COLORECTAL CANCER

This early-phase trial tests a two-vaccine strategy in 18 adults with advanced colorectal or small bowel cancer that has not responded to standard treatments. The first vaccine is given as a shot, followed by two doses of a second vaccine given through a vein. The goal is to find…

This early-phase study tests a technique called In Vivo Lung Perfusion (IVLP) that delivers chemotherapy directly into one lung during surgery to remove lung tumors. The goal is to kill any remaining cancer cells while reducing side effects on the rest of the body. About 10 adult…

This trial tests a personalized cancer vaccine made from tumor cells grown in a lab. The cells are modified to boost the immune system, then killed and injected into the patient. The goal is to help people with metastatic melanoma, breast, ovarian, colorectal, gastric, lung, or k…

This study tests a new combination of three drugs (tucidinostat, sintilimab, and bevacizumab) against a standard single drug (fruquintinib) in people with a common type of advanced colorectal cancer that has not responded to at least two prior treatments. The goal is to see if th…

This study looks at whether adding an immunomodulator (a drug that helps the immune system) to standard cancer treatments can help people with colorectal cancer live longer. Researchers will compare survival and tumor response in 250 adults who received standard therapy with or w…

This study tests a device called xBar that monitors healing inside the body after colorectal cancer surgery. About 80 adults having a specific type of colorectal surgery will use the system. The goal is to see if it helps catch problems early and reduces serious complications com…

This study tests three experimental treatments for people with advanced esophageal, stomach, or colorectal cancer that has spread. The goal is to see if these drug combinations can shrink tumors or slow disease progression. About 376 adults aged 18 to 75 will participate, and the…

This study tests whether a single, high-dose session of MRI-guided radiation can stop liver tumors from growing in people with colorectal cancer that has spread. About 32 adults with up to 3 small liver lesions will receive the treatment. Researchers will monitor tumor control, s…

This study tests whether adding a special type of PET scan-guided radiation to standard second-line treatment works better than standard treatment alone for colorectal cancer that has spread to the abdomen. About 40 adults whose cancer worsened after first-line therapy will be ra…

This early-stage trial tests a combination of three treatments for people with advanced colorectal cancer who have already tried two standard therapies. The approach combines a special immune cell therapy (DC-CIK), an immunotherapy drug, and a targeted pill to attack the cancer f…

This study tests whether adding an experimental drug (ONO-4578) to a standard chemotherapy and immunotherapy regimen can shrink tumors better than standard care alone in people with advanced colorectal cancer that has a specific marker (PD-L1 positive). About 144 adults who have …

This study tests an experimental drug called FMC-376 in people with advanced solid tumors that have a specific genetic change (KRAS G12C). The goal is to find a safe dose and see if the drug can shrink tumors. About 400 adults whose cancer has worsened after standard treatments w…

This early-phase study tests a new drug called BL-M17D1 in people with advanced HER2-positive or low-HER2 gastrointestinal cancers and other solid tumors. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 20 adults will take part, …

This study tests whether giving two targeted drugs (encorafenib and cetuximab) before surgery can shrink tumors in people with a specific genetic mutation (BRAF V600E) in colon or upper rectal cancer. About 30 participants will receive the drug combination for a short time, then …

This early-stage study tests a new drug called STRO-004 in about 200 adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in m…

This study is for people with advanced colorectal cancer that has a certain genetic makeup (RAS/BRAF wild type) in the tumor but shows a different genetic change (RAS mutation) in a blood test. The goal is to see if a combination of chemotherapy (FOLFIRI) plus a drug called bevac…

This study tests a combination of two drugs, anlotinib and sintilimab, as a first treatment for people with advanced colorectal cancer that has spread but not to the liver. The goal is to see if this drug pair can shrink tumors and control the disease without standard chemotherap…

This study tests a new drug called JR8603 in people with advanced solid tumors (like stomach or colorectal cancer) that have not responded to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 94 adults will take part in this ear…

This study tests a vaccine called PD1-Vaxx given before surgery to people with a specific type of colorectal cancer (MSI-high). The goal is to see if the vaccine can shrink the tumor or even make it disappear before the operation. About 44 participants will receive three doses of…

This early-phase study tests an experimental drug called MRG007 in people with advanced solid tumors (like colorectal, gastric, or pancreatic cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors.…

This study compares two liquids—chlorhexidine and saline—used to flush the surgical area during colorectal cancer surgery. The goal is to see which one better prevents surgical site infections and other complications within 30 days after surgery. About 532 adults aged 18-85 with …

This early-phase study tests an experimental drug called IVX037, injected directly into tumors, for people with advanced colorectal, gastric, or ovarian cancers that have stopped responding to standard treatments. The study has two parts: first, testing IVX037 alone, and then com…

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer or colorectal cancer that has spread to the liver from returning after surgery. About 60 adults with these cancers will receive t…

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This study tests if a new combination of drugs (DSP107 and atezolizumab) works better than an existing treatment (fruquintinib) for people with advanced colorectal cancer that is microsatellite stable (MSS). About 90 adults who have already tried other therapies will be randomly …

This study tests whether two immunotherapy drugs, cemiplimab and fianlimab, can eliminate tumors in older patients (70+) or those unfit for surgery with a specific genetic type of colorectal cancer (MSI-H). Participants receive the drugs and are monitored with scans and scopes to…

This study tests whether the drug tislelizumab can shrink tumors in 40 people with colorectal cancer in Nigeria. Participants have a specific type of cancer (mismatch repair deficient) and have not received any prior treatment. The goal is to see if the drug is effective and safe…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study is testing several new experimental drugs (RAS(ON) inhibitors) combined with standard chemotherapy or other targeted therapies for people with advanced colorectal or pancreatic cancer. The goal is to see if these combinations are safe and can shrink tumors. About 1,130…

This study tests a drug called futibatinib combined with other cancer treatments in people with advanced colorectal cancer or other solid tumors. The goal is to see if the combination can shrink tumors and help control the disease. About 33 adults will take part, and researchers …

