cancer from coming back in people with high-risk HR+/HER2- early breast cancer. About 1,520 participants will receive either elacestrant or standard hormone therapy for up to 7.5 years. The goa…

This study tests a new treatment for people with certain cancers (pancreatic, kidney, breast, melanoma, or ovarian) that have a protein called CD70. Doctors take a sample of your blood, remove white blood cells, modify them in the lab to recognize and attack CD70, and then give t…

This study tests two different chemotherapy combinations given before surgery for people with triple-negative breast cancer. The goal is to see which combo works better at shrinking tumors, making surgery easier and more effective. About 520 participants will be randomly assigned…

This study tests a new combination of three drugs (CDK4/6 inhibitors, Fulvestrant, and L-Ornithine L-Aspartate) in 20 women with HR-positive/HER2-negative advanced breast cancer that has worsened after standard treatments. The goal is to see if this triple therapy can shrink tumo…

This study tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). About 55 p…

This study tests an immunotherapy called GLSI-100 in people with HER2-positive breast cancer who are at high risk of their cancer returning after standard treatment. The goal is to see if the treatment can help prevent the cancer from coming back. About 750 participants will rece…

This study tests a new drug called elacestrant against standard hormone therapy in people with a certain type of early breast cancer that has a high chance of returning. About 4,220 women and men with ER-positive, HER2-negative breast cancer that has spread to lymph nodes will ta…

This study looks at whether using a tiny camera (endoscope) during mastectomy and immediate breast reconstruction is safe and works well for breast cancer patients. The goal is to see if this newer method helps prevent cancer from coming back in the same area. About 800 women wit…

This study tests whether proton radiation, a precise type of radiation, can control early-stage breast cancer while causing fewer side effects than standard radiation. About 132 women aged 50 and older with certain types of breast cancer will receive proton therapy only to the ar…

This study tracks about 300 women with HER2-positive breast cancer that has spread. They receive a three-drug combination (tucatinib, capecitabine, trastuzumab) as part of their normal care. The goal is to see how well the treatment works and how safe it is in everyday medical pr…

This study tests whether aggressively lowering blood pressure during breast cancer treatment is safer and more effective than standard care at preventing heart damage. About 130 women with breast cancer and high blood pressure will be assigned to either intensive or standard bloo…

This study looks at whether women with early breast cancer that has spread to lymph nodes can safely avoid additional surgery or radiation to the armpit after chemotherapy, if tests show the cancer is gone from those nodes. The goal is to see if skipping extra treatment is just a…

This study looks at whether a blood test (liquid biopsy) can find DNA changes in tumors to match patients with the most effective treatments. It involves 484 people with ER+/HER2- metastatic breast cancer that no longer responds to standard CDK4/6 inhibitors. The goal is to impro…

This study is testing a precise, high-dose radiation treatment called SBRT as an alternative to surgery for breast cancer in elderly patients (over 70) or those with other health issues. The goal is to find the safest highest dose that can destroy the tumor without major side eff…

This study tests the safety of trastuzumab deruxtecan, a targeted drug that delivers chemotherapy directly to HER2-positive cancer cells. It involves 100 Indian adults with advanced or spreading breast cancer who have already tried another HER2-targeted treatment. The main goal i…

This study tests a new type of radiation therapy that adjusts the beam in real time to match the patient's body shape each day. It includes 40 women who have had breast cancer surgery and need radiation. The goal is to see if this approach delivers the dose more accurately and ca…

This study tests if a shorter, 3-week course of proton radiation is as safe and effective as the standard 5-week course for women with breast cancer who also need radiation to nearby lymph nodes. About 276 participants will receive either the shorter or longer treatment. The goal…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study tests a personalized approach to breast radiotherapy, adjusting treatment based on each patient's risk of cancer returning and their chance of side effects. It involves 854 women with invasive breast cancer who have had surgery and need radiation. The goal is to reduce…

This study tests whether adding the drug capivasertib to standard hormone therapy helps people with advanced HR+/HER2- breast cancer stay on treatment longer and maintain quality of life. About 250 adults whose cancer worsened after prior hormone therapy will take capivasertib pl…

This study tests whether adding a drug that blocks a certain immune cell (CSF-1R inhibitor) and radiation to standard immunotherapy (pembrolizumab) can improve outcomes for people with high-risk triple-negative breast cancer. About 35 participants will receive the combination bef…

This study is for premenopausal women with a common type of breast cancer (HR+/HER2-). It tests a drug called elacestrant, given alone or with another drug (triptorelin), for 4 weeks before surgery. The goal is to see if the treatment lowers a marker of cancer growth (Ki67) in th…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check the drug's safety, find the right dose, and se…

This study tests whether injecting a very dilute hydrogen peroxide solution into breast tumors can make standard radiotherapy work better. It is for people with advanced or returning breast cancer who need radiation. The treatment, called KORTUC, is given twice a week during radi…

This study tests a new radioactive drug (177Lu-NeoB) combined with chemotherapy (capecitabine) in adults with a specific type of advanced breast cancer (ER+/HER2-) that has worsened after standard hormone therapy. The goal is to find the best dose and see if the combination can s…

This study tests a new drug called HRS-6209 combined with other treatments for breast cancer. About 80 women aged 18-75 whose cancer has worsened after prior therapy will participate. The goal is to find safe doses and see if the combination shrinks tumors.

This study will follow 800 Chinese adults with advanced HER2-positive or HER2-low breast cancer who are taking trastuzumab deruxtecan (T-DXd). Researchers will track how long the drug keeps the cancer from getting worse and note any side effects. The goal is to see how well the t…

This early-stage study is testing a new drug called SYN818 combined with olaparib in adults with advanced solid tumors (like ovarian or breast cancer) that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 110 part…

This study tests a combination of two drugs, tucatinib and Doxil, in people with HER2+ breast cancer that has spread or cannot be removed. The goal is to see how well the combo shrinks tumors and what side effects it causes. About 36 adults with this type of cancer will take part…

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer) that have not responded to other treatments. The main goals are to check safety, find the right…

This study tests an experimental pill called INX-315 in 150 people with advanced cancers, including certain breast and ovarian cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study has three…

This study is for people with advanced breast cancer (T3 or T4) who responded well to chemotherapy. Instead of the usual approach—mastectomy, then radiation, then delayed reconstruction—researchers are testing if giving radiation before surgery allows for immediate reconstruction…

This study tests a new drug combination (inavolisib plus other treatments) in 60 people with untreated, early-stage breast cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if the combination is safe and can shrink or eliminate tumors before surgery.…

This study tests whether giving a single dose of radiation during breast-conserving surgery can lower the chance of cancer coming back and improve how the breast looks afterward. It involves 620 women aged 55 or older with early-stage, HER2-negative breast cancer. The approach co…

This phase 3 study tests whether a new drug called palazestrant, combined with ribociclib, works better than the standard treatment (letrozole plus ribociclib) for people with a common type of advanced breast cancer (ER+/HER2-). About 1,000 adults who have not had prior treatment…

This study tests whether taking dapagliflozin (a drug used for diabetes) daily during chemotherapy can reduce heart damage in breast cancer patients. About 70 women with low to medium heart risk will take the drug while receiving anthracycline chemotherapy. The goal is to see if …

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive breast cancer. About 34 participants will …

This study tests whether adding a third drug (entinostat) to a two-drug combination (dalpiciclib and letrozole) before surgery can shrink tumors more effectively in people with HR-positive, HER2-negative early breast cancer. About 60 women will receive either the three-drug or tw…

This study tests whether giving radiation only to the lower armpit lymph nodes works as well as radiating a larger area in breast cancer patients whose cancer has spread to 1 or 2 lymph nodes. About 1,600 women with early-stage breast cancer will be randomly assigned to one of tw…

This study tests a shorter, 5-day radiation treatment for women aged 50 and older with early-stage breast cancer or DCIS. The goal is to see if this ultra-fast approach is as safe and effective as longer courses, with fewer side effects and less disruption to daily life. About 90…

This early-phase trial tests whether combining two drugs, neratinib and ruxolitinib, is safe and effective for people with metastatic triple-negative breast cancer that has come back on the chest wall after chemotherapy. About 20 women aged 18 and older will receive the drug comb…

This study tests whether giving radiation for breast cancer in only 3 treatments over 1.5 days is safe and works as well as longer schedules. It involves 170 women aged 45-79 with early-stage breast cancer who have had a lumpectomy. The main goal is to check for side effects and …

This study tests whether two FDA-approved pills—abemaciclib (Verzenio) and hydroxychloroquine (Plaquenil)—can reduce or eliminate leftover breast cancer cells hiding in the bone marrow. About 66 patients with high-risk breast cancer will take one or both drugs for six months. The…

This study looks at whether women with a low-risk type of breast cancer can safely avoid extra radiation to the lymph nodes and chest wall. About 2,140 participants will either receive standard care (including regional radiation) or skip it. The goal is to see if skipping this tr…

This study looks at whether adding radiation therapy to standard medications can shrink or slow advanced breast cancer in people who cannot or choose not to have surgery. About 30 adults with invasive breast cancer that has spread locally or to distant sites will receive radiatio…

This early-phase study tests an investigational drug called BL0175 in postmenopausal women with advanced breast, ovarian, or endometrial cancer that is hormone receptor-positive. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink or cont…

This study is testing a new drug called patritumab deruxtecan in people with a type of advanced breast cancer (HER2-positive) that cannot be removed by surgery or has spread to other parts of the body. The main goals are to check the drug's safety and see if it can shrink or stop…

This study tests a combination of three drugs (tucatinib, eribulin, and trastuzumab) in 30 people with advanced HER2+ breast cancer that has not responded to prior treatments. The goal is to see if the combo can shrink tumors or slow cancer growth while monitoring side effects. P…

This study is for women with a common type of breast cancer (HR+/HER2-) that is growing quickly. It tests whether giving chemotherapy more often (dose-dense) can better shrink tumors before surgery. The goal is to find out which patients benefit most from this approach and to che…

This study tests whether giving a combination of three drugs (neratinib, an aromatase inhibitor, and trastuzumab) for 24 weeks before surgery can eliminate all signs of cancer in the breast tissue of people with ER-positive, HER2-positive breast cancer. About 30 postmenopausal wo…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This early-stage trial tests a new treatment called ES2B-C001, given alone or with an adjuvant, for people with HER2-positive metastatic breast cancer that has not responded to at least two prior therapies. The main goal is to check safety and find the best dose, while also looki…

This early-phase study tests a new combination of three drugs (cyclophosphamide, axatilimab, and retifanlimab) in 24 people with metastatic triple-negative breast cancer that has spread and is no longer responding to standard treatments. The main goal is to find the safest dose a…

This study tests a program designed to help people with early-stage breast cancer take their hormone therapy and heart medications as prescribed. Researchers will enroll 350 adults who have trouble sticking to their medication routine. The program includes support and reminders, …

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This study is for people with breast cancer that has spread to the brain. It tests a treatment plan that starts with focused radiation plus a drug called olaparib, followed by an immunotherapy drug (durvalumab) and standard chemotherapy. The goal is to see if this combination is …

This study observes how a biosimilar version of pertuzumab is used in routine care for HER2-positive breast cancer. It includes 1,000 patients receiving the drug before surgery (neoadjuvant) or as first treatment for advanced disease. Researchers will track treatment patterns, tu…

This study tests whether a drug called leucogen can prevent severe neutropenia (dangerously low white blood cell counts) in people with early-stage hormone receptor-positive, HER2-negative breast cancer who are taking ribociclib and hormone therapy. About 94 participants will rec…

This study tests a technique called cryoablation, which uses liquid nitrogen to freeze and destroy small breast cancer tumors. It is for postmenopausal women with early-stage, hormone-sensitive breast cancer. The goal is to see if freezing the tumor can be as effective as surgery…

This study tests a new 3D-printed biodegradable mesh used during breast reconstruction after mastectomy for breast cancer. The goal is to see if it improves cosmetic results and patient satisfaction while being safe. About 25 women aged 18-70 who need a full mastectomy and choose…

This early-phase study tests a new drug called BL-B16D1 in 21 adults with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. Participant…

This study looks at whether people with early-stage HR+HER2- breast cancer can safely take a higher dose of the drug abemaciclib along with hormone therapy. The goal is to see if more patients can stay on the full approved dose for 84 days. About 50 participants will be enrolled,…

This study tests a prehabilitation program for adults aged 65 and older with breast cancer. The program includes exercise, nutrition advice, and a health assessment before surgery. The goal is to see if it helps maintain physical function and reduce complications. Researchers wil…

This study is for women aged 45 and older with early-stage breast cancer or DCIS who have had a lumpectomy. It tests whether a very short course of targeted radiation (over a few days instead of weeks) is safe and works as well as standard radiation. The main goal is to see if th…

This study tests a 1-week radiation treatment for women who have had breast cancer come back in the same breast after prior radiation. After surgery to remove the recurrence, participants receive a short course of focused radiation to only part of the breast. The goal is to see i…

This study is testing whether using MRI scans before surgery can identify women with early breast cancer who have a very low risk of the cancer returning, allowing them to skip post-operative radiotherapy. About 1,400 women aged 50 and older with certain types of breast cancer wi…

This study tests a new drug, OP-1250, against the usual treatments (fulvestrant or an aromatase inhibitor) in people with a certain type of advanced breast cancer (ER+, HER2-). The goal is to see if OP-1250 can delay cancer growth better than standard care. About 510 adults whose…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 gene change (mutation) in the tumor itself. The goal is to see if the drug can slow cancer growth or shrink tumors. About 30 participants will take the pill and be monitor…

