Astrazeneca

This study tests whether adding dapagliflozin to baxdrostat better reduces protein in urine (a sign of kidney damage) than baxdrostat alone in 218 adults with chronic kidney disease and high blood pressure. Participants must already be on a stable dose of standard blood pressure …

This study follows 200 adults with systemic lupus erythematosus (SLE) who are starting anifrolumab as part of their normal treatment. Researchers will measure disease activity, skin symptoms, fatigue, and quality of life over time to see how the drug performs outside of clinical …

This early-phase study tests a new treatment called AZD0120 for adults with multiple myeloma, a type of blood cancer. The therapy uses a patient's own immune cells, modified to attack two cancer targets (BCMA and CD19). The main goals are to check safety and find the right dose, …

This study tests a new medicine called volrustomig in women with high-risk cervical cancer that hasn't spread after standard chemoradiation. About 800 women will receive either volrustomig or a placebo to see if the drug can delay cancer growth and improve survival. The goal is t…

This study tests a new drug called AZD0901, alone or with other cancer drugs, in people with advanced solid tumors that have a specific protein (CLDN18.2). The goal is to see if the drug is safe and can shrink tumors. About 224 adults with stomach, bile duct, or pancreatic cancer…

This study tests an experimental drug called AZD7798 in 30 adults with active Crohn's disease who have an ileostomy (a surgically created opening in the belly for waste). The goal is to see if the drug is safe and can help repair the lining of the small intestine compared to a pl…

This study looks at how well tezepelumab works for adults with chronic sinusitis and nasal polyps (with or without asthma). About 110 people will be followed for up to a year to see if their nasal polyps shrink and congestion improves. The drug is already approved, and this resea…

This study follows 100 Polish adults with systemic lupus erythematosus (SLE) who are receiving anifrolumab as part of their routine care. Researchers will track changes in disease activity and overall health over time to see how well the treatment works in real-world settings. Th…

This study tests the safety of trastuzumab deruxtecan, a targeted drug that delivers chemotherapy directly to HER2-positive cancer cells. It involves 100 Indian adults with advanced or spreading breast cancer who have already tried another HER2-targeted treatment. The main goal i…

This study is for people with advanced or metastatic non-small cell lung cancer. It tests new combinations of cancer drugs to see if they are safe and can shrink tumors. About 152 participants will receive different drug mixes, and researchers will monitor side effects and how we…

This study is collecting real-world data from 150 women in Germany with advanced or recurrent endometrial cancer. Participants receive standard chemotherapy plus durvalumab, followed by maintenance therapy with durvalumab alone or with olaparib. The goal is to see how well this t…

This study follows 50 adults in Poland with generalized myasthenia gravis (gMG) who are taking ravulizumab for the first time. Researchers will track how well the drug improves daily activities and symptoms over time. The goal is to see how ravulizumab works in real-world setting…

This study tests whether adding the drug saruparib to standard radiation and hormone therapy can delay or prevent the spread of prostate cancer in men with high-risk disease and BRCA gene mutations. About 700 participants will receive either saruparib or a placebo alongside their…

This large study tests an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. The goal is to see if adding this drug to standard care can prevent death or the need for a breathing machine or life support. Part…

This study is testing a new drug called AZD0486, either by itself or with other cancer treatments, in people with certain types of blood cancers like chronic lymphocytic leukemia and lymphoma. The main goals are to check if the drug is safe and to find the best dose. About 408 pa…

This study tests an experimental drug called AZD6621 for men with metastatic prostate cancer that has spread. The drug is designed to help the immune system attack cancer cells. The trial has two parts: first, finding the safest dose, then testing that dose in more people to see …

This study tests a drug called sodium zirconium cyclosilicate (SZC) to safely lower high potassium levels in children under 18. About 140 kids will receive the drug for up to 3 days to correct potassium levels, then continue for 28 days to maintain normal levels, with an option f…

This early-stage study tests a new drug called AZD0486 in about 227 people with B-cell non-Hodgkin lymphoma, including types like diffuse large B-cell and follicular lymphoma. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals…

This study tests a new drug called AZD1163 in 320 adults with moderate-to-severe rheumatoid arthritis who haven't responded well to standard treatments. The goal is to see if the drug reduces joint swelling and pain over 12 weeks. Participants will receive either AZD1163 or a pla…

This study tests an experimental drug called AZD6750, designed to help the immune system fight cancer. It is for adults with advanced solid tumors (like melanoma, lung, or breast cancer) that have spread. The trial will first find the safest dose, then test if it works alone or w…

This study tests new drug combinations in people with metastatic colorectal cancer that has spread. The goal is to see if these treatments can shrink tumors or slow cancer growth. About 120 adults with measurable disease and good performance status will participate. The trial foc…

This study tests a new treatment called AZD0120 for people with multiple myeloma that has returned or stopped responding to at least three prior therapies. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and attack two targets (CD19 and B…

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This early-phase study tests a new drug called AZD3470 in people with advanced solid tumors that lack a gene called MTAP. The drug is designed to block a protein these cancer cells need to grow. The study will check safety, find the best dose, and see if the drug shrinks tumors w…

This study tests a new drug, puxitatug samrotecan, against standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new dr…

This study tests whether a new drug called rilvegostomig, combined with standard chemotherapy, works better than the current standard treatment (pembrolizumab plus chemo) for people with advanced squamous non-small cell lung cancer that has spread. The trial involves about 880 pa…

This study tests an experimental tablet called AZD6793 in 1,160 adults with moderate to very severe COPD. Participants take one of three doses or a placebo for 24 weeks to see if it safely reduces the number of serious flare-ups. All participants must already be on standard tripl…

This early-stage trial tests a new treatment called AZD0120 for people with certain autoimmune diseases like systemic sclerosis, myositis, or hard-to-treat rheumatoid arthritis. AZD0120 uses a patient's own immune cells, which are modified in a lab to target and attack faulty imm…

This study tests a combination of two drugs, acalabrutinib and rituximab, in patients aged 80+ or 65-79 who are too frail for standard chemotherapy. The goal is to see if this gentler approach is safe and effective for treating diffuse large B-cell lymphoma. About 80 participants…