This study aims to find the right dose of chemotherapy for people with digestive cancers who have a genetic condition called DPD deficiency, which makes standard chemo doses dangerous. About 400 participants will receive a reduced dose based on their DPD activity and be monitored…

This early-phase study is testing whether adding low-dose radiotherapy to standard immunochemotherapy is safe and feasible for people with colorectal cancer that has spread only to the liver. About 9 to 18 adults aged 18-75 who have not had prior treatment will receive the combin…

This early-phase study tests a new treatment called PeptiCRAd-1, a virus-based cancer vaccine, combined with the immunotherapy drug pembrolizumab. The goal is to see if this combination is safe and can boost the immune system to fight several types of solid tumors, including mela…

This study tests whether using a person's genetic makeup to decide the dose of chemotherapy can lower the risk of severe side effects. About 178 adults with colorectal or pancreatic cancer will be randomly assigned to either standard dosing or dosing based on their UGT1A1 gene ty…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and targeted therapy can help people with a specific type of advanced colorectal cancer live longer without their disease getting worse. About 238 adults whose cancer has spread and cann…

This study tests a new device called ColoSeal that is placed inside the colon after surgery for rectal or rectosigmoid cancer. The device is designed to protect the surgical connection from stool for up to 21 days, which may help prevent leaks and other complications. The study w…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control or shrink advanced solid tumors like lung, pancreas, and colorectal cancers. The study involves 54 adults who…

This early-stage study tests a new drug called SIM0610 in about 260 adults with advanced solid tumors (e.g., lung, colorectal, head and neck, liver cancer) that have spread. The main goals are to check the drug's safety and find the right dose, while also looking for signs that i…

This early-stage study tests an experimental drug called MOMA-341, taken as a pill, for people with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The study includes up to 132 adults whose cancer has not responded to prior treatments. The main goal is …

This study looks at whether drinking 6 grams of instant coffee daily can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 participants will be randomly assigned to drink coffee or not for a period of time. T…

This study tests whether adding hydroxychloroquine (a drug used for malaria) to standard targeted therapy can help shrink tumors in people with advanced BRAF-mutated colon cancer that has stopped responding to other treatments. About 43 adults will receive the combination to see …

This study tests a new oral drug, VS-7375, in people with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific KRAS G12D mutation. The trial will first find the safest dose, then check if the drug shrinks tumors when used alone or with other ca…

This study looks at 340 people with high-risk stage II colorectal cancer who still have tumor DNA in their blood one month after surgery. Researchers want to see if using this blood test to decide on stronger chemotherapy can help clear the cancer DNA and improve survival. The go…

This early-phase study tests a new drug called PT0511 in about 195 adults with advanced solid tumors that have a KRAS mutation or amplification, including colorectal, pancreatic, and lung cancers. The main goals are to check safety, find the best dose, and see how the drug works …

This study tests an experimental pill called IPN01194 in adults with advanced solid tumors (cancers that have spread). The goal is to find the right dose and see if it is safe and can shrink tumors. About 220 people with specific genetic mutations will take the drug by mouth. Thi…

This study looks at adults whose platelet counts stayed low after finishing chemotherapy for gastrointestinal cancers (like stomach, pancreas, or colorectal). Participants get either a standard platelet-boosting drug alone or combined with another medicine (ATRA) for 12 weeks. Th…

This study tests whether adding two antibiotics (ciprofloxacin and metronidazole) plus aspirin to standard chemotherapy can improve outcomes for people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome therapy. The…

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer) that have not responded to other treatments. The main goals are to check safety, find the right…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, help people with advanced colorectal cancer that cannot be removed by surgery and has stopped responding to standard treatments live longer. About 834 participants will receive either the drug combina…

This study tests two different radiation schedules (long or short course) combined with chemotherapy (CAPOX), an immunotherapy drug (PD-1 inhibitor), and a COX-2 inhibitor in people with a specific type of locally advanced rectal cancer (MSS). The goal is to see which approach le…

This early-stage study tests a new treatment called GCC19CART for people with metastatic colorectal cancer that has come back or not responded to standard therapies. The treatment uses a patient's own immune cells, modified to target cancer cells. The main goals are to check safe…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard liver-directed chemotherapy can help people with certain cancers that have spread to the liver. About 70 adults with colorectal cancer, bile duct cancer, or adrenal cancer that is mainly in the liver w…

This study tests two experimental drugs, elironrasib and daraxonrasib, given alone or together, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drugs are safe and can shrink or control tumors. About 534 adults with lung, col…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This study tests different combinations of immunotherapy drugs (with or without radiation) in people with colorectal cancer that has spread to the liver and who are scheduled for surgery. The goal is to see if these combinations change the immune environment in the liver tumors a…

This study tests whether adding a second drug (TAS-102) to the standard drug fruquintinib helps people with advanced colorectal cancer live longer without their cancer growing. About 120 adults whose cancer has not responded to prior treatments will be randomly assigned to receiv…

This study tests a drug called AMB-05X in 15 people with colorectal cancer who have no visible tumors but still have cancer DNA in their blood (ctDNA positive). The goal is to see if the drug can eliminate these hidden cancer cells and prevent the cancer from coming back. Partici…

This study tests a new treatment called CHM-2101 for people with advanced gastrointestinal cancers (stomach, colon, or neuroendocrine tumors) that have stopped responding to standard therapies. The treatment uses a patient's own immune cells, modified to recognize and attack canc…

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This early-phase trial tests a new drug called ZM008, alone and with another drug (toripalimab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 100 adults with canc…

This study tests a new drug called MK-2870, alone or with other cancer treatments, for people with advanced colorectal, pancreatic, or bile duct cancers that have spread or cannot be removed by surgery. The main goals are to check the drug's safety and see how many patients' tumo…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by helping the body's immune cells attack cancer cells. The main goals are to check safety and find the best dose, while…

This study tests an experimental drug, LY3962673, in people with advanced solid tumors (like pancreatic, lung, or colorectal cancer) that have a specific genetic change called KRAS G12D. The goal is to find safe doses and see if the drug shrinks tumors, both alone and with other …