This study tests whether combining two drugs—elacestrant and trastuzumab deruxtecan—can shrink tumors in people with a specific type of advanced breast cancer (HR+/HER2-low) that no longer responds to standard hormone therapy or CDK4/6 inhibitors. About 65 participants will recei…

This study tests a surgical technique called targeted axillary dissection (TAD) in women aged 45 and older with early-stage ER+ breast cancer that has spread to lymph nodes found on ultrasound. The goal is to see if removing these nodes upfront, along with standard breast surgery…

This study is testing how well the drug ribociclib, combined with standard hormone therapy, prevents breast cancer from coming back in people with HR+ HER2- stage II or III breast cancer. About 2,766 participants in Russia will be followed for up to 5 years. The goal is to see if…

This study tests a new approach to breast reconstruction for women who have had breast cancer or have Poland syndrome. It uses a special tissue expander (Motiva Flora®) to stretch the skin, followed by injections of the patient's own fat and finally a permanent implant. The goal …

This study tests whether a full-body exercise program can help protect the heart in women undergoing chemotherapy for breast cancer. Researchers will measure heart and blood vessel function before and after the exercise program. The goal is to find a safe, practical way to reduce…

This study is for people with early-stage (stage I) HER2-positive breast cancer who have had surgery. It compares two treatment plans: one uses the drug T-DM1 followed by trastuzumab, and the other uses paclitaxel plus trastuzumab. The goal is to see which approach causes fewer s…

This study tests two different doses of inavolisib (a targeted drug) plus fulvestrant (hormone therapy) in 80 people with a specific type of advanced breast cancer (PIK3CA-mutated, HR+, HER2-). The goal is to see if a lower dose works as well with fewer side effects. Participants…

This study is for women aged 51 or older whose breast cancer has returned in the same breast or is a new cancer in that breast. It tests whether giving a short, targeted course of radiation before surgery is safe and feasible. The goal is to allow breast-conserving treatment agai…

This study compares two treatments for advanced estrogen receptor-positive (ER+) breast cancer that has stopped responding to standard therapies. About 297 participants will receive either a combination of elacestrant and capecitabine or capecitabine alone. The goal is to see if …

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This study compares a new oral drug, D-0502, to a standard injected drug (fulvestrant) in 640 people with a common type of advanced breast cancer (ER-positive, HER2-negative). The goal is to see if D-0502 can delay cancer growth better than the current treatment. Participants mus…

This study tests a new drug (PF-07220060) plus letrozole against standard treatments for a common type of advanced breast cancer (HR-positive, HER2-negative). About 1,020 adults who have not had prior treatment for their advanced disease will be randomly assigned to either the ne…

This study tests whether tirzepatide, a weight-loss medication, can help eliminate tiny amounts of cancer left after standard treatment in people with obesity or overweight and a certain type of early breast cancer. About 48 participants will receive tirzepatide plus standard hor…

This study is for people with a high-risk type of breast cancer (triple negative) who still have cancer after standard treatment and surgery. Researchers will use a simple blood test to look for tiny bits of cancer DNA that might be left in the body. If the blood test finds cance…

This study compares a generic version of the chemotherapy drug paclitaxel to the standard brand in 24 people with breast cancer. Participants receive one dose of each drug in random order to see if the generic works the same way in the body. The goal is to confirm the generic is …

This study tests if dapagliflozin, a drug used for diabetes, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. About 46 adults with early-stage breast cancer who have not had chemo before will take dapagliflozin or a placebo during th…

This early-phase study tests a new drug called BL-B01D1 in people with advanced breast cancer or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 36 adults aged 18 to 75 will take part.

This study tests a new minimally invasive treatment that freezes and then heats breast tumors, comparing it to standard breast-conserving surgery. About 264 women aged 50+ with early-stage, hormone-positive breast cancer will be randomly assigned to one of the two treatments. The…

This early-phase study tests a new drug called OCT-598 in about 51 adults with advanced solid tumors (breast, lung, prostate, head/neck, or stomach cancer). The main goal is to find the safest dose and check for side effects when given alone or with standard treatments. Participa…

This program provides early access to the drug alpelisib (BYL719) for people with PIK3CA-related overgrowth spectrum (PROS) or breast cancer who have no other treatment options and cannot join a clinical trial. Doctors must request the drug for individual patients who may benefit…

This study looks at how well and how safely the drug dalpiciclib works for people with a type of advanced breast cancer called HR-positive. Researchers will follow 420 patients who are already taking or about to take dalpiciclib as part of their normal care. The goal is to see ho…

This program provides ribociclib (LEE011) to people with serious or life-threatening breast cancer who have no other treatment options and cannot join a clinical trial. Doctors can request the drug for eligible patients who may benefit. The goal is to offer a potential treatment …

This study tests whether a combination of three drugs (disitamab vedotin, pertuzumab, and toripalimab) given before surgery can completely eliminate HER2-positive breast cancer in 40 adults. The main goal is to see if no cancer remains in the breast or lymph nodes after treatment…

This study tests a drug called trastuzumab deruxtecan (T-DXd) in 250 people with advanced breast cancer that has low or no HER2 protein. The goal is to see how long the drug can control the cancer before another treatment is needed. Participants must have cancer that cannot be re…

This study looks at whether doing Pilates exercises for 12 weeks can help prevent bone loss in breast cancer survivors who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for osteoporosis because the treatment lowers estrogen. The study will meas…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, lung, or ovarian cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors, either alone or combined with ot…

This early-stage trial tests a new drug, GDC-0587, in people with advanced ER-positive, HER2-negative breast cancer whose cancer worsened after CDK4/6 inhibitor therapy. The study aims to find safe doses of GDC-0587 given alone or with another drug (giredestrant). About 136 parti…

This study tests whether adding a new drug (JS105) to two standard medications (dalpiciclib and fulvestrant) can help people with a certain genetic form of advanced breast cancer (PIK3CA-mutated, HR-positive, HER2-negative) live longer without their cancer growing. About 312 adul…

This study tests whether a combination of two drugs, Sac-TMT and KL-A167, can shrink or eliminate triple-negative breast tumors before surgery. About 40 adults with early-stage, non-metastatic triple-negative breast cancer will receive the treatment. The goal is to see if this ap…

This study is for women with a common type of early-stage breast cancer (ER+/HER2-) who have already had radiation and now need a second lumpectomy. Researchers want to see if giving another round of radiation after surgery is safe and helps prevent the cancer from coming back. A…

This study tests whether a special low-calorie diet that mimics fasting can make standard chemotherapy and immunotherapy work better for people with early-stage triple-negative breast cancer. About 80 women will follow this diet for a few days before and during their treatment cy…

This study tests if dapagliflozin, a drug used for diabetes, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 40 adults with breast cancer who are scheduled for anthracycline treatment will take dapagliflozin or a placebo. Researchers…

This study tests a medicine called disitamab vedotin in people with advanced breast cancer that has spread and is hard to treat. Participants must have tumors with a protein called HER2 and have had prior treatment. Everyone receives the drug through a vein every two weeks to see…

This study tests a new drug called HRS-8080 against standard hormone therapy in women with high-risk early breast cancer. Participants must have already received at least 2 years of standard hormone therapy after surgery. The goal is to see if HRS-8080 better prevents cancer from…

This study tests a drug called elacestrant combined with other medicines in people with a common type of advanced breast cancer (ER+/HER2-). The goal is to find safe doses and see if these combinations help stop the cancer from growing. About 435 adults will take part in this ear…

This study tests whether adding a low-dose chemotherapy pill (capecitabine) to the standard two-drug combination (dalpiciclib plus hormone therapy) can help control HR+/HER2- breast cancer that has spread to organs like the liver or lungs. About 258 women with advanced disease wi…

This phase 3 trial tests whether adding the targeted drug abemaciclib to standard hormone therapy can prevent breast cancer from coming back in people with a specific type of breast cancer (HR+/HER2-) who have already had a local recurrence. About 290 participants will be randoml…

This study tests a drug called zanidatamab in 20 people with early-stage HER2-positive breast cancer. The goal is to see if the drug can make the cancer disappear before surgery. Participants will receive the drug and then have surgery to check if the cancer is gone.

This study is for premenopausal women with a common type of early-stage breast cancer (ER-positive, HER2-negative) that has a low risk of coming back. It compares two treatment plans: hormone therapy alone versus hormone therapy plus chemotherapy. The goal is to see if adding che…

This study tests whether adding the drug gedatolisib to standard hormone therapy and CDK4/6 inhibitors can help people with a certain type of advanced breast cancer (HR+/HER2-) live longer without their cancer growing. About 674 adults with advanced or metastatic breast cancer wi…

This study tests a new robotic surgery that removes breast tissue through a single small cut while keeping the nipple. It is for people with breast cancer or a very high risk of getting it. The goal is to see if this method is as safe and effective as standard surgery, with less …

This study tests whether adding pembrolizumab (Keytruda) to sacituzumab govitecan (Trodelvy) helps people with a specific type of advanced breast cancer (triple-negative, PD-L1-negative) live longer without the disease getting worse. About 110 participants will be randomly assign…

This study tests a new drug called AZD8205, alone or with other cancer drugs, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have spread or come back. The main goals are to check safety and find the right dose. About 460 adults whose cancer has n…

This early-stage trial tests a new drug, BL-M07D1, in people with advanced breast cancer or other solid tumors that have a specific protein called HER2. The study aims to find a safe dose and check for side effects. About 26 adults whose cancer has not responded to standard treat…

This study compares two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. About 60 adults will be randomly assigned to receive either pyrotinib plus trastuzumab and docetaxel or pertuzumab plus trastuzumab and docetaxel. R…

This early-stage trial tests a new treatment called GC203 TIL, which uses a patient's own immune cells that are engineered in a lab to better attack cancer. It is for people with advanced solid tumors (like breast, lung, or gastrointestinal cancer) who have not responded to stand…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have run out of standard options. The goal is to find a safe dose and see if the drug can shrink tumors. About 27 adults will take part in this …

This early-phase study is testing a new drug called OP-1250 (palazestrant) combined with other targeted therapies for people with advanced or metastatic ER-positive, HER2-negative breast cancer. The main goals are to find the safest dose and understand side effects. About 190 adu…

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran capsules dai…

This study tests a new drug called YL202 combined with other cancer treatments in people with advanced solid tumors, including breast and lung cancer. The goal is to find a safe dose and see if the combination can shrink tumors. About 414 adults aged 18-75 who have already tried …

This early-phase study tests a new drug called BL-M17D1 in about 20 adults with advanced breast cancer (HER2-positive or negative) or other solid tumors that have spread. The main goals are to check safety, find the right dose, and see early signs of tumor shrinkage. Participants…

This study is for people with breast cancer who cannot have surgery due to health reasons or who choose not to for cosmetic concerns. It uses a special device that first freezes and then heats the tumor to destroy it. The goal is to see if this treatment is safe and effective at …

This study tests whether two drugs, trastuzumab deruxtecan and durvalumab, can safely shrink or eliminate tumors in people with stage III inflammatory breast cancer that has a protein called HER2. About 63 participants will receive the drugs before surgery. The main goal is to se…

This study tests a new oral drug (PF-07248144) combined with fulvestrant in 400 people with advanced HR-positive, HER2-negative breast cancer that worsened after prior CDK4/6 inhibitor treatment. Half receive the new combo; the other half get standard care (everolimus plus endocr…

This study tests a new drug called KIVU-107 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to find the safest dose and check fo…

This study aims to help Latina women who are at high risk for breast cancer get the right screening and genetic testing. Researchers will provide phone-based coaching and navigation support to 600 participants over three weeks. The goal is to see if this support helps more women …

This study is for people with advanced triple-negative breast cancer whose disease is under control after initial immunotherapy. It compares giving the same dose of immunotherapy less often versus the standard schedule. The goal is to see if the longer interval can keep the cance…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if the drug can delay cancer growth. About 100 adults whose cancer cannot be removed by s…

This study tests a new way to treat early-stage, hormone-positive breast cancer using a single, high-dose radiation session before any surgery. About 53 women will receive this radiation, and doctors will check if the tumor disappears completely using scans and biopsies. If it do…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. About 46 adults with metastatic breast cancer (ER+ or HER2+) will continue their usual drug therapy …

This study looks at whether giving antibody-drug conjugates (ADCs) a second time is safe and effective for people with advanced breast cancer that has spread. About 160 adults who have already received ADCs will be enrolled. The goal is to see if the tumors shrink or stop growing…

This study compares a new targeted therapy (dalpiciclib plus an aromatase inhibitor) against standard chemotherapy for postmenopausal women with a specific type of early breast cancer (ER-positive, HER2-negative, low growth rate). The goal is to see if the new combo works just as…

This study is testing a drug called Disitamab vedotin (RC48-ADC) in 45 people with breast cancer. The goal is to see how long the drug can keep the cancer from growing and to check for side effects. Participants must have already used or be currently using this drug as part of th…

This study is for people with operable, lymph node-positive triple negative breast cancer. It tests whether giving a low or high dose of radiation to the breast tumor along with immunotherapy (pembrolizumab) before standard chemotherapy can improve the chance of eliminating all c…

This study tests whether customizing follow-up treatments—like radiation, surgery, or stronger drugs—based on how well the tumor shrinks after initial therapy can help people with advanced breast cancer live longer without the disease getting worse. About 157 women with cancer th…

