COLORECTAL CANCER

This study is comparing two different radiation treatment schedules, both combined with chemotherapy and two other drugs, for people with locally advanced rectal cancer that hasn't spread. The goal is to see which approach leads to better tumor shrinkage and higher rates of avoid…

This study is testing whether a special care team focused on older adults can improve recovery after colon cancer surgery. It will compare the new team approach to standard hospital care for 90 patients aged 70 and over. The main goal is to see if this approach helps patients reg…

This study is testing whether adding a combination of two common antibiotics (ciprofloxacin and metronidazole) and aspirin to standard chemotherapy helps people with advanced colorectal cancer. Researchers want to see if changing the bacteria in the gut (the microbiome) can make …

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This study is looking back at the medical records of 250 people with colorectal cancer to see if adding an immune-boosting drug (Astragalus Polysaccharide) to their standard cancer treatments helped them live longer or better. The goal is to understand if this combination is bene…

This study is testing a new medical device that uses magnets to connect sections of intestine during colon surgery. The goal is to see if this magnet system is safe and works properly for patients having surgery for colorectal cancer or diverticular disease. Researchers will foll…

This early-stage study is testing a new drug called IDE161, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have spread. The main goals are to find safe doses and see if the treatment shows early signs of shrinkin…

This study is testing whether cancer survivors who get a personalized referral to a nutrition and exercise program will adopt healthier habits. It's enrolling 306 people who have finished treatment for breast, prostate, or colorectal cancer but aren't currently meeting standard d…

This is an early-stage study to test the safety and initial effectiveness of a new drug called RO7502175 for people with advanced solid tumors that have spread or cannot be cured. The drug will be tested both by itself and combined with other approved cancer drugs. The main goals…

This study is testing whether it's practical for colon cancer patients to eat more fiber in the weeks before their surgery. Researchers want to see if this dietary change is possible and might lead to fewer complications after the operation. They are comparing personalized diet a…

This study is testing a new, personalized follow-up program for people who have been treated for early-stage colon or rectal cancer. The program uses a smartphone app and blood tests to monitor for cancer recurrence and help manage long-term side effects like anxiety, fatigue, an…

This study is testing whether giving two targeted cancer drugs—encorafenib and cetuximab—before surgery can shrink tumors in patients with a specific genetic mutation (BRAF V600E) in their localized colon or upper rectal cancer. The goal is to see if this 'neoadjuvant' treatment …

This early-stage study is testing the safety and side effects of a new treatment called GCC19CART for adults with advanced colorectal cancer that has spread and has not responded to standard therapies. The treatment involves collecting a patient's own immune cells, modifying them…

This is an early-stage trial testing a new drug called LY3962673 in people with advanced pancreatic, lung, or colorectal cancer that has a specific genetic change called KRAS G12D. The main goals are to find a safe dose and see if the drug, given alone or with other chemotherapie…

This early-stage study is testing a new drug called BL-M17D1 in adults with advanced gastrointestinal cancers and other solid tumors that have a specific marker called HER2. The main goal is to find the safest dose and see how the body processes the drug. Researchers will also ch…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This study is testing whether giving immunotherapy drugs before surgery can help people with a specific type of advanced colorectal cancer. The trial will enroll about 270 adults with locally advanced cancer that has a genetic feature making it less responsive to standard chemoth…

This early-stage study is testing a new oral medication called PF-08032562, both alone and in combination with other cancer drugs, for people with advanced or metastatic breast or colorectal cancer. The main goals are to find a safe dose and see how the body processes the drug. R…

This early-stage trial is testing a new drug called ALE.P03 in adults with advanced or spreading cancers that have a specific protein marker (CLDN1+). The study aims to find a safe and effective dose and see if the drug can shrink tumors. It will enroll 180 patients with cancers …

This study is testing a new, personalized vaccine designed to teach the immune system to attack leftover cancer cells after surgery. It is for people with colorectal or pancreatic cancer who have a specific genetic change (KRAS mutation) and a high risk of the cancer returning. T…

This study aims to understand how targeted cancer treatments affect tiny amounts of remaining cancer DNA in the blood of colorectal cancer patients who have completed initial treatment. Researchers will monitor 40 patients receiving standard targeted therapies based on their spec…

This study is testing whether a combination of two drugs, fruquintinib and tislelizumab, can help control colorectal cancer in patients who have finished their initial chemotherapy but still have tiny amounts of cancer left in their body, detected by a special blood test. The goa…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a new oral drug, S241656, alone and in combination with other cancer therapies. It aims to find a safe and effective dose for adults with advanced cancers, including lung, pancreatic, and colorectal cancers, that have specific genetic mutations like KRAS or …

This study tests whether combining a non-invasive ultrasound treatment called histotripsy with standard chemotherapy works better for people with advanced colorectal cancer that has spread to the liver. About 100 participants will receive both treatments to see if this combinatio…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing a new oral medication called Alintegimod, given alongside the immunotherapy drugs ipilimumab and nivolumab. It aims to see if this combination is safe and can help control advanced cancers that have spread or returned after other treatments. The study will e…