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests whether a blood test that detects tumor DNA can help doctors decide how long chemotherapy should last for people with certain types of colorectal cancer. About 340 adults with T4N0 or low-risk stage III colorectal cancer will be randomly assigned to standard 3-mo…

This early-stage study tests a new treatment called DISP-10 for people with advanced colorectal, stomach, or esophageal cancers that have spread. The treatment combines a virus that may help the immune system attack cancer cells with specially engineered immune cells (CAR T cells…

This study tests a new way of giving chemotherapy to people with advanced gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemo drug (5-FU) based on how well each patient tolerates the initial dose, aiming to give a stronger, more…

This study tests a new drug called IDE196 in people with certain cancers that have specific gene mutations (GNAQ/11 or PRKC fusions), including metastatic uveal melanoma and colorectal cancer. The trial has two phases: first to find safe doses, then to see if the drug shrinks tum…

This study tests an experimental drug called YL202 in about 100 adults with advanced solid tumors, including lung, colorectal, and cervical cancers that have not responded to other treatments. The main goal is to see if YL202 can shrink tumors. Participants will receive the drug …

This early-phase study tests a new treatment called Anti-CEA CAR-T for people with advanced solid tumors (like colorectal or stomach cancer) that have not responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to target a protein calle…

This early-phase trial tests a new treatment for colorectal cancer patients who have minimal residual disease (tiny amounts of cancer left after treatment). The therapy uses specially engineered immune cells (TROP2-CAR-NK cells) combined with a targeted drug called cetuximab. The…

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This early-stage study tests an experimental oral drug, VVD-133214, in people with advanced solid tumors that have specific genetic changes (MSI or dMMR). The drug works by blocking a protein called Werner that helps these cancers grow. The main goals are to check the drug's safe…

This study tests whether giving a short course of targeted drugs before surgery can shrink tumors in people with colorectal cancer that can be removed. Participants must have a specific genetic change in their tumor and will receive a drug matched to that change for a few weeks b…

This study looks at people with colorectal cancer that spread to the liver, who had surgery to remove up to 10 liver tumors after responding well to a specific chemotherapy (FOLFIRI). The goal is to see if restarting that same chemotherapy after surgery helps prevent the cancer f…

This study looks at whether giving chemotherapy after removing or destroying all visible tumors can help people with metastatic colorectal cancer live longer without the cancer coming back. About 507 adults whose tumors were fully treated will be randomly assigned to receive eith…

This study compares robot-assisted surgery to traditional open surgery for people with colon cancer near the right flexure or transverse colon. Researchers want to see if the robot approach removes the tumor just as completely, while possibly leading to fewer complications and a …

This study tests whether a combination of two drugs, botensilimab and balstilimab, can clear remaining cancer DNA in people with colorectal cancer who still have signs of disease after surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (MSS) will…

This study tests a new treatment called EBNK-001, which uses donor natural killer (NK) cells to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive the NK cells along with ch…

This study tests a PD-1 immunotherapy drug, given alone or with chemotherapy, before surgery for people who have two or more colorectal cancers at the same time. The goal is to shrink the tumors so surgery can be less extensive, possibly preserving more of the colon. About 17 par…

This study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable. These cancers are hard to treat and don't respond well to sta…

This study tests whether adding a non-invasive sound wave treatment called histotripsy to standard chemotherapy can help people with advanced colorectal cancer that has spread to the liver. About 100 adults whose cancer cannot be removed by surgery will receive both treatments. R…

This early-phase study tests a new drug (177Lu-DFC413) that delivers radiation directly to cancer cells in adults with advanced solid tumors like pancreatic, lung, breast, colorectal, and soft tissue cancers. The main goals are to check safety, find the right dose, and see if it …

This study tests a new surgical technique called Q-ISR for people with ultra-low rectal cancer. It compares Q-ISR to two standard surgeries to see if it can better preserve anal function while still effectively removing the cancer. About 100 participants will be followed for shor…

This early-phase trial tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. The therapy uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells, given both through a vein and directly into the abdomen.…

This study tests a new drug called datopotamab deruxtecan (Dato-DXd) alone or with other cancer drugs in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gas…

This study tests a combination of two drugs (fruquintinib and sintilimab) with or without radiation therapy for people with colorectal cancer that has spread to the liver and hasn't responded to two prior treatments. The goal is to see if this approach can control the cancer long…

This study is for people with a specific type of colorectal cancer (dMMR/MSI-H) that hasn't spread far. It tests giving an immunotherapy drug (toripalimab) with or without an anti-inflammatory drug (celecoxib) before surgery. The goal is to see if this approach can shrink or elim…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests whether a drug called TAS-102, alone or with celecoxib, can clear tiny amounts of cancer DNA left in the blood after standard chemotherapy for colorectal cancer. About 25 adults who have finished initial treatment but still show cancer signals in their blood will…

This study tests an experimental oral drug called NEO212 in people with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control the disease. About 134 adults will take part across t…

This early-phase study tests whether a combination of two chemotherapy drugs (trifluridine/tipiracil and irinotecan) can clear leftover cancer cells in people with colon cancer whose blood still shows cancer DNA after standard treatment. About 22 adults with stage II–IV colon can…

This study tests whether adding a GSL synthetase inhibitor (eliglustat) to standard treatments can shrink tumors or slow cancer growth in people with advanced colorectal cancer that has not responded to at least two prior therapies. About 120 adults with a specific tumor type (pM…

This study is testing a new drug, enzelkitug, for people with advanced solid tumors that have spread or cannot be removed by surgery. The trial includes many cancer types like lung, head and neck, melanoma, breast, and others. The main goal is to check the drug's safety and find …

This study tests a new drug called KIVU-107 in people with advanced solid tumors that have stopped responding to standard treatments. The drug is designed to target and kill cancer cells while limiting harm to healthy cells. The main goals are to find the safest dose and check fo…

This study tests whether combining two or three drugs (cabozantinib, durvalumab, and tremelimumab) can safely shrink tumors in people with advanced stomach, esophageal, liver, or colorectal cancer. About 117 adults with stage 3 or 4 disease that cannot be removed by surgery will …

