New hope for Hard-to-Treat breast cancer: Dato-DXd trial opens
NCT ID NCT07205822
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is testing a drug called Dato-DXd in 100 people with a type of advanced breast cancer (HR-positive, HER2 IHC 0) that has stopped responding to hormone therapy. Participants receive the drug by IV every 3 weeks. The goal is to see if it can slow cancer growth and to check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dato-DXd (a drug given by IV every 3 weeks)
What this could lead to
If it works, this could offer a new treatment option for people with a common type of advanced breast cancer that has stopped responding to hormone therapy.
What could go wrong
This is an early Phase 3 study with only 100 participants, so results may not apply to everyone. Side effects like mouth sores and eye problems are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Research Site
WITHDRAWNLargo, Florida, 33770, United States
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RECRUITINGFort Wayne, Indiana, 46825, United States
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RECRUITINGOmaha, Nebraska, 68130, United States
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NOT_YET_RECRUITINGNew York, New York, 10021, United States
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RECRUITINGHouston, Texas, 77024, United States
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RECRUITINGPuyallup, Washington, 98373, United States
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RECRUITINGBeijing, 100021, China
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NOT_YET_RECRUITINGChangsha, 410013, China
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RECRUITINGGuangzhou, 510060, China
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RECRUITINGLinyi, 276001, China
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NOT_YET_RECRUITINGShandong, 250117, China
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NOT_YET_RECRUITINGWuhan, 430071, China
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NOT_YET_RECRUITINGZhengzhou, 450008, China
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RECRUITINGClermont-Ferrand, 63050, France
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RECRUITINGLa Roche-sur-Yon, 85925, France
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RECRUITINGMontpellier, 34070, France
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RECRUITINGParis, 75005, France
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RECRUITINGPierre-Bénite, 69310, France
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RECRUITINGAviano, 33081, Italy
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RECRUITINGFlorence, 50134, Italy
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RECRUITINGMeldola, 47014, Italy
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RECRUITINGMilan, 20141, Italy
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RECRUITINGNaples, 80131, Italy
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RECRUITINGRoma, 00168, Italy
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RECRUITINGBukgu, 41404, South Korea
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RECRUITINGGoyang-si, 410-769, South Korea
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RECRUITINGSeoul, 03080, South Korea
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RECRUITINGSeoul, 06273, South Korea
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RECRUITINGSeoul, 06351, South Korea
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RECRUITINGSeoul, 06591, South Korea
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RECRUITINGSeoul, 136705, South Korea
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RECRUITINGSeoul, 3722, South Korea
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RECRUITINGSeoul, 5505, South Korea
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RECRUITINGA Coruña, 15006, Spain
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RECRUITINGBarcelona, 08035, Spain
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NOT_YET_RECRUITINGGranada, 18007, Spain
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NOT_YET_RECRUITINGMadrid, 28033, Spain
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RECRUITINGMadrid, 28040, Spain
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RECRUITINGSeville, 41009, Spain
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NOT_YET_RECRUITINGValencia, 46009, Spain