Astrazeneca

This study is testing a new experimental drug called AZD9574, given alone or with other cancer treatments, in people with advanced solid tumors that have come back or gotten worse. The main goals are to check the drug's safety, find the right dose, and see if it helps shrink tumo…

This study tests a drug called sodium zirconium cyclosilicate (SZC) to safely lower high potassium levels in children under 18. About 140 kids will receive the drug for up to 3 days to correct potassium levels, then continue for 28 days to maintain normal levels. The goal is to s…

This study tests whether a new drug combination (trastuzumab deruxtecan plus immunotherapy) works better than standard chemotherapy for people with advanced or returning endometrial cancer that has a specific protein (HER2) and is mismatch repair proficient. About 600 adults will…

This study tests a new drug called AZD1163 in 320 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to standard treatments. The goal is to see if AZD1163 can reduce joint swelling and pain better than a placebo over 12 weeks. Participants will receive…

This early-stage study tests a new drug called AZD3470 in adults with advanced solid tumors that lack a gene called MTAP. The drug is designed to block a protein these cancer cells need to grow. The main goals are to check safety, find the right dose, and see if it shrinks tumors…

This study tests a weekly shot called anifrolumab for people with lupus who have not taken strong immune-suppressing drugs before. The goal is to see if adding this medicine to standard care helps more patients reach remission and safely reduce or stop steroid use. About 245 adul…

This study tests a new oral drug, AZD3470, in people with certain blood cancers like lymphoma. The goal is to see if it is safe and works, either alone or with other cancer drugs. About 161 adults and teens will take part. This is an early-stage trial, so the main focus is on saf…

This study compares a new drug, puxitatug samrotecan, with standard chemotherapy for people whose advanced endometrial cancer has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new drug or a chemo chos…

This study tests whether adding a second immunotherapy drug (domvanalimab) to the standard drug durvalumab can better control stage III lung cancer that hasn't gotten worse after initial chemo-radiation. About 860 adults with a specific type of lung cancer will receive either the…

This study follows 335 adults with severe eosinophilic asthma who are taking benralizumab. Researchers want to see if the drug can help patients reach partial or complete clinical remission—meaning fewer symptoms, no need for steroid pills, and better lung function—over 12 to 24 …

This study tests a new drug, AZD7798, to see if it can safely help heal the gut lining in people with active Crohn's disease who have an ileostomy. About 30 adults aged 18 to 80 will receive either the drug or a placebo. The main goals are to check for side effects and see if the…

This study looks at how well a drug called anifrolumab works for people with lupus when used in normal doctor visits. About 125 adults will receive the medication as a shot under the skin and be followed for 2 years. The main goal is to see if the drug can help control disease ac…

This study tests a new drug called volrustomig combined with other cancer medicines in people with advanced non-small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. About 180 adults will take part, and the study is currently recruiting.

This study compares a new drug, rilvegostomig, to the current standard treatment, pembrolizumab, for people with advanced non-small cell lung cancer that has high levels of PD-L1. The goal is to see if the new drug works better at helping people live longer or stopping the cancer…

This study tests a targeted cancer drug (trastuzumab deruxtecan) combined with immunotherapy, with or without chemotherapy, as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called HER2. The main goal is to check safety and…

This study tests whether a new drug called AZD0486 combined with rituximab works better than standard chemotherapy plus rituximab for people with untreated follicular lymphoma, a slow-growing blood cancer. About 1,018 adults who have not had prior treatment will be randomly assig…

This study tests an experimental drug called AZD4512, alone or with other cancer drugs, in adults with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has returned or stopped responding to standard treatments. The main goals are to check the drug's safety, find the best…

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed, localized prostate cancer. The goal is to see how the drugs affect tumor cells and check for side effects. About 120 men will take part.

This study tests an experimental drug called AZD0516, given alone or with other cancer medicines, for men with metastatic prostate cancer (cancer that has spread). The main goals are to check safety, find the best dose, and see if it can shrink tumors or lower PSA levels. About 1…

This study tests a drug called benralizumab in 200 children and teens aged 6 to 17 with severe eosinophilic asthma that is not well controlled despite high-dose inhalers and other medications. The goal is to see if the drug can reduce asthma attacks and improve symptoms. Particip…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if the drug can slow cancer growth and to check its safety. About 100 adults whose cancer…

This study tests whether a new drug called rilvegostomig works better than the standard drug pembrolizumab when both are given with chemotherapy for people with advanced non-squamous lung cancer that has spread. About 878 adults whose tumors have a protein called PD-L1 will take …

This study follows 1,000 people aged 12 and older with severe eosinophilic asthma who are prescribed benralizumab in China. Researchers will track how well the drug controls asthma symptoms over time and why some patients may stop or switch treatments. The goal is to see how benr…

This study is for people with advanced HER2-positive stomach or esophageal cancer. It tests a drug called trastuzumab deruxtecan (T-DXd) alone or with chemotherapy and/or immunotherapy to see if it can shrink tumors and be safe. About 450 adults will take part. The goal is to con…

This study is testing whether people with severe asthma who take tezepelumab can safely cut back on their other daily asthma medications without losing control of their symptoms. About 400 participants aged 12 to 80 will be enrolled. The goal is to see if they can reduce or stop …

This large Phase 3 study is testing an experimental daily pill called AZD0780 to see if it can reduce the chance of serious heart problems like heart attacks, strokes, and emergency procedures in people who already have heart disease or are at high risk. About 15,100 participants…

This study tests a new drug called volrustomig in people with advanced head and neck cancer that has not spread. Participants have already completed standard chemoradiation and their cancer has not grown. Half will receive volrustomig and half will be watched. The goal is to see …

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This early-stage study tests a new drug called AZD1390 given together with radiation therapy for people with glioblastoma or brain metastases. The main goals are to find safe dose levels and understand side effects. About 180 participants will receive different doses to see how t…

This study tests an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. The goal is to see if adding this drug to standard care can prevent death or the need for a breathing machine or life support. Participan…