This is an early-stage study testing the safety of a new experimental cancer treatment called IVX037. The treatment is a modified virus that is injected directly into tumors. Researchers are testing it alone and in combination with an existing immunotherapy drug in 70 people with…

This study is testing whether restricting eating to a 10-hour daily window during cancer treatment can reduce side effects and improve tumor response. Researchers are enrolling 175 adults with breast or colorectal cancer who are receiving chemotherapy with curative intent. The go…

This study is testing a new experimental drug called CNSI-Fe, which is an iron-loaded nanoparticle suspension injected directly into tumors. The goal is to see if it is safe and can help control cancer in people with advanced solid tumors that have stopped responding to standard …

This study aims to improve a treatment for cancers that have spread to the lining of the abdomen. The treatment involves surgery to remove visible tumors, followed by a wash of heated chemotherapy inside the abdomen. Researchers want to see if testing tumor samples in special lab…

This study aims to find out if patients with locally advanced colorectal cancer still need chemotherapy after they've already had successful pre-surgery treatment that reduced their cancer stage. Researchers will compare outcomes between patients who receive standard chemotherapy…

This early-stage study is testing a new drug called MRG007 in people with advanced solid tumors that have spread and cannot be surgically removed. The main goals are to find a safe dose and see if the drug helps shrink tumors in patients with colorectal, gastric, pancreatic, and …

This study is testing whether a new digital care system can improve quality of life for older adults who have cancer along with other health conditions. It will involve 720 patients aged 70+ with breast, lung, colorectal, or prostate cancer across eight hospitals in France. The m…

This is the first study testing the experimental drug JR8603 in people. It aims to find a safe dose and see if it helps control advanced solid tumors, particularly stomach, esophageal junction, and colorectal cancers, when standard treatments have stopped working. The study will …

This study is testing whether immunotherapy drugs (cemiplimab with or without fianlimab) can effectively treat a specific type of colorectal cancer in patients aged 70 and older, or in adults who are poor candidates for surgery. The main goal is to see if the treatment can comple…

This study is testing if a short course of the antibiotic metronidazole can reduce levels of a specific bacteria found in colon tumors. The bacteria, Fusobacterium nucleatum, is linked to worse outcomes and may make cancer less responsive to treatment. Researchers will give the a…

This study is testing a new personalized cell therapy called CHM-2101 for people with advanced stomach, colon, or neuroendocrine cancers that have come back or stopped responding to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to be…

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This early-stage trial is testing a new radioactive drug called 177LuBetaBart in adults with advanced solid cancers that have stopped responding to standard treatments. The study aims to find a safe dose and see if the drug shows early signs of fighting tumors. Participants will …

This study is for people with colorectal cancer that has spread to the lining of the abdomen (peritoneal metastasis) and has worsened after initial treatment. It tests if using a special PET scan to guide precise abdominal radiation, combined with standard second-line therapy and…

This study is testing whether a single, powerful session of MRI-guided radiation can stop liver tumors from growing in people whose colorectal cancer has spread there. Researchers will see if this one-time treatment is effective and safe, and if special MRI images can predict how…

This study is testing whether adding two new immunotherapy drugs (ONO-4578 and Opdivo®) to standard chemotherapy works better than standard care alone for people with a specific type of advanced colorectal cancer. It will involve about 144 adults who have not yet received treatme…

This study is testing if using a patient's genetic information to personalize their chemotherapy dose is better than the standard approach. It will enroll 178 adults with pancreatic or colorectal cancer who are starting treatment. The main goal is to see if the personalized dosin…

This study is testing whether the immunotherapy drug tislelizumab is a safe and effective treatment for colorectal cancer patients in Nigeria who have not yet received any cancer treatment. The trial focuses on patients whose cancer has a specific genetic feature called mismatch …

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This study is testing new targeted drugs called RAS inhibitors in combination with standard cancer treatments for people with advanced colorectal or pancreatic cancer. The goal is to find safe and effective doses while seeing if these new drug combinations can help control cancer…

This study is testing whether adding hydroxychloroquine (an existing drug) to a standard two-drug combination can help control advanced colon cancer that has a specific genetic change (BRAF V600E) and has progressed after at least one prior treatment. The researchers believe canc…

This large, late-stage trial is testing whether a combination of two immunotherapy drugs (botensilimab and balstilimab) helps people with advanced colorectal cancer live longer than standard supportive care. The study involves over 800 adults whose cancer cannot be surgically rem…

This study is testing whether adding a new immune-stimulating drug called PDS01ADC to a specialized liver cancer treatment can better control advanced cancers that have spread to the liver. The treatment involves surgically placing a pump that delivers chemotherapy directly to th…