This early study tests if a mild electrical pulse to a nerve in the ear can help protect the heart in people receiving chemotherapy for breast cancer or lymphoma. Researchers will check heart function and inflammation markers in 104 adults who recently started chemo. The goal is …

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. About 319 participants will receive the drug to…

This study tests whether a shorter course of radiation before mastectomy and breast reconstruction works as well as the standard longer course. About 126 adults with invasive breast cancer will be randomly assigned to one of the two radiation schedules. The goal is to see if the …

This study compares a single, high-dose radiation treatment to the standard five-session approach for women with early-stage breast cancer. It aims to see if the one-time treatment is just as effective at preventing the cancer from coming back. Participants must be 40 or older wi…

This study is for people whose breast cancer has returned after previous breast-conserving surgery and whole-breast radiation. The standard treatment after repeat surgery is radiation twice a day for 30 sessions. This trial tests whether giving radiation once a day for 15 session…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This early-phase study tests a new drug called AVA6000, a chemotherapy that is designed to activate only inside tumors, potentially reducing side effects. It is for people with advanced solid tumors (like breast, ovarian, or salivary gland cancer) that have not responded to stand…

This early study tests a new way to treat small breast cancers using short electric pulses (IRE) instead of heat or cold. The goal is to see if it can safely destroy the tumor, which would then be removed by surgery to check. 24 women with early-stage breast cancer will take part…

This study tests a new drug called JSKN003 against standard chemotherapy in about 400 people with HER2-low breast cancer that has spread or come back. Participants are randomly assigned to receive either JSKN003 or a standard chemo drug chosen by their doctor. The main goal is to…

This study tests a combination of two drugs, abemaciclib and bicalutamide, for people with a specific type of advanced breast cancer that has spread (metastatic). The cancer must test positive for androgen receptors and negative for HER2. The goal is to find the best dose and see…

This study tests a combination of two drugs, ribociclib and anastrozole, in people with a common type of advanced breast cancer (hormone receptor-positive, HER2-negative) that has spread or come back. The goal is to see if the combination works better and is safe. About 86 adults…

This early-phase study tests a radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head and neck, or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for side effects. About 22 par…

This study tests whether the drug sacituzumab govitecan (SG) can still shrink tumors in people with a certain type of advanced breast cancer (HR+/HER2 low) who have already received a similar drug called T-DXd. About 75 adults will receive SG at its standard dose. The goal is to …

This study is for Nigerian women with a specific type of breast cancer called HER2-positive. Doctors want to see if giving a combination of targeted drugs before and after surgery can destroy the cancer completely. About 74 women will receive the treatment, and researchers will c…

This study tests whether adding the drug inavolisib to a standard two-drug combination (ribociclib and fulvestrant) can shrink tumors or slow disease progression in people with a specific type of advanced breast cancer (HR+/HER2- with chromosome 8p loss). About 80 participants wh…

This study tests a personalized gene therapy for people with metastatic cancers that haven't responded to standard treatments. Doctors take a patient's own white blood cells, genetically engineer them in a lab to recognize and attack unique mutations in their tumor, and then infu…

This early-stage study is testing whether giving radiation therapy along with two drugs (abemaciclib and letrozole) before surgery is safe for people with a common type of early breast cancer (HR+/HER2-). The study involves 15 participants and aims to see how well the body handle…

This study tests whether a new drug (RLY-2608) combined with fulvestrant works better than another approved combination (capivasertib + fulvestrant) for people with advanced or metastatic HR+/HER2- breast cancer that has a PIK3CA mutation. About 540 adults whose cancer worsened a…

This study tests a new drug called VS-6766 combined with two standard drugs (abemaciclib and fulvestrant) in people with advanced HR+/HER2- breast cancer that has spread. The goal is to find the safest dose and see if the combination helps control the cancer. About 63 participant…

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their growth. About …

This early-phase study tests an experimental drug called BL-M07D1 in 280 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug is safe and can shrink tumors in cancers like breast, lung, stomach, and ovarian cancer. Participants must have tr…

This early-phase study tests a new drug, OKI-219, designed to block a specific cancer-driving mutation (PI3KαH1047R) found in some advanced solid tumors and breast cancers. About 200 adults whose cancer has this mutation will receive OKI-219 alone or combined with other anti-canc…

This early-stage study tests an experimental oral drug called BBI-940 in adults with advanced or metastatic breast cancer. The drug works by breaking down a protein that helps cancer cells grow. It is given alone or with another drug (fulvestrant). The main goals are to check saf…

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II or III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors hope to improve response and identify patients who may not need chemotherapy. The trial enrolls 81 parti…

This study tests whether a new drug called tinengotinib, given with or without fulvestrant, can shrink tumors in people with a certain type of advanced breast cancer (HR+/HER2-). About 94 participants will receive the treatment to find the best dose and see if the combination wor…

This study tests a breast reconstruction method that combines fat grafting with a muscle flap from the back. It is for women who have had a mastectomy and want delayed reconstruction. The main goal is to see if this approach reduces wound infections or healing problems.

This study tests a new drug called NBQ72S in 10 people with breast cancer that has spread to the lining of the brain or spinal cord. The goal is to see if the drug can control the disease and help people live longer. Participants receive the drug every 28 days until it stops work…

This study tests a new drug (GDC-4198) alone or with another drug (giredestrant) for people with advanced ER+/HER2- breast cancer that has worsened after prior treatment. About 285 participants will be enrolled to see if the new combination is safer or works better than an existi…

This early-phase study tests a new drug called LNCB74 in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. LNCB74 is an antibody-drug conjugate designed to deliver a cancer-killing agent dir…

This study tests whether a combination of three drugs (anastrozole, fulvestrant, and abemaciclib) can shrink or control tumors in people with advanced hormone receptor-positive, HER2-negative breast cancer. About 20 participants will receive the treatment, and researchers will me…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. Half the participants will have standard sentinel node surgery; the other half will have no armpit surgery at all. Research…

This study tests a personalized, lighter chemotherapy approach for women with early-stage triple-negative breast cancer. The treatment plan is adjusted based on immune system activity in the tumor and how the tumor shrinks on scans. The goal is to see if many patients can achieve…

This study tests a new drug combination (BMS-986507) in about 416 adults with advanced solid tumors, specifically lung and breast cancers. The goal is to find safe doses and see if the treatment can shrink tumors. Participants must have measurable tumors and be in fairly good hea…

This early-phase trial tests an investigational drug called SYS6043 in adults with advanced or metastatic solid tumors that have spread or no longer respond to standard treatments. The main goals are to find a safe dose, understand side effects, and see if the drug can slow tumor…

This study looks at whether a handheld robotic tool called HandX can help surgeons perform a nipple-sparing mastectomy through a single small side incision, reducing scarring and improving recovery. About 15 women who already need a mastectomy for early breast cancer or genetic r…

This early-phase study tests a new treatment called CAR-T cells, which are immune cells engineered to target a protein called CEA found on certain cancer cells. The study includes up to 48 adults with advanced non-small cell lung cancer or breast cancer that has not responded to …

This study tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), works better than standard chemotherapy for people with a certain type of advanced triple-negative breast cancer that has PD-L1 protein. About 625 participants w…

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests whether adding the drug QL1706 to standard chemotherapy before surgery can eliminate more cancer cells in women with early HR+/HER2- breast cancer. About 238 participants will receive either the combination or chemo alone for 6 cycles, then undergo surgery. After…

This study tests a new drug, STX-478, designed to attack cancer cells with a specific genetic change (PI3Kα mutation). It is for adults with advanced solid tumors, including breast cancer, that have not responded to other treatments. The study will test the drug alone or combined…

This study tests whether adding the antifungal drug posaconazole to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk breast cancer will participate…

This study tests two different drug combinations given before surgery for HER2-positive breast cancer. About 100 adults with early-stage disease will receive either TCHP or THP to see which leads to a higher rate of complete tumor disappearance. The goal is to improve treatment a…

This study is for people with stage 2 or 3 breast cancer. It tests whether giving a special type of radiation (SBRT) and an immunotherapy drug (pembrolizumab) directly into the tumor before standard chemotherapy can help shrink the cancer more effectively. The goal is to see if t…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, which are …

This study tests whether adding the drug zanidatamab to standard chemotherapy can completely eliminate cancer in the breast and armpit before surgery in people with early-stage HER2-positive breast cancer. About 125 adults with stage II or III disease will receive the combination…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. It is for patients whose cancer has not responded to available treatments. About 404 adul…

This study looks at whether adding CDK4/6 inhibitors after surgery can help prevent breast cancer from returning in people with hormone receptor-positive, HER2-negative breast cancer. About 229 adults will receive these drugs as part of their standard follow-up care. The main goa…

This study tests whether the drug ribociclib can safely replace chemotherapy for women with a common type of early breast cancer (HR+ HER2-) that has an intermediate risk of coming back. About 3,900 participants will receive either standard chemotherapy followed by hormone therap…

This study tests whether adding targeted radiation and immunotherapy to standard hormone therapy can turn a woman's own breast tumor into a personalized vaccine. It involves 100 post-menopausal women with HR+ HER2- breast cancer who have not yet had surgery. The goal is to see if…

This study looks at people with advanced HER2-positive breast cancer whose first treatment stops working. It compares two different targeted therapy combinations to see which works better when switched. About 600 participants will be followed to track how long the cancer stays co…

This study compares high-intensity interval training (HIIT) to moderate-intensity continuous exercise for improving heart health in 158 women who completed chemotherapy for breast cancer. Participants will be assigned to one of two exercise programs to see which better reduces ca…

This study tests a treatment called cryoablation, which uses extreme cold to freeze and destroy small, low-risk breast tumors. It aims to see if freezing the tumor works as well as surgery, while offering a better quality of life with less pain, no general anesthesia, and better …

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This study looks at whether using a mobile app helps people with HR+ HER2- stage II or III breast cancer stick to their prescribed ribociclib and aromatase inhibitor therapy for a full year. The app provides reminders and information about side effects and relapse risks. About 24…

This study tests whether adding a CDK4/6 inhibitor to standard hormone therapy can help prevent breast cancer from returning in women with a high-risk type called HR+/HER2+ early breast cancer. About 1,900 women who have already completed anti-HER2 treatment will be randomly assi…

This study tests a new drug, HMBD-501, in people with advanced cancers (melanoma, lung, or breast) that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink tumors. About 180 adults will take part in two phases: first to check s…

This early-stage study tests a new drug, RLY-2608, designed to block a faulty protein in cancer cells with a specific gene change (PIK3CA mutation). It is for adults with advanced solid tumors or certain breast cancers that have not responded to other treatments. The study will t…

This study tests whether adding a probiotic supplement called Biolosion to standard chemotherapy before surgery can help more people with early-stage triple-negative breast cancer achieve a complete remission. About 192 women will be randomly assigned to receive either standard t…

This study tests a combination of two drugs, neratinib and capecitabine, in people with a type of breast cancer that has spread to the brain. The cancer is HER2-negative by standard tests but shows abnormal HER2 activity on a special test. The goal is to see if this treatment can…

This early-stage study tests an experimental drug called VSV-02 in 6 adults with advanced solid tumors (like melanoma, breast, or lung cancer) who have run out of standard options. The drug is given both into a vein and directly into the tumor to see if it can shrink or control t…

This study tests a new way to care for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It brings together cancer doctors and primary care providers to improve communication and support. The goal is to help patients better manage their …

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This study is tracking how well a single dose of radiation given during breast cancer surgery works to keep the cancer from coming back. It includes 500 women aged 45 and older with early-stage breast cancer who are good candidates for partial breast radiation. The goal is to see…

This study looks at whether holding your breath deeply during breast cancer radiation can keep the heart safe from radiation damage. About 400 women with early-stage breast cancer will either use a special breathing device or breathe normally during treatment. The goal is to meas…

This early-phase trial tests a new drug called IKS014 in people with advanced HER2-positive solid tumors, including breast, stomach, and gastroesophageal cancers. The drug is designed to deliver a cancer-killing agent directly to HER2-positive tumor cells. The main goals are to f…

This study tests whether adding an antivascular drug to standard chemotherapy helps prevent breast cancer from returning in people with a specific, high-risk type of triple-negative breast cancer. About 764 women with stage II to III cancer will receive either the combination or …

This study tests whether adding a new drug (patritumab deruxtecan) to standard chemotherapy and immunotherapy before surgery can eliminate more cancer cells in people with high-risk early-stage triple-negative or hormone-receptor-low breast cancer. About 372 participants will be …

This study tests a device that uses heat to destroy any remaining cancer cells in the tissue around a removed breast tumor. Ten women aged 50 and older with a specific type of breast cancer will receive this treatment right after their lumpectomy. The goal is to see if the device…

This study looks at whether giving hormone therapy before surgery helps women with a certain type of breast cancer (invasive lobular carcinoma) have cleaner surgical results. The goal is to see if this approach lowers the chance of cancer cells being found at the edges of removed…

This study tests whether adding a type of radiation (stereotactic radiosurgery) and an immunotherapy drug (zimberelimab) to a standard chemotherapy (sacituzumab govitecan) is safe and works better than the chemotherapy alone for people with triple negative breast cancer that has …

This study tests whether giving two different antibody drug conjugates (Dato-DXd and T-DXd) one after the other can shrink tumors in people with HER2-negative metastatic breast cancer whose cancer has already progressed after prior antibody drug conjugate therapy. About 357 parti…

This study is for people with stage II or III breast cancer who will receive chemotherapy before surgery. It compares standard treatment with several experimental drug combinations to see which works better at eliminating all signs of cancer. About 100 participants will be enroll…