This early-phase study tests a new treatment called PTC13, which uses a patient's own immune cells (T cells) engineered to target a protein called CEA found on certain cancer cells. The goal is to see if it is safe and tolerable for people with advanced solid tumors like colorect…

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This study tests a new drug called SHR-8068 combined with other cancer treatments for people with colorectal cancer. The goal is to see if the combination can shrink tumors and keep the cancer from growing. About 200 adults aged 18 to 75 are being recruited. This is a phase 2 tri…

This study compares two minimally invasive procedures—EMR and ESD—for removing large, flat colon growths (LST-G) that can turn into cancer. About 282 adults will be randomly assigned to one of the two techniques. The goal is to see which method leads to fewer growths coming back …

This study tests whether adding two drugs (serplulimab and bevacizumab) to standard chemotherapy can improve outcomes for people with colorectal cancer that has spread to the liver and can be surgically removed. About 156 adults with a specific genetic type (RAS/BRAF wild-type, p…

This study tests whether a combination of two drugs, fruquintinib and tislelizumab, can control colorectal cancer in people who have completed chemotherapy but still have signs of minimal residual disease (MRD) based on a sensitive blood test (ctDNA). About 20 adults with stable …

This early-phase study tests a new radioactive drug, [177Lu]Lu-NNS309, in adults with advanced pancreatic, lung, breast, or colorectal cancers that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink t…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This study is for people with high-risk stage III colorectal cancer. It uses a blood test (ctDNA) to see if adding a targeted drug (bevacizumab) to standard chemotherapy works better than chemo alone. About 100 participants will be randomly assigned to one of two treatment groups…

This study tests a combination of two cancer drugs (fruquintinib and FOLFIRI) as a second treatment option for people with metastatic colorectal cancer whose first treatment stopped working. About 60 adults will receive the drug combo to see if it can slow cancer growth and how s…

This study tests a new drug, ASP5834, in people with advanced solid tumors that have certain changes in the KRAS gene. The goal is to find a safe dose and check for side effects. Some participants with colorectal cancer will also receive another drug called panitumumab. The study…

This study tests a new drug called BOLD-100 combined with standard chemotherapy (FOLFOX) in people with advanced solid tumors like colorectal, pancreatic, gastric, and bile duct cancers. The goal is to see if the combination is safe and can shrink or slow tumor growth. About 220 …

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This study tests a new cancer pill (PF-08032562) in people with advanced breast or colorectal cancer that has spread. The goal is to find the safest dose and see how well it works alone or with other treatments. About 260 adults will take the pill daily in 28-day cycles, with som…

This early-phase study tests a new treatment called 177LuBetaBart for people with advanced solid tumors that have stopped responding to standard therapies. The treatment combines a targeting antibody with a radioactive particle to deliver radiation directly to cancer cells. The s…

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their growth. About …

This study tests a combination of two drugs, fruquintinib and serplulimab, in people with advanced colorectal cancer that has not spread to the liver and has stopped responding to standard treatments. The goal is to see if the combination can shrink tumors or slow the disease. Re…

This study tests a procedure called pulmonary suffusion, which delivers chemotherapy directly to the lungs through a minimally invasive method. It is for people with sarcoma or colorectal cancer that has spread to the lungs and can be surgically removed. The goal is to control an…

This study compares a new AI-enabled robotic stapler to a conventional stapler in 200 adults undergoing robotic or laparoscopic surgery for non-metastatic colorectal cancer. The goal is to see if the AI tool helps lower the risk of serious complications like anastomotic leaks. Pa…

This early-stage study tests a new drug called IDE034 in 150 adults with advanced solid tumors (like lung, ovarian, or colon cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors…

This study tests whether taking the antibiotic metronidazole before surgery can reduce levels of a specific bacteria (Fusobacterium nucleatum) in colorectal cancer tumors. About 40 adults with untreated colorectal cancer will receive the drug before their tumor is removed. The go…

This early-stage study tests a new vaccine that targets a common cancer-driving protein (mutant KRAS) combined with two immunotherapy drugs (balstilimab and botensilimab) in people with advanced colorectal or pancreatic cancer that has not responded to standard chemotherapy. The …

This phase 3 trial tests whether a stronger chemotherapy combination (mFOLFOXIRI) plus bevacizumab works better than a standard combo (mFOLFOX-6) plus bevacizumab for people with advanced colorectal cancer that cannot be removed by surgery. The study focuses on Asian patients, wh…

This study tests a new drug called MCLA-129 in people with advanced solid tumors like lung, head and neck, or colorectal cancer that has not responded to standard treatments. The drug is a bispecific antibody designed to attach to two cancer-related proteins (EGFR and c-Met) to b…

This study tests whether taking a low-dose aspirin daily after colon cancer surgery can lower the chance of the cancer returning. It is for patients whose tumors have a specific genetic change called PI3K mutation. The trial compares aspirin to a placebo (a pill with no medicine)…

This early-phase study tests a new drug called RGT-61159 in people with two types of cancer that have come back or not responded to treatment: adenoid cystic carcinoma (a rare salivary gland cancer) and colorectal cancer. The main goals are to check the drug's safety, find the be…

This study is testing a combination of three drugs (trastuzumab-deruxtecan, capecitabine, and bevacizumab) as a first treatment for people with a specific type of advanced colorectal cancer that has spread (HER-2 positive). The goal is to see how well this drug combo shrinks tumo…

This study tests a new drug called APL-5125 in about 100 adults with advanced solid tumors, including colorectal, pancreatic, and ovarian cancers. The goal is to check safety and see if the drug can shrink tumors. Participants must have tried standard treatments first.