This study is testing an experimental drug called YL202 in people with advanced solid tumors, including lung, colorectal, and cervical cancer, that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease, and to unders…

This study is testing whether a combination of two immunotherapy drugs can help prevent colorectal cancer from coming back in patients who have already had surgery and chemotherapy. The treatment is for people who still have tiny traces of cancer DNA in their blood after standard…

This early-stage study is testing a new radioactive drug treatment for people with advanced solid tumors that have stopped responding to standard therapies. Researchers will first use a special imaging scan to see if patients' tumors are likely to respond, then give the radioacti…

This is the first study in people testing a new cancer drug called AGX101. It aims to find a safe and effective dose for patients with advanced solid tumors that have spread or cannot be removed by surgery, and who have no other standard treatment options left. The drug is given …

This study is for people who had surgery to remove colorectal cancer that spread to their liver after responding well to a specific chemotherapy. It aims to see if restarting that same chemotherapy after surgery is better than no further treatment at keeping the cancer from comin…

This study is testing whether the drug TAS-102, with or without the anti-inflammatory celecoxib, can clear tiny amounts of leftover cancer DNA from the blood of colorectal cancer patients. It's for people who have finished surgery and chemotherapy but still have detectable cancer…

This study compares three different surgical techniques for removing very low rectal cancer while trying to preserve the patient's natural bowel control. It will enroll 100 patients to see which method provides the best balance between completely removing the cancer and maintaini…

This early-stage study is testing FT836, a new type of 'off-the-shelf' CAR T-cell therapy, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates FT836, which is given al…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing a new, minimally invasive way to deliver chemotherapy directly to the lungs. It aims to kill any tiny, leftover cancer cells after surgery in patients whose sarcoma or colorectal cancer has spread to the lungs. The goal is to prevent the cancer from coming b…

This study is testing whether a new drug called SHR-8068, when given alongside other cancer treatments, is safe and effective for people with colorectal cancer. It will involve about 200 adults and measure how well the combination shrinks tumors and controls the cancer's growth. …

This study is testing whether adding the drug fruquintinib to a standard chemotherapy regimen (FOLFIRI) can better control advanced colorectal cancer that has spread. It is for people whose cancer has worsened after their first treatment. The main goals are to see if this combina…

This study is testing whether giving chemotherapy after all visible tumors have been surgically removed or destroyed helps prevent the cancer from coming back in people with metastatic colorectal cancer. About 507 participants will be randomly assigned to receive either six month…

This study is testing a new oral drug called IPN01194 in adults with advanced solid tumors that have spread and have specific genetic changes. The main goals are to find a safe and tolerable dose and to see if the drug can help shrink tumors. The study is open to people with cert…

This early-stage study is testing a new oral drug called VS-7375, which is designed to block a specific cancer-driving mutation known as KRAS G12D. Researchers will give the drug alone and in combination with other cancer therapies to adults with advanced solid tumors, including …

This study is testing the safety and effectiveness of combining two drugs, VS-6766 and cetuximab, for people with advanced colorectal cancer that has a specific genetic change called a KRAS mutation. The study is for people whose cancer has continued to grow despite trying standa…

This is the first human study of an experimental drug called PT0511 for people with advanced solid tumors that have specific KRAS genetic changes. The main goals are to find safe doses and see how the body processes the drug, both alone and combined with another cancer medication…

This early-stage trial is testing a new drug called FOG-001 for people with advanced or spreading cancers that have specific genetic mutations. Researchers want to find the safest dose and see if the drug can shrink tumors or slow cancer growth. The study will include 575 partici…

This early-stage study is testing a new combination treatment for people with colorectal cancer who have had surgery but still have tiny amounts of cancer left in their blood. Researchers are giving patients specially engineered immune cells from donated cord blood, along with an…

This study is comparing two methods for monitoring older adults who have had colon polyps in the past. Researchers want to see if an annual at-home stool test works as well as a colonoscopy at finding serious colon problems. The goal is to offer older adults a safer, less invasiv…

This study is testing whether using less or no opioid painkillers during anesthesia for colorectal cancer surgery affects cancer cell behavior and patient recovery. Researchers are comparing three different anesthesia plans in 90 patients undergoing surgery. They will measure mar…

This study is testing a new drug called BI 765049, given alone and with another drug called ezabenlimab, for Asian adults with advanced cancers that have stopped responding to standard treatments. The main goals are to find safe doses and see if the treatment can shrink tumors by…

This early-stage study is testing a new drug called APL-5125 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can shrink tumors, especially in colorectal canc…

This large, late-stage trial is testing if adding an immunotherapy drug (atezolizumab) to a standard, strong chemotherapy combination can better control advanced colorectal cancer that has spread and cannot be surgically removed. It will enroll about 238 patients with specific tu…

