PROSTATE CANCER

This study is testing a new treatment sequence for men whose advanced prostate cancer has progressed despite standard hormone therapy. The approach cycles through three drugs—DFMO, high-dose testosterone, and enzalutamide—over 119-day periods, aiming to control cancer growth and …

This study is testing whether adding cycles of testosterone injections to standard prostate cancer drugs can delay the cancer from spreading to other parts of the body. It involves about 69 men whose prostate cancer has become resistant to standard hormone therapy but hasn't yet …

This study is testing a new, highly focused radiation treatment for men with early-stage prostate cancer that is confined to one spot in the prostate. The goal is to see if delivering a high dose of radiation directly to the tumor in just two sessions can effectively control the …

This is the first time researchers are testing the experimental drug DXC008 in people. The study aims to find the safest dose and check for early signs that it might help control advanced prostate cancer and other solid tumors like Ewing sarcoma. It will involve about 110 adults …

This study compares two radiation treatments for early-stage prostate cancer to see which causes fewer side effects. Researchers will enroll 208 men with low or favorable intermediate-risk prostate cancer. One group receives targeted external radiation (SBRT), while the other rec…

This study is testing whether taking curcumin, the active compound in turmeric, can help prevent prostate cancer from returning after surgery. The trial will enroll 650 men who have had their prostate removed and have undetectable PSA levels. Participants will take either curcumi…

This study is testing whether a single, high-precision dose of radiation can treat prostate cancer with similar side effects as the standard five-session treatment. It will involve 58 men with intermediate or high-risk prostate cancer that hasn't spread. Researchers will carefull…

This small pilot study is testing whether a personalized diet and exercise program is practical and helpful for men with advanced prostate cancer who are on hormone therapy. Researchers want to see if this lifestyle approach can improve quality of life, manage treatment side effe…

This study is testing whether freezing just the cancerous part of the prostate gland can effectively control prostate cancer. Researchers will treat 30 men with intermediate-risk prostate cancer using this targeted freezing approach, then monitor them for cancer recurrence and qu…

This study is testing if a special heart scan can help personalize treatment to reduce heart disease risk in men with prostate cancer who are on hormone therapy. Researchers will compare patients who get the scan and tailored treatment to those who receive usual care. The goal is…

This early-stage study is testing a new drug called BL-M14D1 in 120 patients with advanced small cell lung cancer and other neuroendocrine cancers that have spread and stopped responding to standard treatments. The main goals are to find the safest dose and see how the body proce…

This early-stage study is testing a new drug called IDE161, both alone and combined with an existing immunotherapy (pembrolizumab), for people with advanced solid tumors that have spread. The main goals are to find safe doses and see if the treatment shows early signs of shrinkin…

This study is testing whether a cancer vaccine called Sipuleucel-T works better when patients continue taking their standard hormone therapy drugs. It's for men with advanced prostate cancer that has spread but isn't causing major symptoms, and whose PSA levels are rising despite…

This study is testing whether cancer survivors who get a personalized referral to a nutrition and exercise program will adopt healthier habits. It's enrolling 306 people who have finished treatment for breast, prostate, or colorectal cancer but aren't currently meeting standard d…

This study is testing whether adding walnuts to the daily diet might help slow prostate cancer growth. Fifty men with prostate cancer who are scheduled for surgery will be randomly assigned to either eat their usual diet or add two ounces of walnuts daily for 4-10 weeks before th…

This study compares two radiation treatment approaches for men with high-risk prostate cancer. It tests whether a shorter, more intense radiation schedule (SBRT) works as well as the standard approach of external radiation plus a brachytherapy boost (where radioactive seeds are p…

This study is testing if adding radiation to nearby lymph nodes helps men whose prostate cancer returns after surgery. It will compare standard radiation to this more extensive approach in 374 participants. The goal is to see if the extra radiation better controls the cancer and …

This is an early-stage study testing a new drug called MT-4561 in people with various advanced solid tumors who have run out of standard treatment options. The main goals are to find a safe dose, see how the body processes the drug, and check for any early signs that it might hel…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This study is testing a new drug called Pocenbrodib to see if it is safe and can help control advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. Researchers will give Pocenbrodib alone or combined with other cancer drugs to about …

This study is testing whether a personalized approach using the drug apalutamide can reduce fatigue and other side effects for men receiving radiation treatment after prostate cancer surgery. Researchers will compare apalutamide-based treatments against standard hormone therapy i…

This study is testing a more targeted form of radiation therapy for men with intermediate- or high-risk prostate cancer. It aims to deliver a strong dose to the tumor while using a lower dose on the rest of the prostate, which may protect nearby organs like the bladder and rectum…

This early-stage trial is testing a new oral medication called MOMA-313, given alone or with an existing cancer drug (olaparib), in people with advanced solid tumors that have stopped responding to other treatments. The main goal is to find safe dose levels and see how the body p…

This study is testing whether a much shorter, 2-week course of radiation is as effective and safe as the standard 6-week course for men whose prostate cancer returns after surgery. It involves 270 men who have had their prostate removed but show signs of the cancer coming back. T…

This study is testing if taking a common cholesterol-lowering drug (simvastatin) for 8 weeks before prostate cancer surgery can help the body's immune system fight the tumor. Researchers want to see if the drug changes certain immune cells inside the prostate to make them less pr…

This study is testing a new injectable form of a prostate cancer hormone therapy called ASP5541. It aims to see if this injection, given every 12 weeks, works as well or better than the standard daily pill version and if it causes fewer side effects. The trial will enroll about 2…

This is a small, early-stage study to see if a drug called dapagliflozin, normally used for diabetes, is safe and tolerable for men with aggressive prostate cancer before they have surgery to remove the prostate. Researchers want to see if taking the pill daily for four weeks bef…

This study is testing a remote monitoring system for men with prostate cancer who are on 'active surveillance'—a plan to watch the cancer closely instead of treating it right away. It aims to see if tracking symptoms and disease progression electronically can help doctors decide …

This study is testing if using common cholesterol-lowering drugs can help the body's own immune cells fight early prostate cancer. It involves 140 men with low-to-intermediate risk prostate cancer who are on active surveillance and scheduled for a biopsy. The goal is to see if lo…

This study is testing whether a new oral drug called HRS-5041, when given alongside other standard prostate cancer treatments, is safe and effective for men with advanced disease. It will involve about 100 male participants to find the best dose and see how well it controls cance…

This study is testing if adding a new drug called Saruparib to standard radiation and hormone therapy can better prevent cancer from spreading in men with high-risk prostate cancer who have a specific genetic mutation (BRCA). About 700 men will be randomly assigned to receive eit…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This study is testing a new, focused treatment for prostate cancer that uses heat from an ultrasound device to destroy tumors. The procedure is guided by MRI imaging to precisely target the cancer. The goal is to control the disease while potentially avoiding the common side effe…