This study tests whether a new drug called rilvegostomig, combined with standard treatments, helps people with advanced liver cancer live longer. About 1220 adults whose cancer cannot be removed or treated with local therapies will receive either the new combination or the curren…

This study tests an experimental drug called AZD0486 in adolescents and adults whose B-cell acute lymphoblastic leukemia has come back or not responded to at least two prior treatments. The goal is to see if the drug is safe and can shrink or eliminate the cancer. About 163 parti…

This study tests an injectable drug called benralizumab in 200 children aged 6 to 17 with severe eosinophilic asthma that is not well controlled by standard inhalers. The goal is to see if it can reduce asthma attacks and improve daily symptoms. Participants must have a history o…

This study follows 218 adults with lupus in Italy who are starting a drug called anifrolumab. The goal is to see if they can reach a state of low disease activity while taking a low dose of steroids (5 mg or less per day) after one year. Researchers will track how many patients a…

This study tests a new drug called volrustomig combined with chemotherapy against standard treatments for people with advanced pleural mesothelioma that cannot be removed by surgery. About 825 adults will take part worldwide. The goal is to see if the new combination helps people…

This study tests whether a new drug combination (saruparib plus camizestrant) works better than current standard treatments for advanced breast cancer that is hormone receptor positive and HER2-negative in people with BRCA1, BRCA2, or PALB2 mutations. About 500 adults with advanc…

This study tests a new experimental drug called AZD4956, alone or with other cancer drugs, in people with advanced or metastatic solid tumors that have a specific DNA repair defect (HRR deficiency). The main goals are to check safety, find the right dose, and see if the drug can …

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig) works better than standard chemotherapy for people with advanced bile duct cancer that has a specific protein called HER2. About 620 adults with untreated, advanced HER2-positive bile duct…

This study tests a new drug called AZD9550, alone or with another drug (AZD6234), in 160 adults who are overweight or obese. Some participants also have type 2 diabetes. The main goals are to check safety, side effects, and how the drugs move through the body. This is an early-st…

This study compares a targeted drug called acalabrutinib to other standard treatments for adults with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. The main goal is to see if acalabrutinib causes fewer heart-related side effects. About 60 part…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This early-stage study tests whether a new drug called AZD5492 is safe and tolerable in adults with lupus, myositis, or rheumatoid arthritis. About 72 participants will receive either one or two doses of the drug and be monitored for side effects over 6 months. The goal is to gat…

This study is checking how safe and effective the asthma drug Fasenra is for children aged 6 to 14 whose asthma is not well controlled with current treatments. The drug is given as a shot under the skin. Researchers will watch for side effects and see if it helps improve breathin…

This study tests a new drug called AZD0901 against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2). About 572 adults who have already tried at least one prior therapy will be randomly assigned to recei…

This early-stage study tests a new drug called surovatamig in 48 adults with rheumatoid arthritis or lupus. The main goal is to check safety and how the body handles the drug. Participants receive increasing doses to find the best and safest amount.

This study tests whether adding glycopyrronium to standard asthma medication improves lung function in children aged 4 to 12. About 69 kids with asthma will receive two different doses of glycopyrronium or a placebo, in addition to their usual treatment. The main goal is to see i…

This study is testing a new drug called AZD9574, either alone or with other cancer medicines, in people with advanced solid tumors that have grown or come back after standard treatments. The main goals are to check the drug's safety, how the body processes it, and whether it can …

This study tests a triple-combination inhaler (Budesonide/Glycopyrronium/Formoterol) against a placebo in 56 adults with COPD and hyperinflation (overinflated lungs). The goal is to see if the inhaler improves both heart and lung function. Participants will be current or former s…

This study tests a drug called acalabrutinib combined with standard chemotherapy (R-CHOP) in 55 adults with untreated mantle cell lymphoma who cannot have a stem cell transplant. The goal is to see how well the combination shrinks tumors and controls the disease. Participants wil…

This study tests a new drug (sonesitatug vedotin) plus chemotherapy, with or without another drug (rilvegostomig), in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specific marker (CLDN18.2) and is HER2-negative. About 2,130 participants…

This study tests a new drug called AZD2962, which blocks a protein (IRAK4) involved in cancer growth. It is for people with certain blood cancers (MDS or CMML) that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the …

This study tests whether adding baxdrostat to the standard drug dapagliflozin can better protect the kidneys and heart in 5,000 adults with chronic kidney disease and high blood pressure. Participants will receive either the combination or dapagliflozin alone, and researchers wil…

This study looks at whether the drug durvalumab can help control limited-stage small-cell lung cancer after initial chemoradiation. About 200 adults in China whose cancer did not worsen after standard treatment will receive durvalumab. Researchers will track how long the cancer s…

This study tests an experimental drug called AZD4144 in adults with sepsis who develop acute kidney injury. About 124 people in intensive care will receive either the drug or a placebo daily through an IV. The main goal is to see if the drug helps the kidneys work better compared…

This study tests an experimental drug called AZD1390 given together with radiation therapy for people with glioblastoma (a fast-growing brain cancer) or brain tumors that have spread from other cancers. The main goals are to check the drug's safety, find the best dose, and see ho…

This study checks how safe and tolerable the inhaler Breztri Aerosphere is for people with moderate to severe COPD. About 150 Indian adults with a history of COPD flare-ups will take the medicine as usual and be monitored for side effects. The goal is to confirm the drug's safety…

This study tests a drug called benralizumab in children aged 6 to 17 with two rare diseases that cause too many eosinophils (a type of white blood cell). The goal is to see if the drug is safe and can help control the disease, possibly allowing kids to take less steroids. About 1…

This study tests several new drug combinations given before and after surgery for people with early-stage non-small cell lung cancer. The goal is to see if these combinations can completely eliminate the cancer in the removed tissue and prevent it from coming back. About 630 adul…

This study tests whether a new drug called rilvegostomig, combined with chemotherapy, works better than another immunotherapy (durvalumab) with the same chemo for people with advanced biliary tract cancer. About 1100 adults whose cancer cannot be removed by surgery or has spread …