This early-stage study tests a new cancer treatment called FT836, a ready-made immune cell therapy, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers. The treatment is given alone or with chemotherapy and/or antibod…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests an experimental pill called zongertinib, which blocks HER2—a protein that makes cancer grow. It is for adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and hasn't responded to prior treatments. The study has two parts: first, findi…

This study tests a new device that uses magnets to reconnect parts of the colon after surgery for colorectal cancer or diverticular disease. About 20 adults will receive the device during their operation. The goal is to see if the magnet connection works well and reduces the need…

This early-stage study tests a new drug called M9140 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works like a guided missile, delivering a cancer-killing agent directly to tumor cells. The main goals are to find a safe dose an…

This study tests a new vaccine made from engineered bacteria that targets KRAS mutations in colorectal and pancreatic cancer patients who have had surgery and chemotherapy but are at high risk of their cancer returning. The vaccine is designed to train the immune system to attack…

This study tests a new drug called ALE.P03 in adults with advanced cancers (cervical, lung, colorectal, bile duct, or bladder) that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to target a protein called Claudin-1 found on these tumor…

This study compares a new technique called total underwater colonoscopy (TUC) with the standard gas method in 1,070 people undergoing colorectal cancer screening after a positive stool test. TUC uses water instead of gas to inflate the colon, which may make flat, hard-to-see poly…

This study tests a drug called zanidatamab in people with advanced solid tumors that have high levels of HER2 protein. Participants must have already tried at least one other cancer treatment. The goal is to see if the drug can shrink tumors or stop them from growing. This is not…

This study tests a new drug, telisotuzumab adizutecan, against standard care in about 140 adults with colorectal cancer who have completed initial treatment but still have cancer DNA in their blood (ctDNA positive) with no visible tumors on scans. The goal is to see if the new dr…

This study tests the drug fruquintinib in 78 adults from minority groups (Black/African American and/or Hispanic/Latino) with advanced colorectal cancer that hasn't responded to other treatments. The main goal is to see how often severe high blood pressure occurs as a side effect…

This study tests a new treatment that delivers a powerful, short-range radioactive particle directly to cancer cells that have a protein called FAP on their surface. The therapy is given in two steps: first a low-dose imaging version to see if the tumor takes up the drug, then a …

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors, such as breast, lung, or gastric cancer. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A few days…

This study is testing a new blood test that looks for circular RNA to find colorectal cancer early. Researchers will collect blood samples from 600 adults with stage I-III colorectal cancer to see how accurate the test is. If successful, this could offer a non-invasive way to det…

This study aims to improve a blood test that looks for DNA fragments to detect colorectal cancer and pre-cancerous growths. Researchers will collect blood samples from 6,500 people, including those newly diagnosed with colorectal cancer and those at average risk getting routine c…

This study is testing a new radioactive tracer that targets a protein called LRRC15, found on many cancers like pancreatic, breast, lung, and brain tumors. The tracer is used with PET scans to see if it can better detect and stage these cancers compared to standard scans. The stu…

This study is testing whether a camera capsule you swallow can be used as a first step to check for colorectal cancer, instead of a traditional colonoscopy. About 800 adults with symptoms will either get the capsule or a standard colonoscopy. The goal is to see if this approach i…

This study tests a new microwave-based device that helps doctors find polyps during colonoscopy. About 50 people who already have a polyp in their rectum will take part. The device is used alongside standard colonoscopy to see if it can detect more polyps without causing harm.

This study is testing whether a simple, non-invasive stool test called FIT can accurately detect colorectal cancer in people with Lynch Syndrome, a genetic condition that raises cancer risk. Researchers will compare FIT results to standard colonoscopy findings in 400 participants…

This early study is testing a new imaging agent called FL-261 to see if it can safely and accurately detect and stage several types of cancer, including lung, colorectal, and head & neck cancers. The agent targets a protein (c-MET) found on many cancer cells but not on most healt…

This study checks if a new blood test can correctly rule out colorectal cancer in people who have other cancers or gut diseases. Researchers will collect blood samples from 250 adults and measure how often the test gives a false positive result. The goal is to see if the test is …

This study is testing a new imaging agent called 18F-T2, which targets a protein (CAIX) found on many solid tumors. About 200 adults with cancers like kidney, bladder, colorectal, or lung cancer will receive a PET/CT scan using this agent. The goal is to see if it can find tumors…

This study tests a new endorectal device that combines ultrasound and photoacoustic imaging to better diagnose rectal cancer and assess how well tumors respond to treatment. About 90 adults with rectal cancer who are scheduled for surgery will be imaged with this device. The goal…

This study is testing a blood test to quickly identify people who may have colorectal cancer. It includes 400 adults who either had a positive stool test or were already diagnosed with colorectal cancer. The goal is to see if the blood test can help prioritize who needs urgent ca…

This study tests a new, non-invasive imaging technique that uses light to measure blood flow during gastrointestinal surgery, comparing it to the standard method that uses a dye called indocyanine green. About 200 adults having elective bowel surgery will be randomly assigned to …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study is developing a blood test to detect colorectal cancer in people under 50, a group where cases are rising. The test looks at tiny particles called exosomes and uses machine learning to find cancer signals. Researchers will enroll 400 participants—half with early-onset …

This study is testing a blood test (called a liquid biopsy) to see how well it can find colorectal cancer, advanced polyps, and Lynch syndrome-related cancers early. Researchers will enroll 1,200 people who have had a colonoscopy and take a blood sample to compare the test result…

This study is testing a new blood test called Signal-C that looks for DNA fragments in the blood to find colorectal cancer and advanced precancerous growths. About 12,000 people aged 45 to 84 who are at average risk and already scheduled for a screening colonoscopy will give a bl…

This study tests a new imaging agent called [18F]FPyQCP for PET scans to detect five types of cancer: colorectal, ovarian, gastric, invasive lobular breast, and pancreatic. About 71 adults will receive a single dose of the agent to check its safety and how well it finds cancer, e…

This study compares a new type of CT scanner (photon-counting CT) to MRI for finding liver tumors that have spread from colorectal cancer. About 100 adults with colorectal cancer will get both scans, and researchers will check if the new CT is as good as MRI at spotting small tum…

This study aims to develop easy, low-cost screening tools to detect colorectal cancer earlier in high-risk people. Researchers will collect blood, breath, stool, and cheek swab samples from 4,100 adults across Europe and compare the results with standard colonoscopy. The goal is …

This study tests a new imaging agent (GEH300079) used with a PET/CT scan to find peritoneal carcinomatosis—cancer that has spread to the lining of the abdomen—in people with colorectal, gastric, ovarian, or pancreatic cancers. About 175 adults with known or suspected spread will …

