New drug cocktail aims to tackle Hard-to-Treat prostate cancer

NCT ID NCT07181161

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 16, 2026 · Updated 3 times

Summary

This study tests a new drug called AZD0516, given alone or with other cancer drugs, in people with metastatic prostate cancer that has spread. The main goals are to check safety, find the best dose, and see early signs of tumor control. About 177 participants will take part across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AZD0516 (given by IV) and AZD9574 (taken by mouth)
What this could lead to: If successful, this could point toward a new treatment option for metastatic prostate cancer that is resistant to current therapies.
What could go wrong: This is an early-phase trial (Phase 1/2a) focused on safety and dosing, so it is too soon to know if the drug will work. Side effects are unknown, and many early cancer drugs do not advance to later trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PROSTATE CANCER

Contacts and locations

Locations

Research Site
RECRUITING

Fayetteville, Arkansas, 72703, United States
Research Site
RECRUITING

Los Angeles, California, 90095, United States
Research Site
SUSPENDED

Towson, Maryland, 21204, United States
Research Site
RECRUITING

Boston, Massachusetts, 02114, United States
Research Site
RECRUITING

Ann Arbor, Michigan, 48109, United States
Research Site
RECRUITING

Detroit, Michigan, 48201, United States
Research Site
SUSPENDED

Buffalo, New York, 14263, United States
Research Site
RECRUITING

New York, New York, 10065, United States
Research Site
RECRUITING

Providence, Rhode Island, 02906, United States
Research Site
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Research Site
RECRUITING

Houston, Texas, 77030, United States
Research Site
NOT_YET_RECRUITING

Barretos, 14784-400, Brazil
Research Site
NOT_YET_RECRUITING

Porto Alegre, 90035-001, Brazil
Research Site
NOT_YET_RECRUITING

São Paulo, 01401-002, Brazil
Research Site
NOT_YET_RECRUITING

Changsha, 410013, China
Research Site
NOT_YET_RECRUITING

Chengdu, 610041, China
Research Site
NOT_YET_RECRUITING

Wuhan, 430022, China
Research Site
WITHDRAWN

Lyon, 69008, France
Research Site
WITHDRAWN

Montpellier, 34298, France
Research Site
WITHDRAWN

Saint-Herblain, 44805, France
Research Site
WITHDRAWN

Suresnes, 92151, France
Research Site
WITHDRAWN

Villejuif, 94805, France
Research Site
NOT_YET_RECRUITING

Milan, 20132, Italy
Research Site
NOT_YET_RECRUITING

Milan, 20133, Italy
Research Site
NOT_YET_RECRUITING

Milan, 20141, Italy
Research Site
NOT_YET_RECRUITING

Naples, 80131, Italy
Research Site
NOT_YET_RECRUITING

Roma, 00168, Italy
Research Site
NOT_YET_RECRUITING

Rozzano, 20089, Italy
Research Site
RECRUITING

Chūōku, 104-0045, Japan
Research Site
NOT_YET_RECRUITING

Kashiwa, 277-8577, Japan
Research Site
RECRUITING

Kōtoku, 135-8550, Japan
Research Site
NOT_YET_RECRUITING

Koszalin, 75-581, Poland
Research Site
NOT_YET_RECRUITING

Piotrkow Trybunalski, 97-300, Poland
Research Site
NOT_YET_RECRUITING

Przemyśl, 37-700, Poland
Research Site
NOT_YET_RECRUITING

Seoul, 03080, South Korea
Research Site
RECRUITING

Seoul, 03722, South Korea
Research Site
RECRUITING

Seoul, 06351, South Korea
Research Site
RECRUITING

Seoul, 06591, South Korea
Research Site
NOT_YET_RECRUITING

Seoul, 5505, South Korea
Research Site
RECRUITING

Barcelona, 08035, Spain
Research Site
NOT_YET_RECRUITING

Barcelona, 08036, Spain
Research Site
NOT_YET_RECRUITING

Barcelona, 08041, Spain
Research Site
NOT_YET_RECRUITING

L'Hospitalet de Llobregat, 08908, Spain
Research Site
RECRUITING

Madrid, 28027, Spain
Research Site
RECRUITING

Pamplona, 31005, Spain
Research Site
NOT_YET_RECRUITING

Santander, 39008, Spain
Research Site
NOT_YET_RECRUITING

Valencia, 46009, Spain
Research Site
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Research Site
RECRUITING

London, EC1A 7BE, United Kingdom
Research Site
RECRUITING

London, SE1 9RT, United Kingdom
Research Site
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Research Site
RECRUITING

Sutton, SM2 5PT, United Kingdom

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