This early-stage study is testing whether a shot of durvalumab given under the skin works as well as the standard IV infusion in adults with solid tumours. About 40 participants with various cancers will receive different doses to find the right amount and check safety. The goal …

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy before bladder removal surgery is safe and effective for people with muscle-invasive bladder cancer. About 150 participants will receive the drug combination, then undergo surgery. The goal…

This study tests a new drug called AZD0486 combined with rituximab against standard chemotherapy plus rituximab in people with untreated follicular lymphoma. About 1,018 adults will take part to see if the new combo works better and is safe. The goal is to improve disease control…

This study is testing an investigational drug called anifrolumab in children aged 5 to 17 with moderate to severe systemic lupus erythematosus (SLE), an autoimmune disease. The goal is to see if adding anifrolumab to standard treatments can better control lupus activity and reduc…

This study tests a drug called osimertinib, given before and after radiation, for people with stage III lung cancer that has a specific gene mutation (EGFR). Participants are those who cannot or choose not to have chemotherapy. The goal is to see if this approach helps control th…

This study tests whether adding a drug called capivasertib to standard hormone therapy and CDK4/6 inhibitors can help people with a certain type of advanced breast cancer (HR+/HER2-). About 895 adults whose cancer has spread or cannot be removed by surgery will take part. The goa…

This study will follow 1,000 people aged 12 and older with severe eosinophilic asthma who are prescribed benralizumab in China. Researchers will track how well the drug controls asthma symptoms over time using questionnaires. The goal is to understand real-world treatment outcome…

This study tests a new treatment called AZD0754, which uses a patient's own immune cells (CAR T-cells) to fight metastatic prostate cancer. About 60 adults with castration-resistant prostate cancer will receive this therapy to see if it is safe and can shrink tumors or lower PSA …

This study tests an investigational drug called tozorakimab in adults aged 18-75 whose asthma is not well controlled despite using medium-to-high dose inhaled steroids. The goal is to see if the drug can lower the number of severe asthma attacks over one year. About 540 participa…

This study tests an experimental drug called AZD5492 in about 174 adults with B-cell cancers (like lymphoma or leukemia) that have come back or stopped responding to at least two prior treatments. The drug is a special antibody that helps the body's own T cells find and attack ca…

This study tests whether a three-drug inhaler (budesonide, glycopyrronium, formoterol) works better than a two-drug inhaler at preventing serious heart and lung events in people with COPD. About 5,000 adults aged 40–80 who smoke or used to smoke will take part. The goal is to see…

This study tests the drug durvalumab as a follow-up treatment for people with limited-stage small cell lung cancer whose cancer has not grown after chemotherapy and radiation. About 70 adults in Spain will receive durvalumab to see how safe it is and how well it works in real-wor…

This study tests whether a combination of two drugs (zibotentan and dapagliflozin) works better than dapagliflozin alone for adults with chronic kidney disease and high protein in their urine. About 224 participants will take either the combo pill or the standard drug for several…

This study looks at how well the drug anifrolumab works for adults with lupus when used in normal doctor visits. About 125 people will receive the drug as a shot under the skin. Researchers will track if patients can reach a state of low disease activity or remission over two yea…

This study looks at how well Airsupra works compared to albuterol for preventing severe asthma attacks in real-world settings. About 4,000 people with asthma who use rescue inhalers will be followed for 12 months. Researchers will track asthma attacks, medication use, and patient…

This study follows 1,400 adults with moderate to severe COPD who are starting a triple-combination inhaler (Breztri/Trixeo). Researchers will track changes in symptoms and quality of life over 12 months in routine clinics across Latin America, Asia, and the Middle East & Africa. …

This study tests a new drug called volrustomig combined with other cancer medicines in people with advanced non-small cell lung cancer. The goal is to see if the combination is safe and can shrink tumors. About 180 adults will take part, and the study is currently recruiting.

This study tests an experimental daily pill called AZD0780 to see if it can lower the risk of major heart problems like heart attacks, strokes, and urgent procedures in people who already have heart disease or are at high risk. About 15,100 adults will take either the drug or a p…

This early-stage study tests a new drug called AZD9592, alone or with other cancer treatments, in people with advanced solid tumors (lung, head & neck, or colorectal cancer that has spread). The main goals are to check safety, find the right dose, and see if it shrinks tumors. Ab…

This study looks at whether people with severe asthma can safely cut down on their usual maintenance medications if they are also taking the drug tezepelumab. The goal is to see if patients can reduce or stop some of their daily inhalers and pills while still keeping their asthma…

This study tests two new treatments for people with advanced non-squamous lung cancer that has high PD-L1 levels. One group gets a combination of two drugs (datopotamab deruxtecan and rilvegostomig), another gets rilvegostomig alone, and a third gets the standard drug pembrolizum…

This study compares two immunotherapy drugs—rilvegostomig and pembrolizumab—each given with standard chemotherapy as a first treatment for people with advanced non-squamous non-small cell lung cancer that has spread and shows a protein called PD-L1. About 878 participants will be…

This study tests a new drug, datopotamab deruxtecan, against a standard chemotherapy (docetaxel) in people with advanced or metastatic non-squamous non-small cell lung cancer that has a specific protein called TROP2. The goal is to see if the new drug helps people live longer or …

This study tests a new drug called volrustomig in people with advanced head and neck cancer that has not spread. Participants have finished standard chemoradiation and their cancer has not grown. Half will get volrustomig, half will just be watched. The goal is to see if the drug…

This study tests new combinations of drugs for people with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. The goal is to see if these combinations can shrink tumors or delay cancer growth. About 163 adults who have not had pr…

This study tests a new drug called datopotamab deruxtecan (Dato-DXd) alone or with other cancer drugs in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gas…

This study tests a new drug called AZD8205, alone or with other cancer drugs, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have spread or come back. The main goals are to check safety and find the right dose. About 460 adults whose cancer has n…

This early-stage study tests the safety of a new drug called AZD1613 in 40 adults with autosomal dominant polycystic kidney disease (ADPKD). Participants receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to see if …

This study tests a weekly injection of anifrolumab in 245 adults with lupus who have never taken strong immune-suppressing drugs. The goal is to see if the drug can help patients reach remission and safely reduce or stop steroid use over 52 weeks. Participants must already be on …