This study tests a new drug, AZD0901, against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has spread and has a specific marker called CLDN18.2. About 572 adults who have already had at least one prior treatment will be randomly as…

This study tests a new drug called surovatamig in 240 adults with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has returned or not improved after at least two prior treatments. The drug is given alone to see if it can shrink tumors and how safe it is. The trial is op…

This study tests an experimental drug called tezepelumab in adults aged 40 to 80 with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups compared to a placebo. Participants must have had at least two moderate or one severe…

This study follows 1,400 adults with moderate to severe COPD who are starting a triple-combination inhaler (Breztri/Trixeo). Researchers will track changes in symptoms and quality of life over 12 months in routine care settings across Latin America, Asia, and the Middle East & Af…

This study tests a new drug called datopotamab deruxtecan (Dato-DXd) against a standard chemotherapy (docetaxel) in people with advanced or metastatic non-squamous non-small cell lung cancer that has a specific protein (TROP2) and no treatable gene changes. About 400 participants…

This study tests an experimental tablet called AZD6793 in about 1,160 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups compared to a placebo over 24 weeks. Participants must have had at least two moderate or one severe …

This study tests an experimental drug called AZD6621 for men with metastatic prostate cancer that has spread. The drug is designed to help the body's immune cells attack cancer cells. The trial has two parts: first finding the safest dose, then testing that dose in more people to…

This study tests whether a new drug combination (datopotamab deruxtecan plus rilvegostomig) or rilvegostomig alone works better than the current standard treatment (pembrolizumab) for people with advanced non-squamous lung cancer that has high PD-L1 levels. About 675 adults with …

This study tests a new drug, AZD0901, alone or with other cancer medicines, in people with advanced solid tumors that have a specific protein called CLDN18.2. The goal is to see if the drug is safe and shrinks tumors. About 224 adults with stomach, bile duct, or pancreatic cancer…

This large Phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the chance of heart failure or heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. About 11,300 adults aged 40 an…

This study tests whether a new combination pill (balcinrenone/dapagliflozin) works better than dapagliflozin alone at preventing heart failure events and heart-related death. About 4,800 adults with heart failure and moderate-to-severe kidney problems will take one pill daily for…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 participants will be followed for up to a year to see if the drug improves nasal blockage and reduces polyp size. The goal is to understand real-w…

This study looks at whether the drug durvalumab can help control limited-stage small-cell lung cancer after standard chemoradiation. About 200 adults in China who have not gotten worse after initial treatment will receive durvalumab. Researchers will track how long the cancer sta…

This study is for people with limited-stage small cell lung cancer whose cancer has not grown after initial chemotherapy and radiation. The goal is to see if the drug durvalumab, given as a follow-up treatment, is safe and works well in a real-world setting. About 70 adults in Sp…

This study tests whether a new combination pill (zibotentan plus dapagliflozin) works better than dapagliflozin alone in adults with chronic kidney disease and high levels of protein in their urine. About 224 participants will take either the combo or the single drug daily for se…

This early-stage study tests the safety of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive either one or two doses and are monitored for side effects and how the drug moves through the body over about 6 months. The goal i…

This study tests whether adding the experimental drug volrustomig to standard chemotherapy helps people with advanced pleural mesothelioma live longer. About 825 adults whose cancer cannot be removed by surgery will receive either the new combination or one of two standard treatm…

This study tests a new treatment called AZD0120 for people with multiple myeloma that has come back or not responded to at least three prior therapies. The treatment uses a patient's own immune cells, modified to target two proteins (CD19 and BCMA) on myeloma cells. The goal is t…

This study tests new combinations of drugs in people with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. The goal is to see if these combinations can shrink tumors or slow the disease. About 163 adults who have not had prior …

This study is testing the safety of a drug called trastuzumab deruxtecan in 100 Indian adults with advanced HER2-positive breast cancer that cannot be removed by surgery or has spread. Participants have already tried another anti-HER2 treatment. The main goal is to track side eff…

This study tests a drug called osimertinib, which targets a specific gene mutation in lung cancer. It is given before and after radiation therapy to people with stage III lung cancer who cannot or choose not to have chemotherapy. The goal is to see if this approach helps control …

This study is testing a new drug called Dato-DXd, either alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prost…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, for weight loss in Chinese adults who are overweight or have obesity. About 871 participants aged 18 to 55 with a BMI of 27 or higher will receive the drugs or a placebo to check safety and effective…

This study compares two inhalers, PT027 and PT007, used as needed in Chinese adults with asthma. The goal is to see if PT027 reduces the risk of severe asthma attacks better than PT007. About 790 participants with a history of at least one severe attack in the past year will be f…

This early-phase study tests a new drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancer). The main goals are to check safety and find the right dose. About 403 adults will take part. This is a fi…

This study tests a new drug called volrustomig, either alone or with chemotherapy, in people with advanced or metastatic solid tumors (cervical, head and neck, esophageal, or mesothelioma). About 257 adults will take part to see if the drug shrinks tumors and how safe it is. The …

This study tests a new treatment called AZD0120, which uses a patient's own immune cells (CAR-T cells) to target two proteins on myeloma cells. It is for people with multiple myeloma that has come back or not responded to prior treatments. The study compares AZD0120 to standard d…

This study tests new drug combinations given before and after surgery for people with a type of stomach cancer that can be removed. About 100 adults with resectable gastroesophageal adenocarcinoma will receive these treatments to see if they are safe and help shrink or eliminate …

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people with various cancer types will be followed in real-world clinics to see if their tumors shrink and how long…

This study tests a new treatment called AZD0754, which uses a patient's own immune cells (CAR T-cells) to fight metastatic prostate cancer. About 60 adults with castration-resistant prostate cancer will receive this therapy to see if it is safe and shrinks tumors. The goal is to …