This large, late-stage trial is testing whether immediately using aggressive treatments like radiation to destroy all visible cancer spread sites helps people live longer than waiting six months. It's for adults with lung, prostate, or colorectal cancer that has spread to 10 or f…

This study is testing whether a new DNA vaccine can help the body's immune system fight prostate cancer when given alongside standard hormone-blocking therapy. It is for men with newly diagnosed, high-risk prostate cancer who are scheduled for surgery to remove the prostate. Rese…

This trial aims to improve treatment for men with high-risk prostate cancer by personalizing their care. Doctors will use two new tests to decide if a patient needs stronger treatment or could safely receive a milder approach. The goal is to help patients live longer without the …

This study is testing whether a new combination treatment is safe for men with prostate cancer that has spread to a few other areas in the body. The treatment combines a targeted radioactive drug (177Lu-PSMA617) that seeks out cancer cells, followed by precise, high-dose radiatio…

This study is testing whether adding immunotherapy drugs to standard radiation and hormone therapy can better control high-risk prostate cancer that is still confined to the prostate area. It will enroll 64 men to see if the drug combination helps lower PSA levels more effectivel…

This study aims to collect long-term safety information on the prostate cancer drug enzalutamide. It is open to about 900 men who are already taking the drug in a previous company-sponsored trial and are still benefiting from it. Participants will continue their treatment and be …

This study is testing whether a new digital care system can improve quality of life for older adults who have cancer along with other health conditions. It will involve 720 patients aged 70+ with breast, lung, colorectal, or prostate cancer across eight hospitals in France. The m…

This study is testing if a compound from licorice root, called glycyrrhizin, can help control prostate cancer before surgery. Sixty men scheduled for prostate removal will take either a low dose, high dose, or no dose of the compound for about five weeks before their operation. R…

This is the first human study of an experimental drug called OCT-598 for people with advanced solid tumors that have stopped responding to standard treatments. Researchers will test increasing doses to find the safest and most effective amount, both when given alone and when comb…

This early-stage study is testing the safety of a new gel called STM-416p that is applied directly to the surgical area during prostate removal surgery. The gel is designed to help the body's immune system recognize and attack any remaining cancer cells after surgery. Researchers…

This study aims to collect detailed information on what happens to men after they undergo cryotherapy (freezing treatment) for prostate cancer that hasn't spread. Researchers will follow 1,000 patients to track side effects and monitor PSA levels over time to understand how well …

This study is testing whether adding a new immunotherapy drug (SHR-1701) to precise, high-dose radiation (SBRT) can better control advanced prostate cancer that has spread and stopped responding to standard hormone therapy. It will involve about 66 men to see if this combination …

This study is testing if adding the diabetes drug metformin to standard lifestyle advice helps men with prostate cancer who are also overweight or have slightly high blood sugar. Researchers want to see if metformin improves weight, blood sugar control, and possibly affects the p…

This study is testing a combination treatment for men with advanced prostate cancer that has spread to other parts of the body. It combines standard hormone therapy and chemotherapy with a focused ultrasound treatment aimed directly at the prostate. The goal is to see if this com…

This is the first study in people testing an experimental drug called AMG 509 for advanced prostate cancer that has spread and stopped responding to standard hormone therapies. The main goals are to find a safe dose, see how the body processes the drug, and check for early signs …

This is an early-stage study testing a new long-acting injection called PRL-02 for men with advanced prostate cancer. The main goals are to find a safe dose, check for side effects, and see how the drug behaves in the body. Men in the study will receive an injection into the musc…

This study is testing whether a shorter, two-session radiation treatment is as effective as the standard five-session treatment for men with low-risk prostate cancer. The main goal is to see if the shorter treatment can better preserve patients' sexual quality of life and cause f…

This study is testing whether adding an experimental drug called BMS986365 to standard hormone therapy before prostate removal surgery is safe and effective for men with high-risk prostate cancer that hasn't spread. Researchers want to see if this combination can completely elimi…

This study is testing if a 12-week exercise program can reduce the number of prostate cancer cells found in the bloodstream of men with advanced disease. Researchers at Johns Hopkins will enroll 20 men to follow a personalized exercise plan. The main goal is to see if exercise he…

This study is testing a new radiation therapy approach that uses MRI scans during treatment to adjust radiation beams in real time. Researchers want to see if this method can better target tumors while sparing healthy tissue in patients with various cancers including pancreatic, …

This study is testing a new, shorter radiation schedule for men with low to intermediate risk prostate cancer. Instead of many weeks of treatment, patients receive just two high-dose radiation sessions, with an extra boost to the main tumor. The main goal is to see if this approa…

This study is testing a new support program for cancer survivors who struggle to afford or access healthy food. Researchers will compare 100 patients who receive help from a patient navigator to those getting standard care, to see if the program improves food security, diet quali…

This large, phase 3 trial is testing if men with advanced prostate cancer can safely take breaks from their continuous hormone-blocking therapy. The goal is to see if stopping treatment when the cancer is well-controlled can significantly improve patients' quality of life—reducin…

This study is testing a short, high-dose radiation boost for men with high-risk prostate cancer. It aims to see if this focused treatment is as safe and effective as a more invasive needle-based method. Researchers will track side effects, cancer control, and quality of life for …

This early-stage study aims to check the safety and measure how a new drug called ASP5541 moves through the body in Chinese men with advanced prostate cancer. The drug is given as a hip muscle injection alongside standard hormone therapy and prednisone. The main goals are to unde…

This study aims to see if adding an experimental drug called mevrometostat to the standard treatment enzalutamide works better for men with metastatic prostate cancer that still responds to hormone therapy. It will involve about 1,000 participants who have not yet received certai…

This study is testing whether using MRI scans to guide radiation treatment can allow doctors to use lower overall radiation doses for prostate cancer. Researchers aim to reduce side effects like bowel problems while still effectively treating the cancer. The trial will enroll 60 …

This study is testing a program designed to help prostate cancer patients start and maintain regular physical activity. It combines personalized exercise plans, support from trained health professionals, and motivational coaching from fellow patients who have successfully stayed …

This study is testing if a much shorter, more intense radiation schedule can control prostate cancer that returns after surgery as well as the standard, longer treatment. It will compare a 5-session treatment to the usual 20-35 sessions. The main goal is to see if the shorter tre…

This study is testing a new combination treatment for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. It combines a targeted radiation drug that seeks out and destroys prostate cancer cells with an immunotherapy drug de…

This study is testing whether adding a drug called homoharringtonine to standard hormone-blocking therapy can better shrink prostate cancer before surgery. It aims to see if this combination leads to less cancer remaining after surgery and improves long-term results. The study is…

