COLORECTAL CARCINOMA

This study tested an immunotherapy drug called pembrolizumab in people with many different types of advanced solid tumors that had stopped responding to standard treatments. The main goal was to see if the drug could shrink tumors and to identify biological markers that might pre…

This study is testing whether a drug called obeticholic acid (OCA), already approved for a liver disease, can safely reduce the number of intestinal polyps in people with familial adenomatous polyposis (FAP). FAP is a genetic condition that causes many polyps to grow in the gut, …

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This study is testing whether a regular endurance exercise program can help prevent cancer from returning in people who have finished chemotherapy for colon or rectal cancer. It will enroll 92 patients who have recently completed their chemo. Participants will be randomly assigne…

This study compares two different non-surgical treatments for colorectal cancer that has spread to the liver. It tests whether targeted radiation therapy or a heat-based ablation technique works better to control tumor growth. The trial involves 100 patients with 1-3 small liver …

This study is testing whether adding a drug called tucatinib to standard cancer treatments is safe and effective for people with HER2-positive cancers of the digestive system, like stomach, colon, and gallbladder cancers. It involves about 40 participants who have advanced cancer…

This large national trial is testing whether choosing cancer drugs based on the specific genetic changes found in a patient's tumor is more effective than standard approaches. It is for adults with advanced solid tumors, lymphoma, or multiple myeloma that have progressed after at…

This study is testing new drug combinations for people with advanced solid tumors that have a specific genetic change called KRAS G12C. It focuses on patients with non-small cell lung cancer or colorectal cancer who have already tried standard treatments. The main goals are to fi…

This study is testing whether a support program helps more people get a needed colonoscopy after an abnormal at-home stool test for colorectal cancer. The program includes a patient navigator, an educational video about colonoscopies, and help with a ride home after the procedure…

This study is testing new artificial intelligence (AI) software designed to improve the quality of CT scan images of the liver. The goal is to see if these AI-enhanced images, taken with a lower dose of radiation, can detect liver metastases (cancer spread) as accurately as stand…

This early-phase study is testing a new radioactive tracer called 18F-αvβ6-BP to see if it can help doctors better locate cancer in the body. The tracer is given by IV, and then patients undergo several PET scans to see where it collects. The main goals are to check the safety of…

This study is testing an experimental vaccine designed to teach the body's immune system to attack and kill colon polyp cells. It aims to prevent these polyps, which can turn into colorectal cancer, from growing back after removal. About 110 people who recently had a large or hig…

This study is testing whether taking aspirin daily or in on-and-off cycles can help prevent colorectal cancer in people who have precancerous growths called adenomas. Researchers are comparing three groups: daily aspirin, intermittent aspirin, and placebo, to see which schedule b…

This trial is testing a vaccine called Nous-209 in people with Lynch syndrome, a genetic condition that greatly increases the risk of colorectal and other cancers. The vaccine is designed to teach the body's immune system to recognize and attack early cancer cells. Researchers wa…

This study is testing if atorvastatin, a common cholesterol-lowering drug, can help prevent colon cancer in people with long-term ulcerative colitis who have a specific genetic change. It involves 42 adults who will take either atorvastatin or a placebo pill daily for one year. R…

This study is testing a practical program to get more people screened for colorectal cancer, which is a leading cause of cancer deaths. It focuses on helping low-income and ethnic minority patients, who often face barriers to screening. The program provides clinics with training,…

This study is testing whether a combination of a three-part vaccine and an immune system booster can prevent colon and other cancers in people with Lynch syndrome, a genetic condition that greatly increases cancer risk. The vaccine aims to train the body's immune system to recogn…

This study aimed to understand how community cancer clinics test for biomarkers—specific genetic changes in tumors—to help guide treatment decisions for common cancers like breast, lung, and colorectal. It planned to survey pathology labs to see what tests they run, how quickly t…

This study is testing an educational program designed to train Hispanic/Latino community members as educators about colorectal cancer genetics. The goal is to increase knowledge about genetic testing and research in communities that are often underrepresented in these studies. Pa…

This study aims to understand why colorectal cancer is increasingly affecting younger adults by comparing genetic and lifestyle factors between patients diagnosed before age 50 and those diagnosed later. Researchers will analyze DNA from 818 patients and their family members to i…

This study is testing a web-based education tool called HOPE-Genomics to see if it helps cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods in abo…

This study aims to understand what helps or prevents people from getting screened for colorectal cancer, particularly in African American, Latinx, and Chinese communities. Researchers will conduct interviews and group discussions to learn about cultural beliefs and knowledge gaps…