This study follows 300 adults with severe eosinophilic asthma who are prescribed benralizumab as part of their normal care. Researchers will track asthma control, quality of life, lung function, and medication use over a year to see how well the drug works in everyday settings. T…

This study is testing a drug called anifrolumab in children aged 5 to 17 with moderate to severe lupus. The goal is to see if it can help control the disease when added to their usual treatments. About 100 children will take part, and the study will measure how well the drug work…

This study tests an experimental drug called AZD5492 in people with certain B-cell blood cancers (like lymphoma or leukemia) that have returned or stopped responding to at least two prior treatments. The drug works by helping the body's own T cells attack cancer cells that carry …

This early-phase trial tests a new treatment called AZD0120, which uses a patient's own immune cells modified to target and calm overactive immune responses. The study includes 27 adults with systemic sclerosis, inflammatory myopathies, or hard-to-treat rheumatoid arthritis. The …

This study tests a drug called trastuzumab deruxtecan (T-DXd) in people with advanced solid tumors that have a specific marker (HER2). The drug is given alone or with other cancer medicines. The goal is to see if it can shrink tumors and control the disease. About 175 adults with…

This study tests new immune-boosting drugs, alone or with other cancer treatments, in people with advanced liver or bile duct cancer. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 294 adults whose cancer has spread or cannot be removed by surger…

This study monitors the safety and effectiveness of two drugs, Imjudo and Imfinzi, in 246 liver cancer patients in Korea. It observes patients already receiving these drugs as part of their normal care, without adding new treatments. The goal is to see how well the drugs work and…

This study looks at whether the drug anifrolumab can help people with lupus reach a state of low disease activity while taking a low dose of steroids (5 mg or less per day). About 218 adults in Italy will be followed for a year to see if this approach works in real life. The goal…

This study tests a new drug combination (rilvegostomig plus chemotherapy and trastuzumab deruxtecan) against the current standard treatment for advanced HER2-positive stomach cancer. About 840 adults whose cancer has spread and who have not had prior treatment will participate. T…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works outside of a strict r…

This study tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), works better than standard chemotherapy for people with a certain type of advanced triple-negative breast cancer that has PD-L1 protein. About 625 participants w…

This study tests a new drug called AZD0305, alone or with other cancer drugs, in about 226 adults with multiple myeloma. The goal is to check safety, find the right dose, and see if it helps control the cancer. Participants must have confirmed multiple myeloma and be in good enou…

This early-stage study is testing a new drug that delivers radiation directly to prostate cancer cells that have spread and stopped responding to hormone therapy. About 95 adults with this advanced cancer will receive the treatment to see if it is safe and what dose works best. T…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can slow the growth of metastatic prostate cancer that still responds to hormone treatment. About 1,800 men with a specific genetic marker (HRRm) or without it will be randomly assigned to…

This study tests an experimental drug called tezepelumab in about 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had …

This study tests a new drug called AZD8205, alone or with other cancer treatments, for people with advanced solid tumors like breast, ovarian, or lung cancer that have spread. About 460 adults whose cancer has not responded to standard care will take part. The main goal is to che…

This early-stage study tests a new drug called AZD0486 in people with B-cell non-Hodgkin lymphoma that has come back or not responded to other treatments. The drug is a special antibody that helps the immune system find and attack cancer cells. The main goals are to check safety …

This study tracks 100 Polish adults with systemic lupus erythematosus (SLE) who are receiving anifrolumab as part of their normal treatment. Researchers will measure changes in disease activity and overall response over time. The goal is to see how the drug performs outside of co…

This study follows 200 adults with systemic lupus erythematosus (SLE) who are starting anifrolumab for the first time as part of their routine care. Researchers will measure disease activity, skin symptoms, fatigue, and quality of life over time to see how well the drug works out…

This study tests a new drug called baxdrostat in about 250 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone, causing high blood pressure. The drug is taken daily and compared to a placebo to see if it lowers blood pressure and res…

This study tests an experimental drug called AZD0292 in people aged 12 and older who have bronchiectasis and a chronic lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo. Abou…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, which are …

This early-phase study tests a new drug that delivers radiation directly to cancer cells in people with advanced solid tumors (like lung, colon, head and neck, pancreatic, stomach, or kidney cancer) that have stopped responding to standard treatments. The main goals are to check …

This study tests an experimental pill called AZD0780 for people with high cholesterol (dyslipidaemia). About 360 adults with elevated LDL-C will take the drug or a placebo for up to 52 weeks to see if it safely lowers cholesterol levels. The goal is to find a new treatment option…

This study tests an investigational drug called tezepelumab in children aged 5 to 12 with severe asthma that is not well controlled by their current medicines. The goal is to see if adding tezepelumab can reduce the number of serious asthma attacks and improve lung function. Abou…

This study tests whether adding benralizumab (an injectable medication) to usual medium-dose inhaler treatment can reduce asthma attacks and improve quality of life in people with eosinophilic asthma that is not well controlled. About 400 participants aged 12 to 75 will receive e…

This study tests whether adding dapagliflozin to baxdrostat reduces protein in urine (a sign of kidney damage) more than baxdrostat alone in people with chronic kidney disease and high blood pressure. About 218 adults with moderate kidney function and high blood pressure will tak…

This study tests a drug called benralizumab in children aged 6 to 17 with two rare diseases that cause high levels of certain white blood cells (eosinophils). The goal is to see if the drug is safe and helps control the disease. About 14 children will take part, and the study wil…

This study tests a new oral drug, AZD3632, in people with advanced blood cancers like leukemia and myelodysplastic syndromes that have certain genetic changes. The main goals are to check the drug's safety and find the right dose. About 84 participants will take the drug alone or…

This study tests a subcutaneous (under-the-skin) version of the drug rilvegostomig in 40 adults with advanced solid tumors who have already tried standard treatments. The goal is to find a dose that works as well as the intravenous (IV) form and to check for side effects. Partici…

This study tests an experimental drug called AZD2373 in 96 adults with a genetic form of kidney disease linked to the APOL1 gene. The goal is to see if the drug can lower protein levels in urine, a sign of kidney damage, compared to a placebo. Participants will take the drug or p…