This study tests several new drug combinations in people with advanced non-small cell lung cancer that has spread. About 278 adults will receive different treatment mixes to see if they shrink tumors and are safe. The goal is to find better ways to control the disease and improve…

This study tests a new drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers that have spread. The goal is to see if the drug can shrink tumors and control the disease. About 257 adults wit…

This study tests a new treatment called AZD0120, which uses a patient's own immune cells engineered to target two proteins (BCMA and CD19) on myeloma cells. It is compared to standard drug combinations in about 508 adults with multiple myeloma that has returned or not responded t…

This study tests an experimental drug called AZD0516, given alone or with other cancer medicines, for men with metastatic prostate cancer (cancer that has spread). The main goals are to check safety, find the best dose, and see if it can shrink tumors or lower PSA levels. About 1…

This study tests whether a shorter course of chemotherapy followed by a targeted drug called AZD0486 works as well as the full standard chemo regimen for older or frail adults newly diagnosed with large B-cell lymphoma. About 420 participants will be randomly assigned to one of t…

This early-stage study tests a new injection form of the drug rilvegostomig in about 40 adults with advanced solid tumors who have already tried standard treatments. The goal is to find a dose that works as well as the IV version and to check for side effects. Participants will r…

This study tests a drug called Dato-DXd in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has stopped responding to hormone therapy. The goal is to see if the drug can delay cancer growth. About 100 adults whose cancer cannot be removed by s…

This study tests a new experimental drug called AZD8421, given alone or with other targeted cancer drugs, in people with advanced ER+ HER2- breast cancer or high-grade serous ovarian cancer. The main goals are to check safety, find the best dose, and see if the drug can shrink tu…

This large Phase 3 study tests whether adding baxdrostat to the standard drug dapagliflozin can lower the chance of heart failure or heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. About 11,300 adults aged 40 an…

This study tests whether a new combination pill (balcinrenone/dapagliflozin) works better than dapagliflozin alone at preventing heart failure events and heart-related death. About 4,800 adults with heart failure and moderate-to-severe kidney problems will take one pill daily for…

This study tests whether a new drug combination (trastuzumab deruxtecan plus immunotherapy) works better than standard chemotherapy for people with advanced or returning endometrial cancer that has a specific protein (HER2) and is mismatch repair proficient. About 600 adults will…

This study tests whether adding a second immunotherapy drug (domvanalimab) to the standard drug durvalumab can better control stage III lung cancer that hasn't gotten worse after initial chemo-radiation. About 860 adults with a specific type of lung cancer will receive either the…

This study follows 335 adults with severe eosinophilic asthma who are taking benralizumab. Researchers want to see if the drug can help patients reach partial or complete clinical remission—meaning fewer symptoms, no need for steroid pills, and better lung function—over 12 to 24 …

This study compares a new drug, rilvegostomig, to the current standard treatment, pembrolizumab, for people with advanced non-small cell lung cancer that has high levels of PD-L1. The goal is to see if the new drug works better at helping people live longer or stopping the cancer…

This study tests a targeted cancer drug (trastuzumab deruxtecan) combined with immunotherapy, with or without chemotherapy, as a first treatment for people with advanced non-small cell lung cancer that has high levels of a protein called HER2. The main goal is to check safety and…

This study tests an experimental drug called AZD4512, alone or with other cancer drugs, in adults with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has returned or stopped responding to standard treatments. The main goals are to check the drug's safety, find the best…

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed, localized prostate cancer. The goal is to see how the drugs affect tumor cells and check for side effects. About 120 men will take part.

This study is for people with advanced HER2-positive stomach or esophageal cancer. It tests a drug called trastuzumab deruxtecan (T-DXd) alone or with chemotherapy and/or immunotherapy to see if it can shrink tumors and be safe. About 450 adults will take part. The goal is to con…

This study is for people in Korea with a rare blood disease called PNH. It looks at how safe and effective the drug Danicopan is when added to their usual treatment. About 8 participants will be followed in regular clinic visits. The goal is to confirm the drug's known safety and…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This study tests a new drug called surovatamig in 240 adults with a type of blood cancer (B-cell non-Hodgkin lymphoma) that has returned or not improved after at least two prior treatments. The drug is given alone to see if it can shrink tumors and how safe it is. The trial is op…

This study tests an experimental drug called tezepelumab in adults aged 40 to 80 with moderate to very severe COPD. The goal is to see if it can reduce the number of moderate or severe flare-ups compared to a placebo. Participants must have had at least two moderate or one severe…

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, for weight loss in Chinese adults who are overweight or have obesity. About 871 participants aged 18 to 55 with a BMI of 27 or higher will receive the drugs or a placebo to check safety and effective…

This study compares two inhalers, PT027 and PT007, used as needed in Chinese adults with asthma. The goal is to see if PT027 reduces the risk of severe asthma attacks better than PT007. About 790 participants with a history of at least one severe attack in the past year will be f…

This study tests new drug combinations given before and after surgery for people with a type of stomach cancer that can be removed. About 100 adults with resectable gastroesophageal adenocarcinoma will receive these treatments to see if they are safe and help shrink or eliminate …

This study follows 300 adults with severe eosinophilic asthma who are prescribed benralizumab as part of their normal care. Researchers will track asthma control, quality of life, lung function, and medication use over a year to see how well the drug works in everyday settings. T…

This study tests new immune-boosting drugs, alone or with other cancer treatments, in people with advanced liver or bile duct cancer. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 294 adults whose cancer has spread or cannot be removed by surger…

This study monitors the safety and effectiveness of two drugs, Imjudo and Imfinzi, in 246 liver cancer patients in Korea. It observes patients already receiving these drugs as part of their normal care, without adding new treatments. The goal is to see how well the drugs work and…

This study tests a new drug combination (rilvegostomig plus chemotherapy and trastuzumab deruxtecan) against the current standard treatment for advanced HER2-positive stomach cancer. About 840 adults whose cancer has spread and who have not had prior treatment will participate. T…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works outside of a strict r…