This study is testing a new, personalized approach to find effective treatments for patients with advanced liver or colorectal cancer that has stopped responding to standard therapies. Doctors will grow miniature 3D models of a patient's own tumor in the lab to test how it respon…

This study compares two different chemotherapy combinations for people with advanced colorectal cancer that has spread and cannot be removed by surgery. Researchers want to see if a three-drug combination works better than a two-drug combination for Chinese patients, while also c…

This study is testing a new first-line treatment for people with advanced, HER2-positive colorectal cancer that cannot be removed by surgery. It combines three drugs—trastuzumab-deruxtecan, capecitabine, and bevacizumab—to see how well they shrink tumors and control the disease. …

This study is testing whether regularly checking for cancer DNA in the blood (a 'liquid biopsy') can help doctors better manage treatment for advanced colorectal or lung cancer. Patients will have their tumor's genetics analyzed, and a team of experts will recommend a treatment p…

This study is testing a new cancer vaccine made from a patient's own or donated tumor cells. The cells are modified in a lab to train the patient's immune system to attack the cancer, then injected back into the patient. The goal is to see if this approach can help people with ad…

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This early-stage trial is testing whether a personalized cancer vaccine that targets specific mutations in tumors, combined with two immunotherapy drugs, can help control advanced colorectal or pancreatic cancer. The study is for patients whose cancer has spread and who have alre…

This study is testing a new oral drug called zongertinib for adults with advanced HER2-positive cancers that have spread and stopped responding to prior treatments. The main goals are to find the safest and most effective dose of zongertinib when given alone or combined with othe…

This study is testing whether a personalized virtual support hub can help people recover better from colorectal cancer surgery. The hub provides education, exercise guidance, nutritional advice, psychological support, and peer groups before and after the operation. Researchers wi…

This is an early-stage study to test the safety of a new type of cell therapy called PTC13 CAR-T in adults with advanced solid tumors that have a specific marker (CEA). The main goal is to find the safest dose and see how well patients tolerate the treatment. The therapy involves…

This study is testing a new type of treatment called EBNK-001, which uses donated immune cells (Natural Killer cells) to fight cancer. It is for adults with advanced solid tumors that have grown or returned after standard treatments. The main goals are to find a safe dose and see…

This study is testing whether combining two drugs, fruquintinib and serplulimab, can help control advanced colorectal cancer that has spread and is no longer responding to standard therapies. It will involve about 50 patients to see if the combination is effective and safe. Resea…

This study is testing which of two common drugs works better to support the body's defenses and recovery after colon cancer surgery. One hundred patients will be randomly assigned to receive either an infusion of lidocaine or a high dose of dexamethasone during their operation. R…

This study is testing whether giving a short course of targeted drugs before surgery can better control colorectal cancer. It enrolls patients with non-metastatic, operable cancer and matches them to a specific drug based on the unique genetic markers found in their tumor. The ma…

This is the first study in people to test a new oral medication called RGT-61159. It aims to see if the drug is safe and can help control tumors in adults with advanced adenoid cystic carcinoma or colorectal cancer that has returned or stopped responding to available treatments. …

This is the first time researchers are giving the experimental drug ASP5834 to people. The study aims to find a safe dose and check for side effects in adults with advanced solid tumors that have specific changes in a gene called KRAS. Some participants with colorectal cancer wil…

This study is testing two new drugs, elironrasib and daraxonrasib, for people with advanced lung, colorectal, or pancreatic cancer that has a specific genetic change called KRAS G12C. The main goals are to find safe doses and see if the drugs, given alone or together, can shrink …

This study is testing whether adding a new drug called BOLD-100 to standard FOLFOX chemotherapy can better control advanced cancers of the colon, pancreas, stomach, and bile ducts. Researchers will first find the safest dose of BOLD-100 and then see if the combination helps slow …

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing a combination of two existing drugs, anlotinib and sintilimab, as a first treatment for advanced colorectal cancer that has spread but not to the liver. The goal is to see if this 'chemotherapy-free' approach can control the cancer effectively with fewer sid…

This is the first study in people to test a new cancer drug called SIM0610. It aims to find a safe dose and see if it can shrink tumors in adults with advanced solid cancers that have stopped responding to standard treatments. The study will enroll 260 people with cancers like lu…

This study is testing a personalized vaccine designed to prevent liver cancer from coming back after surgery. The vaccine is custom-made for each patient using their own tumor and immune cells, and is given alongside an immunotherapy drug called nivolumab. The goal is to see if t…

This study is for people with advanced colorectal cancer that has stopped responding to standard treatments. It aims to see if taking two oral drugs, fruquintinib and TAS-102, together works better at controlling the cancer and helping patients live longer without it getting wors…

This study is testing whether a new combination of two drugs (DSP107 and atezolizumab) works better and is safer than an existing treatment (fruquintinib) for people with advanced colorectal cancer that has stopped responding to standard therapies. About 90 participants will be r…