This study follows 50 adults in Poland with generalized myasthenia gravis (gMG) who are taking ravulizumab for the first time. Researchers will track changes in daily activities and muscle function over time. The goal is to see how well the drug works outside of a controlled tria…

This study tests whether adding a new drug (AZD0780) to a standard statin (rosuvastatin) can lower bad cholesterol more than the statin alone. About 76 adults with dyslipidaemia in Russia will take either the combination or a placebo plus statin for 12 weeks. The goal is to see i…

This study tests whether a three-drug inhaler (budesonide, glycopyrronium, and formoterol) works better than a two-drug inhaler (glycopyrronium and formoterol) at preventing serious heart and lung events in people with COPD. About 5,000 adults aged 40–80 with COPD and elevated ri…

This study tests a new daily pill, camizestrant, against standard hormone therapies to see if it better prevents breast cancer from returning in people with ER+/HER2- early breast cancer who have already completed initial treatments. About 4,300 participants at intermediate or hi…

This early-phase study tests a new drug called AZD2962, which blocks a protein called IRAK4, in people with certain blood cancers (like MDS or CMML) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug helps …

This study tests several new drug combinations given before and after surgery for early-stage non-small cell lung cancer. About 630 people with stage II to IIIB lung cancer will receive these treatments to see if they improve outcomes. The goal is to find safer and more effective…

This study will test a standard treatment plan for managing high potassium levels in people with chronic kidney disease who are not on dialysis. About 1,000 adults will follow a guideline-based approach to see if it helps control potassium and optimize their heart-kidney medicati…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before bladder cancer surgery is safe and effective. About 150 adults with muscle-invasive bladder cancer will receive the drug combination, then undergo surgery. The goal is to improve tre…

This early-phase study tests the safety of a new drug called surovatamig in 48 adults with rheumatoid arthritis or systemic lupus erythematosus. Researchers will monitor side effects and how the drug moves through the body after injection. The goal is to find a safe dose for futu…

This phase 3 study tests whether a new drug combination (saruparib plus camizestrant) works better than standard treatments for advanced breast cancer that is hormone receptor-positive and HER2-negative in people with BRCA1, BRCA2, or PALB2 gene mutations. About 500 adults with a…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard therapy. The main goals are to check safety and find the right dose. About 506 participan…

This study tests a new drug called AZD4512 in people with a hard-to-treat blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to other treatments. The goal is to see if the drug is safe and how well it works, either alone or with ot…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig) works better than standard chemotherapy for people with advanced bile duct cancer that has a specific protein called HER2. About 620 adults with untreated, advanced bile duct cancer will t…

This study tests a new drug, acalabrutinib, combined with standard chemotherapy (R-CHOP) for people with untreated mantle cell lymphoma who cannot have a stem cell transplant. The goal is to see how well the combination shrinks or controls the cancer. Participants will continue t…

This study tests new drug combinations in 120 people with metastatic colorectal cancer that has spread. The goal is to see if these treatments can slow tumor growth and improve survival. Participants must have measurable disease and good overall health.

This early-stage study tests the safety of a new medicine called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD), a condition that causes fluid-filled cysts to grow in the kidneys. Participants receive either the drug or a placebo to check for side …

This study tests a new drug (sonesitatug vedotin) plus chemotherapy, with or without another drug (rilvegostomig), in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specific marker (CLDN18.2) and is HER2-negative. About 2,130 participants…

This study tests whether adding glycopyrronium (an inhaled medication) to standard asthma therapy improves lung function in children aged 4 to under 12. About 69 children with asthma will receive two different doses of glycopyrronium and a placebo in random order, each for a shor…

This study tests a new drug called AZD4360 in adults with advanced solid tumors, including stomach, gastroesophageal junction, bile duct, and pancreatic cancers that have not responded to prior treatments. The main goals are to find a safe dose and check for side effects, while a…

This early-stage trial tests a new treatment called AZD0120 for people with multiple sclerosis (MS) that has not responded to other therapies. The treatment uses a patient's own immune cells, modified to target and attack harmful cells linked to MS. The main goal is to check if t…

This study follows 150 women with advanced or recurrent endometrial cancer who are receiving a standard treatment: chemotherapy plus durvalumab, followed by maintenance therapy with durvalumab alone or with olaparib. Researchers will track how long it takes for the cancer to prog…

This study tests whether a new drug combination (rilvegostomig plus bevacizumab, with or without tremelimumab) helps people with advanced liver cancer live longer compared to a standard treatment. About 1220 adults whose cancer cannot be removed by surgery or local treatments wil…

This study tests a combination of two drugs, acalabrutinib and rituximab, in patients aged 80 and older, or those 65-79 who are too frail for standard chemotherapy, with untreated diffuse large B-cell lymphoma. The goal is to see if this treatment is safe and effective for these …

This study tests a new medicine called anifrolumab, given as a shot under the skin, for adults with moderate to severe polymyositis or dermatomyositis—rare diseases that cause muscle weakness and skin rashes. About 240 people will receive either the drug or a placebo, added to th…

This study tests a new drug called AZD4956, alone or with other cancer drugs, in 180 people with advanced solid tumors that have specific DNA repair defects. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. It is an early-phase trial…

This study looks at how safe and tolerable the drug Breztri Aerosphere is for people with moderate to severe COPD. About 150 Indian adults with a history of COPD flare-ups will take the drug as a maintenance treatment. Researchers will track side effects to ensure the drug is saf…

This study tests several new drug combinations in people with advanced non-small cell lung cancer that has spread. The goal is to see if these combinations are safe and can shrink tumors. About 278 adults with good performance status and measurable tumors will participate across …

This study is checking how safe and effective the asthma drug Fasenra is for children aged 6 to 14 whose asthma is not well controlled with current treatments. About 40 kids will receive the medicine and be monitored for side effects and improvements in lung function and asthma s…