This study tests whether a new drug, datopotamab deruxtecan (Dato-DXd), given alone or with another drug (durvalumab), works better than standard chemotherapy for people with a certain type of advanced triple-negative breast cancer that has PD-L1 protein. About 625 participants w…

This study tests a new drug called AZD0305, alone or with other cancer drugs, in about 226 adults with multiple myeloma. The goal is to check safety, find the right dose, and see if it helps control the cancer. Participants must have confirmed multiple myeloma and be in good enou…

This early-stage study is testing a new drug that delivers radiation directly to prostate cancer cells that have spread and stopped responding to hormone therapy. About 95 adults with this advanced cancer will receive the treatment to see if it is safe and what dose works best. T…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can slow the growth of metastatic prostate cancer that still responds to hormone treatment. About 1,800 men with a specific genetic marker (HRRm) or without it will be randomly assigned to…

This study tests an experimental drug called tezepelumab in about 990 adults with moderate to very severe COPD. The goal is to see if it can reduce the number of serious flare-ups (exacerbations) compared to a placebo over 76 weeks. Participants must be 40-80 years old, have had …

This study tests a new drug called baxdrostat in about 250 adults with primary aldosteronism, a condition where the adrenal glands make too much of a hormone, causing high blood pressure. The drug is taken daily and compared to a placebo to see if it lowers blood pressure and res…

This study tests an experimental drug called AZD0292 in people aged 12 and older who have bronchiectasis and a chronic lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo. Abou…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, which are …

This early-phase study tests a new drug that delivers radiation directly to cancer cells in people with advanced solid tumors (like lung, colon, head and neck, pancreatic, stomach, or kidney cancer) that have stopped responding to standard treatments. The main goals are to check …

This study tests an experimental pill called AZD0780 for people with high cholesterol (dyslipidaemia). About 360 adults with elevated LDL-C will take the drug or a placebo for up to 52 weeks to see if it safely lowers cholesterol levels. The goal is to find a new treatment option…

This study tests an investigational drug called tezepelumab in children aged 5 to 12 with severe asthma that is not well controlled by their current medicines. The goal is to see if adding tezepelumab can reduce the number of serious asthma attacks and improve lung function. Abou…

This study tests whether adding benralizumab (an injectable medication) to usual medium-dose inhaler treatment can reduce asthma attacks and improve quality of life in people with eosinophilic asthma that is not well controlled. About 400 participants aged 12 to 75 will receive e…

This study tests a new oral drug, AZD3632, in people with advanced blood cancers like leukemia and myelodysplastic syndromes that have certain genetic changes. The main goals are to check the drug's safety and find the right dose. About 84 participants will take the drug alone or…

This study tests an experimental drug called AZD2373 in 96 adults with a genetic form of kidney disease linked to the APOL1 gene. The goal is to see if the drug can lower protein levels in urine, a sign of kidney damage, compared to a placebo. Participants will take the drug or p…

This study tests whether adding a new drug (AZD0780) to a standard statin (rosuvastatin) can lower bad cholesterol more than the statin alone. About 76 adults with dyslipidaemia in Russia will take either the combination or a placebo plus statin for 12 weeks. The goal is to see i…

This study tests a new daily pill, camizestrant, against standard hormone therapies to see if it better prevents breast cancer from returning in people with ER+/HER2- early breast cancer who have already completed initial treatments. About 4,300 participants at intermediate or hi…

This study will test a standard treatment plan for managing high potassium levels in people with chronic kidney disease who are not on dialysis. About 1,000 adults will follow a guideline-based approach to see if it helps control potassium and optimize their heart-kidney medicati…

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard therapy. The main goals are to check safety and find the right dose. About 506 participan…

This study tests a new drug called AZD4512 in people with a hard-to-treat blood cancer called B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to other treatments. The goal is to see if the drug is safe and how well it works, either alone or with ot…

This study tests a new drug called AZD4360 in adults with advanced solid tumors, including stomach, gastroesophageal junction, bile duct, and pancreatic cancers that have not responded to prior treatments. The main goals are to find a safe dose and check for side effects, while a…

This early-stage trial tests a new treatment called AZD0120 for people with multiple sclerosis (MS) that has not responded to other therapies. The treatment uses a patient's own immune cells, modified to target and attack harmful cells linked to MS. The main goal is to check if t…

This study tests a new medicine called anifrolumab, given as a shot under the skin, for adults with moderate to severe polymyositis or dermatomyositis—rare diseases that cause muscle weakness and skin rashes. About 240 people will receive either the drug or a placebo, added to th…

This study tests a new drug called AZD7760 to see if it is safe and how it works in the body. First, healthy volunteers will receive a single dose. Then, people with end-stage kidney disease who get dialysis through a central line will receive one or two doses. The goal is to pre…

This study tests an inhaler (PT027) that combines two medicines—budesonide and albuterol—against a standard albuterol inhaler (PT007) for teens aged 12 to 17 with asthma. The goal is to see if the combination inhaler reduces the number of severe asthma attacks over a year. About …

This study tests whether adding an experimental drug (Dato-DXd) to a standard targeted therapy (osimertinib) helps people with advanced EGFR-mutant lung cancer live longer without their cancer growing. About 582 adults with stage IIIB/IV non-small cell lung cancer will receive ei…

This study tests a new drug called AZD9793 for people with advanced liver cancer that has spread. The drug is an antibody designed to help the body's immune cells attack cancer cells. The main goals are to check if the drug is safe and to see if it can shrink tumors. About 304 ad…

This study tests a new drug called Dato-DXd, given alone or with osimertinib, against standard chemotherapy for people with a specific type of advanced lung cancer (EGFR-mutated) that has gotten worse after osimertinib treatment. About 744 adults will take part to see if the new …

This early-stage study tests a new medicine called AZD4063 in 31 adults with a specific genetic heart condition (PLN R14del dilated cardiomyopathy). The main goal is to check if the drug is safe and how the body processes it. Participants must have a weakened heart pump and be on…

This study monitors the safety and effectiveness of Ondexxya, a drug used to reverse the effects of certain blood thinners (apixaban, rivaroxaban, or edoxaban) during life-threatening or unstoppable bleeding. Researchers will track side effects and how well the drug works in 300 …

