Your gut bacteria might reveal hidden cancer risk

NCT ID NCT06738173

Recruiting now Diagnosis Sponsor: Catholic University of the Sacred Heart Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study is looking at whether the mix of bacteria in the gut can serve as a warning sign for colorectal cancer and advanced polyps. Researchers will collect stool samples from people aged 50-74 who are part of a national screening program and have had a positive fecal immunochemical test (FIT). By analyzing the microbiome and comparing it with colonoscopy results, they aim to build a scoring tool that could one day make screening more accurate and less invasive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Gut microbiome testing
What this could lead to: If successful, this could lead to a non-invasive stool test that improves colorectal cancer screening, reducing unnecessary colonoscopies and catching more cancers early.
What could go wrong: The test is still in development and may not prove accurate enough to replace current methods. Also, the study is observational, so it can't prove cause and effect.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER

Contacts and locations

Locations

Catholic University of the Sacred Heart
RECRUITING

Rome, RM, 00168, Italy

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