This study tests a new drug called AZD7760 to see if it is safe and how it works in the body. First, healthy volunteers will receive a single dose. Then, people with end-stage kidney disease who get dialysis through a central line will receive one or two doses. The goal is to pre…

This study tests an inhaler (PT027) that combines two medicines—budesonide and albuterol—against a standard albuterol inhaler (PT007) for teens aged 12 to 17 with asthma. The goal is to see if the combination inhaler reduces the number of severe asthma attacks over a year. About …

This study compares a targeted drug called acalabrutinib to other standard treatments in 60 adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The goal is to see if acalabrutinib causes fewer heart-related side effects and allows patien…

This study tests whether adding an experimental drug (Dato-DXd) to a standard targeted therapy (osimertinib) helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 582 adults with stage IIIB/IV non-small cell lung cancer will receive ei…

This study tests a new drug called AZD9793 for people with advanced liver cancer that has spread. The drug is an antibody designed to help the body's immune cells attack cancer cells. The main goals are to check if the drug is safe and to see if it can shrink tumors. About 304 ad…

This study tests an experimental drug called AZD6750, which is designed to guide the immune system to attack cancer cells. It is for adults with advanced solid tumors like melanoma, lung cancer, or breast cancer that have not responded to other treatments. The study will first fi…

This study tests a new drug called surovatamig (AZD0486) alone or with other cancer drugs in people with certain blood cancers like chronic lymphocytic leukemia and lymphoma. The main goals are to see if the drug is safe and works. About 408 adults will take part in this early-ph…

This study tests a new experimental drug called AZD8421, given alone or with other targeted cancer drugs, in people with advanced ER+ HER2- breast cancer or high-grade serous ovarian cancer that has spread. The main goals are to check the drug's safety, find the right dose, and s…

This study tests a new drug called Dato-DXd, given alone or with osimertinib, against standard chemotherapy for people with a specific type of advanced lung cancer (EGFR-mutated) that has gotten worse after osimertinib treatment. About 744 adults will take part to see if the new …

This study is testing new combinations of cancer drugs for people with advanced or metastatic non-small cell lung cancer. The goal is to find safer and more effective treatments. About 152 participants will receive different drug mixes, and researchers will monitor side effects a…

This study tests whether a new drug called rilvegostomig, when given with standard chemotherapy, helps people with advanced biliary tract cancer live longer compared to another drug (durvalumab) with the same chemo. About 1100 adults with bile duct or gallbladder cancer that cann…

This early-stage study is testing a new under-the-skin injection of the cancer drug durvalumab for adults with solid tumours. The goal is to see if the shot delivers the same amount of medicine into the body as the standard IV drip, and to check its safety. About 40 participants …

This study tests whether adding a drug called capivasertib to standard hormone therapy and CDK4/6 inhibitors can help people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer growing. About 895 adults whose cancer has spread or cannot be re…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 participants will receive either the drug or a placebo daily while in the hospital. The main goal is to see if the drug helps improve kidney function compared to …

This study tests a combination of three drugs (durvalumab, tremelimumab, and lenvatinib) as the first treatment for people with advanced liver cancer that cannot be removed by surgery. About 114 participants will receive the drugs to see if they can shrink tumors or slow cancer g…

This study tests an investigational drug called tozorakimab in adults whose asthma is not well controlled despite using medium-to-high dose inhaled steroids. The goal is to see if the drug can reduce the number of severe asthma attacks. About 540 participants will receive either …

This early-stage study tests a new medicine called AZD4063 in 31 adults with a specific genetic heart condition (PLN R14del dilated cardiomyopathy). The main goal is to check if the drug is safe and how the body processes it. Participants must have a weakened heart pump and be on…

This study tests whether adding baxdrostat to the standard drug dapagliflozin works better than dapagliflozin alone at slowing kidney disease and preventing heart-related death in 5000 adults with chronic kidney disease and high blood pressure. Participants will receive either th…

This study tests an experimental drug called AZD0486 in teenagers and adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or eliminate cancer cells. Part…

This study monitors the safety and effectiveness of Ondexxya, a drug used to reverse the effects of certain blood thinners (apixaban, rivaroxaban, or edoxaban) during life-threatening or unstoppable bleeding. Researchers will track side effects and how well the drug works in 300 …

This study tests whether a new drug called rilvegostomig, when added to standard chemotherapy, helps people with advanced squamous non-small cell lung cancer live longer or delay cancer growth. It is for people whose tumors have a specific protein (PD-L1). About 880 participants …

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study looks back at health records of 4,000 adults with asthma in the US to compare two rescue inhalers: Airsupra and the common albuterol inhaler. Researchers want to see which medication better prevents severe asthma attacks that require emergency care or steroid pills. Th…

This study tests a new treatment called AZD0120 for adults with severe lupus that hasn't improved with standard therapies. AZD0120 uses a patient's own immune cells, modified to target and destroy faulty cells that drive lupus. The trial will check safety and whether it can reduc…

This study tests a new drug, AZD5335, against current standard treatments for women with a tough-to-treat type of ovarian cancer that has stopped responding to platinum chemotherapy. About 1,100 women with high or low levels of a protein called FRα will be randomly assigned to re…

This study tests a triple-combination inhaler (budesonide/glycopyrronium/formoterol) against a placebo in 56 people with COPD and lung overinflation. The goal is to see if the inhaler improves heart function (how well the heart fills with blood) and reduces trapped air in the lun…

This study is testing whether an investigational drug called volrustomig can help prevent cancer from returning in women with high-risk cervical cancer who have completed initial chemoradiation treatment. About 800 participants will receive either volrustomig or a placebo to see …

This early-phase study tests a new treatment called AZD0120 for adults with multiple myeloma, a type of blood cancer. The therapy uses a patient's own immune cells, modified to target two proteins (BCMA and CD19) on cancer cells. The main goals are to check safety and find the ri…