This study is testing new drug combinations for people with advanced colorectal cancer that has stopped responding to standard treatments. It will compare three different treatment groups to see if adding a repurposed drug called eliglustat to existing cancer therapies can help c…

This is the first human study of an experimental drug called M9140 for people with advanced colorectal cancer that has progressed after standard treatments. Researchers will test different doses to find the safest amount and see if the drug shows early signs of helping control th…

This study compares two different drug combinations for people with advanced colorectal cancer that has spread. Researchers want to see if using a simple blood test to guide treatment decisions helps control cancer growth better. The trial will enroll 280 adults who haven't recei…

This study is testing if taking a daily low-dose aspirin pill can prevent colon cancer from returning after surgery. It will involve 264 patients whose cancer has a specific genetic change (PI3K mutation). Participants will be randomly assigned to take either aspirin or a placebo…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This trial is testing a new three-part treatment for people with advanced colorectal cancer that cannot be surgically removed. It combines a standard chemotherapy, an immunotherapy drug (tislelizumab), and an experimental targeted drug (futibatinib). The main goal is to see how w…

This study is testing a new medical device called the ColoSeal ICD System. It's designed to protect the healing area after colon cancer surgery from contact with stool for up to 21 days, which could help prevent dangerous infections. The study will enroll 15 adult patients with r…

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This is the first human study testing a new oral drug called MOMA-341 for people with advanced solid tumors that have specific genetic features (MSI-H or dMMR). The main goal is to find safe doses and see how the body handles the drug when taken alone or combined with other cance…

This study is testing a new drug called MK-2870, both by itself and combined with other cancer treatments, for people with advanced colorectal, pancreatic, or biliary tract cancers. The main goals are to see if the treatment is safe and if it helps shrink or eliminate tumors. The…

This study is testing an investigational drug called AMB-05X for people with colorectal cancer who have finished their main treatment and have no visible tumors, but still have a positive blood test indicating tiny amounts of leftover cancer. The goal is to see if AMB-05X can cle…

This study is testing three different treatment approaches for people with advanced cancers of the esophagus, stomach, colon, and other digestive organs. Researchers want to see if new drug combinations can shrink tumors and control the disease better than current options. The tr…

This study is comparing a new AI-assisted robotic stapler to a standard stapler during surgery for colorectal cancer. The goal is to see if the smart robotic tool can reduce serious complications like leaks and bleeding where the intestine is reconnected. Researchers will measure…

This early-stage trial is testing a two-part personalized treatment for adults with advanced solid cancers that have spread and contain specific KRAS gene mutations. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cells w…

This study is testing whether a simpler one-staple technique for reconnecting the colon after surgery is safer than the standard two-staple method. Researchers will follow 500 patients having planned colon surgery for cancer or diverticulitis to see if the simpler technique reduc…

This study is testing whether an experimental drug can prevent colorectal cancer from returning better than the current standard of care. It is for patients who have finished initial treatment and have no visible cancer on scans, but still have traces of cancer DNA in their blood…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This trial is testing whether combining two drugs, cabozantinib and durvalumab, is safe and effective for people with advanced cancers of the digestive system. It is for adults whose stomach, esophageal, liver, or colorectal cancer has progressed after standard treatments. The go…

This study is testing a new approach to chemotherapy for advanced gastrointestinal cancers. It aims to see if doctors can safely increase the dose of a key chemo drug for patients who tolerate the standard dose well. The goal is to see if this personalized, higher-dose approach i…

This study is testing a new drug called FMC-376 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find a safe and effective dose and to see if the drug can shrink or control tumors. It is for patients whose cancer ha…

This study is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful dose of radiation directly to cancer cells. Th…

This study compares two surgical approaches for colon cancer: traditional open surgery and newer robot-assisted surgery. Researchers want to see if the robotic method removes cancer tissue just as effectively while helping patients recover faster with fewer complications. The stu…

This early-stage study is testing a new three-part treatment for advanced colorectal cancer that has stopped responding to standard therapies. It combines an immunotherapy drug, a targeted cancer drug, and a personalized cell therapy made from the patient's own immune cells. The …

This study is testing a new drug called IDE196, both alone and combined with other drugs, for people with advanced cancers that have specific genetic changes (GNAQ/11 mutations or PRKC fusions). The main goals are to find safe doses and see if the treatments can shrink tumors. It…

This study is testing a new drug called MCLA-129 in people with advanced cancers, including lung, head and neck, and colorectal cancer, that have progressed after standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. The drug is design…

This early-stage study is testing the safety and initial effects of a new oral medicine, PF-07799544, when taken with another drug, PF-07799933. It is for adults with advanced solid tumors, like melanoma or lung cancer, that have a specific genetic change called a BRAF V600 mutat…

This early-stage study is testing a new radioactive drug called [177Lu]Lu-NNS309 in patients with advanced pancreatic, lung, breast, or colorectal cancers that have stopped responding to standard treatments. Researchers will first use a special imaging scan to see if patients' tu…