This early-stage study is testing three different dose levels of an experimental drug called CLR 125 in people with advanced triple-negative breast cancer that has returned or stopped responding to other treatments. The main goals are to find the safest and most effective dose fo…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study looks at whether a special ultrasound using a contrast agent (Sonazoid) can find the first lymph node where cancer might spread, called the sentinel node, as accurately as the current radioactive method. About 91 adults with melanoma, breast cancer, or head & neck canc…

This study compares two newer screening methods—contrast-enhanced mammography and a shorter MRI—to standard mammography alone for women aged 50-75 with extremely dense breast tissue. Dense tissue makes tumors harder to see and raises cancer risk. The goal is to find which method …

This study tests if a special green dye called indocyanine green (ICG) can find cancer in lymph nodes as accurately as the standard two-dye method in people with breast cancer who have already had chemotherapy. About 100 adults will receive both the new dye and the standard dyes …

This study is testing a new way to detect breast cancer using a breath sample. About 1,200 women scheduled for routine breast cancer screening will breathe into a mask. The samples will be analyzed by trained dogs and an AI system to see if they can accurately identify breast can…

This study is testing a new device that uses engineered bacteria and special laser technology to find and study rare tumor cells in the blood of breast cancer patients. The goal is to improve early detection and help doctors choose the best treatment for each patient. The study w…

This study is gathering images from 800 women who have suspicious breast findings (BI-RADS 4 or 5) to test a new 3D automated ultrasound system called ATUSA. The goal is to see if this radiation-free, operator-independent device can accurately detect breast cancer compared to sta…

This study is testing whether a breath test can detect breast cancer in women aged 40 to 74. Researchers will collect breath samples from over 5,000 women before they have a biopsy or MRI. They will then compare the breath profiles of women found to have breast cancer with those …

This study tests whether a newer PET tracer, 68Ga-FAPI-46, can find more cancer spots than the standard tracer in people with ER-positive breast cancer. About 20 women with advanced or recurrent breast cancer will receive both types of scans. The goal is to see if the new tracer …

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection and moni…

This study tests a new imaging method that combines MRI with near-infrared light to get clearer pictures of breast cancer. Twenty women recently diagnosed with breast cancer will be scanned before surgery. The goal is to see if this tool can help doctors better detect and underst…

This study tests whether a special PET/CT scan (68Ga-FAPI) can accurately tell if breast cancer remains in the armpit lymph nodes after chemotherapy. About 150 women who have finished at least 3 rounds of treatment will get the scan before surgery. If the scan works well, it may …

This study tests a new type of PET scan that uses a radioactive tracer to see how well breast cancer patients respond to a targeted therapy called antibody-drug conjugate (ADC). The scan measures changes in tumor activity before and after treatment. Researchers aim to find out if…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study tests whether a special type of mammogram using contrast dye can find breast cancer better than standard 3D mammograms in women with dense breast tissue. About 2,000 women with dense breasts but no symptoms will get both types of mammograms to see which one catches mor…

This study tests if a safe green dye (indocyanine green) can help surgeons find cancer-spreading lymph nodes through the same cut used for mastectomy, avoiding a separate armpit incision. About 90 women with early breast cancer will receive the dye during surgery. The goal is to …

This study tests a new, non-invasive imaging device that uses light to monitor how breast tumors respond to chemotherapy. Researchers want to see if it can accurately predict when the cancer has been completely eliminated (called a complete pathological response). The study invol…

This study tests a new way to find sentinel lymph nodes in breast cancer patients using a fluorescent dye called indocyanine green (ICG). The dye is injected near the tumor and glows under special light, helping surgeons locate the first lymph nodes that cancer might spread to. T…

This study tests whether non-experts can use AI-supported ultrasound to screen for breast cancer in communities with limited resources. About 4,800 women (asymptomatic from age 30, or symptomatic from age 18) will receive a clinical breast exam and AI-guided ultrasound. The goal …

This study compares robotic ultrasound to traditional sonographer-led screening for breast cancer in 70,000 women aged 35-64. Participants will receive either a robot or human-performed ultrasound and be followed based on results. The goal is to see if robotic screening detects m…

This study is testing a new imaging method called Contrast Enhanced Super-Resolution (CESR) ultrasound to see if it can better find cancer in the breast, liver, and kidney. About 40 people will take part: 30 patients with known lesions and 10 healthy volunteers to help fine-tune …

This early-phase study aims to develop a new blood test that detects cancer by measuring specific enzyme activity in plasma. Researchers will compare enzyme levels in 120 patients with localized breast, lung, or pancreatic cancer against 100 healthy volunteers. The goal is to see…

This study is testing two new experimental methods—a blood test called liquid biopsy and a special camera called PEM—to see if they can help doctors find breast cancer more accurately in women at high risk. About 100 women who are already scheduled for an MRI-guided biopsy will a…

This study is testing a new imaging agent called 18F-T2, which targets a protein (CAIX) found on many solid tumors. About 200 adults with cancers like kidney, bladder, colorectal, or lung cancer will receive a PET/CT scan using this agent. The goal is to see if it can find tumors…

This study tests if a special mammogram with contrast dye can predict whether breast cancer has been completely eliminated by chemotherapy, just as well as an MRI does. About 30 women with locally advanced breast cancer will get 1-2 of these mammograms during or after chemo, befo…

This study compares a newer imaging test called molecular breast imaging (MBI) to the standard breast MRI for finding breast cancer in women at high risk. About 300 women will get both scans to see which one is better at spotting cancer and ruling it out. The goal is to find a mo…

This study is testing whether MRI scans can detect brain metastases that cause no symptoms in people with aggressive breast cancer types (triple negative or HER2+ at stage IIb or III). About 100 participants will get a brain MRI, give a blood sample, and answer a questionnaire. T…

This study tests a new way to find the first lymph node where breast cancer might spread. Instead of using a radioactive tracer, doctors use a green dye and a special camera during surgery. The goal is to make the procedure safer, easier, and more available in hospitals across th…

This study is testing a new device called ARTIDIS that measures the stiffness of breast tissue to help diagnose cancer and predict how aggressive it might be. About 2,700 adults with suspicious breast lumps will have their biopsy samples tested with ARTIDIS, and results will be c…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study tests whether a simple handheld ultrasound can tell if a breast lump is likely harmless or possibly cancer. 600 women in Indonesia who have a breast lump found by a doctor will get an ultrasound to sort them. The goal is to avoid extra mammograms and biopsies for most …

This study is testing a new blood test that uses laser technology and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancers. Researchers will collect blood samples from 1,400 people aged 45 and older who have or are suspected to have …

This study tests a new device called SPCTRone that helps surgeons check if all cancer has been removed during breast-conserving surgery. About 100 women with breast cancer will have their surgical tissue scanned by the device, and results will be compared to standard lab tests. T…

This study is testing two new imaging agents that light up breast cancer cells on PET scans. Researchers want to see if these agents can find tumors and their spread more accurately than current methods. About 200 women with breast cancer or suspected breast cancer will receive t…

This study is testing a new blood test that looks at tiny particles from breast cancer cells to determine the cancer's subtype. The goal is to see if this test is as accurate as the standard tissue biopsy. 1500 adults with advanced breast cancer will provide blood and tissue samp…

This early-phase study is testing whether a special PET-CT scan using a tracer called PYLARIFY (piflufolastat F18) can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan, and doctors will co…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with breast findings that are suspicious but not highly suspicious (BI-RADS 4A or 4B). About 2,100 women scheduled for a biopsy will first get a CEM. The goal is…

This study looks at whether adding a special type of mammogram (contrast-enhanced mammography, or CEM) every two years to the standard yearly 3D mammogram can find breast cancer earlier in women who have already had breast cancer. About 1,500 women aged 30-79 who are at least one…

This study compares a newer X-ray-based breast imaging method (contrast-enhanced digital breast tomosynthesis, or CE-DBT) with standard contrast-enhanced MRI in women with known breast lesions. The goal is to see if CE-DBT gives radiologists similar confidence in identifying and …

This study tests whether a special PET scan (FES PET/CT) can improve detection and treatment planning for brain metastases in people with estrogen-receptor positive breast cancer. About 20 participants will receive the scan before standard radiation therapy and be followed for 12…

This study tests a new device that uses special lights and artificial intelligence to check for leftover cancer cells during breast cancer surgery. The goal is to help surgeons remove all the cancer in one operation, reducing the need for a second surgery. About 104 women having …

This early-phase study tests a new imaging device that combines a special PET scan with 3D mammography to better see estrogen receptor positive breast cancer. About 20 adults with newly diagnosed breast cancer will receive a radioactive tracer and then be scanned. The results wil…

This study tests a new dye called pHLIP ICG that makes breast cancer cells glow during surgery, helping surgeons see and remove all cancer. About 55 adults with early-stage breast cancer will get the dye before surgery. The goal is to see if this method is safe and improves cance…

This study is testing whether using artificial intelligence (AI) together with one or two breast radiologists can find breast cancers in mammograms just as well as the current standard of two radiologists reading independently. About 150,000 women in Norway's BreastScreen program…

This study is testing a new blood test that looks for tiny molecules called MicroRNA in people with breast cancer. The goal is to see if this test can accurately detect the disease. About 100 healthy volunteers will take part to help measure how sensitive and specific the new met…

This study trains Nigerian radiologists to use a tablet-based ultrasound system to perform breast biopsies. The goal is to make breast cancer diagnosis more accessible and reliable in Nigeria. About 900 women with suspicious breast lumps will take part.

This early-phase study tests whether a PET scan using a radioactive tracer (89Zr-trastuzumab) can show which HER2-positive breast cancer patients are likely to benefit from targeted therapy. Ten newly diagnosed adults will receive the tracer and undergo PET/MRI imaging. The goal …

This study is testing whether a special PET/MRI scan can predict how breast cancer will respond to hormone therapy given before surgery. About 53 postmenopausal women with newly diagnosed, hormone-sensitive breast cancer will receive the scan before and after starting therapy. Th…

This study tests whether contrast-enhanced mammography (CEM) can find breast cancers that standard mammography might miss in women with dense breasts. About 1,000 women aged 30-75 with dense breasts will get both types of mammograms. The goal is to see if CEM improves early detec…

This study tests whether dapagliflozin, a drug used for diabetes, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 100 women will receive either dapagliflozin or a placebo daily during their chemo. Researchers will monitor heart funct…

This study tests whether applying diclofenac gel (like Voltaren) to the skin before radiation therapy can prevent painful burns. About 156 adults with head/neck or breast cancer will use the gel daily during their radiation course. The goal is to see if this simple anti-inflammat…

This study tests whether drinking tart cherry juice can help prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice daily …

This study tests whether a low dose of exemestane or tamoxifen can help prevent breast cancer in postmenopausal women at high risk. About 140 women will take one of the two drugs for a year. The main goal is to see which one causes fewer side effects and better maintains quality …

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study looks at whether different types of preventive surgery can lower the chance of getting ovarian cancer in women with certain gene changes (like BRCA). About 480 women will choose between standard surgery, delayed ovary removal, or close monitoring. Researchers will trac…

This study tests whether giving the numbing drug lidocaine through a vein during breast cancer surgery can prevent persistent pain that often lasts for months after the operation. About 1,600 adults having a lumpectomy or mastectomy will be randomly assigned to receive either lid…

This study tests an online program that teaches women at high or very high risk of breast cancer how to lower their risk through healthy lifestyle changes like diet and exercise. About 1,500 women aged 40-74 who already took part in a larger breast cancer screening study will be …

This study aims to increase breast cancer screening among Native American women on the Navajo Nation. About 200 women aged 40-74 who haven't had a mammogram in the past year will receive either a tablet-based education program alone or with added one-on-one support from a Diné pe…

This study tests if a local antibiotic called Stimulan Rapid Cure can lower the risk of infections in women who get tissue expanders placed during mastectomy. About 392 women will take part. The goal is to see if this treatment works better than standard care at preventing infect…

This study tests whether a comprehensive prevention program can reduce the risk of lymphedema (arm swelling) in women with breast cancer who have lymph nodes removed. About 285 participants will be followed for at least a year. The program focuses on helping lymph fluid drain pro…

This study tests whether acupuncture, compression therapy, or both can prevent nerve damage (peripheral neuropathy) caused by taxane chemotherapy in breast cancer patients. About 384 adults with early or intermediate-stage breast cancer will be enrolled. The goal is to find a saf…

This study looks at how exercise might reduce breast cancer risk in women with dense breast tissue. Researchers will measure changes in blood and breast tissue in 46 women who are inactive. Half will start an exercise program, and the other half will wait. The goal is to see if e…

This study tests whether organized dragon boat training helps breast cancer patients recover better than unsupervised home exercises. 72 women who had breast cancer surgery will be assigned to either a 12-week dragon boat program or home workouts. The goal is to see which approac…

This early-phase study tests whether a single dose of psilocybin, given with therapy, can reduce the intense fear of cancer returning in women who have completed treatment for early-stage breast or ovarian cancer and are now in remission. Twenty participants will receive preparat…

This study is testing a 5-session radiation treatment for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and causes fewer side effects than standard longer radiation. About 40 participants aged 50 and old…

This study tests two types of ultrasound-guided nerve blocks to manage pain after breast cancer surgery. Fifty women having a mastectomy will receive either a newer SPSIP block or a standard ESPB block. The goal is to see which one reduces the need for morphine and improves recov…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This study compares two treatments for breast cancer that has spread to lymph nodes: radiotherapy versus surgical removal of those nodes. About 1,060 participants will be randomly assigned to one of the two approaches. The goal is to see which treatment better preserves arm funct…