This study is testing whether adding an experimental drug called saruparib to standard hormone and radiation therapy can better prevent cancer spread in men with high-risk prostate cancer who have a specific genetic mutation (BRCA). About 700 men will be randomly assigned to rece…

This is an early-stage study testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize and attack can…

This study is testing whether a shorter course of standard chemotherapy followed by a new drug called AZD0486 works better and is safer than the full six cycles of chemotherapy for older adults or those too frail for standard treatment. It will involve 420 participants newly diag…

This early-stage study is testing an experimental drug called AZD5863 in adults with advanced stomach, esophageal junction, esophageal, or pancreatic cancers that have spread. The drug is designed to work like a bridge, connecting the patient's own immune cells to cancer cells to…

This study looks at whether two simple breathing tests, oscillometry and FeNO, can help primary care doctors correctly diagnose asthma and COPD. About 600 adults with breathing symptoms will take these tests at their doctor's office, and their diagnosis will be compared to one fr…

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. Participants will get low-dose CT scans to find suspicious lung nodules. The goal is to see how well the program works in a public health setting and to improve early detection.

This early-stage study tests a new imaging agent called [111In]-FPI-2107 in 12 Chinese adults with a specific type of lung cancer (EGFR mutation-positive NSCLC). The goal is to see if the agent is safe and how it spreads in the body, not to treat the cancer. Participants receive …

This study is testing a new AI tool that collects family cancer history through WhatsApp to predict a woman's genetic risk for breast cancer. Researchers will compare the AI's predictions with standard genetic tests in 800 women already identified as high-risk by their doctors. T…

This study tests whether the drug AZD5148 can prevent C. difficile infection from returning in adults who have already had it. About 230 participants will receive either the drug or a placebo. The goal is to see if the drug reduces the chance of another infection.

This study is testing the safety of a monthly injection called palivizumab in infants and children under 2 years old who are at high risk for severe RSV disease. Participants will receive up to 5 injections over the study period. The goal is to see how safe the drug is and to tra…

This study tests two different inhalers that deliver the same asthma medicine (budesonide and formoterol) in children aged 4 to 12 with asthma. The goal is to see how much medicine gets into the blood and how safe each inhaler is. About 12 children will take part, and they must h…

This study combines data from multiple countries to see how the BGF inhaler (a triple-combination medication) affects COPD symptoms in routine care. About 2000 adults with moderate to severe COPD who are starting BGF will have their health status measured at 1, 3, and 12 months. …

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug reduces nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks and report th…

This study follows 850 people with COPD in China for up to 3 years to learn more about the disease. Researchers will collect medical history, lung function tests, and blood samples to find patterns that could lead to more personalized treatments in the future. Participants must b…

This study will follow about 4,490 adults with liver or bile duct cancer who are receiving durvalumab-based treatment as part of their regular care or an early access program. Researchers want to see how long patients live and how well the treatment works outside of clinical tria…

This study follows 300 men with metastatic castration-resistant prostate cancer who are taking olaparib as part of their normal treatment. Researchers will track how long patients stay on the drug, how well it controls the cancer, and any side effects. The goal is to learn how ol…

This study looks at a chronic lung condition called non-cystic fibrosis bronchiectasis, which causes persistent cough and infections. Researchers will collect data from 320 Chinese patients and healthy volunteers to find patterns and markers in the body that may explain why the d…

This study uses a survey to find out what factors are most important to Chinese patients and doctors when choosing a first-line targeted therapy for advanced lung cancer. About 590 participants (patients and physicians) will answer questions about treatment preferences. The goal …

This early-stage study tests whether a new drug, AZD1613, is safe and how the body processes it. About 136 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This study watches how doctors in Russia treat adults with a rare muscle-weakening disease called generalized myasthenia gravis. It does not test any new medicine—it simply collects information from medical records and routine checkups. About 450 people will take part, and the go…

This study follows 126 people with early-stage HER2-negative breast cancer who are prescribed olaparib by their doctor. Researchers will track how many complete the full 12-month treatment and look at genetic factors like BRCA mutations. The goal is to understand real-world use a…

This study watches how doctors treat aggressive, high-volume prostate cancer that has spread but still responds to hormone therapy. Researchers will collect blood samples to look for certain gene changes. No new treatments are given—the goal is to learn about current care pattern…

This study looks at how three experimental drugs (AZD6234, AZD9550, and their combination) affect the way birth control pills work in healthy women who are overweight or have obesity. About 50 women will take the drugs and then a single dose of birth control pills to see if the l…

This study looks at how the liver handles two experimental drugs, AZD9550 and AZD6234. Researchers will give a single dose to 28 adults with different levels of liver function, from healthy to severely impaired. The goal is to see if liver problems change how the drugs work in th…

This study is observing 355 adults with asthma in China to learn more about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung f…

This study will collect information from 500 adults in Moscow who have moderate to very severe COPD and have had frequent flare-ups. Researchers will look at their age, lifestyle, medical history, and treatments to better understand the disease. No new drugs or treatments are bei…

This study will observe 600 adults with bladder cancer in Russia to see what treatments they receive and how common certain biomarkers (HER2 and PD-L1) are. It does not test a new drug but aims to understand current care patterns. Participants must have confirmed bladder cancer a…

This observational study will follow over 52,000 people with ATTR amyloidosis, a rare disease that affects the heart and nerves. Researchers will look at medical records to see how the disease is diagnosed, what treatments patients receive, and how their health changes over time.…

This early-stage study tests whether a single dose of the experimental drug AZD2389 can be seen binding to a target in the liver using a special PET scan. It involves 12 adults with advanced liver scarring (fibrosis or cirrhosis). The main goal is to measure how much of the drug …

This study looks at how often a protein called HER2 is found at high levels in gynecological cancers like endometrial, ovarian, and cervical cancer. Researchers will test tumor samples from 350 adult patients in Brazil using standard lab methods. The goal is to better understand …

This study looks at how two experimental drugs (laroprovstat and AZD4954) affect each other in the body. It involves 32 healthy adults who will take both drugs and have their blood levels measured. The goal is to gather safety and dosing information, not to treat any disease.