This is the first study in people testing a new cancer drug called AGX101. It aims to find a safe and effective dose for patients with advanced solid tumors that have spread or cannot be removed by surgery, and who have no other standard treatment options left. The drug is given …

This study is for men with a specific type of intermediate-risk prostate cancer. It aims to see if a shorter, more intense course of radiation therapy (SBRT) works as well as the same radiation combined with 6 months of hormone-blocking drugs (ADT). Participants will choose which…

This study is testing whether adding an immunotherapy injection (PDS01ADC) to a standard prostate cancer pill (enzalutamide) works better than the pill alone for men whose cancer has returned after initial treatment. The goal is to control the cancer and delay its progression for…

This study is testing three different higher doses of targeted radiation to see which works best for controlling early-stage prostate cancer while causing the fewest side effects. Researchers will enroll 36 men with early prostate cancer to receive one of the radiation doses and …

This trial is for men whose prostate cancer has spread to nearby pelvic lymph nodes but not further. It aims to find the best way to use high-dose, targeted radiation to control the disease and prevent it from spreading to other parts of the body. The study will compare focusing …

This large, late-stage study is testing a new targeted drug called ifinatamab deruxtecan against standard chemotherapy for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The main goal is to see if the new drug helps patients live long…

This study is testing a new, more precise way to deliver radiation when prostate cancer returns after surgery. Using a special scan to pinpoint exactly where the cancer has come back, doctors will give a stronger radiation dose to those spots and a lower dose to healthy areas. Th…

This study compares two types of radiation therapy (proton and conventional) given after prostate removal surgery. It aims to see which approach better prevents cancer from returning while measuring side effects and quality of life. The research involves 70 men whose prostate can…

This study is testing a new long-acting injection called Debio 4228 for men with advanced prostate cancer. The goal is to find the best dose that safely lowers testosterone levels to help control cancer growth. Researchers will measure how the drug moves through the body and how …

This study is testing an experimental drug called AAA817 against standard treatments for men with advanced prostate cancer that has spread and stopped responding to hormone therapy, chemotherapy, and a specific type of targeted radiation therapy. The goal is to see if AAA817 can …

This study is testing a new combination of two radiation treatments for men with higher-risk prostate cancer. The goal is to see if delivering a stronger dose of radiation using both an external beam and an internal implant is safe and well-tolerated. Researchers will closely mon…

This study aims to see if a shorter, more intense radiation schedule (5 treatments) can control prostate cancer as well as or better than the current standard schedule (20 treatments). It will enroll 484 men with intermediate or high-risk prostate cancer. The goal is to improve l…

This study compares two different robotic surgery techniques for removing the prostate in men with intermediate or high-risk prostate cancer. Researchers want to see which approach—coming from the back or the front—leads to better cancer control while preserving urinary control a…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is for men whose prostate cancer has returned after initial surgery. It tests whether removing pelvic lymph nodes from just the side where a scan shows cancer is as effective at controlling the disease as removing them from both sides. The goal is to see if the one-sid…

This study is testing a new, personalized plan for radiation therapy in men whose prostate cancer shows signs of returning after surgery. Instead of giving everyone the same intensive treatment, doctors will first give a shorter course of radiation to the prostate area. Based on …

This study aims to find out which treatment is better for men with high-risk prostate cancer that hasn't spread: surgery to remove the prostate or radiation combined with hormone therapy. Researchers will follow about 840 men in the Netherlands to compare side effects, quality of…

This study is testing a new immune-stimulating drug, injected directly into the prostate tumor, for men with prostate cancer who are scheduled for surgery. The goal is to see if this approach, sometimes combined with standard hormone therapy, can help the body's own immune system…

This study is testing a new radioactive drug called 225Ac-LNC1011 for men with advanced prostate cancer that has spread and stopped responding to standard hormone therapy. The main goal is to find the safest and most effective dose. Researchers will give the drug to small groups …

This study is testing if a weight loss program using the drug tirzepatide is practical and safe for men to use before prostate cancer surgery. It will enroll 30 overweight or obese men with intermediate-risk prostate cancer and type 2 diabetes. The main goal is to see if particip…

This early-stage trial is testing a new drug called FOG-001 for people with advanced or spreading cancers that have specific genetic mutations. Researchers want to find the safest dose and see if the drug can shrink tumors or slow cancer growth. The study will include 575 partici…

This study is testing whether elderly men with prostate cancer who have been on long-term hormone therapy can safely stop their treatment. Researchers want to see if their bodies remain in a low-testosterone state without the medication, which could reduce side effects and health…

This study is testing whether adding an experimental drug called tinengotinib to standard prostate cancer medications is safe and effective for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The trial will enroll 50 participants who a…

This study is testing if a new drug called enoblituzumab, given for 12 weeks before prostate removal surgery, can help men with high-risk prostate cancer. The goal is to see if this approach helps keep the cancer from coming back better than standard care alone. Researchers will …

This early-stage study is testing a new drug called xaluritamig in men with intermediate or high-risk prostate cancer that hasn't spread. The main goal is to see if it's safe to give the drug before planned surgery to remove the prostate. Researchers will check if the treatment c…

This early-stage study is testing a new drug called APL-5125 in adults with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose, check for side effects, and see if the drug can shrink tumors, especially in colorectal canc…

This study is testing whether a medication called 4-aminopyridine can help nerves heal faster after prostate removal surgery for cancer. Men undergoing robotic prostate surgery will receive either the study drug or a placebo around their operation date. Researchers will measure i…

This study is testing if a shorter course of an oral hormone-blocking drug (Relugolix), given alongside a precise, high-dose radiation treatment (SBRT), works better than the radiation alone for men with a specific type of intermediate-risk prostate cancer. The goal is to see if …

This study is testing whether adding a drug called talazoparib to standard hormone therapy (enzalutamide and ADT) is more effective at treating prostate cancer that has spread to nearby lymph nodes. The goal is to see if this combination can better control the cancer before patie…

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This study is testing a new oral drug called ACE-86225106 to see if it is safe and can help control advanced solid tumors in adults. It is for people with cancers like ovarian, breast, or prostate cancer that have not responded well to standard treatments. The main goals are to f…

This study is testing if taking a targeted pill called olaparib, along with hormone therapy, for 6 months before prostate removal surgery helps men with high-risk prostate cancer. It is for men whose cancer has specific genetic changes. The main goal is to see if this pre-surgery…

This study is testing a new drug called REGN5678 in men with high-risk prostate cancer that hasn't spread. The main goal is to see if the drug is safe and what side effects it might have. Participants will receive the drug before having their prostate surgically removed, so resea…