This study is testing a new imaging system that uses a special dye to make cancer cells glow, helping surgeons see and remove them more completely. About 66 adults with colorectal, pancreatic, esophageal, or gastric cancer will take part before their scheduled surgery. The goal i…

This study aims to create a new, non-invasive screening tool for colorectal cancer by analyzing gut bacteria in stool samples. Researchers will collect samples from 1,006 people aged 50-74 who are part of a national screening program and have had a positive fecal test. The goal i…

This study tests whether a telehealth program, developed with community input, can help more people get screened for colorectal cancer. About 6,000 adults aged 45-64 who are due for screening will receive the intervention. The goal is to see if this approach increases screening r…

This study tests whether community health workers can help people aged 45 and older who are not up-to-date with colorectal cancer screening get tested and adopt healthier lifestyles. The program combines cancer screening support with a web-based lifestyle program to also reduce h…

This study aims to increase colorectal cancer screening among African Americans, who face higher risks and lower screening rates. About 1,200 participants aged 45-75 will receive a free at-home test kit, educational materials, and reminders. Some will also see targeted social med…

This study tests whether giving personalized diet and lifestyle advice to people at high risk for colorectal cancer helps them adopt healthier habits. About 800 participants who had a negative screening result will receive guidance based on cancer prevention recommendations. The …

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 participants will take one of these drugs or a placebo for a short time. Researchers will mea…

This study is testing whether eating a high-fiber, low-fat diet for three weeks before colorectal cancer surgery can change gut bacteria to help prevent the cancer from returning or spreading. About 80 adults with colorectal cancer who are scheduled for surgery will take part. Re…

This study tests whether taking polyunsaturated fatty acid supplements can prevent nerve damage in the hands and feet of people with colorectal cancer who receive oxaliplatin chemotherapy after surgery. About 120 participants will be randomly assigned to receive the supplement or…

This study tests a new approach to prevent a serious complication called anastomotic leakage after colorectal cancer surgery. About 110 adults having surgery for colorectal cancer will either get a temporary tube placed inside the bowel (endoscopic vacuum therapy) right after sur…

This study tests a new digital follow-up program for people who had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, fear of cancer returning, and late side effects, and provides personalized care. It compares this approach to standard follow-…

This study is testing a digital health program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage common symptoms like pain, fatigue, and emotional distress, and encourages participants to stay engaged with their follow-up medical care. Abo…

This study tests a new, technology-supported care plan for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) along with other health problems. The goal is to see if this approach improves their quality of life after 6 months. About 720 participants …

This study tests three common pain management methods used during minimally invasive cancer surgery. About 48 adults having surgery for cancers like liver, stomach, or colorectal cancer will be randomly assigned to one of three groups: a nerve block with numbing medicine, the ner…

This study is testing whether a telerehabilitation program (exercise and breathing exercises done at home with remote guidance) can help people recover their strength and quality of life after surgery for colorectal cancer. The study will involve 54 adults scheduled for surgery a…

This study looks at whether people with colorectal cancer can increase their fiber intake before surgery. Researchers will test two methods: personalized digital diet advice or a dried vegetable product, and compare them to usual eating habits. The goal is to see if these approac…

This study tests whether the drug riluzole can prevent memory and thinking problems (often called 'chemo brain') in people receiving chemotherapy for various cancers. About 24 adults with breast, lung, or other cancers will receive either riluzole or a placebo during their chemo.…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This study looks at whether a dedicated geriatric peri-operative care team can help adults aged 70 and older recover daily function better than standard care after colorectal cancer surgery. About 90 participants will be randomly assigned to either the specialized team or usual c…

This study tests whether offering free legal services to people caring for someone with advanced colorectal cancer can reduce their stress and improve their finances and well-being. About 20 patient-caregiver pairs will receive personalized legal help from a nonprofit organizatio…

This study tests whether an AI tool can help doctors better manage chemotherapy side effects in people with breast or colorectal cancer. About 174 adults will be split into two groups: one where doctors use AI suggestions for symptom care, and another receiving standard care. The…

This study tests a smartphone app called ASSIST that uses artificial intelligence to help people with breast cancer, lymphoma, or colorectal cancer manage symptoms during treatment. About 60 adults starting or recently starting systemic therapy will either use the app for 12 week…

This study tests whether adding two targeted nerve blocks (one around the colon and one in the belly wall) to standard pain relief can lower pain and the need for strong painkillers after minimally invasive left-sided colon cancer surgery. About 140 adults having elective laparos…

This study tests whether adding acupuncture to standard anti-nausea medicine can better control nausea caused by chemotherapy. About 90 adults with various cancers who still feel sick despite medication will either receive acupuncture plus medicine or medicine alone. Researchers …

This study tests whether giving lidocaine (a numbing medicine) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can improve the body's immune response and help patients recover better. About 100 adults having colon cancer surgery will be randoml…

This study tests an experimental drug called NGM120 in 136 people with colorectal cancer who are experiencing cancer-related weight loss (cachexia). The goal is to see if the drug helps patients maintain or gain weight over 12 weeks compared to a placebo. The study is currently r…

This study tests a mobile health program that combines exercise and nutrition advice to help older adults (60+) with colorectal cancer reduce frailty and improve physical fitness. About 140 participants will use the program on their smartphones and be compared to those receiving …

This study tests if limiting when you eat (time-restricted eating) can reduce side effects from cancer treatment, improve mood, and even affect tumor biology. Researchers will enroll 175 adults with rectal or breast cancer who are receiving treatment. Participants will follow a s…

This study tests whether a virtual hub offering personalized education, exercise, nutrition, and peer support before and after surgery can reduce complications within 30 days. About 564 adults in Australia having colorectal cancer surgery will be randomly assigned to the hub plus…

This study tests whether mandala art therapy (a structured coloring activity) can improve psychological resilience and coping skills in people recovering from colorectal cancer surgery. About 70 adults will be randomly assigned to either receive the art therapy or standard care. …