This study looks at how the drug saruparib moves through the body in 8 people with advanced solid tumors that no longer respond to standard treatments. Participants receive a single oral dose and a single intravenous dose of a radioactive form of the drug to track its absorption,…

This study will follow about 693 people in Brazil who have severe or very severe COPD. Researchers will track how often patients are hospitalized, have flare-ups, or die. The goal is to collect national data on this group, since such information is currently missing. No new treat…

This study looks at how the drug opemalirsen behaves in people with different levels of kidney function. About 50 adults aged 18 to 80 will receive a single dose, and researchers will measure drug levels and safety. The goal is to understand kidney impact, not to treat any diseas…

This study will look at 5,000 adults in Russia who have severe asthma that is not well controlled. Researchers will collect information on the medicines patients are already taking and their health details. The goal is to better understand current treatment patterns and patient c…

This study will review health records of 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what outcomes patients have, and how much care costs. It aims to provide a clear picture of current treatment patterns and healthcare resource …

This study follows 442 pregnant women with lupus to check if taking anifrolumab during pregnancy is linked to birth defects or other problems in babies. Researchers will compare women who took the drug with those who did not. No new treatments are given—just careful observation t…

This early-stage study tests the safety and how the body processes a new drug called AZD4954. It involves 136 healthy volunteers and people with dyslipidemia (abnormal cholesterol levels). The goal is to check for side effects and measure drug levels, not to treat the condition.

This study is a registry that will follow 3,000 Chinese adults with chronic kidney disease (CKD) to learn how they are treated and what happens to their health over time. Researchers will collect information on medications, kidney function, heart health, and hospital visits. The …

This study follows 200 Chinese patients with chronic sinusitis and nasal polyps after they have surgery. Researchers will track symptoms, quality of life, and disease control for one year using questionnaires and nasal exams. The goal is to understand real-world outcomes and trea…

This study looks at health records from over 14,000 people with chronic kidney disease in Spain to see how the drug dapagliflozin is used in real life and how it affects kidney function, hospital visits, and costs. No new treatments are given—researchers simply analyze existing d…

This study is looking at 500 women in Russia with advanced or aggressive endometrial cancer. Researchers will test their tumor tissue for specific genetic changes and see which first treatments doctors choose. The goal is to learn more about the disease, not to test a new treatme…

This study looks at how the antifungal drug itraconazole changes the way the body processes a new cancer drug (AZD5335) in people with ovarian, primary peritoneal, or fallopian tube cancer. About 24 participants will receive both drugs in a fixed order to measure drug levels in t…

This study looks back at medical records of about 350 people with chronic lymphocytic leukemia (CLL) who received the drug acalabrutinib through a UK early access program. Researchers want to see how long patients go without their cancer getting worse and how long they live. No n…

This study looks at the medical records of 200 people with advanced non-small cell lung cancer in Brazil to understand their characteristics and the treatments they receive. Researchers will also survey doctors to learn why they choose certain treatments. The goal is to see how w…

This study looks at over 6,000 adults in Brazil who have heart or kidney problems to understand how common high potassium levels are and what factors raise the risk. Researchers will use existing medical records to find patterns and help doctors better manage this condition. The …

This study is observing how doctors in Russia treat a specific type of advanced prostate cancer that has spread but still responds to hormone therapy. Researchers will track which treatments (like hormone therapy, chemotherapy, or radiation) patients receive and look at tumor sam…

This study looks at how capivasertib changes the way the body processes dextromethorphan (a common cough suppressant). It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study tracks 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib as their only treatment. Researchers will record how long patients stay on the drug and why they stop, aiming to understand real-world effectiveness and safety. The goal is to fill …

This study is not testing a new treatment. Instead, it will gather information from 9,000 adults with uncontrolled asthma across 70 clinics in Russia. Researchers will look at patients' health history, current medications, and lab results to better understand who has uncontrolled…

This study looks at how well different HER2 tests agree when used on tumor samples from Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers will compare results from several test kits to see if they give the same positive or negative readings. The …

This study will look at medical records from 15,000 adults with high blood pressure in Brazil's public health system. Researchers want to understand how doctors treat high blood pressure and how often they fail to adjust treatment when blood pressure stays high. The goal is to fi…

This study looks back at medical records of 250 adults in Brazil with advanced non-squamous lung cancer whose first chemotherapy stopped working. Researchers want to understand what treatments patients received next and how they fared. No new drugs are tested—the goal is to learn…

This study looks at how often people with high blood pressure also have signs of chronic kidney disease in Kazakhstan. Researchers will track over 1,200 adults to see how many have kidney damage markers like protein in urine or low kidney function. The goal is to better understan…

This study looks at how the drug osimertinib is used in real-life settings for people with a specific type of lung cancer (EGFR-mutated non-small cell lung cancer) in Spain. Researchers will collect information from about 500 patients to see how well the drug works, how long peop…

This study observes 750 women with advanced ovarian cancer in Germany who are starting first-line platinum-based chemotherapy. It collects information on how patients are treated, their experiences, and outcomes like cancer progression. The goal is to learn more about the effecti…

This study looks at how certain genetic changes (ESR1 mutations) appear in the blood of people with metastatic breast cancer. Researchers will compare patients who have had prior treatments with those who haven't. The goal is to better understand why some cancers become resistant…

This study looks at how ovarian cancer is treated in Brazil by collecting information from 250 patients. Researchers will review medical records and follow patients over time to see what treatments are used and what the outcomes are. The goal is to find ways to improve care and s…

This study is for breastfeeding mothers with lupus who are already taking the medicine anifrolumab. Researchers will measure how much of the drug passes into breast milk and into the baby's blood. The goal is to understand safety for infants, not to test a new treatment. About 16…

This early-stage study tests whether the experimental drug AZD3974 is safe and how it moves through the body. It involves 176 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effe…

This study is tracking 24,000 people with type 2 diabetes across seven European countries to see if those who started taking the drug exenatide have a higher risk of developing pancreatic cancer compared to those taking other diabetes medications. Researchers will analyze medical…

This study tracks 240 pregnant women with lupus who have taken the drug anifrolumab. Researchers want to see if the drug increases the risk of birth defects or other pregnancy problems. The goal is to gather safety information, not to test a new treatment.