This study aims to collect long-term data on men with early-stage prostate cancer who choose a treatment called High-Intensity Focused Ultrasound (HIFU). Researchers will follow 300 men to see how well the treatment controls the cancer and how it affects their urinary and sexual …

This study is testing whether adding the common heartburn medication omeprazole to standard chemotherapy (cabazitaxel) helps control advanced prostate cancer that has stopped responding to other treatments. It will involve about 50 men whose cancer has progressed despite prior ho…

This study aims to see if having patient navigators—guides who help patients through the healthcare system—improves completion rates of radiation therapy for breast and prostate cancer. It focuses on African American, Native American, and Hispanic/Latino patients. Researchers wil…

This study compares two radiation therapy schedules for men who have had prostate cancer surgery. It tests whether a shorter 2-week treatment (5 sessions) affects quality of life differently than the standard 4-8 week treatment. The main goal is to see if the shorter schedule mai…

This study is testing a targeted treatment called NanoKnife for men with intermediate-risk prostate cancer. It uses electrical pulses to kill cancer cells in the prostate while trying to avoid damaging nearby healthy tissue, which could help preserve urinary and sexual function. …

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers. It is for people who may not have other treatment options. The drug aims to help the body's immune system fight cancer, and early reports show mostly mild…

This study is testing a new injection called INR102 for men with advanced prostate cancer that has spread and stopped responding to standard hormone and chemotherapy treatments. The main goals are to see if the treatment is safe, how the body processes it, and if it can help redu…

This study is testing whether a 16-week home exercise program can improve heart health in Black men with prostate cancer who are receiving hormone therapy. Researchers will compare a group doing supervised virtual workouts with a group maintaining their usual activity. The goal i…

This study is testing a new light-based treatment for men with early-stage prostate cancer that is still confined to the prostate. The treatment involves injecting a light-sensitive drug and then using special fiber-optic probes to shine light inside the prostate to destroy cance…

This early-stage study is testing a new experimental drug called AZD6621 for men with metastatic prostate cancer that has stopped responding to standard treatments. The research will first find safe dose levels in a small group, then test those doses in more participants to see i…

This is the first study in people to test a new drug called JANX007 for men with advanced prostate cancer that has spread and no longer responds to standard hormone-blocking treatments. The main goals are to find a safe dose and see how the body handles the drug. Researchers will…

This study is testing a combination of three drugs given before surgery (prostate removal) for men with high-risk prostate cancer. The goal is to see if this treatment can shrink the tumor so much that very little cancer is left after surgery. The study will enroll 40 men whose c…

This study is testing a focused radiation treatment for men with intermediate-risk prostate cancer. It uses advanced MRI guidance to deliver a high-dose radiation boost directly to the main tumor while using lower doses on the rest of the prostate. Researchers will check if this …

This early-stage study is comparing two different targeted radiation drugs for men with high-risk prostate cancer who are planning to have surgery. The goal is to see which drug might be more effective at delivering radiation to the tumor and potentially priming the immune system…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This study is testing whether a radioactive drug called AAA817, when given with standard hormone therapy, can better control advanced prostate cancer that has spread and stopped responding to standard treatments. The trial will compare this combination against other standard trea…

This study is testing if adding precise, high-dose radiation to the standard treatment for prostate cancer that has spread to a few other spots in the body can help men live longer without their cancer getting worse. It will compare two groups of men: one gets standard drugs and …

This study is testing a new, highly precise form of radiation therapy for men with prostate cancer that has not spread widely. It uses a special machine that combines an MRI scanner with a radiation beam to target tumors more accurately while trying to spare healthy tissue. The m…

This early-stage study is testing a new two-drug combination for men with advanced prostate cancer that has spread and is no longer responding to standard hormone treatments. The main goals are to find the safest and most effective dose and to see how well the body tolerates the …

This study is testing whether adding a drug called fasudil hydrochloride to immunotherapy helps control advanced prostate cancer that has spread and stopped responding to standard hormone therapy and chemotherapy. It will involve about 30 men who have already tried other treatmen…

This is the first human study of an experimental cell therapy called A-CAR032 for men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The trial will test the safety of different doses and see if the therapy can shrink tumors. I…

This study is testing a new, highly targeted radiation treatment for men with aggressive prostate cancer. It uses advanced imaging to guide the radiation precisely to the most dangerous parts of the tumor in just five sessions. The goal is to see if this more personalized approac…

This study is testing whether cancer patients can safely receive more of their routine care through video visits from home instead of traveling to the clinic. It involves 1,750 people with breast or prostate cancer who have already had several clinic visits. The goal is to see if…

This study is testing whether blocking the nerves around the prostate can slow or stop the spread of prostate cancer in men with high-risk disease. Researchers will compare one versus two injections of a nerve-blocking agent (ethanol) to see which is more effective at reducing ne…

This study is testing if an ultra-short course of radiation is as safe and effective as a moderately short course for treating localized prostate cancer. It will involve about 205 men and combines internal radiation (brachytherapy) with external beam radiation. The main goal is t…

This study is testing a new, more precise way to deliver radiation treatment for prostate cancer. It uses advanced imaging to target only the aggressive tumor areas while avoiding healthy parts of the prostate. The goal is to control the cancer effectively while aiming to reduce …

This study is testing whether adding one of two new oral drugs (HS-20093 or SHR2554) to standard hormone therapy helps men with advanced prostate cancer that has spread. It will enroll 218 men to see if these combinations are safe and can better control the cancer by lowering PSA…

This study is testing if a genetic test on a man's prostate cancer can help doctors choose the best treatment. Men with favorable genetic results will get a targeted therapy that treats only the cancer area to reduce side effects. Men with high-risk genetic results will be advise…

This study aims to determine whether adding hormone therapy to proton beam radiation provides better results than radiation alone for men with intermediate-risk prostate cancer. Researchers will compare two treatment approaches: a shorter course of proton radiation versus the sam…

This study is testing a new radioactive drug called [²¹²Pb]Pb-ADVC001 for men with prostate cancer that has spread. The first part aims to find the safest and most effective dose. The second part will see how well that dose works to control the cancer in different groups of patie…

This study is testing a new radioactive drug called lutetium (177Lu) rhPSMA-10.1 for men with advanced prostate cancer that has spread and is no longer responding to standard hormone therapies. The goal is to find a safe and effective dose that can shrink tumors by delivering rad…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This study is testing a new treatment strategy for men with advanced prostate cancer that has stopped responding to standard hormone-blocking therapy. The goal is to see if using highly precise radiation to target all visible tumors, combined with a radioactive drug that seeks ou…

This study is testing a new drug, HRS-1167, combined with standard prostate cancer medications (abiraterone and prednisone) in men whose cancer has spread. The main goals are to find the safest and most effective dose and to see how well the combination works to control the cance…

