New hope for Hard-to-Treat cancers: APL-5125 enters human trials

NCT ID NCT06399757

Ongoing Disease control Sponsor: Apollo Therapeutics Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study tests a new drug, APL-5125, in adults with advanced solid tumors like colorectal, pancreatic, and ovarian cancer. The goal is to see if the drug is safe and can shrink or control tumors. About 100 participants will receive the drug in two phases to find the best dose and measure its effects.

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Conditions

The condition(s) this trial relates to.

appendix adenocarcinoma cholangiocarcinoma colorectal cancer colorectal carcinoma colorectal neoplasm endometrium adenocarcinoma gastric adenocarcinoma mucinous adenocarcinoma ovarian cancer pancreatic adenocarcinoma prostate cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APPENDICEAL ADENOCARCINOMA CHOLANGIOCARCINOMA COLORECTAL CANCER ENDOMETRIAL ADENOCARCINOMA GASTRIC ADENOCARCINOMA OVARIAN CANCER PANCREATIC ADENOCARCINOMA PROSTATE CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

Locations

Carolina BioOncology Institute

Huntersville, North Carolina, 28078, United States
City of Hope

Duarte, California, 91010, United States
City of Hope Orange County Lennar Foundation Cancer Center

Irvine, California, 92618, United States
Duke Cancer Institute

Durham, North Carolina, 27710, United States
Florida Cancer Specialists & Research Institute

Sarasota, Florida, 34232, United States
Mary Crowley Cancer Research

Dallas, Texas, 75251, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
NEXT Oncology- San Antonio

San Antonio, Texas, 78229, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.