This study is testing whether a special exercise and nutrition program before surgery helps people with rectal cancer. About 40 participants will be randomly assigned to either follow this 'prehabilitation' program or receive usual care. The main goal is to see if the program is …

This study aims to understand if the cancer drug fruquintinib causes high blood pressure more often in Black and Hispanic patients with advanced colorectal cancer that has stopped responding to other treatments. It will enroll 78 adults from these groups to monitor their blood pr…

This study is testing a new imaging system designed to help surgeons better see cancer cells during operations for gastrointestinal cancers. Patients scheduled for surgery for colorectal, pancreatic, or esophageal cancer receive an intravenous imaging agent before their procedure…

This study is testing a new colonoscopy technique that uses water instead of air to inflate the colon during screening. Researchers want to see if this 'underwater' method helps doctors find and completely remove more flat, hard-to-see growths that can turn into cancer, especiall…

This study is testing whether a simple rectal mucus sample can detect lung, pancreatic, bladder, and colorectal cancers by looking for DNA changes. Researchers will collect samples from 450 people using a special swab device to see if cancer-related genetic markers appear in the …

This study is testing whether a new blood test can accurately detect colorectal cancer. Researchers want to see if this test could help identify which patients need urgent colonoscopies when healthcare systems are busy. The study involves 400 adults who either have suspected colo…

This study aims to create and validate a new, non-invasive blood test to detect early-onset colorectal cancer in adults under 50. Researchers will analyze tiny genetic signals in the blood using advanced computer models to build a highly accurate test. The goal is to provide a si…

This study aims to see if a simple, at-home stool test (called FIT) can be as accurate as colonoscopy for detecting colorectal cancer in people with Lynch syndrome. Lynch syndrome is a genetic condition that greatly increases the risk of colon cancer, requiring frequent colonosco…

This study is testing a new blood test designed to detect colorectal cancer early. It will collect blood samples from 6,500 people, including those newly diagnosed with cancer and those undergoing routine colonoscopies. The goal is to see if the test can accurately spot cancer by…

This study aims to create a new test to help doctors predict which colon cancer patients will benefit from chemotherapy after surgery. Researchers will use artificial intelligence to analyze tumor samples from 200 patients who have already completed treatment. The goal is to deve…

This study is testing a new imaging device that combines ultrasound and light to create detailed pictures of rectal tumors. The goal is to help doctors more accurately tell which patients have no cancer left after initial treatment and can safely avoid major surgery. About 90 pat…

This study is testing a new way to check the colon using a pill-sized camera that patients swallow. The goal is to see if this method can be a good first step for adults with symptoms, reducing the need for more invasive and uncomfortable colonoscopies. Researchers will compare t…

This study is testing a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect five specific cancers: colorectal, ovarian, gastric, breast, and pancreatic. Researchers will check if the tracer is safe, measure its radiation dose, and see how accura…

This study aims to develop and test a new blood test that uses artificial intelligence to detect cancer early and monitor how well treatment is working. Researchers will analyze RNA from blood cells in 6,000 participants, including people with 8 common cancers and healthy individ…

This study aims to develop and test new, easier ways to screen for colon cancer. Researchers will collect breath, blood, and stool samples from 4,100 participants to see if new tests can detect cancer early. The goal is to create simple, low-cost screening options that more peopl…

This study is testing a new type of CT scanner to see if it can find liver cancer that has spread from colorectal cancer as well as or better than an MRI scan. It will involve 100 adults with colorectal cancer who will get both scans. The goal is to see if this new scanner, which…

This study is testing a new camera-based method (iPPG) against the current standard dye method (ICG) to see which is better at checking blood flow in tissue during surgery for stomach or colorectal cancer. The goal is to help surgeons make better decisions during the operation to…

This study is testing a new blood test called Signal-C that aims to detect colorectal cancer and precancerous growths. Researchers will enroll 12,000 average-risk adults aged 45-84 who are already scheduled for a routine colonoscopy. The study will compare the blood test results …

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing a new blood test to see if it can accurately detect colorectal cancer and precancerous growths called adenomas. It aims to provide a less invasive screening option to help find these conditions earlier. The test will also be evaluated for people with Lynch s…

This large study aims to find the most effective way to screen average-risk people for colorectal cancer. It will compare three methods: a one-time colonoscopy, yearly stool tests, and a new approach combining yearly stool and blood tests. The main goal is to see if the simpler s…

This study is testing a new diagnostic platform that uses artificial intelligence to analyze small pieces of a patient's tumor. The goal is to predict whether a patient's cancer will respond to immunotherapy drugs before they start treatment. Researchers will compare the AI's pre…

This study is testing a new blood test that looks for special RNA markers to detect colorectal cancer early. Researchers want to see if this simple test can find cancer as effectively as current methods like colonoscopies. The study involves 600 adults with and without colorectal…

