COLORECTAL CARCINOMA

This early-phase study tests a new drug called MGC028 in adults with advanced solid tumors (like lung, bile duct, pancreas, or colon cancer) that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink or control the cancer…

This study tests a new treatment approach for people with rectal cancer that has spread to a limited number of other organs (called oligometastases). The treatment combines short-course radiation, chemotherapy, and an immunotherapy drug called serplulimab. The goal is to see if t…

This study tests a personalized vaccine made from a patient's own immune cells combined with an immunotherapy drug (nivolumab) to prevent liver cancer or colorectal cancer that has spread to the liver from returning after surgery. About 60 adults with these cancers will receive t…

This study tests a drug called TPST-1495 in 38 people with familial adenomatous polyposis (FAP), an inherited condition that causes many polyps in the colon and small bowel and raises colon cancer risk. The drug works by blocking certain signals that help polyps grow. The main go…

This study tests a drug called zanidatamab in adults with certain advanced cancers (lung, endometrial, colorectal, head & neck, or sarcoma) that have a specific change in the HER2 gene. The goal is to see if the drug can shrink tumors. Participants receive the drug by IV every 3 …

This study tests a drug called zanidatamab given before surgery for people with HER2-positive colorectal cancer that has not spread widely. The goal is to see if the drug can shrink tumors and improve outcomes. About 38 adults will take part, and the study is currently recruiting…

This study tests an experimental drug called CP-383 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if CP-383 can slow or stop cancer growth and to find the safest and most effective dose. About 150 participants will take th…

This early-phase trial tests a new drug called JANX008 in adults with advanced solid tumors (like lung, kidney, breast, or colorectal cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shri…

This early-stage trial tests a new medicine, BI 765049, in adults with advanced colorectal, stomach, or pancreatic cancer that cannot be removed by surgery or has spread. The main goal is to find the highest safe dose and best way to give the drug. BI 765049 is designed to help t…

This early-phase study tests an oral drug called S241656 in adults with advanced cancers that have certain gene changes (KRAS, BRAF, and others). The drug is given alone or with other cancer treatments. The goal is to find safe doses and see if the drug shrinks tumors. About 554 …

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific genetic mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 uses a patient's own immune cells, which are …

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or are not responding to standard treatments. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest …

This is an early-stage study testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors will collect a patient's own immune cells, genetically modify them in a lab to recognize and attack can…

This study looks at whether a stool DNA test can accurately detect colorectal cancer or pre-cancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 750 adults with Lynch syndrome or early-…

This study aims to create a blood test that can detect colorectal cancer and advanced polyps early by combining molecular markers with personal risk factors using artificial intelligence. About 510 adults undergoing colonoscopy or surgery will provide blood samples to help build …

This early-phase study tests the safety of a drug called ONC201 (dordaviprone) in 36 people at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming normal ones. Researcher…

This study aims to reduce colorectal cancer disparities in Black and underserved communities in the Phoenix area by providing free, home-based screening tests and education. Participants aged 45 and older who have not had a recent colonoscopy or FIT test can join. The goal is to …

This study tests a web-based program designed to help colorectal cancer patients on chemotherapy and their caregivers manage common symptoms like fatigue, depression, sleep problems, pain, and brain fog. About 56 patient-caregiver pairs will use the online tool and report how wel…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study looks at how chemotherapy and radiation affect the reproductive and sexual health of young adults with early-onset colorectal cancer. Researchers will track hormone levels and ask participants about their sexual health and ability to have children. The goal is to bette…

This study is creating a culturally tailored online program to help African American cancer survivors understand and decide about genetic counseling and testing. About 85 participants from Detroit who have had breast, prostate, or colorectal cancer will try the program and answer…

This study is following 2000 adults with newly diagnosed breast, colorectal, lung, melanoma, or lymphoma cancer who are receiving chemotherapy or immunotherapy. Researchers will track whether using cannabis or cannabinoids helps with symptoms like pain, nausea, or fatigue. No tre…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to guide future research. About 1,366 participants will provide medical informatio…

This study tests whether a simple planning tool helps more people get screened for colorectal cancer. About 2,200 patients from 20 clinics will use the tool to decide on stool tests or colonoscopy. The goal is to see if clinics can successfully add this tool to routine care and i…

This study looks at how what you eat and the bacteria in your gut might influence the development of colorectal cancer. Researchers will collect tissue, stool, and blood samples from 30 people undergoing screening colonoscopies. The goal is to understand connections between diet,…

This study evaluates a training program for community specialists to help Hispanic/Latino adults learn about colorectal cancer prevention and genetic testing. About 140 participants from Los Angeles County will take surveys before and after the program to see if their knowledge a…

This study looks at the genes and health records of 500 Hispanic people with colorectal cancer. The goal is to understand why the same cancer can behave differently in different people. By linking genetic information with treatment results, researchers hope to find better ways to…

This study tests an online platform for people with lung, colorectal, breast, or prostate cancer to track medication side effects and concerns at home. About 80 participants will use the tool and report on its ease of use and how it affects their health. The goal is to see if sel…

This study tests a multi-level program to help patients with high-risk colon polyps get a follow-up colonoscopy within 3 years, as recommended. About 1,680 patients, along with their doctors and clinic staff, will take part. The program uses reminders and support to overcome barr…

This study tests a new clinic program to help more patients get a follow-up colonoscopy after an abnormal stool-based screening test (FIT). The program includes better coordination, standard referrals, and education for both patients and doctors. About 1,500 adults from six clini…

This study looks at whether moderate-to-vigorous exercise can change the gut bacteria in people who have had stage II or III colorectal cancer. Researchers want to see if these changes might help improve cancer outcomes. The study involves 30 survivors and focuses on whether the …

This study tests a community program to increase cancer screening rates among low-income women in Ohio. The program includes patient education, media campaigns, and training health workers. Researchers will compare screening rates before and after the program to see if it helps m…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…