This study is testing a daily herbal supplement called INM176, made from Angelica Gigas Nakai root, in men with a history of prostate cancer. The main goals are to find a safe dose and see if taking the supplement for six months can lower or stop the rise of PSA, a blood marker l…

This study is testing if a shorter, 12-month course of powerful prostate cancer drugs works as well as taking them continuously. It's for men whose cancer has spread but is considered 'low-volume.' The goal is to see if stopping the drugs after a year, and restarting only if need…

This study is testing a new radiation technique for men with high-risk or locally advanced prostate cancer. It combines shorter, more intense radiation treatments with an extra 'microboost' dose focused on the most aggressive tumor areas. Researchers want to see if this approach …

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is testing whether a newer type of radiation (proton therapy) causes fewer bowel side effects than standard radiation (photon therapy) for men who need radiation after prostate cancer surgery. It also checks if a shorter, more intense radiation schedule works as well a…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing if a newer drug called darolutamide, when given for 6 months alongside standard radiation therapy, can effectively control prostate cancer. It is being compared to the current standard treatment, which combines radiation with a different type of hormone ther…

This study is looking at whether a man's race or ethnicity affects how well standard prostate cancer drugs work. Researchers will follow about 130 men with advanced prostate cancer that has spread, who are starting treatment with the drugs abiraterone and prednisone. The goal is …

This study is for men newly diagnosed with prostate cancer that has spread to a few other spots in the body. It tests if adding targeted radiation to those specific cancer spots, on top of standard hormone therapy and prostate treatment, helps control the disease better and for l…

This study is testing if a two-part treatment works better than one to control prostate cancer that has spread to a few spots. Men with 1-3 small metastases will receive either targeted radiotherapy alone or radiotherapy plus a targeted radioactive drug called Lu-PSMA. The goal i…

This study is testing a new approach for men whose prostate cancer has returned in the same area after previous radiation treatment. It combines a very precise, high-dose second round of radiation with the drug metformin, which may help make the cancer cells more sensitive to the…

This study is testing a new, shorter radiation schedule for men with high-risk prostate cancer. It combines two types of radiation: proton therapy to the pelvis and a high-dose internal boost. The main goal is to see if this faster approach is safe and if it effectively controls …

This VA study is testing if adding targeted radiation or surgery to standard drug therapy works better for controlling prostate cancer that has spread to a few spots. It will involve about 464 Veterans whose cancer has returned or spread to 1-10 locations. The goal is to see if t…

This study is testing a new technique called 'Spot Delete' during proton beam therapy for prostate cancer. Researchers want to see if carefully controlling where the proton beams stop in the body can reduce common and painful side effects like diarrhea, rectal bleeding, and urina…

This study is testing a new, focused approach to treating prostate cancer. For early-stage patients, doctors will deliver one high-dose radiation session directly to the tumor, not the whole prostate, aiming to cure the cancer. The trial will also see if adding a very short cours…

This study is testing a new approach to diagnose serious prostate cancer while helping men avoid unnecessary biopsies. Researchers are comparing the standard MRI-based method to a new strategy that also uses a specific blood test (PHI). The goal is to see if the new method finds …

This study is testing new computer software designed to help doctors better analyze prostate MRI scans. The software creates detailed maps showing areas most likely to contain cancer, which could help guide biopsy procedures more accurately. Researchers will compare the software'…

This study is testing whether a genetic test can help doctors better decide which men should be screened for prostate cancer. It will enroll 5,000 male Veterans aged 55-69 to see if the test can accurately identify those at high risk for serious cancer while helping low-risk men …

This study is testing a new type of MRI scan that uses a special form of sugar (called hyperpolarized pyruvate) to create detailed pictures of prostate cancer cells. The goal is to see if this scan can help doctors better monitor 60 men with low-to-intermediate risk prostate canc…

This study aims to test a new AI-based early warning system designed to improve how prostate and bladder cancers are found in men. It will involve 3,000 male residents of Beijing aged 50 and older. The goal is to create a better pathway from initial community screening to final d…

This study is testing a new saliva-based DNA test designed to estimate a person's future risk of developing prostate cancer. It aims to recruit 1000 men aged 40-55 from three different ethnic backgrounds to see how well the test works for everyone. Participants identified as high…

This study is testing whether a special type of PET scan can accurately find prostate cancer that comes back after a patient has received targeted, non-surgical treatment. Researchers will enroll 70 men who have had this type of treatment. They will compare the scan results to a …

This study is testing a new type of PET scan to see how accurately it can detect prostate cancer that has spread to nearby lymph nodes. It will involve about 383 men with high-risk prostate cancer who are scheduled for surgery to remove their prostate. Researchers will compare th…

This early-stage study is testing a new radioactive tracer called TRDC002 to see if it can help doctors better locate prostate cancer that has returned or spread. The study will enroll 6 men with this type of cancer to see which dose and timing gives the clearest scan images. Res…

This study aims to determine if a PET-CT scan is better than standard MRI and bone scans at finding prostate cancer that has spread in men with specific inherited genetic mutations. Researchers will compare how well each method detects cancer in lymph nodes and distant organs in …

This study is testing a new system to help manage the growing demand for prostate MRI scans. It will see if specially trained radiographers, supported by a computer system, can make the same decisions as radiologists about when patients need contrast injections during their scans…

This study is developing and testing a computer (AI) model designed to analyze prostate MRI scans. The goal is to help doctors better predict which patients have aggressive prostate cancer that needs treatment. It uses data from 3000 men who had both an MRI and a biopsy. The hope…

This study is testing new types of MRI scans to see if they can more accurately identify aggressive prostate cancer that needs treatment. It involves 300 men who are already scheduled for prostate removal surgery. Researchers will compare the detailed pictures from these advanced…

This study is testing whether a new, more comfortable upright MRI scanner works as well as the standard enclosed MRI for detecting prostate cancer. Researchers will compare both types of scans in 550 men at risk for prostate cancer over about 5 years. The goal is to see if the up…

This study is testing a new approach for men at moderate risk of prostate cancer. Instead of getting an immediate biopsy, participants are monitored for up to four years using regular blood tests (PSA) and MRI scans. The goal is to see if this strategy can safely reduce unnecessa…

This study is testing if a new type of imaging scan, which combines two technologies (PSMA PET and MRI), is better at finding prostate cancer than the current standard of care. It will enroll 204 men who have never had a prostate biopsy but are suspected of having cancer based on…

This study is testing a new, non-invasive imaging method called iRAI that uses sound waves to monitor proton radiation therapy for prostate cancer in real-time. The goal is to see if this technology can accurately track where the radiation dose is being delivered inside the body …