This study tests whether a series of online group discussions, called Project SOAR Awakenings, can help Black American women with breast cancer feel less depressed and fatigued and improve their overall well-being. About 90 women will be randomly assigned to either join four smal…

This study tests whether a web application can help breast cancer patients better follow their hormone therapy and improve their quality of life. About 438 patients starting hormone treatment will either use the app or receive standard care. The goal is to see if the app makes it…

This study tests a team-based pain management program that uses cognitive behavioral therapy (CBT) to help breast cancer survivors cope with joint and muscle pain caused by their hormone-lowering medications. About 115 women with early-stage breast cancer will either join the pro…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea or colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for s…

This study compares two medications, solifenacin and clonidine, to see which better reduces hot flashes in breast cancer patients taking hormone therapy. About 110 women who have at least 14 hot flashes per week will participate. The goal is to improve comfort and daily functioni…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study tests whether a gentle radiofrequency treatment inside the vagina can reduce dryness and pain in breast cancer patients taking hormone therapy. About 75 women will either receive standard moisturizers alone or moisturizers plus three radiofrequency sessions. The goal i…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study looks at whether a simple strength-training program can help breast cancer survivors manage fatigue. Researchers will work with 60 women from different income levels to see who sticks with the program and why. The goal is to make exercise support fair and accessible fo…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study looks at whether a mobile app can help young women (ages 18-45) with breast cancer feel less distressed. About 120 participants will use the app for 26 weeks, and researchers will check if distress scores improve. The goal is to see if the app is a practical and helpfu…

This study is testing a remote program called PRISM that teaches stress management and resilience skills to people recently diagnosed with metastatic breast cancer. The goal is to see if it improves quality of life and possibly survival, especially for Black women who often have …

This study is testing a virtual program called Mindful After Cancer (MAC) to help breast and gynecologic cancer survivors with sexual health and body image concerns. About 60 participants will be randomly assigned to either the 8-week MAC program or receive educational materials …

This study compares two ultrasound-guided nerve block techniques (RISS block vs. erector spinae plane block) for pain control after mastectomy in 40 women with breast cancer. The goal is to see which method reduces the need for morphine and other opioids after surgery. Better pai…

This study tests whether training the muscles used for breathing can improve exercise tolerance in obese women who have finished treatment for early-stage breast cancer. Researchers will measure how long participants can exercise before getting tired. The goal is to find a simple…

This study tests a 6-week online program to help breast cancer survivors feel better emotionally and reduce worry about cancer coming back. It includes 72 women who finished treatment at least a year ago. Participants will take part in weekly video sessions focused on coping and …

This study tests if a 4-week program combining exercise with a gentle, noninvasive brain stimulation technique (tACS) can help breast cancer survivors who struggle with memory, focus, and thinking after treatment. Researchers will enroll 40 survivors to see if the program is prac…

This study tests if computerized brain training can improve memory and thinking problems in breast cancer survivors. About 386 women who had breast cancer and report mental fogginess will be randomly assigned to either a brain training program or a placebo. The goal is to see if …

This study tests a smartphone app that connects young adults (ages 18-40) who have finished treatment for certain cancers (lymphoma, breast, testicular, or sarcoma) with trained peer navigators. The goal is to see if this digital support program is feasible and helps participants…

This study looks at whether coloring mandala patterns for 30 minutes during chemotherapy can help breast cancer patients feel less distressed and anxious, and more comfortable. About 60 women will be randomly assigned to either color mandalas or receive usual care. Researchers wi…

This study tests whether walking exercise can help reduce fatigue in older breast cancer survivors. About 24 women aged 60 and older who finished cancer treatment within the past year will take part. They will either walk at a center or at home for 12 weeks. The goal is to see if…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study aims to describe sexual quality of life in women with breast cancer who receive a non-hormonal light therapy (photobiomodulation) for menopausal symptoms like vaginal dryness and pain during sex. About 25 women will complete a questionnaire about their sexual health be…

This study tests a new, technology-supported care plan for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) along with other health problems. The goal is to see if this approach improves their quality of life after 6 months. About 720 participants …

This study tests a course called BBCSI, designed by and for Black breast cancer survivors, to see if it improves quality of life. About 46 women who have had stage 0-3 breast cancer and identify as Black will take part. The course is led by trained peers from the community, not d…

This study tests a new type of radiation therapy (adaptive radiotherapy) for breast cancer patients who are at high risk of developing fibrosis (scarring) from standard radiation. The goal is to see if this approach can reduce moderate to severe side effects. The study will inclu…

This study tests whether a treatment that uses radiofrequency (a gentle heat therapy) together with pelvic floor muscle exercises can reduce vaginal dryness and other menopause-related symptoms in women who have had breast cancer. About 50 participants will receive either the act…

This study tests whether a supervised online brain-training program can reduce memory and thinking problems (often called 'chemo brain') in breast cancer patients after chemotherapy. About 300 patients will either get the program with a neuropsychologist coach or do the same exer…

This study is testing an early version of a mobile app called TEAMWork, designed to help breast cancer patients talk to their employers and doctors about work. Researchers want to see if the app helps patients keep their jobs during and after treatment. About 546 breast cancer pa…

This study tests whether a program of exercise and personalized nutrition, started right after a breast cancer diagnosis and continued through treatment, can improve fitness, strength, and quality of life. Researchers will enroll 66 women with early-stage breast cancer. The goal …

This study looks at whether a 15-week cycling program can help women with early-stage breast cancer maintain their physical fitness while undergoing chemotherapy. About 156 participants will either do weekly cycling sessions or receive standard care. The goal is to see if the cyc…

This study looks at whether a 12-week exercise program can improve heart and muscle function in women over 60 who had chemotherapy for breast cancer. Chemo can sometimes weaken the heart, and exercise might help. Researchers will compare a structured exercise program to a stretch…

This study tests whether using opioid-free anesthesia during mastectomy can lower the chance of long-term breast pain. Researchers will compare two groups of 230 breast cancer patients: one receiving opioid-free anesthesia and the other receiving standard opioid-based anesthesia.…

This study looks at whether giving gabapentin before and after mastectomy can improve pain control and reduce the need for stronger opioid painkillers. About 1,896 adults having mastectomy at a single center will take part. The goal is to see if gabapentin should become a standar…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women who are overweight and have insomnia will get either sleep therapy or sleep education, followed by a weight loss program. The goal is to see if better sleep leads to greater weig…

This study tests whether a brief guided meditation during daily radiation therapy can lower anxiety for people with breast or gynecologic cancer. About 34 adults will either listen to a meditation or receive standard care. Researchers will measure anxiety right before and after e…

This study looks at whether resistance training and a high-protein drink after workouts can help women with breast cancer maintain muscle and reduce fat while undergoing chemotherapy. About 30 women will be randomly assigned to exercise and protein or standard care. The goal is t…

This study looks at whether a 16-week virtual exercise program can improve fitness, muscle strength, and quality of life in people with indolent (slow-growing) metastatic breast cancer. Participants must be 18 or older, have stable disease (no progression in the last 12 months), …

This study looks at whether progressive resistance exercise (like lifting weights) can improve symptoms and arm function in people who develop lymphedema after breast cancer treatment. About 50 adults aged 18-60 who are at least 3 months past surgery will be randomly assigned to …

This study looks at whether a gentle energy therapy called Medical Reiki, given before breast cancer surgery, can help improve mood, reduce stress, and speed up recovery. About 32 women with early-stage breast cancer will take part. The goal is to see if this approach is practica…

This study tests whether avoiding opioids during breast reconstruction surgery can reduce the need for morphine afterward. About 158 women having free flap breast reconstruction will be randomly assigned to receive either opioid-free or standard opioid anesthesia. The goal is to …

This study looks at whether eating all food within an 8-hour window each day is practical and helpful for people receiving chemotherapy for early-stage or advanced breast cancer. Researchers will test three different eating windows compared to a control group over 24 weeks. The g…

This study explores whether a group exercise program called Strength After Breast Cancer can be offered in a physical therapy clinic to help women who have finished breast cancer treatment improve their physical function. About 40 women will take part, completing questionnaires a…

This study is testing a smartphone app called iCareBreast+ designed to help women with breast cancer manage their care during chemotherapy. The app provides information and support to improve self-confidence and knowledge about treatment. About 40 women will use the app, and rese…

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer complete their full chemotherapy schedule. Participants will either do resistance exercises at home or receive health education. The goal is to see i…

This study tests a technique called systematic shaving, where surgeons remove a thin layer of extra tissue around the tumor during breast-conserving surgery. The goal is to see if this lowers the chance that cancer cells are left behind, reducing the need for a second operation. …

This study is testing a free, personalized exercise program called 'Moving Together' for women with breast cancer. The program offers supervised or at-home options and is designed to fit each patient's needs and treatment stage. Researchers want to see if it improves quality of l…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. Twenty participants will try the session and report how helpful it was. The goal is to see if this quick support can imp…

This study compares two standard pain-block methods for women having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers …

This study tests whether an AI tool can help doctors better manage chemotherapy side effects in people with breast or colorectal cancer. About 174 adults will be split into two groups: one where doctors use AI suggestions for symptom care, and another receiving standard care. The…

This study looks at two different exercise programs to see which one helps women gain muscle mass after finishing breast cancer treatment. Researchers will track changes in muscle and fat, as well as how well participants stick with the program. The goal is to find the best way t…

This study tests whether a diet called MIND can improve memory and thinking problems in breast cancer survivors. Researchers will enroll 200 women who have finished treatment and still have brain fog. Participants will follow the MIND diet for 12 weeks, then a maintenance phase f…

This study compares a standard physical therapy program to one that adds visual biofeedback—a system that shows real-time movement on a screen—for women recovering from breast cancer surgery. About 40 women with shoulder pain or limited motion will participate. The goal is to see…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. The study will involve 172 participants…

This study tracks how often skin discoloration happens after using Magtrace, a dye injected to find lymph nodes during breast cancer surgery. About 184 women having lumpectomy will be followed for up to 24 months. The goal is to understand how skin staining affects patients' dail…

This study tests two online mindfulness programs for younger breast cancer survivors (diagnosed at or before age 50) who have finished primary treatment and feel depressed. One program is a live class over Zoom, the other is a self-paced app. The goal is to see which approach bet…

This study follows 104 breast cancer patients whose cancer has spread to the chest wall. They will have surgery to remove the affected area. The goal is to see if the surgery improves their quality of life and how well it controls the cancer.

This study looks at whether a program of exercise and psychological support before cancer treatment (called prehabilitation) can improve physical and mental well-being in people with solid tumors, like breast cancer. About 125 participants will either receive this program or stan…

This study looks at whether mindfulness-based breathing exercises can help control symptoms and lower stress in breast cancer patients receiving chemotherapy. About 72 patients will be split into two groups: one doing the breathing exercises and one receiving standard care. Resea…

This early-phase study tests a device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors in women with breast cancer. About 34 participants will have half of one tumor ablated before their standard surgery. The goal is to see if the procedure is s…

This study is testing whether a short, focused upper-body massage after each radiation treatment can reduce muscle and joint pain, improve arm and shoulder mobility, and boost quality of life for people with breast cancer. About 55 participants will receive the massages and repor…

This study tests whether combining electroacupuncture (a gentle electric current through thin needles) with self-acupressure (pressing specific points on the body) can improve quality of life for people with early-stage breast cancer who are undergoing chemotherapy. About 192 par…

This study tests whether a genetic test can help doctors choose the best anti-nausea medicines for Chinese women with early breast cancer undergoing their first chemotherapy. About 200 participants will be randomly assigned to either receive a personalized anti-nausea plan based …

This study tests whether a nutritional supplement called Epidiferphane can lessen common side effects of taxane chemotherapy, like anemia and nerve damage, in breast cancer patients. About 74 adults starting taxane chemo will take Epidiferphane alongside their treatment. Research…

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when not needed. About 402 participants will …

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study looks at whether giving only radiation after lumpectomy, without hormone therapy, can keep cancer under control and improve quality of life for women aged 60 and older with early-stage, low-risk breast cancer. About 300 participants will receive radiation alone and be …

This study looks at whether changing the order of mammogram pictures can make the exam less painful and more satisfying for women who have had breast cancer. About 400 women who had breast-conserving surgery in the last five years will be randomly assigned to one of four differen…

This study compares a new care pathway called AMADeuS, where women have awake mastectomy with same-day discharge and follow-up via telemedicine, to standard hospital care. Researchers want to see if it controls pain just as well and is as safe within 30 days after surgery. About …

This study tests a stress management program called Vietnamese Self Help Plus (vSH+) for women with breast or gynecologic cancer in Vietnam. The goal is to see if it helps reduce anxiety and depression and improves quality of life. About 285 participants will be randomly assigned…

This study aims to see if a Chinese herbal medicine (Shengbai Oral Liquid) works better than a standard drug (Leucogen) at raising low white blood cell counts caused by cancer treatments. About 60 breast cancer patients will take both treatments in different cycles to compare the…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes or be placed on a waiting list. The goal is to fin…

This study tests whether taking tart cherry concentrate and fish oil together can reduce joint pain and stiffness caused by aromatase inhibitors, a common breast cancer treatment. Thirty women with breast cancer who have joint pain will be randomly assigned to take the supplement…