This study is testing a new microwave-based device designed to be used during a standard colonoscopy. The goal is to see if it can safely help doctors find more colorectal polyps, which are growths that can sometimes turn into cancer. The device is being tested in 50 patients who…

This study is testing a new blood test to see if it can better predict which colon cancer patients are at high risk of their cancer returning after surgery. The test looks for tiny pieces of cancer DNA left in the blood. Researchers will enroll 1,600 patients to see if this test …

This study is testing a new blood test designed to help diagnose colorectal cancer. Researchers want to see how often the test incorrectly suggests cancer in people who have other types of cancer or gastrointestinal diseases. They will enroll 250 participants who will provide a s…

This study is testing whether a 6-month anti-inflammatory diet can reduce body inflammation and improve gut health in obese adults who have had colon polyps, a risk factor for early colon cancer. Researchers are also enrolling an overweight partner or child from the same househol…

This study aims to identify women at risk for hereditary breast, ovarian, and colorectal cancers by offering genetic screening and education through mobile mammography units. It will enroll 1,000 underserved women in Texas who are already scheduled for a mammogram. The goal is to…

This study tests a church-based program where community health workers help adults get screened for colorectal cancer and adopt healthier habits to lower their risk of both cancer and heart disease. It focuses on English-speaking adults aged 45 and older who are not up-to-date wi…

This study tests whether a community-based telehealth program can help more people get screened for colon cancer. The program sends video text messages, mails home test kits, and provides patient navigation support to overcome barriers like misinformation and access issues. Resea…

This study is testing if a special high-fiber, low-fat diet given for 21 days before colon cancer surgery can change the gut's bacteria and environment to help prevent the cancer from returning or spreading. Researchers will provide all meals and track participants' health for up…

This study aims to increase colorectal cancer screening among African American adults aged 45-75, a group that faces higher rates of the disease. Researchers are partnering with a local DMV to offer free, at-home screening kits and support. They will test if adding a social media…

This study is testing whether two common over-the-counter pain relievers, aspirin or naproxen, can help prevent cancer in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. Researchers will give 40 participants one of the drugs for a year and use …

This study tests whether placing a special vacuum device after colon cancer surgery can prevent dangerous leaks where the intestine is reconnected. Researchers will compare this new approach to standard care in 110 patients to see if it reduces leaks, complications, and recovery …

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing whether a personalized mobile app program can help older adults with colorectal cancer stay stronger and healthier. The program provides guidance on exercise and nutrition. Researchers will compare the app users to patients receiving standard care to see if …

This study is testing whether a home-based digital exercise program can help people recover better from colorectal cancer surgery. It compares a digital program to a standard paper booklet. The goal is to see if the digital approach improves walking ability, strength, and quality…

This study is testing a new pain management strategy for people having minimally invasive colon surgery. Researchers will compare a combination of two targeted nerve blocks against standard pain medication to see if it better reduces pain and the need for opioid drugs in the firs…

This study is testing a digital health program called AYA STEPS that helps young adult cancer survivors manage symptoms like pain, fatigue, and emotional distress. The program teaches skills to improve communication with healthcare providers and engagement with recommended follow…

This study aims to find the most effective pain management approach for patients undergoing minimally invasive cancer surgery. Researchers will randomly assign 48 participants to one of three pain control methods used during their operation. The study will compare pain levels, me…

This study is testing whether an artificial intelligence (AI) tool can help doctors better manage the difficult side effects of chemotherapy. Adults with breast or colorectal cancer will be randomly assigned to receive either standard care or care where doctors use AI-generated s…

This study is testing whether connecting caregivers of colorectal cancer patients with free legal services can help reduce their stress and financial strain. The pilot program will provide personalized legal care to 20 patient-caregiver pairs for 3 months. Researchers will measur…

This study is testing whether adding acupuncture to standard anti-nausea medicine helps reduce nausea better for cancer patients undergoing chemotherapy. It will involve 90 patients who are already experiencing nausea despite taking their prescribed anti-sickness drugs. Participa…

This study is creating a large registry of colonoscopy reports and videos from real patient exams. The goal is to collect real-world data on how well different polyp removal techniques work and how safe they are. This information will be used to train doctors, support medical res…

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study aims to discover new biological markers that could help detect gastrointestinal cancers earlier. Researchers are collecting tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy, endoscopy, or surgery. The goal is to identify substances that …

This study aims to create new computer software that uses artificial intelligence to analyze complex biological data from 15 colorectal cancer patients. The software will help researchers understand how cancer cells change and spread over time and space within the body. Participa…

This research aims to understand why colorectal cancer is increasing in younger adults by collecting blood, tissue, and stool samples. The study will compare samples from people aged 18-49 with colorectal cancer to samples from healthy people of the same age. Researchers will ana…

