Can a plasma beam stop colon polyps from coming back?
NCT ID NCT04015765
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps are removed in pieces, they can recur in 12-30% of cases. The study will include people with non-cancerous colon polyps of at least 20 mm. Half will receive standard EMR alone, and half will receive EMR plus h-APC ablation of the margins. The goal is to see if this extra step reduces recurrence to 5% or less.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hybrid Argon Plasma Coagulation (h-APC) procedure
- What this could lead to
- If effective, this technique could significantly lower the chance of colon polyps returning after removal, potentially reducing the need for repeat procedures and lowering colorectal cancer risk.
- What could go wrong
- This is a single-center trial, and results may not apply broadly. The procedure carries risks like bleeding or perforation, and the recurrence reduction may not be as high as hoped.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre Hospitalier Universitaire de Montréal (CHUM)
Montreal, Quebec, Canada
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