This study is for women with early-stage hormone receptor-positive breast cancer who are on hormone therapy. It will test whether a 12-week physical activity program can improve their quality of life and reduce pain. The goal is to find simple ways to help patients feel better du…

This study looks at whether short bursts of physical activity after meals can help breast cancer survivors on hormone therapy manage their blood sugar better than a standard 30-minute walk. Researchers will compare different activity patterns in 24 women, including cancer survivo…

This study is for women with early-stage breast cancer. It tests a single, focused dose of radiation given before surgery to remove the tumor. The goal is to find a safe and effective dose that limits side effects and improves comfort. About 50 participants will receive the radia…

This study compares two ways of providing sexual health support to breast cancer patients: proactive personalized care versus support only when requested. The goal is to see which approach better improves sexual quality of life. The trial will enroll 264 adults who have completed…

This study tests a procedure called shoulder denervation to treat shoulder pain that can occur after breast cancer surgery and radiation. The procedure involves numbing specific nerves in the shoulder joint. The study will include 60 adults aged 18-65 who have this type of should…

This study tests whether a negative pressure wound therapy (a vacuum dressing) can reduce complications like infection, wound reopening, and slow healing after complex breast cancer surgery with immediate reconstruction. About 254 women at high risk for scarring problems (e.g., o…

This study tests a new way to help breast cancer survivors become more physically active. It compares an exercise plan based on how you feel during activity to a standard plan. About 85 survivors who finished treatment within the last 5 years will wear an activity monitor and ans…

This study explores whether regular video or phone check-ins between patients with advanced breast cancer, their caregivers, and their cancer care teams can improve the hospice experience. About 200 participants receiving in-home hospice care in Massachusetts will take part. The …

This early study looks at whether breast cancer patients can use azelaic acid cream twice a day during radiation to help manage skin irritation. About 33 adults with darker or sun-sensitive skin who are getting radiation will try the cream. The goal is to see if it's practical an…

This study tests whether a short-term, periodic fasting-mimicking diet can safely lower high cholesterol and reduce side effects in post-menopausal women with early-stage breast cancer who are on hormone therapy (aromatase inhibitors). About 60 participants will be randomly assig…

This study looks at whether a 12-week online dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who have ongoing pain after surgery. About 30 adults who had a lumpectomy or mastectomy and still have moderate to severe pain will tak…

This study tests whether a set of recovery steps called ERAS can help people who have breast-conserving surgery for breast cancer. The goal is to control pain with fewer opioids and improve recovery. About 260 adults will be randomly assigned to receive either the ERAS plan or st…

This study looks at whether a 16-week cardiac rehabilitation exercise program can improve heart health and fitness in women who have had early-stage breast cancer. About 100 participants will take part in the program at the Toronto Rehabilitation Institute. Researchers will measu…

This study tests whether adding acupuncture to standard anti-nausea medicine can better control nausea caused by chemotherapy. About 90 adults with various cancers who still feel sick despite medication will either receive acupuncture plus medicine or medicine alone. Researchers …

This study is testing a new surgical technique for breast cancer that removes breast tissue through a single small cut in the armpit, avoiding a large scar on the breast. It involves 10 women with early-stage breast cancer who are eligible for nipple-sparing mastectomy and immedi…

This study looks at whether a community-based exercise program called Get Real and Heel can help people with metastatic breast cancer become more physically active. Researchers want to see if the program improves quality of life, physical function, and social support while reduci…

This study tests whether Revaree Plus, a vaginal moisturizer, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants who have completed primary cancer therapy or are on maintenance treatment will use the product for 8 weeks. The g…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women undergoing chemotherapy for early-stage breast cancer. About 90 participants will be split into three groups: on…

This study looks at whether a 16-week high-intensity interval training (HIIT) program can help women with breast cancer maintain their thinking and memory skills while undergoing chemotherapy. About 30 women will be enrolled and will have their brain function, heart fitness, and …

This study tests whether a special nutrient supplement (APPORTAL®) can help reduce severe tiredness in women with breast cancer who are on chemotherapy. About 92 participants will take either the supplement or a placebo for 8 weeks, along with recommended exercise. Researchers wi…

This study tests a new method of arm massage guided by a special dye (ICG) to prevent swelling after breast cancer surgery. About 30 women having lymph node removal will be assigned to either standard massage or dye-guided massage. The goal is to see if the new method helps patie…

This study tests if a mobile app can improve quality of life for 180 women with early-stage breast cancer who are taking hormone therapy. Participants will either use the app plus standard care or standard care alone for 12 weeks. The goal is to see if the app helps reduce side e…

This study looks at whether taking creatine supplements can help breast cancer survivors build strength and endurance faster through exercise. Researchers will compare results from 60 women who recently finished chemotherapy with healthy women of the same age. The goal is to impr…

This study tests whether a telehealth exercise program can reduce cancer-related fatigue in rural breast and prostate cancer survivors. About 134 participants will receive personalized virtual exercise coaching and collect small blood samples at home to track changes. The goal is…

This study is testing a program called WeCan-Rural for breast cancer survivors living in rural, underserved areas. The program uses weekly video sessions to help participants build healthy habits like better eating and more physical activity, with the goal of reducing heart disea…

This study looks at whether a new version of the chemotherapy drug docetaxel, which does not contain ethanol (alcohol), causes fewer alcohol-like side effects in breast cancer patients. About 1,052 participants will be observed before and after surgery to track symptoms like flus…

This study looks at two ways to manage side effects from aromatase inhibitors, a hormone therapy for early-stage breast cancer. About half of women stop taking these drugs early due to side effects, raising the risk of cancer returning. The study will compare switching to a diffe…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') after cancer treatment. About 50 breast or gynecological cancer patients who finished chemotherapy within the last 90 days will wear the headban…

This study tests whether regular phone or video calls from a nurse can help breast cancer patients on CDK inhibitor drugs catch and manage side effects early. About 124 women will be split into two groups: one gets standard care, the other adds structured telenursing check-ins. T…

This study tests whether a special spa therapy program can improve skin-related quality of life for people who have skin hardening or scarring (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly…

This study looks at whether combining resistance and aerobic arm exercises can improve arm strength, function, and quality of life in breast cancer patients. About 40 women who are at least 15 months past surgery will take part. The goal is to find simple, safe ways to reduce com…

This study tests two different walking programs for women with breast cancer who are getting chemotherapy. One program has a fixed amount of walking each week, while the other adjusts the walking amount based on how the person responds. The goal is to see which approach better im…

This study tests whether radiofrequency therapy, pelvic floor exercises, or both can reduce symptoms like vaginal dryness and pain in breast cancer survivors. About 117 women who have finished breast cancer treatment and have pelvic floor issues will take part. The goal is to fin…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part, and researchers will measure changes in quality of life, stress, and othe…

This study tests if a newer, less invasive mastectomy (endoscopic skin-sparing) leads to fewer wound complications and higher patient satisfaction compared to standard mastectomy. About 258 women with breast cancer will be randomly assigned to one of the two surgeries. The goal i…

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study looks at whether a supervised exercise program with moderate aerobic and resistance training can safely reduce pain in breast cancer survivors who have ongoing pain. Ten women who finished treatment at least six months ago will take part. The goal is to see if the prog…

This study tests if a supervised exercise program (high-intensity interval and resistance training) during chemotherapy can help breast cancer tumors disappear completely. About 712 patients will be randomly assigned to exercise or usual care and followed for two years. The goal …

This study tests a nasal spray medication (dexmedetomidine) to help women relax and stay comfortable while awake during breast-conserving surgery for breast cancer. About 394 women aged 20–70 will receive either the active spray or a placebo before surgery. Researchers will measu…

This study looks at women who have had breast surgery and radiation before and need another breast surgery. Because radiation makes healing harder, researchers want to find the best way to prevent wound problems. They will compare three options: a week of antibiotics, a wound vac…

This study tests whether a program combining physical therapy, yoga, and patient education can reduce joint and muscle pain caused by hormone therapy in breast cancer patients. About 108 adults with non-metastatic breast cancer and moderate-to-severe pain will be randomly assigne…

This large study tests whether giving lidocaine (a common numbing medicine) through an IV during breast cancer surgery can prevent moderate to severe pain that lasts for a year or more. About 4,300 women having mastectomy or lumpectomy will be randomly assigned to receive lidocai…

This study looks at how different supervised group exercise programs affect fitness and body composition in women who have completed breast cancer treatment. About 15 women aged 20-89 will try one of four resistance training regimens to see which best improves heart-lung fitness …

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study tests whether a 6-week online mindfulness-based stress reduction (MBSR) program can lower stress, anxiety, depression, and other side effects in women with breast cancer who are starting chemotherapy. About 200 participants will be randomly assigned to either the onlin…

This study is for women with a high-risk type of breast cancer (HR+/HER2-). It tests whether adding the drug ribociclib to standard radiation therapy after surgery is safe and tolerable. About 30 participants will take ribociclib daily for up to 6 weeks while receiving radiation.…

This study tests whether a diet called MIND (a mix of Mediterranean and DASH diets) can help protect memory and thinking in women with breast cancer who are receiving chemotherapy or other systemic treatments. About 43 women with stage II-IV breast cancer will be randomly assigne…

This study tests short, easy-to-use digital tools (called micro-interventions) designed to help breast cancer survivors manage stress and improve their mood. Researchers will enroll 120 women who were diagnosed with early-stage breast cancer in the past 5 years and have some symp…

This study is testing whether taking a daily probiotic powder for six months can help reduce the unpleasant side effects of chemotherapy in people with breast cancer. It will involve 100 participants who are receiving common chemotherapy drugs. Researchers will track side effects…

This study is testing if giving high-dose steroids can prevent or reduce severe skin reactions on the hands and feet caused by a specific chemotherapy drug (liposomal doxorubicin) used for breast cancer. Researchers will compare high-dose steroids, standard-dose steroids, and no …

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study is creating a Spanish-language version of a decision aid called BREASTChoice to help Spanish-speaking Latina breast cancer survivors make informed choices about breast reconstruction after mastectomy. Researchers will work with 50 women to adapt the tool culturally and…

This study looks at whether a new telehealth program can safely reduce the number of in-person visits for people with breast or prostate cancer. About 1,750 patients will be assigned to either standard care or enhanced telehealth. The goal is to see if telehealth can save time an…

This study aims to find genetic markers that make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment. The goal …

This study looks at how a gene called BRCA2 affects the way breast cancer responds to hormone therapy before surgery. Researchers will compare changes in a tumor marker called Ki67 in women with and without the BRCA2 mutation. The goal is to learn whether these two groups respond…

This study is testing whether DNA mutations found in the blood (ctDNA) can help predict if breast cancer will return in patients who had chemotherapy before surgery. Researchers will take blood samples over time from 180 people whose tumors did not fully disappear after chemo. Th…

This study looks at whether giving doctors extra genetic information about a patient's metastatic breast cancer helps them choose better treatments. About 500 adults with metastatic breast cancer will join. Doctors will get a special test result (PAM50) that shows the tumor's mol…

This study looks at whether giving a longer infusion of the chemotherapy drug paclitaxel to cancer patients with low muscle mass can make drug levels in their blood more like those in patients with normal muscle mass. About 22 women with breast, stomach, or esophageal cancer will…

This study follows 475 women with breast cancer or lymphoma to see how cancer treatments impact their sexual health and ability to have children. Participants will fill out questionnaires and may also choose to give blood samples to measure ovary function. The goal is to better u…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and counseling at mobile mammography units. About 1,000 underserved women in Texas will be invited to participate when they come for their routine mammog…

This study compares pain levels in younger (45 and under) versus older women receiving pegfilgrastim, a drug that helps boost white blood cells during chemotherapy for non-metastatic breast cancer. Researchers want to see if younger women report more frequent or intense pain. The…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study looks at how hormone treatments for prostate and breast cancer affect sleep quality. Researchers will track 60 patients using sleep tests, questionnaires, and activity monitors before treatment starts, at 6 months, and again at 12 months. The goal is to see if these tr…

This study aims to understand why some breast cancers become resistant to therapy. Researchers will analyze tumor and blood samples from 320 people with HER2-positive, hormone receptor-positive, or triple-negative breast cancer. The goal is to identify changes in cancer cells tha…

This study looks at how a 13-week physical activity program called KHEOPS changes motivation and psychological symptoms in 80 women being treated for breast cancer. Participants will fill out questionnaires about their feelings and attitudes toward exercise. The goal is to unders…

This study tests whether a 14-day mobile daily diary is a practical way to measure daily stress and thinking (cognitive) performance in breast cancer survivors from different racial backgrounds. Researchers will enroll 30 women aged 40 and older who are at least five years past t…

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to learn how these variants affect health and how people understand and share their results. Up to 5,000 participants will co…

This study looks at how much protein people with colorectal or breast cancer need to prevent severe muscle loss, which can lead to disability and poor quality of life. Researchers will use a simple, non-invasive test to measure protein needs in 40 patients. The goal is to create …

This study looks at whether special imaging can help find the first lymph nodes that cancer might spread to in women with inflammatory breast cancer. About 50 women will take part. The goal is to improve surgery and understand the risk of arm swelling after treatment.