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study tests a new treatment called AZD0120 for adults with severe lupus that hasn't improved with standard therapies. AZD0120 uses a patient's own immune cells, modified to target and destroy faulty cells that drive lupus. The trial will check safety and whether it can reduc…

This study tests a new drug, AZD5335, against current standard treatments for women with a tough-to-treat type of ovarian cancer that has stopped responding to platinum chemotherapy. About 1,100 women with high or low levels of a protein called FRα will be randomly assigned to re…

This is an early-stage study testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize and attack can…

This early-stage study is testing an experimental drug called AZD5863 in adults with advanced stomach, esophageal junction, esophageal, or pancreatic cancers that have spread. The drug is designed to work like a bridge, connecting the patient's own immune cells to cancer cells to…

This study aims to see if two easy breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD without needing complex equipment. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their local c…

This early-stage study tests a new imaging drug, [111In]-FPI-2107, in 12 Chinese adults with a specific type of lung cancer (EGFR mutation-positive NSCLC). The goal is to see if it is safe and how it spreads in the body, not to treat the cancer. Participants receive the drug and …

This study is testing a lung cancer screening program for current and former smokers aged 45 to 74. Participants will get low-dose CT scans to find suspicious lung nodules. The goal is to see how well the program works in a public health setting and to improve early detection.

This study is testing a new AI tool that collects family cancer history through WhatsApp to predict a woman's genetic risk for breast cancer. Researchers will compare the AI's predictions with standard genetic tests in 800 women already identified as high-risk by their doctors. T…

This study checks the safety of palivizumab, a medicine given as monthly shots to prevent severe RSV lung infections in infants under 2 years old who are at high risk. About 138 children will receive up to 5 injections, and researchers will monitor for side effects. The goal is t…

This study tests an experimental drug called AZD5148 to see if it can prevent repeat Clostridioides difficile infections in adults aged 18 and older. About 230 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces the chance of anothe…

This study analyzes data from 2,000 people with moderate to severe COPD who started taking the triple-combination inhaler BGF as part of their normal care. Researchers will compare patients' self-reported breathing and quality-of-life scores at 3 months, 1 month, and 12 months af…

This study tests a drug called tezepelumab in 180 adults with chronic sinusitis and nasal polyps who are eligible for surgery. The goal is to see if the drug can reduce nasal congestion and other sinus symptoms over 24 weeks. Participants receive the drug every 4 weeks and report…

This study is observing 355 adults with asthma in China to learn about their symptoms, treatments, and biological markers. The goal is to identify different types of asthma to help develop more personalized treatment strategies in the future. Participants will undergo lung functi…

This study looks at how three experimental drugs (AZD6234, AZD9550, and their combination) affect the way birth control pills work in healthy women who are overweight or have obesity. Researchers will measure drug levels in the blood to see if these weight-loss treatments change …

This early-stage study tests whether a single dose of the experimental drug AZD2389 can bind to a protein called FAP in the liver, which is linked to scarring. Twelve adults with advanced liver fibrosis will receive the drug and then have a PET scan to measure changes. The goal i…

This study looks at how ovarian cancer is currently treated in Brazil. Researchers will collect information from 250 patients to see what is working well and what could be improved. The goal is to use these findings to set better quality standards for ovarian cancer care across t…

This study looks at the real-world treatment of advanced non-small cell lung cancer in Brazil. Researchers will review medical records of 200 patients and survey doctors to see if treatments follow national guidelines. The goal is to understand patient characteristics and improve…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study is a large registry that will collect information from 9,000 adults with uncontrolled asthma in about 70 clinics across Russia. Researchers will look at patient backgrounds, treatments, and lab results to better understand the disease. No new treatments are given—parti…

This study looks at how doctors in Russia currently treat a rare muscle-weakening disease called generalized myasthenia gravis (gMG). Researchers will collect medical records and follow about 450 adults with the AChR-antibody form of the disease to see which treatments are used a…

This study is for healthy adults to see how well andexanet reverses the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. Participants will receive andexanet or a placebo, and researchers will measure blood clo…

This study is for breastfeeding mothers with moderate to severe lupus who are already taking the medication anifrolumab. Researchers will measure how much of the drug passes into breast milk and into the baby's blood. The goal is to understand safety for infants, not to test a ne…

This study follows about 300 people with non-small cell lung cancer who are already taking approved AstraZeneca drugs as part of their normal care. Researchers will track how long the drugs control the cancer and when patients need to switch treatments. No new drugs or treatments…

This study aims to collect information about 200 adults in Russia who have neurofibromatosis type 1 (NF1) and related tumors called plexiform neurofibromas. Researchers will look at patients' medical records and interview them to understand their age, symptoms, and overall health…

This study is observing 600 adults in Russia with bladder cancer to see what treatments they receive and how often their tumors have HER2 or PD-L1 markers. It does not test a new drug but collects real-world data to understand current care patterns. Participants must have confirm…

This early-stage study tests whether a new drug called AZD4954 is safe and how the body processes it. About 136 healthy volunteers and people with high cholesterol will receive either the drug or a placebo. The main goal is to check for side effects, not to treat the condition.

This study follows 442 pregnant women with moderate to severe lupus to see if the drug anifrolumab affects pregnancy or baby health. Some women took anifrolumab during pregnancy, others did not. Researchers will compare birth defects and other outcomes. No new treatment is given—…

This study will follow over 52,000 people with ATTR amyloidosis, a rare disease where abnormal protein builds up in organs. Researchers will look at medical records to see how the disease is diagnosed, what treatments people receive, and how their health changes over time. The go…

This study looks at how the antifungal drug itraconazole changes the levels of a cancer drug in the blood of people with ovarian, primary peritoneal, or fallopian tube cancer. About 24 participants will take both drugs in a fixed order to measure drug levels over time. The goal i…

This study looks at how the drug saruparib is absorbed, distributed, broken down, and removed from the body in 8 people with advanced solid tumors. Participants receive a single oral dose and a single IV dose with a tiny radioactive tracer to track the drug. The goal is to unders…

This study is observing how doctors in Russia treat a specific type of advanced prostate cancer (metastatic hormone-sensitive) and what biological markers (biomarkers) are present. It will involve 400 men and will not test any new treatments—it simply collects information from me…

