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Could a simple stool test spot cancer early in lynch syndrome patients?

NCT ID NCT05410977

Recruiting now Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new stool DNA test (mt-sDNA 2.0) to see how well it detects colorectal cancer or advanced growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 950 participants and compare test results with findings from colonoscopy. The goal is to find a less invasive way to screen for cancer in this high-risk group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
stool DNA test (mt-sDNA 2.0)
What this could lead to
If successful, this could lead to a simple, non-invasive stool test to catch colorectal cancer early in people with Lynch syndrome, potentially reducing the need for frequent colonoscopies.
What could go wrong
This is an early-stage study focused on accuracy, not treatment. The test may not be sensitive or specific enough to replace current screening methods, and results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal carcinoma colorectal neoplasm Colorectal Neoplasms, Hereditary Nonpolyposis Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CARCINOMA LYNCH SYNDROME

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Beth Israel Deaconess Medical Center

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02215, United States

  • Dana Farber Cancer Institute

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Email: •••••@•••••

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact Email: •••••@•••••

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94115, United States

  • University of Colorado Anschutz Medical Center

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98102, United States

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