This study tests a telehealth program to help people with colorectal or bladder cancer who have an ostomy (a surgically created opening for waste). Participants and their caregivers will join seven group video sessions before and after surgery to learn self-management skills. The…

This study looks at how chemotherapy and radiation affect the reproductive and sexual health of young adults with early-onset colorectal cancer. Researchers will track hormone levels and ask participants about their sexual health and ability to have children. The goal is to bette…

This study is a registry for adults having surgery for colorectal cancer. It collects medical information and stores tumor tissue and blood samples to analyze genetic changes and biomarkers. The goal is to better understand the disease and track long-term outcomes like survival a…

This study looks at which type of fluid given through an IV during laparoscopic surgery best helps maintain blood volume and heart function. About 60 adults having abdominal surgery will receive either a salt-based solution or albumin. The goal is to find the safest and most effe…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback. The goa…

This study aims to confirm that a blood test detecting tumor DNA after colorectal cancer surgery can better predict the risk of cancer returning than current methods. Researchers will follow 1,600 patients who had surgery for stage I-III colorectal cancer to see if the test resul…

This study looks at 60 people with a specific type of advanced colorectal cancer (dMMR/MSI-H) who are receiving immunotherapy. Researchers want to see if changes in a blood test called ctDNA can tell if the cancer is truly gone, even when scans don't show it. The goal is to find …

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colorectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death and injury occurs. The go…

This study looks at how a person's physical function and breathing ability relate to long-term health after colorectal cancer. Researchers will measure walking distance and lung function in 52 adults aged 18-80. The goal is to see if these simple tests can help predict recovery a…

This study is collecting blood, tissue, and stool samples from 160 people aged 18-49, both with and without colorectal cancer. Researchers will analyze the genetic makeup of these samples to better understand why some young adults develop this disease. The goal is to create a dat…

This study looks at why some colorectal cancer patients lose muscle mass (cachexia), which is linked to higher death rates. Researchers will take small muscle samples and use scans to compare muscle structure in 60 people: those with cachexia, those without, and healthy volunteer…

This study is collecting stool and saliva samples from 2,500 people with colorectal cancer to look for genetic markers (microRNAs) and bacterial patterns. The goal is to improve how doctors diagnose and predict the course of the disease. Participants provide samples at key points…

This study watches 40 adults with colorectal cancer who have no visible tumors but have minimal residual disease (MRD) detected by a blood test. Participants receive standard biomarker-directed therapy chosen by their own doctor. The goal is to see how this therapy affects cancer…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to guide future research. About 1,366 participants will provide medical informatio…

This study screens up to 7,000 adults with cancers like melanoma, lung, or colorectal cancer to see if they qualify for experimental treatments developed by the National Cancer Institute's Surgery Branch. These treatments involve taking a patient's own immune cells, growing them …

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy, including those with GI cancers, polyps, or inflammatory bowel disease, as well as healthy volunteers. Researchers aim to find new biomarkers that could lead to earl…

This study looks at how different types of anesthesia affect the body's immune response and cancer cells in people having surgery for colorectal cancer. 90 adults will be randomly assigned to receive opioid-free, opioid-sparing, or standard opioid-based anesthesia. Researchers wi…

This study is for people with colorectal cancer that has spread only to the liver. Researchers want to see if MRI scans can help doctors decide who should have surgery to remove liver tumors. About 100 adults will take part, and the study will track how often surgery plans change…

This study looks at how the position of the stapler spike during colorectal surgery affects bleeding where the bowel is reconnected. About 102 adults with colorectal cancer or diverticulitis will take part. Doctors will check for bleeding during and after surgery using a camera. …

This study looks at whether artificial intelligence (AI) can help doctors write more accurate and efficient treatment reports for patients with common cancers like lung, breast, and colon cancer. The researchers will have 40 junior doctors use either an AI tool or traditional met…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and counseling at mobile mammography units. About 1,000 underserved women in Texas will be invited to participate when they come for their routine mammog…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study looks at whether additional chemotherapy is helpful for people with colorectal cancer who have already received chemotherapy or chemoradiotherapy before surgery and whose cancer was found to be at an early stage after surgery. The goal is to see if skipping extra chemo…

This study looks at whether a prehabilitation program (exercise and nutrition coaching) before surgery is practical for people with stage II or III rectal cancer. About 40 participants will either receive the program or usual care. The main goal is to see if enough people join an…

This study looks at how much protein people with colorectal or breast cancer need to prevent severe muscle loss, which can lead to disability and poor quality of life. Researchers will use a simple, non-invasive test to measure protein needs in 40 patients. The goal is to create …

This study is building a large registry of colonoscopy reports and videos from about 1,800 people. The goal is to track how well different removal techniques work in real-world settings, improve doctor training with up-to-date materials, and provide researchers with a rich datase…

This study looks at how a person's physical function and breathing ability before surgery affect their recovery after colorectal cancer surgery. Researchers will measure these factors in 42 adults to see if they can predict complications and hospital stay length. The goal is to h…

This study looks at whether changes in a blood marker called ctDNA can help doctors tell early on if immunotherapy is working for people with advanced cancers like lung, breast, colorectal, stomach, or liver cancer. Researchers will also check other markers like PD-L1 and TMB to …

This study is developing a computer model that uses genetic information from tumors to predict which colorectal cancer patients will benefit from chemotherapy after surgery. The goal is to avoid giving chemo to those who won't respond, while ensuring those who need it get the rig…

This study compares two types of self-management training for people who have had gastrointestinal (GI) cancer. One group gets a personalized program (RISE-PSMT) and the other gets a standard program. The goal is to see which helps patients better follow healthy lifestyle recomme…

This study looks at a new way to reconnect the colon after surgery for cancer or diverticular disease. The single-stapled technique may cause fewer leaks than the standard method. About 500 adults will be followed for 90 days after surgery to see how safe and effective this appro…

This study looks at how changing the amount of cysteine (a building block of protein) in the diet affects gut bacteria and inflammation in Black and White adults aged 45-75 who have had colon polyps. Participants will eat both high-cysteine and low-cysteine diets for three weeks …

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a nutrition and exercise program helps them eat better and move more. About 306 survivors and their healthcare providers will take part. The goal is to see if survivors agr…

