COLORECTAL CARCINOMA

This early-stage study is testing a new drug called BI 765049 in adults with advanced colorectal, stomach, or pancreatic cancer that has spread or cannot be removed by surgery. The main goal is to find the highest dose patients can safely tolerate and determine the best way to gi…

This is the first study in humans of an experimental drug called MGC028 for people with advanced solid tumors that have stopped responding to standard treatments. Researchers will test increasing doses in about 124 participants to find the highest safe amount and check for side e…

This study is testing a new oral drug, S241656, alone and in combination with other cancer therapies. It aims to find a safe and effective dose for adults with advanced cancers, including lung, pancreatic, and colorectal cancers, that have specific genetic mutations like KRAS or …

This early-stage study is testing a new oral drug called CP-383 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see if the drug can slow or stop cancer growth. It is for patients who have run out of standard treatment …

This study is testing if an existing cancer drug called zanidatamab can help control several different types of advanced cancer. It is for adults with lung, colon, head & neck, uterine, or sarcoma cancers that have stopped responding to standard treatments and have a specific cha…

This study is testing a new clinic-wide system designed to help patients get their recommended follow-up colonoscopy on time. It targets people aged 45-75 who have had high-risk colon polyps removed, as they need a repeat colonoscopy in 3 years to prevent cancer. The system combi…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack canc…

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This study is testing a new drug called tegavivint in children, teens, and young adults whose solid tumors or lymphomas have come back or haven't responded to other treatments. The main goals are to find the safest dose, understand the side effects, and see if the drug can help s…

This study is testing a new clinic-wide program designed to help more patients get a follow-up colonoscopy after receiving an abnormal stool test result. The program involves better care coordination, patient education, and communication between doctors. Researchers will compare …

This study is testing a personalized vaccine designed to prevent liver cancer from coming back after surgery. The vaccine is custom-made for each patient using their own tumor and immune cells, and is given alongside an immunotherapy drug called nivolumab. The goal is to see if t…

This is the first human study of an experimental drug called JANX008 for people with advanced solid tumors that have spread and stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body handles the drug. Researchers will also look…

This study is testing a new combination treatment for people with rectal cancer that has spread to a few other places in the body. The goal is to see if a short course of radiation, followed by chemotherapy and an immunotherapy drug, can better control the cancer and reduce the c…

This study is testing two new blood tests designed to screen for 11 different cancers at the same time. It will enroll 24,000 healthy adults aged 45-75 to see how well these tests work for early detection and to understand how people and their doctors respond to the results. The …

This study aims to develop and validate a new blood test for early detection of colorectal cancer and advanced precancerous growths. Researchers will combine molecular markers found in blood with patient risk factors and clinical data, using artificial intelligence to create an a…

This study aims to reduce colon cancer disparities by providing free at-home screening tests and education to Black and underserved communities in Phoenix. Participants receive a simple stool test kit, complete a health questionnaire, and get support navigating follow-up care if …

This early-stage study is testing a drug called ONC201 (dordaviprone) to see if it is safe and can help prevent colorectal cancer. It is for adults who have a high risk of developing colon cancer due to a condition called Familial Adenomatous Polyposis (FAP) or a history of many …

This study is testing a new way to help more people get screened for colorectal cancer in their regular doctor's offices. Researchers are working with 20 primary care clinics across the US to see if a special planning tool and team-based approach can increase screening rates. The…

This study is testing a community program designed to help more low-income and uninsured women get screened for breast, cervical, and colorectal cancer. The program works with clinics, healthcare providers, patients, and entire communities through education, reminders, and outrea…

This study is testing whether cancer patients prefer to receive their standard drug treatments at home instead of in a clinic. Researchers want to see if home-based care reduces the burden of travel and improves treatment satisfaction and quality of life for patients. A specializ…

This study is testing a new online support program designed for people with colorectal cancer who are receiving chemotherapy and their primary caregivers. The 8-week program aims to help manage common and distressing symptoms like severe fatigue, pain, depression, sleep problems,…

This study aims to understand if using cannabis or related products helps people manage symptoms like pain and nausea during cancer treatment. It will follow 2,000 adults newly diagnosed with certain cancers who are starting chemotherapy or immunotherapy. Researchers will track p…

This small pilot study is testing whether an 8-week exercise program changes the types of bacteria in the gut of people who have survived stage II or III colorectal cancer. Researchers want to see if these changes in gut bacteria might be one reason why exercise is linked to bett…

This research study aims to understand why colorectal cancer affects Hispanic patients differently and how treatments might be better matched to individual patients. Researchers will collect genetic information, tumor samples, and health data from 500 Hispanic participants with c…

This study aims to understand how chemotherapy and radiation treatments affect the ability to have children and sexual health in younger adults with colorectal cancer. Researchers will track hormone levels and ask participants about their reproductive and sexual health over time.…

This study is testing whether an online self-monitoring platform is a useful tool for cancer patients. It aims to help patients track side effects and concerns about their oral cancer medications while they are at home. The research will see if using the app improves how patients…

This small pilot study aims to understand how a person's diet might change the bacteria in their gut and whether those changes could lead to cell damage that starts colon cancer. Researchers are comparing people who eat vegetarian diets with those who eat omnivorous diets. Partic…

This study is testing a training program for community members to become specialists who can talk to their communities about preventing colorectal cancer and the role of genetic testing. Researchers want to see if this program helps people learn more about cancer risks, healthy l…

This study aims to create and test an online educational program designed with community input to help African American cancer survivors learn about and access genetic counseling and testing. Researchers will work with 85 eligible survivors from Detroit to see if the program incr…

This study aims to build a large database of information about colorectal cancer in adults under 50. Researchers will collect data from younger patients and compare it to data from older patients to learn how the disease might differ. The goal is to gather knowledge that can guid…