This is an early, first-in-human study to check the safety and basic behavior of a new imaging agent called Flotufolastat F-18. The agent is designed to help detect prostate cancer. The study involves 6 healthy Chinese volunteers who will receive a single injection, followed by s…

This study aims to find out if a prostate MRI scan is better than a panel of blood and urine tests at identifying aggressive prostate cancer in men who are scheduled for their first biopsy. Researchers will compare the accuracy of these methods in about 950 men. The goal is to he…

This study is testing whether adding MRI scans to standard PSA blood tests can improve prostate cancer detection in high-risk men. Researchers are enrolling 100 men aged 40-55 who have higher-than-average risk factors but normal PSA levels. Participants will receive MRI scans and…

This study aims to find out which of two prostate biopsy methods is better at detecting prostate cancer. Researchers will compare a traditional method with a newer method that uses MRI images to guide the biopsy needle. The study involves 80 men who have never had a prostate biop…

This study aims to find a better way to screen for serious prostate cancer. Researchers will test 1,500 men aged 40-69 by combining a genetic risk score with a special MRI scan. The goal is to see if this two-step method can more accurately identify high-grade cancers that need t…

This study is testing whether artificial intelligence (AI) software can help radiologists spot prostate cancer better on MRI scans. It will enroll 150 men who are scheduled for a prostate biopsy after an MRI. Researchers will compare how well a radiologist, a radiologist using th…

This study is testing if a computer-based risk calculator can be as good as an MRI scan at finding serious prostate cancer in men with a suspicious PSA blood test. It aims to see if using the calculator first can reduce the number of men who need uncomfortable biopsies and scans,…

This study aims to see if artificial intelligence (AI) can analyze a new, highly sensitive type of PET scan to predict how prostate cancer will progress and how patients will respond to treatment. It will enroll 1000 patients at a Montreal hospital who are already scheduled for t…

This study is testing a new type of PET/CT scan that uses a radioactive tracer to look for prostate cancer that may have spread. It aims to see if this scan is more accurate than current methods at finding cancer in lymph nodes before a patient has surgery to remove the prostate.…

This study is testing a new dye called Gadopiclenol used during prostate MRI scans. The goal is to see if this dye makes aggressive prostate cancer show up more clearly, helping doctors better identify which areas need a biopsy. Researchers will compare the MRI results with biops…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing a new type of imaging scan to see if it can clearly show where prostate cancer has spread in the body. It will compare this new scan to another type of scan that is already used. The goal is to see if the new scan is a good tool for patients who are schedule…

This study is testing a new type of scan (PSMA PET/MRI) to see if it can better guide doctors during prostate biopsies. It aims to find out if this method is more accurate at detecting serious cancer and if it can safely help some men avoid having a biopsy when it's not needed. T…

This study is testing if a new type of MRI scan can better detect prostate cancer. The scan looks at the size and density of cells inside the prostate, which may give doctors a clearer picture than standard MRI. About 2,000 men with suspected prostate cancer will get both the new…

This study is testing a new, FDA-approved imaging device called the Histolog Scanner. It is used during prostate cancer surgery to quickly check if cancer cells are left at the edges of the removed tissue. The main goal is to see if this scanner can save surgeons at least 20 minu…

This study is testing a new blood test to find tiny amounts of leftover cancer cells in men who have had prostate removal surgery for high-risk prostate cancer. Researchers want to see if this test can predict which patients are most likely to have their cancer return within a ye…

This study is comparing two different methods for performing prostate biopsies in men who have a suspicious area on an MRI scan. It aims to find out which method—using a computer to fuse the MRI with ultrasound images or relying on the doctor's mental map—is better at finding ser…

This study is testing a new artificial intelligence (AI) tool designed to predict whether high-risk prostate cancer has spread to nearby lymph nodes. The tool analyzes MRI scans and digital images of prostate tissue samples from 2,000 patients. The goal is to see if the AI can ac…

This study is testing whether adding a special 15-minute MRI scan to a standard prostate MRI is safe and practical. The goal is to see if this extra scan can provide clearer measurements of prostate tissue to help doctors. It involves men aged 40-90 who are already scheduled for …

This study is testing whether a new robotic system can help doctors perform more accurate prostate biopsies. Researchers will compare the robotic system against current standard biopsy methods in 483 men who need a prostate check due to elevated PSA levels or an abnormal exam. Th…

This study is testing a new type of imaging scan called PSMA-PET CT to see if it can accurately tell when a man's low-risk prostate cancer is not dangerous. It involves 200 men who have chosen active surveillance, which means monitoring their cancer instead of immediate treatment…

This study is testing a new imaging agent called 68Ga-P16-093 to see if it can detect prostate cancer tumors as well as or better than the current standard tracer, 68Ga-PSMA-11. Fifty men with newly diagnosed, untreated prostate cancer will receive both types of scans within a we…

This study is testing how well a new type of PET/CT scan works for finding prostate cancer that has spread to nearby lymph nodes. It will involve 380 men newly diagnosed with high-risk prostate cancer who plan to have surgery. The goal is to see if this scan is more accurate than…

This study aims to determine which of two MRI-guided biopsy techniques is better at detecting serious prostate cancer. Researchers will compare a computer-assisted fusion method against a doctor's visual estimation method in 1,306 men with suspicious MRI findings. The goal is to …

This study is testing a new type of imaging scan called PSMA-PET to see if it can better detect prostate cancer that has returned or spread in men who are at high risk based on a genetic test. It will enroll 60 men who previously had high-risk genetic test results and were treate…

This study is testing a new type of imaging scan called PSMA PET/CT to see if it can more accurately detect whether prostate cancer has spread to nearby lymph nodes. It involves men with intermediate or high-risk prostate cancer who are scheduled for surgery to remove their prost…

This study is testing a new type of PET scan to find prostate cancer tumors. Researchers will compare this new scan, called 68Ga-XACP3 PET/CT, to the current standard scan to see if it's better at spotting cancer. The goal is to improve how doctors detect and locate prostate canc…

This large study is testing a new type of PET/CT scan that uses a special tracer to find prostate cancer cells that have spread in the body. It aims to see if this scan is safe and accurate for men whose cancer may be returning or who are at high risk of it spreading. The main go…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing a special needle that uses light and sound waves to examine prostate tissue during a standard biopsy procedure. The goal is to see if this tool can reliably measure tissue and potentially tell the difference between healthy and cancerous areas without having…

This study is comparing two types of MRI scans used to diagnose prostate cancer. It aims to see if a new, more comfortable external coil is as good at finding aggressive cancer as the standard internal coil. The goal is to improve the accuracy of diagnosis and help doctors plan t…

This early-stage study is testing whether a new imaging tracer made with tiny silica particles can safely help surgeons better see prostate cancer cells during surgery. The tracer is designed to attach to cancer cells and show up on scans, potentially helping surgeons remove more…