This study tracks 50 adults with chronic lymphocytic leukemia (CLL) who are starting acalabrutinib alone (no other cancer drugs). Researchers will watch how long patients stay on the drug and why they might stop, aiming to fill a gap in real-world data. No new treatment is tested…

This early-stage study tests the safety of a new drug called AZD4248 in healthy volunteers and people with chronic kidney disease and type 2 diabetes. Researchers will give single or multiple doses of the drug and watch for side effects. The study also checks if people can reliab…

This study looks at how two different inhalers deliver asthma medicine into the bodies of children aged 4 to 12. The goal is to compare the amount of drug absorbed and check for safety. About 12 children with stable asthma will take part. The results will help doctors understand …

This study looks at how two experimental drugs (AZD9550 and AZD6234) behave in people with moderate to severe liver problems compared to healthy adults. About 28 participants will receive a single dose of one drug. The goal is to understand safety and how the liver processes thes…

This study looks at how capivasertib changes the way the body processes dextromethorphan, a common cough suppressant. It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study measures how two experimental drugs (laroprovstat and AZD4954) affect each other's levels in the blood. About 32 healthy adults will receive single doses of both drugs. The goal is to gather safety and dosing information, not to treat any disease.

This study looks back at the medical records of 200 people in Egypt diagnosed with atypical hemolytic uremic syndrome (aHUS), a rare and serious disease that can damage the kidneys and other organs. Researchers want to learn more about the patients' characteristics, how the disea…

This study looks at whether tezepelumab, a medicine for severe asthma, increases the risk of serious heart problems like heart attack or stroke. It will follow over 16,000 teens and adults with severe asthma who take tezepelumab or standard treatment. Researchers will compare hea…

This study looks at how a single dose of capivasertib is processed by the body in people with moderate liver impairment compared to those with normal liver function. About 20 participants will take part. The goal is to understand safety and drug levels, not to treat a disease.

This study looks at medical records of over 14,000 people with chronic kidney disease in Spain to see how the drug dapagliflozin is used in routine care and how well it works. Researchers will compare health outcomes and costs before and after the drug became widely available. No…

This study tracks 240 pregnant women with lupus who have taken the drug anifrolumab during pregnancy or shortly before conception. Researchers will monitor for birth defects and other pregnancy complications to better understand the drug's safety. The goal is to gather informatio…

This study monitors about 3,200 adults with moderate-to-severe lupus to see if the drug anifrolumab raises the risk of serious infections or cancer compared to standard treatments. Researchers will analyze medical records over time, focusing on hospitalizations, infections needin…

This study collects information from pregnant or breastfeeding women who have taken eplontersen for transthyretin amyloidosis, and their babies. The goal is to describe any pregnancy complications or health problems in the baby up to one year old. No new treatment is given; the s…

This early-stage study in 64 healthy volunteers aims to understand how different pill versions of AZD5004 are absorbed and processed by the body, and whether taking them with food changes that. Participants will receive single doses of the drug in different forms, and researchers…

This study is a disease registry that will collect information from 200 people in Egypt with neurofibromatosis type 1 (NF1), a genetic condition that causes tumors on nerves. The goal is to understand how common NF1 is, how it progresses, and how it is managed in Egypt. No new tr…

This study will follow about 1,850 people with ATTR amyloidosis, a disease that causes abnormal protein buildup in the heart and nerves. Researchers will collect information on symptoms, treatments, and outcomes over time to learn how the disease naturally progresses and how well…

This study observes 400 men with aggressive, high-volume metastatic hormone-sensitive prostate cancer in Russia. It tracks which treatments doctors choose and tests blood for genetic changes. No new treatment is given; the goal is to learn about current care patterns and genetic …

This study looks back at medical records of 350 people with chronic lymphocytic leukemia (CLL) who received acalabrutinib through a UK early access program. Researchers want to see how long patients go without their cancer worsening and how long they live. The goal is to understa…

This study is observing 850 people with COPD in China to understand how the disease progresses and what factors affect it. Researchers will collect medical history, lung function tests, and blood samples over 1 to 3 years. The goal is to identify different types of COPD and find …

This study follows 600 adults in Germany with a type of advanced lung cancer that has spread and carries certain high-risk gene mutations. Participants receive a standard triple-drug treatment (tremelimumab, durvalumab, and platinum chemo) as their first therapy. Researchers will…

This study looks at how many smokers aged 40 and older who visit heart clinics also have a lung condition called COPD, which often goes undiagnosed. Researchers will use breathing tests to check for airflow limitation. The goal is to better understand how common this hidden lung …

This study looks at how the drug opemalirsen is processed in people with kidney problems compared to those with healthy kidneys. About 50 adults aged 18 to 80 will receive a single dose, and researchers will measure drug levels and safety. The goal is to understand if kidney impa…

This study is a large registry that will follow 3000 Chinese adults with chronic kidney disease (CKD) to see what treatments they receive and how their health changes over time. Researchers will track things like kidney function, heart problems, and hospital visits. The goal is t…

This study will look at how doctors currently diagnose lung and breast cancer by examining tissue samples. Researchers will also test new computer programs that use artificial intelligence to help read the samples faster and more accurately. The goal is to see if AI can improve t…

This study looks at how a new medicine called elecoglipron changes the way the body processes two common cholesterol-lowering drugs, atorvastatin and rosuvastatin. About 40 healthy adults will take elecoglipron along with one of the statins to measure drug levels in the blood. Th…

This study is not testing a new treatment. Instead, it will collect information from about 500 people in Moscow who have moderate to very severe COPD and frequent exacerbations. Researchers want to learn about their age, lifestyle, medical history, and current treatments to bette…

This study follows 300 men with metastatic castration-resistant prostate cancer who are taking olaparib as part of their normal treatment. Researchers will track how long patients stay on the drug, how well it controls the cancer, and any side effects. The goal is to see how olap…

This study follows 693 adults in Brazil with severe or very severe COPD to understand how often they are hospitalized, have flare-ups, or die. Researchers want to collect national data that currently doesn't exist. Participants will be observed over time, but no new treatments ar…

This study looks at medical records from over 6,000 Brazilian adults with heart or kidney problems to understand how common high potassium levels are and what factors increase the risk. The goal is to learn more about patient profiles and current treatments to help doctors better…

This early-stage study tests a new drug, AZD1613, in healthy volunteers to see if it is safe and how the body processes it. About 136 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to gather information, no…

This study measures how people with chronic lymphocytic leukemia (CLL) feel and function while taking the drug acalabrutinib. Researchers will look at quality-of-life questionnaires filled out by 120 patients in France over 12 months. The goal is to understand real-world experien…

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers want to see if different HER2 tests give the same results. No treatment is given—only existing tissue samples are analyzed.