This study is testing whether a single tablet containing two drugs (laroprovstat and rosuvastatin) works as well as taking them separately. It involves 44 healthy adults aged 18 to 55 who will receive different doses in a crossover design. The goal is to measure how much of each …

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples, and tests whether artificial intelligence (AI) can help make the process faster and more accurate. Researchers will review medical records from 600 adults to measure how long diagnosis…

This study will follow about 300 people with non-small cell lung cancer who are already taking or about to take approved AstraZeneca drugs. Researchers will watch how long the cancer stays away or doesn't get worse, and how patients respond to treatment. No new medicine is being …

This early-stage study tests a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. The main goal is to check if the drug is safe and how the body processes it. The study also looks at whether people can reliably measure their …

This study will collect information from medical records of 2,000 people with advanced lung cancer (NSCLC or SCLC) who are receiving chemoradiotherapy at 50 cancer centers across Russia. The goal is to understand real-world treatment patterns and short-term results. No new treatm…

This early-stage study is testing different pill versions of a drug called AZD5004 in 64 healthy adults. Researchers want to see how the body absorbs each version and whether taking it with food changes those results. The study does not aim to treat any disease—it is purely to ga…

This study is monitoring the safety and effectiveness of the drug capivasertib when used in routine care for breast cancer patients in Korea. About 130 people who are already prescribed the drug by their doctor will take part. The goal is to find any side effects and see how well…

This study looks at whether tezepelumab, a medicine for severe asthma, increases the risk of serious heart problems like heart attack, stroke, or heart-related death. It will follow over 16,000 teens and adults with severe asthma who take tezepelumab or standard care. The goal is…

This study observes 250 men with metastatic castration-resistant prostate cancer (mCRPC) who are taking the drugs olaparib and abiraterone together as part of their routine care. Researchers will track how long patients stay on this treatment and what therapies they use next. The…

This study looks at children and teens aged 1 to 18 in Russia who may have a rare genetic condition called lysosomal acid lipase deficiency (LAL-D). Researchers will check for the disease using blood tests and genetic testing in up to 1,200 participants who have certain warning s…

This study aims to understand how hypophosphatasia (HPP), a rare genetic bone disease, naturally progresses in children and adults in Russia. Researchers will collect detailed information on symptoms, genetics, and health outcomes from 55 participants. The goal is to better chara…

This study aims to find out how many people with heart disease also have a lung condition called COPD. Researchers will follow 3,000 adults with coronary heart disease, atrial fibrillation, or chronic heart failure to track their health and hospital visits. The goal is to better …

This study follows 800 adults with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers will track how long patients stay on treatment, their quality of life, and an…

This study is not testing a new treatment. Instead, it will follow about 1,850 people with ATTR amyloidosis, a rare disease that can damage the heart and nerves. Researchers will collect information on symptoms, treatments, and quality of life to better understand the disease and…

This study observes about 3,200 adults with moderate-to-severe lupus to see if those taking anifrolumab have more serious infections or cancers than those on standard treatment. Researchers will track hospitalizations, infections needing IV antibiotics, and new cancer diagnoses. …

This study is observing 200 people in South Korea who are already prescribed Koselugo for neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will track side effects and how well the drug works in everyday medical practice. The goal is to confirm the drug's s…

This early-stage study is testing how well andexanet reverses the effects of common blood thinners (rivaroxaban, apixaban) and how it interacts with another blood thinner, enoxaparin. About 186 healthy adults will receive andexanet or a placebo. The goal is to understand dosing a…

This study looks at how many smokers aged 40 and older who visit heart clinics have undiagnosed chronic lung disease (COPD). Researchers will use breathing tests to check for lung problems. The goal is to better understand how often COPD goes unnoticed in this group, which could …

This study measures how chronic lymphocytic leukemia (CLL) patients feel and function while taking the drug acalabrutinib in everyday life. Researchers will review medical records of 120 adults in France who started acalabrutinib for the first time. They will track quality of lif…

This study looks at how the drug capivasertib is processed in people with moderate liver impairment compared to those with normal liver function. About 20 participants will receive a single dose, and researchers will measure drug levels and safety. The goal is to understand dosin…

This study monitors pregnant or breastfeeding women who have taken eplontersen for transthyretin amyloidosis, along with their babies. It aims to describe any pregnancy complications or effects on the developing fetus and infant. About 10 participants will be followed to gather s…

This study is watching 600 adults in Germany with a type of advanced lung cancer that has spread. They are getting a standard treatment of two immunotherapy drugs plus chemotherapy. The goal is to see how long people live, especially those with certain gene mutations. This is not…

This study looks back at the medical records of 200 people in Egypt diagnosed with atypical hemolytic uremic syndrome (aHUS), a rare and serious disease that damages kidneys and other organs. Researchers want to learn more about the patients' symptoms, treatments, and long-term o…

This study reviews medical records from 150 Chinese adults with advanced papillary kidney cancer who received sunitinib or sorafenib as their first treatment. Researchers aim to see how long the drugs control the cancer and track side effects. The study does not involve new treat…

This study is gathering information about 200 adults in Russia who have neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will look at patients' medical records and interview them to learn about their symptoms, health history, and daily life. The goal is to…

This study is a large registry that will collect information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments patients rec…

This study aims to understand how Neurofibromatosis Type 1 (NF1) affects people in Egypt by collecting real-world data from 200 patients diagnosed between 2010-2023. Researchers will track how the disease progresses over time, what treatments patients receive, and how common diff…