This study is testing whether a new type of PET scan can find aggressive prostate cancer better than the standard MRI scan in men who are being monitored instead of immediately treated. About 120 men with low-risk prostate cancer on active surveillance will get both the new PET s…

This study is testing if a new type of scan (PSMA PET/MRI) is better than the standard MRI at finding prostate cancer that comes back after a focused ultrasound treatment. Researchers will compare the two scans in 60 men who had the ultrasound treatment. The goal is to see if the…

This study is testing a new type of PET/CT scan to see if it can accurately find prostate cancer that has come back after initial treatment. It will involve about 220 men who have rising PSA levels after surgery or radiation. The main goal is to see how well this new scan detects…

This early-stage study is testing if lisinopril, a common blood pressure medication, can prevent urinary side effects in men receiving radiation treatment for prostate cancer. Researchers will give the drug to about 30 men during and after their radiation therapy to find the best…

This study is testing a community outreach program to help more people get screened for breast, lung, and prostate cancer. It aims to connect 200 underserved adults at community spots to screening services and help them navigate follow-up care if needed. The goal is to see if thi…

This study is testing a smartphone app designed to educate African American men about prostate cancer and encourage them to get screened. Researchers will compare the new app to an existing health app to see which one better increases knowledge and readiness for screening. The go…

This study is testing which methods work best to encourage and help Black or African American men aged 40 and older get screened for prostate cancer. Researchers will compare three different support approaches: providing education, offering navigation help to schedule a test, and…

This study is testing two different support methods to help men follow through with their prescribed sexual rehabilitation exercises after prostate cancer surgery. Researchers want to see which approach helps men better stick with their rehabilitation program and improve their er…

This study is testing a mobile app designed specifically for Black men who have or have had prostate cancer. The app provides education, tracks symptoms, and offers support to help improve daily life and well-being. Researchers want to see if using the app for a year helps partic…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study is testing a more precise form of radiation therapy for prostate cancer that aims to avoid damaging the nerves and blood vessels needed for erections. It will involve 70 men with low- or intermediate-risk prostate cancer. The goal is to see if this targeted approach ca…

This study is testing a new pain management plan for men recovering from robotic prostate cancer surgery. The plan uses multiple non-opioid pain medications first, with opioids available only if patients call to request them. Researchers want to see if this approach safely reduce…

This study is evaluating a national online program called SHAReClinic, designed to support sexual health and intimacy for prostate cancer patients and their partners after treatment. It aims to see if this virtual clinic improves sexual function, reduces distress, and strengthens…

This study is testing whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. Researchers will compare these methods to the usual care in 208 men undergoing the procedure. The goal is t…

This study tests whether a digital exercise program with live virtual group sessions helps men with prostate cancer stick to regular exercise while on hormone therapy. Researchers want to see if this convenient approach overcomes common barriers like travel time and motivation, h…

This study is testing a new surgical procedure that grafts a nerve from the groin to the penis. The goal is to restore erectile function in 100 men who have had long-term erectile dysfunction for over 18 months following prostate cancer surgery. Researchers will track recovery an…

This study is testing a small, implanted device that uses gentle electrical pulses to calm an overactive bladder in men. It's specifically for men who have frequent, urgent urination, often after prostate cancer treatment or surgery for an enlarged prostate. The goal is to see if…

This study is testing a new, personalized type of radiation therapy for low to intermediate risk prostate cancer. The goal is to see if using daily imaging to adjust the radiation beams and avoid the urethra can reduce common urinary side effects like frequent or painful urinatio…

This study is testing whether a home-based exercise program can improve fitness and reduce heart disease risk in men with prostate cancer who are undergoing hormone therapy (ADT). Sixty participants will be assigned to either the exercise training group or a healthy living educat…

This study is testing whether a 12-week, completely remote exercise program can help reduce the severe fatigue that often follows cancer treatment. It is designed specifically for breast and prostate cancer survivors living in rural areas who have finished their main treatment. R…

This study is testing whether adding electrical muscle stimulation to a standard exercise program helps prostate cancer patients maintain leg strength while on hormone therapy. Researchers will compare two groups of patients—one doing exercise alone and one doing exercise plus mu…

This study is testing whether a medication called fezolinetant can safely reduce the frequency and severity of hot flashes in men with prostate cancer who are undergoing hormone-blocking therapy. Researchers will compare the drug to a placebo in 60 participants over 4 weeks to se…

This study is testing whether a digital support tool can help people with breast, prostate, or colorectal cancer sit less during their treatment. The goal is to see if reducing long periods of sitting improves their well-being, reduces side effects, and lowers future health risks…

This study is testing whether placing a special graft made from donated umbilical cord tissue during robotic prostate cancer surgery helps men regain bladder control and sexual function more quickly. It will involve 100 men who are scheduled for a specific type of nerve-sparing s…

This study is testing whether a more precise, MRI-guided radiation technique can better protect the nerves and blood vessels needed for erectile function in men with prostate cancer. Researchers will compare this advanced method to standard radiation in 200 patients, measuring se…

This study is testing whether a 16-week supervised exercise program can help reduce frailty and muscle loss in men with metastatic prostate cancer who are on hormone therapy. About 80 participants who are already experiencing weakness or frailty will be randomly assigned to eithe…

This study is testing if a new, more structured support plan before prostate cancer surgery helps men recover bladder control faster. The plan includes a one-on-one education session with a nurse and a direct referral to a physiotherapist. Researchers will compare this approach t…

This study is testing a 6-month patient empowerment program designed to help men newly diagnosed with prostate cancer. The program teaches life skills and healthy habits through daily emails, videos, and group support, with the goal of improving mental health, fitness, and overal…

This study is testing whether daily text message reminders help men do their pelvic floor exercises after prostate surgery. Researchers want to see if these reminders help men regain bladder control faster and reduce incontinence symptoms. The study will compare two groups: one t…

This study is testing a 12-week wellness program designed to help men recover after prostate removal surgery. The program combines online education, group exercise, and pelvic floor muscle training to improve bladder control, sexual function, and overall fitness. Researchers want…

This study is testing whether adding acupuncture to standard anti-nausea medicine helps reduce nausea better for cancer patients undergoing chemotherapy. It will involve 90 patients who are already experiencing nausea despite taking their prescribed anti-sickness drugs. Participa…

This study is testing whether giving doctors and patients AI-generated feedback after a prostate cancer consultation improves their conversations and helps patients make better treatment choices. About 283 men with newly diagnosed, localized prostate cancer will be enrolled. Doct…

This study aims to collect detailed medical and imaging data from 10,000 men with or at risk for prostate cancer. Researchers will analyze this information over at least five years to understand how different scan results relate to a patient's disease and outcomes. The goal is to…

