COLORECTAL CARCINOMA

This study tests a vaccine called Nous-209 in 45 people with Lynch syndrome, an inherited condition that raises the risk of colorectal and other cancers. The vaccine is designed to train the immune system to recognize and attack cells with cancer-like changes. Researchers want to…

This study tests a vaccine designed to help the immune system target and destroy abnormal colon growths called advanced adenomas, which can turn into cancer. About 110 people who recently had these high-risk polyps removed will receive either the MUC1 vaccine or a placebo. The go…

This study looks at whether a structured endurance exercise program, started after finishing chemotherapy, can improve outcomes for people with colorectal cancer. About 92 participants who have completed their chemo will be randomly assigned to an exercise group or a standard car…

This study looks at whether giving chemotherapy before and after surgery (plus heated chemotherapy inside the abdomen) helps people with colorectal cancer that has spread to the lining of the belly live longer compared to having surgery alone. About 358 adults with resectable tum…

This study is testing whether a drug called tucatinib can be safely combined with other cancer medicines (trastuzumab, chemotherapy, and pembrolizumab) to treat HER2-positive cancers of the digestive system. About 40 adults with advanced stomach, bowel, or gallbladder cancer are …

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This study compares two treatments—microwave ablation and stereotactic body radiation therapy—for colorectal cancer that has spread to the liver in up to three spots. About 100 patients whose liver tumors cannot be surgically removed will be randomly assigned to one of the two tr…

This study tests whether offering a patient navigator, an educational video, and free rideshare rides helps more people complete a follow-up colonoscopy after an abnormal at-home stool test for colorectal cancer. About 682 adults aged 45-75 who are due for this follow-up will tak…

This study tests whether a daily pill called obeticholic acid (OCA) can safely reduce the number of polyps in the small bowel and colon in people with familial adenomatous polyposis (FAP), a rare inherited condition that greatly raises the risk of intestinal cancer. About 80 adul…

This study tests a new drug called JDQ443, given alone or with other treatments, for people with advanced solid tumors that have a specific change in the KRAS gene (G12C). The goal is to find safe doses and see if the drug can shrink tumors. About 74 adults with lung or colorecta…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively image several types of cancer, including breast, colorectal, lung, and pancreatic cancers. About 27 adults with primary or metastatic cancer will receive the tracer an…

This study tests whether a low-radiation CT scan, enhanced with artificial intelligence software, can find liver tumors as accurately as a standard CT scan. About 146 adults with colorectal cancer that has spread to the liver will participate. The goal is to see if the new method…

This study tests whether atorvastatin, a widely used cholesterol-lowering drug, can reduce the risk of colon cancer in people with long-standing ulcerative colitis who carry a specific genetic mutation (P53). About 42 participants will take either atorvastatin or a placebo for a …

This study tests a two-part vaccine (Tri-Ad5 plus N-803) to see if it can prevent colon cancer and precancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. About 186 participants will receive either the vaccine or a placebo. The goal is to …

This study looks at whether taking aspirin on an intermittent schedule can help prevent colorectal cancer in people who have had colorectal adenomas (precancerous polyps). Researchers will measure changes in cell growth and death markers in the colon lining. The study involves 81…

This study looks at how to get more people from low-income and ethnic minority groups screened for colorectal cancer. Colorectal cancer is a leading cause of cancer death, and these groups are often missed. The main tool is a simple at-home test (FIT) that checks for blood in the…

This study tests a training program for Hispanic/Latino community members to learn about colorectal cancer genetics. About 20 participants will attend weekly sessions for 6 weeks. The goal is to see if the program increases their knowledge and confidence to share this information…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study aims to understand what helps or hinders people from getting screened for colorectal cancer, focusing on African American, Latinx, and Chinese communities. Researchers will interview and hold focus groups with 90 participants to learn about knowledge, beliefs, and cult…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study explores genetic and lifestyle factors that may raise the risk of colorectal cancer in people under 50. Researchers will compare data from 818 patients and their family members to find genetic markers linked to early-onset disease. The goal is to better understand who …