This study aims to find out if older adults (age 75+) who had polyps removed previously need another colonoscopy. It will compare cancer risks between those who get a repeat procedure and those who don't, because the risks of complications from colonoscopy increase with age. The …

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study is testing a simple weekly survey tool to see if patients can help identify when their cancer treatment is at risk of being delayed. It aims to understand why delays happen, especially looking at differences between racial groups, to help design better support systems …

This study aims to understand if having low muscle mass at diagnosis makes older adults with advanced colorectal cancer more likely to experience severe side effects from chemotherapy. Researchers will follow 300 patients receiving standard first-line chemotherapy to see if muscl…

This study is testing whether a blood test that detects tiny pieces of tumor DNA can predict how well immunotherapy works for people with advanced colorectal cancer. Researchers will follow 60 patients receiving immunotherapy to see if changes in this 'liquid biopsy' blood test c…

This study aims to understand how severe weight loss (cachexia) affects muscles in people with colorectal cancer. Researchers will compare small muscle samples from patients with and without cachexia, and from healthy volunteers. The goal is to learn more about the muscle changes…

This study aims to learn if finding cancer cells or cancer DNA in a person's blood, urine, or bone marrow can help doctors better understand how cancer spreads. Researchers will collect samples from 100 people with cancer and 200 people at high risk for lung cancer to see if thes…

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study aims to better understand cancer cachexia—a condition where patients lose muscle and weight, which can worsen outcomes even for those undergoing potentially curative surgery. Researchers will track 200 UK patients with certain digestive cancers, along with a small comp…

This study aims to understand how chemotherapy and radiation treatments affect the ability to have children and sexual health in younger adults with colorectal cancer. Researchers will track hormone levels and ask participants about their reproductive and sexual health over time.…

This study aims to better understand how liver tumors respond to a targeted radiation treatment called Y90 radioembolization. Researchers will collect small tissue samples from participants' tumors after treatment to examine the effects. The findings could help improve how this t…

This study aims to understand how a cancer diagnosis impacts the health, needs, and quality of life of both patients and their family members over time. Researchers will follow 240 Danish patients with certain cancers and their caregivers for 18 months, using surveys and intervie…

This study aims to see if a short online training video can help general doctors (endoscopists) get better at spotting signs that a colon polyp or early cancer has come back at the site of a previous removal. 141 doctors will look at colonoscopy pictures before and after watching…

This study aims to collect tissue samples and health information from 1,120 people to better understand why some families get colorectal or endometrial cancer. Researchers will store these samples to study in the future, hoping to discover new genetic causes and potential targets…

This study aims to see if using MRI scans helps doctors better decide which colorectal cancer patients with cancer spread only to the liver can safely have surgery. It will observe 100 patients to see if the MRI changes the surgical plan, either ruling patients in or out for the …

This study aims to find out if simple blood tests can predict how well patients with advanced cancers respond to immunotherapy drugs. Researchers will track 50 patients with late-stage lung, breast, colorectal, liver, or stomach cancer who are starting immunotherapy. They will co…

This study aims to collect tumor tissue and blood cells from people with advanced solid tumors to prepare for future CAR T-cell therapy. Researchers will analyze the cancer tissue to understand how tumors hide from the immune system and collect participants' own immune cells thro…

This study aims to understand how colorectal cancer survivors feel and function in the years after their treatment ends. Researchers will follow 368 working-age survivors for up to 2 years, checking in at 6, 12, and 24 months. The goal is to identify common long-term side effects…

This study aims to identify Black individuals and families in Houston, Texas who may be at increased risk for hereditary breast and colorectal cancers. Researchers will work with trusted community organizations to screen 1,000 participants using a simple questionnaire. Those iden…

This study aims to identify what factors increase the risk of a serious complication called an anastomotic leak after colon or rectal surgery. Researchers will follow 430 patients undergoing this type of surgery to collect data before, during, and after their operation. The goal …

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to find out if receiving radiation therapy before colon cancer surgery leads to more complications during recovery, like infections or longer hospital stays. Researchers will compare 80 patients who had radiation before surgery to those who did not by reviewing th…

This study aims to build a large database of information about colorectal cancer in adults under 50. Researchers will collect data from younger patients and compare it to data from older patients to learn how the disease might differ. The goal is to gather knowledge that can guid…

This study aims to find a better way to predict which colon cancer patients are at high risk for the cancer spreading to their liver after surgery. Researchers will test a specific protein (PRDX1) found in a special type of blood sample taken during surgery. They will follow 260 …

This study aims to create better educational materials about genetic testing for cancer patients who speak different languages and come from diverse cultural backgrounds. Researchers will work with 445 patients who have breast, ovarian, prostate, pancreatic, or colorectal cancer …

This study is monitoring the safety and effectiveness of Fruzaqla (fruquintinib) in real-world colorectal cancer patients in South Korea. Researchers will track side effects and survival outcomes in 600 adults taking this already-approved medication. The goal is to better underst…