Can a plasma beam stop colon polyps from coming back?

NCT ID NCT04015765

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps are removed in pieces, they can recur in 12-30% of cases. The study will include people with non-cancerous colon polyps of at least 20 mm. Half will receive standard EMR alone, and half will receive EMR plus h-APC ablation of the margins. The goal is to see if this extra step reduces recurrence to 5% or less.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Hybrid Argon Plasma Coagulation (h-APC) procedure
What this could lead to
If effective, this technique could significantly lower the chance of colon polyps returning after removal, potentially reducing the need for repeat procedures and lowering colorectal cancer risk.
What could go wrong
This is a single-center trial, and results may not apply broadly. The procedure carries risks like bleeding or perforation, and the recurrence reduction may not be as high as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COLORECTAL ADENOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Centre Hospitalier Universitaire de Montréal (CHUM)

    Montreal, Quebec, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.