This study is testing whether a decision aid tool called RECONJOINT is practical for helping women with breast cancer or a genetic risk make informed choices about breast reconstruction after mastectomy. Researchers will enroll 131 participants to see if a larger study is feasibl…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at curing their disease. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA that might remain after treatment. The goal is to lea…

This study looks at how a ketogenic diet (low-carb, high-fat) affects the area around breast cancer tumors. Twelve postmenopausal women with early-stage breast cancer will follow the diet for 3 weeks before their surgery. Researchers will measure changes in immune cells and keton…

This study looks at whether a special blood test (NovaGray RILA Breast®) can predict serious side effects from radiotherapy in women who have had a mastectomy with immediate breast implant reconstruction. Researchers will follow 250 patients to see if the test can identify who is…

This study looks at how sleep problems impact thinking skills and quality of life in 75 women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their memory and mood. The goal is to better understand these links and …

This study is an audit that will track 300 breast cancer patients with limited lymph node involvement who undergo a newer, less invasive surgery called targeted sentinel node biopsy (TSNB). The goal is to see how well this technique finds cancerous nodes and to measure rates of a…

This study aims to create personalized tumor models (called PDX and organoids) from breast cancer patients who still have cancer after initial therapy. By growing these models in mice, researchers hope to test new drug combinations and understand why some cancers resist treatment…

This study compares two methods for marking non-palpable breast tumors before surgery: a magnetic clip and a thin wire. Researchers will track costs, how well surgeons find and remove the tumor, patient satisfaction, and quality of life in 772 women. The goal is to see which meth…

This study aims to map the genetic makeup of breast and prostate cancers in patients treated through Brazil's public health system. Researchers will analyze tumor and normal DNA from 882 participants to build a national database for future precision medicine. The goal is to under…

This early-phase study tests whether an artificial intelligence platform can personalize cancer treatment for people with solid tumors (like breast or gastrointestinal cancer). Researchers will use a patient's own tumor sample to pick the best drug combination, then an AI system …

This study is for women aged 80 and older who have had breast cancer (stage 0 to III) but no recurrence. It tests a shared decision-making toolkit to help them and their doctors decide whether to continue yearly mammograms. The goal is to see if the toolkit leads to more informed…

This study is collecting blood samples from 1,000 people with digestive, gynecologic, or breast cancer to study tiny bits of tumor DNA and particles called exosomes floating in the blood. Researchers want to see if these markers can help predict how the cancer will behave, whethe…

This study looks at whether special scans and blood tests can help doctors know if endocrine therapy is working in people with a certain type of advanced breast cancer (lobular breast cancer). About 8 participants will get a PET scan and give blood samples before and after 4 week…

This study enrolls 3,000 women who are at least twice as likely as average to develop breast cancer. Researchers collect tissue and blood samples to build a better risk-prediction tool. The goal is to understand risk factors and find markers that could one day help prevent the di…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback. The goa…

This study tests a new type of MRI called TMEM-MRI to see if it can show how likely breast cancer is to spread. About 95 people with operable breast cancer will get this special scan before surgery. The goal is to see if the scan can measure tumor features linked to metastasis, w…

This study looks back at the medical records of 200 women with breast cancer to compare two types of breast-conserving surgery: one done with a robot and one done with an endoscope. The goal is to see which method leads to fewer complications, shorter operation times, and better-…

This study looks at whether taking cannabidiol (CBD) pills can change how breast cancer cells grow or die. About 84 women with invasive breast cancer will take either a low or high dose of CBD or a placebo for up to 56 days before their surgery. The goal is to see if CBD affects …

This study checks if a new device can prepare blood samples to look for cancer signals. It involves 45 people: 20 healthy volunteers and 25 with advanced breast cancer. Each gives one blood sample. The goal is to see if the tool works well, not to treat or cure any disease.

This study is for people with triple-negative breast cancer who still have cancer cells after standard chemotherapy. Researchers will use a simple blood test (liquid biopsy) to look for tumor DNA before and during treatment with the drug capecitabine. The goal is to learn whether…

This study tests a new type of CT scan (HyperSight) that may produce clearer images during radiation therapy for cancer. About 50 adults with various cancers will get extra scans to see if the new method improves image quality and could help doctors plan treatment more accurately…

This study looks at whether deep inspiration breath-hold (DIBH) radiotherapy plans for breast cancer patients who need radiation to the internal mammary lymph nodes stay accurate during treatment. Researchers will measure how well the radiation dose covers the target area and how…

This study aims to create a 'living biobank' of breast cancer organoids—tiny 3D tumor models grown from a patient's own cancer tissue. Researchers will test whether these organoids mimic the original tumor's behavior and can predict how the cancer will respond to treatments. The …

This study aims to match breast cancer patients with the most effective experimental drugs based on their tumor's unique features. Up to 5,000 participants will receive standard chemotherapy plus an experimental agent before surgery. Researchers will use MRI scans, tissue, and bl…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works for breast cancer. Researchers will collect blood samples and track tumor responses in 100 premenopausal women with triple-negative breast cancer. …

This study collects tumor samples from 400 breast cancer patients at key moments—diagnosis, surgery, and if the cancer returns or spreads. Researchers will grow mini-tumors in the lab and study genes and immune cells to better understand the disease. The goal is to learn, not to …

This study aims to improve how women in rural areas decide about getting mammograms. Researchers are testing a decision aid called MyMammogram, with or without a summary for their doctor, compared to usual care. About 39 women aged 39-49 and their primary care providers will help…

This study is a registry for people with triple negative breast cancer or those with inherited gene mutations like BRCA1/2. It aims to learn how often these mutations occur and how they affect treatment response and long-term survival. Up to 1,500 participants will be followed ov…

This study follows 1,250 women who have had lymph nodes removed during breast cancer surgery to see how many develop lymphedema (arm swelling). Researchers will also look at breast tissue removed during surgery for signs of inflammation that might raise risk. Participants will an…

This study looks at why some women with breast cancer have worse outcomes than others, especially African American and American Indian women. Researchers will collect medical and genetic information and also teach participants how to better communicate with their healthcare team.…

This study looks at breast cancer risk and screening in people taking hormone therapy. Researchers will collect breast imaging data and talk to participants about their experiences and barriers to screening. The goal is to better understand how to support this group. About 130 ad…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemotherapy drugs. Participants will give blood samples a…

This study looks at how social factors like stress and support relate to inflammation in women newly diagnosed with breast cancer. About 200 participants will fill out questionnaires and give one blood sample. The goal is to understand these connections, not to test a treatment.

This study gathers information from 30,000 breast cancer patients treated at Institut Bergonié since the 1990s. Researchers will analyze the data to learn about survival rates, treatment practices, and factors that affect the disease's outlook. The goal is to better understand br…

This study looks at a less invasive technique called target axillary dissection (TAD) to check if cancer has spread to lymph nodes after chemotherapy in people with locally advanced breast cancer. The goal is to see if TAD is accurate enough to replace more extensive lymph node r…

This study looks at specific gene changes (HRD/HRR) in people with HER2-low breast cancer, a type that doesn't have high levels of the HER2 protein. Researchers will collect tumor and blood samples from 255 participants to see how common these gene changes are and whether they af…

This study looks at whether a blood test can find tiny bits of tumor DNA left after surgery in women with early-stage breast cancer. The goal is to see if this test can help identify patients who are more likely to have their cancer come back. The study includes a special focus o…

This study follows 100 people with stage III triple-negative breast cancer who are receiving standard chemotherapy before or after surgery. Researchers will collect information from medical records and ask participants to fill out quality-of-life questionnaires on a phone app at …

This study explores whether using alternative or complementary therapies (like herbal supplements) influences how well patients with early-stage breast cancer stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure adherence and check tamox…

This study looks at how often breast cancer spreads to other parts of the body in patients who still have cancer in their lymph nodes after chemotherapy and surgery. About 120 participants will get CT scans at the start and again at 6 months to check for any spread. The goal is t…

This study is looking at how antibiotics change the bacteria in the gut and breast after a mastectomy with implant reconstruction. Researchers want to see if certain bacteria make infections more likely. About 200 women with breast cancer or a high genetic risk will provide sampl…

This study is for people with high-risk early breast cancer, including inflammatory breast cancer. Researchers want to see if tiny clusters of tumor cells found in the blood can help predict how well treatment works and whether the cancer stays away. By studying these cell cluste…

This study compares two approaches to breast cancer screening: the standard annual mammogram starting at age 40 versus a personalized schedule based on each woman's individual risk. Researchers will enroll 100,000 women aged 30-74 across the U.S. to see if personalized screening …

This study is creating a registry of 200 people with stage III or IV inflammatory breast cancer (IBC) who have had a blood test called Signatera to look for leftover cancer cells (MRD). Researchers will collect medical data and quality-of-life survey results to better understand …

This study looks at why some hormone receptor-positive breast cancers become resistant to standard hormone-blocking therapy. About 100 women with early-stage breast cancer will receive anti-estrogen treatment for 4-12 weeks before surgery. Researchers will analyze tumor samples t…

This study looks at whether changes in a blood marker called ctDNA can help doctors tell early on if immunotherapy is working for people with advanced cancers like lung, breast, colorectal, stomach, or liver cancer. Researchers will also check other markers like PD-L1 and TMB to …

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. It does not provide any treatment. Up to 1,750 participants will give blood samples, and some may also provide tissue, urine, or stool. The …

This study explores whether certain genetic variations can predict severe side effects from powerful breast cancer drugs called antibody-drug conjugates. Researchers will analyze blood samples from 70 patients with advanced breast cancer to see if a specific gene (UGT1A1) is link…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, it checks their health once a year for 15 years to watch for any long-term side effects. Up to 750 participants with various cance…

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study aims to find out how much a specific gene change (CTNNA1) raises the risk for stomach and breast cancer. Researchers will collect family health histories from 100 adults who carry this gene change or are close relatives of a carrier. The goal is to better understand th…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a nutrition and exercise program helps them eat better and move more. About 306 survivors and their healthcare providers will take part. The goal is to see if survivors agr…

This study is testing whether routine brain MRI scans can detect breast cancer that has spread to the brain in patients with certain types of advanced breast cancer. Researchers will follow 214 participants over time to see if early detection improves quality of life and reduces …

This study is testing a new type of mastectomy (breast removal) for breast cancer that uses a small camera and tools through a single cut in the armpit, leaving no visible scar on the breast. It aims to see if this technique is safe and works well for 20 women with small to mediu…

This study aims to collect information from cancer patients (breast, lung, ovarian, multiple myeloma, or AML) using weekly online surveys about their symptoms. The goal is to build a database that helps doctors better understand and manage side effects during treatment. Participa…

This study looks at whether it's possible to routinely scan the brains of people with HER2-positive breast cancer that has spread to other parts of the body. These patients are at high risk for brain metastases, which can cause serious symptoms. The study will compare regular bra…

This study aims to learn why different people have different risks and outcomes for breast cancer. Researchers will collect blood, tissue samples, and survey data from 800 men and women in South Florida. The goal is to find genetic and non-genetic factors that may explain these d…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Participants will fill out a simple questionnaire and can receive genetic counseling and testing through video calls. The goal …

This study looks at whether women who finished breast cancer treatment can safely switch to a simpler follow-up plan. Instead of regular in-person check-ups, they would only get yearly mammograms. The goal is to see if this approach is just as safe and improves quality of life. A…

This study aims to understand how BRCA gene mutations and cancer treatments affect the ovaries in premenopausal women with early-stage breast cancer. Researchers will measure hormone levels in the blood before, during, and after treatment to see which women are more likely to hav…

This study looks at 750 women who have had or will have a mastectomy (full breast removal) for breast cancer and also need radiotherapy. The goal is to find out which type of breast reconstruction—using implants or the patient's own tissue—and what timing (before or after radiati…

This study looks at how common and severe menopause-related symptoms (like vaginal dryness and pain) are in breast cancer survivors compared to healthy women. Researchers will follow 264 women with breast cancer who receive either hormone therapy or chemotherapy, plus a healthy c…

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study collects tissue, blood, and urine samples from up to 4,000 women with or without breast cancer. The samples are stored in a central repository so researchers can study DNA, RNA, and proteins to better understand the disease. No treatment is given; the goal is to create…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study is looking for blood markers that could help predict where breast cancer might spread. Researchers will measure two types of markers in the blood of 160 women: some with cancer that has spread, some with early-stage cancer, and some healthy. The goal is to develop a no…

This study is looking back at medical records of 300 adults with breast cancer that has spread to only a few places in the body (oligometastatic). Researchers want to see if a precise type of radiation called stereotactic body radiotherapy (SBRT) can help control the cancer and h…

This study aims to create a registry of 400 women at high risk for breast cancer to test whether a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will be scanned every 6 months. The goal is to develop faster, personalized screen…

This study looks at whether it is possible and acceptable to take multiple tissue samples (biopsies) from different tumor sites over time in people with metastatic breast cancer. The goal is to understand how the cancer changes and becomes resistant to treatment. Researchers will…

This study is building a platform to better understand a person's risk of developing cancer or having it come back. Researchers will analyze blood samples from 850 people with certain cancers to find genetic markers, immune system changes, and other biological clues. The goal is …

This study collects tumor tissue from 10,000 women having breast cancer surgery. The samples are stored and used for future research to help doctors better understand breast cancer. Participants do not receive any treatment as part of this study.

