Can a pill outsmart Tumors' defenses?

NCT ID NCT05272709

Recruiting now Disease control Sponsor: Cancer Research UK Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests an experimental oral drug called TT-702 in people with advanced solid tumors. The drug works by blocking a protein that tumors use to hide from the immune system. The study aims to find the safest dose of TT-702 when given alone and in combination with an immunotherapy drug, and to see if it can shrink tumors. Participants receive TT-702 daily for up to 12 months, with some also receiving an anti-PD-1/PD-L1 agent.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TT-702, an oral drug that blocks a protein called adenosine A2BR, tested alone and with an anti-PD-1/PD-L1 immunotherapy agent.
What this could lead to: If successful, this could provide a new treatment option for people with advanced solid tumors, potentially slowing or shrinking their cancer.
What could go wrong: This is an early-phase trial with a small number of participants, so the drug may not work as hoped or may cause significant side effects. The combination partner is not yet finalized.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ADVANCED SOLID TUMORS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma colorectal cancer colorectal neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

Locations

Royal Marsden Hospital NHS Foundation Trust
RECRUITING

London, SM2 5PT, United Kingdom
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
University Hospital Southampton NHS Foundation Trust
RECRUITING

Southampton, SO16 6YD, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.