This study looks at a chronic lung disease called non-cystic fibrosis bronchiectasis, which causes persistent cough and infections. Researchers will study 320 patients and healthy volunteers in China to find biological markers and disease patterns. The goal is to better understan…

This study looks at how doctors in Russia treat advanced lung cancer (NSCLC and SCLC) with chemoradiotherapy. Researchers will collect information from medical records of 2000 patients across 50 cancer centers. The goal is to understand real-world treatment approaches and short-t…

This study observes 126 adults with HER2-negative early breast cancer who are starting treatment with olaparib. Researchers will track how many patients complete the full 12-month course and look at genetic mutations. The goal is to understand real-world treatment patterns, not t…

This study will look at health records from 15,000 adults with high blood pressure in Brazil's public health system. The goal is to understand how doctors treat the condition and whether they adjust medications when blood pressure stays high. No new treatments are being tested; i…

This study reviews medical records of 150 Chinese adults with advanced papillary kidney cancer who received sunitinib or sorafenib as their first treatment. The goal is to see how long patients live without their cancer getting worse. Since this is a retrospective study, it does …

This study aims to find out how many children and teens in Russia have a rare genetic condition called lysosomal acid lipase deficiency (LAL-D). Researchers will check kids with certain warning signs, like an enlarged liver or abnormal cholesterol levels, to see if they have the …

This study will follow about 4,490 adults with liver or bile duct cancer who are receiving durvalumab-based treatment as part of their regular care or an early access program. Researchers want to see how long patients live and how well the treatment works outside of clinical tria…

This study uses a survey to find out what factors are most important to Chinese patients and doctors when choosing a first-line targeted therapy for advanced lung cancer. About 590 participants (patients and physicians) will answer questions about treatment preferences. The goal …

This study observes about 500 Spanish adults with a specific type of lung cancer (EGFR-mutated non-small cell lung cancer) who are taking the drug osimertinib in everyday medical practice. Researchers will track how long patients live, how well the drug controls the cancer, and t…

This study looks back at medical records of 250 adults in Brazil with advanced non-squamous non-small cell lung cancer. It aims to describe what treatments patients receive after platinum chemotherapy stops working, and how they fare. No new treatments are given—researchers simpl…

This study looks at how often a protein called HER2 is found at high levels in gynecological cancers like endometrial, ovarian, and cervical cancer. Researchers will test tumor samples from 350 adult patients in Brazil using standard lab methods. The goal is to better understand …

This study will look at 5,000 adults in Russia who have severe asthma that is not well controlled. Researchers will collect information on the medicines patients are already taking and their health details. The goal is to better understand current treatment patterns and patient c…

This study will review health records of 60,000 people with lung cancer in Alberta and Ontario to understand how the disease is treated, what outcomes patients have, and how much care costs. It aims to provide a clear picture of current treatment patterns and healthcare resource …

This study follows 200 Chinese patients with chronic sinusitis and nasal polyps after they have surgery. Researchers will track symptoms, quality of life, and disease control for one year using questionnaires and nasal exams. The goal is to understand real-world outcomes and trea…

This study is looking at 500 women in Russia with advanced or aggressive endometrial cancer. Researchers will test their tumor tissue for specific genetic changes and see which first treatments doctors choose. The goal is to learn more about the disease, not to test a new treatme…

This study looks at how often people with high blood pressure also have signs of chronic kidney disease in Kazakhstan. Researchers will track over 1,200 adults to see how many have kidney damage markers like protein in urine or low kidney function. The goal is to better understan…

This study observes 750 women with advanced ovarian cancer in Germany who are starting first-line platinum-based chemotherapy. It collects information on how patients are treated, their experiences, and outcomes like cancer progression. The goal is to learn more about the effecti…

This study looks at how certain genetic changes (ESR1 mutations) appear in the blood of people with metastatic breast cancer. Researchers will compare patients who have had prior treatments with those who haven't. The goal is to better understand why some cancers become resistant…

This early-stage study tests whether the experimental drug AZD3974 is safe and how it moves through the body. It involves 176 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effe…

This study is tracking 24,000 people with type 2 diabetes across seven European countries to see if those who started taking the drug exenatide have a higher risk of developing pancreatic cancer compared to those taking other diabetes medications. Researchers will analyze medical…

This study is monitoring the safety and effectiveness of the drug capivasertib when used in routine care for breast cancer patients in Korea. About 130 people who are already prescribed the drug by their doctor will take part. The goal is to find any side effects and see how well…

This study observes 250 men with metastatic castration-resistant prostate cancer (mCRPC) who are taking the drugs olaparib and abiraterone together as part of their routine care. Researchers will track how long patients stay on this treatment and what therapies they use next. The…

This study aims to understand how hypophosphatasia (HPP), a rare genetic bone disease, naturally progresses in children and adults in Russia. Researchers will collect detailed information on symptoms, genetics, and health outcomes from 55 participants. The goal is to better chara…

This study aims to find out how many people with heart disease also have a lung condition called COPD. Researchers will follow 3,000 adults with coronary heart disease, atrial fibrillation, or chronic heart failure to track their health and hospital visits. The goal is to better …

This study follows 800 adults with advanced HER2-positive, HER2-low, or HER2-ultralow breast cancer who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers will track how long patients stay on treatment, their quality of life, and an…

This study is observing 200 people in South Korea who are already prescribed Koselugo for neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will track side effects and how well the drug works in everyday medical practice. The goal is to confirm the drug's s…