This study is collecting blood and tumor tissue from 1,200 people undergoing surgery for colorectal cancer that has spread to the liver. The goal is to look for biomarkers that might help predict how the disease will progress. Participants are followed over time to track cancer r…

This study collects live tumor tissue from 2,000 people with various cancers to understand why some respond to immunotherapy and others don't. Participants give a biopsy as part of their normal care, and researchers analyze the samples in the lab. The goal is to develop better wa…

This study collects tissue samples, medical data, and family history from 1,120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers aim to discover new genes and immune system clues that could lead to better prevention and targeted treatments for…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Participants will fill out a simple questionnaire and can receive genetic counseling and testing through video calls. The goal …

This study looks at medical records of 100 people with colorectal cancer, comparing those under 35 to those over 35. The goal is to understand how the disease and its treatment differ in younger patients. No new treatments are tested; instead, researchers analyze existing data to…

This observational study collects tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for possible futur…

This study is for people with advanced colorectal or non-small cell lung cancer. It tests whether adding a special blood test (ctDNA) to regular scans helps doctors choose the best treatment. About 332 participants will be randomly assigned to either standard care or the extra bl…

This study looks at whether older adults with advanced colorectal cancer who have low muscle mass are more likely to have severe side effects from chemotherapy. Researchers will follow 300 people starting treatment to track side effects and survival. The goal is to better underst…

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study compares three colorectal cancer screening methods in 60,300 average-risk adults aged 45-74 in China: colonoscopy, a stool test (FIT), and a stool test plus a blood test. The goal is to see which approach works best to find cancer early and reduce deaths over 10 years.…

This study collects samples from 320 people, including those with solid cancers and those undergoing lung cancer screening, to detect tumor cells and DNA in blood, urine, and bone marrow. The goal is to learn more about how cancer spreads and to improve early detection and person…

This study is testing whether growing a patient's tumor cells in the lab (called organoids) can help doctors choose the most effective drugs. Researchers will take a small biopsy from 40 people with advanced liver or colorectal cancer that no longer responds to standard treatment…

This study takes tumor samples from people with breast, colorectal, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to match patients with effective treatments and…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This study is testing whether a new, simple method of collecting rectal mucus can find DNA changes linked to lung, pancreatic, bladder, and colorectal cancers. Researchers will collect samples from 450 adults using a special device and analyze them for genetic and epigenetic mark…

This study examines whether receiving radiation therapy before colorectal cancer surgery leads to more complications during or after the operation. Researchers will compare 80 patients who had radiation with those who did not, looking at issues like infections, wound problems, an…

This study looks at whether checking for leaks in the new connection made during colorectal cancer surgery can lower the chance of serious problems like leaks, bleeding, or infection. About 264 adults having surgery for colorectal cancer will be randomly assigned to receive leak …

This study is developing an AI-powered blood test to find cancer early and see how well treatments are working. Researchers will analyze blood samples from 6,000 adults with or without cancer to identify unique RNA signals in platelets and immune cells. The goal is a safe, non-in…

This study aims to understand why colorectal cancer is rising in people under 50. Researchers will compare 2,300 participants—those recently diagnosed with early-onset colorectal cancer and healthy volunteers—to see how diet, smoking, exercise, and genetics contribute to risk. Th…

This study looks at how well doctors can see leftover polyp tissue at the scar from a previous colonoscopy removal. It compares experts to non-experts and tests whether a short video training can improve detection. About 141 endoscopists will review images before and after traini…

This study follows 368 colorectal cancer survivors aged 25-65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, and look for late side effects linked to their spec…

This study enrolls 620 adults with solid cancers (lung, esophageal, stomach, pancreatic, liver, colorectal) to collect blood, urine, and bone marrow samples. Researchers will measure circulating tumor cells and DNA to see how they relate to cancer recurrence and survival. The goa…

This study is tracking 430 adults having colorectal surgery to understand why some develop a serious complication called an anastomotic leak (a leak where the bowel is reconnected). Researchers will look at factors before, during, and after surgery to build a risk prediction mode…

This study looks at two ways to check for colon cancer in adults aged 65 to 82 who have had colon polyps before. One group will get a yearly stool test (FIT), and the other will have a colonoscopy. Researchers want to see which method finds advanced growths better over time. Abou…

This study observes 600 adults with colorectal cancer who are already taking the drug fruquintinib as part of their normal care in South Korea. The goal is to track any side effects and see how many patients are alive and without cancer growth after 6 months. No new treatments or…

This study aims to build a new computer tool that can analyze complex biological data from 15 people with colorectal cancer. Researchers will collect blood, stool, and tumor tissue samples before and after surgery to study how the cancer changes over time and space. The goal is t…

This study looks at how cancer impacts not just the patient, but their entire family. Researchers will survey 240 Danish patients with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. The goal is to understand family health, needs, and emotional well…

This study looks at whether older adults (75+) who had precancerous polyps removed in the past still benefit from repeat colonoscopies. Researchers will analyze health records from 130,000 Veterans to compare cancer risks and gather opinions from patients and doctors. The goal is…

This study looks at whether a protein called PRDX1, found in blood collected from the surgical site during colon cancer removal, can help predict if the cancer will spread to the liver. Researchers will follow about 260 patients who had curative surgery to see who develops liver …

This study is for people with stomach, pancreas, or bowel cancer who are having surgery, as well as some people without cancer for comparison. The goal is to understand why some patients lose muscle and weight (cachexia) and how it affects their recovery. Researchers will track c…

This study aims to see if lab-grown tumor models can predict how well heated chemotherapy (HIPEC) works during surgery for cancers that have spread to the abdomen. About 60 adults whose tumors cannot be fully removed safely will take part. Researchers will compare tumor responses…

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study looks at the immune cells and bacteria inside the colon and rectum of people with or without colorectal cancer. By analyzing tissue samples, researchers hope to learn how the body's defenses change as cancer develops. No new treatments are tested; the goal is simply to…

This study looks at whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps (a risk factor for colon cancer). It also includes their overweight partner living in the same home. The goal is to understand how diet affec…