This study looks at how well CDK4/6 inhibitors (like palbociclib or abemaciclib) work in real-world settings for people with HR+/HER2- advanced breast cancer. It also explores what treatments doctors choose when the cancer stops responding to these drugs. The goal is to gather in…

This study is testing whether a blood test can find tiny bits of cancer DNA left in the body after breast cancer treatment. The goal is to see if this test can predict if the cancer will come back. About 900 people with different types of breast cancer will give blood samples ove…

This study looks at a community-based program to help adults who often miss cancer screenings get tested for lung, breast, and prostate cancers at local resource spots. About 200 adults who meet screening guidelines will take part. The goal is to see if this approach increases sc…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to match patients with effective treatments and…

This study will look at how doctors currently diagnose lung and breast cancer by examining tissue samples. Researchers will also test new computer programs that use artificial intelligence to help read the samples faster and more accurately. The goal is to see if AI can improve t…

This study is testing a new PET-CT scanner that takes detailed pictures of cancer tissue right after it is removed during surgery. Researchers want to see if these images match what the lab finds under a microscope. About 850 people with prostate, breast, head and neck, or other …

This study tracks how a common breast cancer drug (aromatase inhibitor) changes the bacteria in your gut and how that might affect estrogen levels. Researchers will collect stool and blood samples from 25 participants before and after starting the medicine. The goal is to underst…

This study is developing artificial intelligence (AI) tools that can help doctors make better, personalized decisions for patients with heart disease, breast cancer, or sepsis. The goal is to make AI recommendations clear and trustworthy for doctors, while also ensuring safety. T…

This study explores whether a computer algorithm called ENLIGHT can recommend approved drugs that might work better for people with advanced breast cancer that has stopped responding to standard treatments. About 175 adults with triple-negative or hormone-resistant breast cancer …

This study looks at whether a probiotic supplement called BIOHM can change the bacteria and fungi living in breast tumors and the gut of people with breast cancer. Researchers want to understand how these tiny organisms might affect cancer development. About 100 participants with…

This study collects small tissue samples (core biopsies) from people with known or suspected breast cancer to create a tissue repository. The goal is to help researchers study the biology of breast cancer, including how tumors grow and respond to therapy. Up to 400 participants w…

This study watches 3,000 people with hormone-positive, HER2-negative stage II or III breast cancer who are already taking ribociclib or abemaciclib with hormone therapy. Researchers will look at medical records and ask patients about their quality of life, side effects, and how w…

This study collects blood or cheek swab samples from people with cancer who are already in treatment at the National Cancer Institute. Researchers will analyze the DNA to find genetic differences that may affect how the body processes cancer drugs and whether side effects occur. …

This study is testing whether a special blood test can help predict if breast cancer will come back in people who have already had chemotherapy and surgery. Researchers will follow 484 women for several years to see if finding cancer cells in the blood is linked to the cancer ret…

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is safe and helpful. About 120 women will be randomly assigned to receive reconstruction with or without mesh. The goal is to understand if the mesh, which is commonly used but not FDA-a…

This study looks at whether patient navigators—people who guide and support patients through their care—can help more African American, Native American, and Hispanic patients complete radiation therapy for breast or prostate cancer. About 420 adults will take part. The goal is to…

This early-phase study tests a special PET/CT scan that uses a modified tryptophan molecule to highlight tumors. Researchers want to see if this scan can better distinguish cancer from healthy tissue in people with brain tumors, breast cancer, neuroendocrine tumors, or rectal can…

This study is looking at tiny molecules in the blood called microRNAs to see if they can predict how well breast cancer responds to chemotherapy given before surgery. Researchers will collect blood samples from 80 women with breast cancer before and after chemotherapy. The goal i…

This study looks at whether certain fats made from dietary fatty acids are linked to breast cancer and body weight in postmenopausal women. Researchers will compare four groups of women (healthy or with breast cancer, and with normal weight or overweight/obesity) to measure these…

This study looks at two methods for removing breast cancer in women with early-stage breast cancer. One method removes extra tissue around the tumor routinely, while the other uses a special marker called Savi Scout to remove only the needed tissue. The goal is to see if the targ…

This study compares blood components between younger and older women with a common type of breast cancer (HR+HER2-). Researchers want to find out if age-related differences in the blood can predict how well treatment works. The study does not test any new drugs—it simply observes…

This observational study is testing whether advanced MRI scans can predict how well breast cancer responds to chemotherapy earlier and more accurately than standard tumor size measurements. About 135 participants receiving standard chemotherapy will undergo additional MRI scans t…

This study looks at whether women having breast reconstruction after mastectomy are comfortable with being randomly assigned to receive either a biological or synthetic mesh. Sixty women will take part and be followed for 6 months. The goal is to see if a larger trial comparing t…

This study looks at whether upper-body aerobic exercise can reduce artery stiffness caused by cancer treatments in women with breast cancer. Researchers will measure blood vessel health in 18 women aged 40-69 who are at least 15 months past surgery. The goal is to understand if e…

This study is testing a new artificial intelligence (AI) tool called Ataraxis that analyzes images of breast cancer biopsy slides to predict how well a patient will respond to chemotherapy before surgery. The goal is to see if the AI can be easily used in real-world clinics and i…

This study looks at what breast cancer survivors and their family members know about chemicals in everyday products like lotions and makeup. Researchers want to see if there is a connection between being overweight and these chemicals that can affect hormones. About 30 people fro…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests whether a large language model (AI) can help junior doctors write more accurate and efficient cancer treatment reports. Forty junior doctors will either use AI assistance or traditional methods to create reports for 20 cancer patients. Experts will then score the…

This study uses a special genetic test on breast cancer tumor samples to find mutations that could help doctors choose more targeted therapies. It involves 1,600 people with primary or brain-metastatic breast cancer. The goal is to see if this testing finds more actionable mutati…

This study is testing a new imaging agent called [18F]F-GLN to see how well it shows breast cancer on PET/CT scans. About 40 adults with known or suspected breast cancer will receive one injection of the tracer and then be scanned. The goal is to gather information on safety and …

This study is looking at proteins called selenoproteins in people with a type of breast cancer called triple-negative breast cancer (TNBC). Researchers want to see if these proteins can help predict how the disease will progress or be used as targets for future treatments. The st…

This study looks at whether women with early-stage breast cancer can stick to a special diet (ketogenic or low-protein) for about 9 days before their surgery. The goal is not to treat the cancer directly, but to see if the diet is feasible and to study how it affects cancer cells…

This study looks at how cancer impacts not just the patient, but their entire family. Researchers will survey 240 Danish patients with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. The goal is to understand family health, needs, and emotional well…

This study looks at how a woman's immune system reacts to breast cancer, especially if she has been pregnant before. Researchers will follow 800 young women with breast cancer to understand these interactions. The goal is to learn more, not to test a new treatment.

This study tests a training program called Just ASK™ that helps doctors and nurses talk to breast cancer patients about clinical trials. Researchers want to see if the training increases how often these discussions happen. About 80 patients and their healthcare teams will take pa…

This study collects mammogram images and survey answers from 20,000 adults to train artificial intelligence (AI) models. The goal is to help doctors read mammograms more accurately for different groups and types of breast cancer. Participants donate their images and get to view t…

This study collects fluid from around the lungs (pleural fluid) from people with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No treatments or new procedures are involved—samples are taken d…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study looks at whether chemotherapy for early-stage breast cancer speeds up aging in organs like the heart and brain. Researchers will measure specific proteins and cell changes in blood samples from 80 women before and after treatment. The goal is to identify patients at hi…

This study aims to understand the current state of breast cancer care by surveying both patients and doctors. The goal is to identify gaps in communication and time management, and to develop better care models together. About 2000 adults with breast cancer and their physicians w…

This study observes 126 adults with HER2-negative early breast cancer who are starting treatment with olaparib. Researchers will track how many patients complete the full 12-month course and look at genetic mutations. The goal is to understand real-world treatment patterns, not t…

This study collects tumor and blood samples from 100 breast cancer patients to grow mini-tumors (organoids) in the lab. Researchers will then test whether specially engineered immune cells called CAR-macrophages can kill these organoids. The goal is to learn which types of breast…

This study is collecting medical data from 300 people with early-stage breast cancer who will receive chemotherapy before surgery. The goal is to build a computer algorithm that can predict whether the tumor will completely disappear after treatment. This could help doctors perso…

This study looks at how well CDK4/6 inhibitors work and what side effects they cause in women aged 70 and older with breast cancer. Researchers will compare these older patients to younger ones to see if age affects treatment outcomes. The goal is to provide better guidance for t…

This study compares three types of remote medical interpreting (simultaneous, consecutive, and video) to see which one leads to fewer mistakes when Spanish- and Mandarin-speaking breast cancer patients talk with their English-speaking doctors. About 700 patients with stage II or …

This study tests whether watching a short educational video about safe opioid use can help people use fewer opioids after breast reconstruction surgery. About 68 women who have had a mastectomy for breast cancer will be randomly assigned to either watch the video or receive stand…

This study is testing a mobile decision aid for breast cancer patients who have had surgery. Twenty participants will use the tool on their phones and share their thoughts out loud. Researchers will measure how much the tool improves knowledge about reconstruction options. The go…

This study is looking at a specific type of breast cancer that has spread (metastatic) and is HER2-negative but has androgen receptors (AR-positive). Researchers want to see if a special PET/CT scan that detects a protein called PSMA can help predict which cancers will not respon…

This study tests whether educational tools can help breast cancer patients and their doctors better recognize and manage side effects from certain targeted drugs (antibody drug conjugates). About 30 patients and their clinicians will receive training and complete surveys to measu…

This study looks at how many breast and lung cancer patients have a strong, ongoing fear that their cancer will return. Researchers will survey 200 patients and interview 40 of them to understand their feelings, thoughts, and whether they feel they get enough support. The goal is…

This study is for 500 adults with breast cancer who are about to start treatment like chemotherapy or immunotherapy before surgery. Researchers will collect tumor tissue, blood, and sometimes MRI scans and stool samples during treatment. The goal is to learn why some cancers shri…

This study tests a new AI program called Mirai that analyzes mammograms to predict breast cancer risk more accurately than current methods. Researchers will invite 200 women identified as high-risk by Mirai to receive an additional MRI scan. The goal is to see if using AI leads t…

This study is building a registry of 1000 breast cancer survivors aged 50 or younger who have dense breast tissue. Researchers will collect information from their regular MRI scans to better understand how well MRI works for finding cancer in dense breasts. The goal is to gather …

This study aims to create an artificial intelligence system that can predict if and where breast cancer will spread to other parts of the body, such as the bones, lungs, liver, or brain. Researchers will analyze tumor samples and health data from 2,000 women with breast cancer to…

This study is testing a digital chatbot that provides educational information about mammograms to women who recently had one. Researchers want to see if using the chatbot helps women, especially those from underserved communities, follow screening recommendations and get needed f…

This study looks at how hormone receptor-positive/HER2-negative breast cancer cells use energy (sugar). About 16 people with early-stage breast cancer will receive a special glucose infusion before surgery. Researchers will then analyze the tumor tissue to understand its metaboli…

This study aims to understand why some breast cancers with BRCA mutations become resistant to PARP inhibitor drugs. Researchers will analyze tumor and blood samples from 120 patients with advanced breast cancer to see if certain proteins (POLQ, Shieldin complex, 53BP1) can predic…

This study looks at 300 people with HER2-positive breast cancer that hasn't spread. Researchers want to see if those with very high HER2 levels respond differently to a combination of two targeted drugs (trastuzumab and pertuzumab). The goal is to understand if HER2 levels can pr…

This study looks at whether artificial intelligence can help analyze tiny particles in the blood (called liquid biopsies) from people with triple negative breast cancer. The goal is to develop a test that tells doctors early on if the cancer has spread and how much tumor remains …

This study is for women with a certain type of breast cancer that is hormone-sensitive, HER2-negative, and has spread to 1-3 lymph nodes. Researchers want to see if it is safe to skip radiation therapy to the lymph nodes in patients whose tumors show a low risk of coming back on …

This study looks at how the cost of cancer treatment affects the finances of people with early-stage breast cancer. Researchers will follow 864 patients for one year, using a questionnaire to measure changes in financial distress. The goal is to understand what causes financial p…

This study looks at a new method to mark the area where breast cancer was removed during surgery. The goal is to help radiation doctors see the exact spot on scans so they can aim radiation more precisely. It also aims to reduce the need for repeat surgeries when cancer cells are…

This study looks at how genes influence breast cancer risk. Anyone 18 or older living in the US can join, even if you don't have cancer. You fill out online surveys and mail in a saliva sample. Participants may get free genetic ancestry information.

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study collects leftover tissue from standard breast cancer surgeries and a one-time blood sample from 200 adults with breast cancer or precancer. Researchers will analyze these samples to identify tumor markers and gene patterns. The goal is to learn more about breast cancer…

This study is testing a new, highly sensitive blood test to detect tiny particles called extracellular vesicles released by breast cancer cells. Researchers will compare levels of these particles in 105 women with early or metastatic breast cancer and healthy volunteers. The goal…

This study is testing whether a new radioactive imaging agent can safely and clearly show tumors in people with many types of solid cancers. About 32 adults will receive a single injection of the agent and then have PET/CT scans to see where it goes in the body. The goal is to le…

This study looks at whether a family history screening program can help more women in rural public health clinics learn about their risk for BRCA-related breast and ovarian cancers. About 3,200 women over age 25 in Southwest Georgia will take part. The goal is to see if the progr…

This study looks at how near-complete estrogen deprivation (NCED) therapy, used to treat breast cancer, affects heart function. Researchers will use heart scans to measure blood flow in 90 women aged 55 or younger who are premenopausal at diagnosis. The goal is to understand if t…

This study is for women aged 60 and older with newly diagnosed breast cancer who are scheduled for chemotherapy. Researchers want to understand how chemotherapy affects thinking skills and the brain over time. Participants will complete thinking tests and some may have brain scan…