This study aims to understand how men at risk for prostate cancer comprehend genetic testing information. Researchers will recruit 90 African American and rural White men to watch an educational video and participate in discussions. The goal is to see if the video improves their …

This study is testing whether adding a genetic test score to standard risk information helps men with newly diagnosed, favorable-risk prostate cancer make better treatment decisions. 900 men will be randomly assigned to either receive their standard risk score alone or their stan…

This international study aims to understand how breast and prostate cancer develop differently in people of African ancestry. Researchers will collect genetic data and health information from 1,500 Black cancer patients across 10 countries. The goal is to identify genetic pattern…

This study is collecting information on how well different focal ablation therapies work for prostate cancer. Researchers will follow 200 patients who receive treatments like focused ultrasound or freezing to destroy cancer cells. The goal is to understand treatment patterns, sid…

This study aims to collect blood, urine, saliva, and tissue samples from men with prostate cancer to understand the genetic and cellular changes that cause the disease. Researchers will analyze these samples to learn how prostate cancer develops and progresses, which could lead t…

This study is testing how well a new type of imaging scanner works for detecting prostate cancer. It involves men who are already scheduled to get a standard PET scan for their cancer. Participants will have an extra scan on the new machine right after their regular scan, but the…

This research aims to understand the unique genetic makeup of prostate cancer in Native American men. By analyzing tumor samples from 150 participants, scientists will compare these genetic patterns to those in Caucasian patients. The goal is to discover differences that could le…

This study is evaluating whether genetic testing can help doctors better understand prostate cancer risk and guide treatment decisions. Researchers will analyze DNA samples from 3,000 men who have prostate cancer or are at high risk for it, looking for genetic variations linked t…

This study aims to find biological markers in the blood that can predict how a patient's prostate cancer will respond to treatment. It will enroll 600 men at different stages of the disease and collect their blood samples at specific times before and after treatment. The goal is …

This study aims to better understand why some prostate cancers return after radiation treatment. Researchers will use detailed MRI scans and biopsies to closely examine the prostate before and after radiation therapy. The goal is to improve the detection of cancer recurrence and …

This study aims to build a collection of prostate tissue samples to better understand how prostate cancer develops in men with inherited genetic risk factors. Researchers will collect samples from men undergoing standard biopsies or prostate removal surgery, comparing those with …

This study is testing whether Spanish-language educational videos can help Latinx patients better understand their radiation therapy for breast or prostate cancer. Researchers want to see if these videos improve treatment adherence and make patients more open to joining future ca…

This study aims to understand if a simple blood test can provide similar information about prostate cancer spread as PET scans. Researchers will collect blood samples from 80 prostate cancer patients before and during their standard treatment and compare these results with their …

This study is testing a new type of MRI scan that uses a special imaging agent to watch how prostate cancer cells use energy (metabolism). The goal is to see if this scan can provide clearer pictures of the cancer before, during, and after radiation therapy. Researchers hope this…

This study aims to learn from the real-world experiences of over 500 patients with advanced prostate cancer. It looks back at medical records to see how well three different types of modern drug treatments worked in everyday practice. The goal is to gather knowledge that can help…

This study aims to understand how much anxiety affects prostate cancer patients who are on active surveillance (watching the cancer instead of immediate treatment) and their life partners. Researchers will survey 432 patient-partner pairs to measure their stress levels and identi…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study is testing a new type of PET scan that uses a special tracer called 64Cu-GRIP B. The goal is to see if this scan can safely detect a marker of immune system activity (granzyme B) in tumors of patients with advanced cancers, including prostate, kidney, and bladder cance…

This study aims to understand why advanced prostate cancer becomes resistant to hormone-blocking treatments. Researchers will use specialized PET/CT scans to track cancer lesions in 25 men who are either starting or already receiving these therapies. By comparing different imagin…

This study aims to map the genetic makeup of breast and prostate cancers in Brazilian patients. Researchers will analyze DNA from both tumors and blood to understand how genetic changes affect the disease and its treatment. The goal is to build a national database to help guide f…

This study aims to improve how doctors use radiation-based cancer drugs. Researchers will use a special type of scan (SPECT) to see exactly where these drugs go in the body and how much radiation they deliver. The goal is to gather information that could help doctors personalize …

This study is testing an educational tool designed to help older men with prostate cancer who are on active surveillance (watchful waiting). The tool aims to help these men and their doctors decide if and when it might be safe to reduce the frequency of cancer monitoring tests li…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study aims to help veterans with advanced prostate cancer make better-informed decisions about genetic testing and personalized treatment options. Researchers are developing and testing a decision support tool to guide patients and their doctors through complex choices. The …

This study aims to understand how prostate cancer progresses in men who have specific inherited gene mutations (like BRCA1/BRCA2) that increase their risk. It will follow over 4,000 men, comparing outcomes for those with and without these mutations. The goal is to gather critical…

This study is testing a new 'force feedback' feature in a robotic surgery system to see if it helps surgeons learn and perform prostate cancer removal more safely. Sixty men with localized prostate cancer will have their surgery performed with the 'touch' feature randomly turned …

This study is testing a blood test that looks for cancer cells that have broken away from a prostate tumor and entered the bloodstream. Researchers want to see if the number of these cells in the blood before and after prostate removal surgery can tell them more about the cancer'…

This study aims to find biological markers in blood and tumor samples that can predict which prostate cancer patients will benefit most from an experimental drug combination being tested in a related trial. It involves 48 participants who are already enrolled in the main treatmen…

This study aims to understand how doctors in Russia treat men with a newly diagnosed, aggressive form of prostate cancer that has already spread. Researchers will observe 400 patients to see what treatments they receive and will test their stored tumor samples for specific biolog…

This study is testing a new type of MRI scan to see if it can detect early signs that a drug treatment is working for men with high-risk prostate cancer. The scan looks at how cancer cells use energy. Researchers want to see if changes on this scan, taken just 4 weeks into treatm…

This study aims to understand why some prostate cancers become resistant to radiation-based treatments. Researchers will examine 125 patients already receiving PSMA-targeted radiation therapy to measure how much radiation reaches tumors and analyze cancer genetics. The goal is to…

This study tests whether a one-on-one educational session helps Black men with aggressive prostate cancer complete recommended genetic testing. Fifty participants will learn about the benefits and risks of testing from a trained staff member, then decide whether to proceed. The g…

This study aims to understand how the amount of radiation delivered by a prostate cancer treatment affects patient outcomes and side effects. Researchers will observe 50 patients with advanced prostate cancer who are receiving a standard treatment called 177Lu-PSMA-617. They will…

This study aims to understand why some prostate cancers stop responding to standard treatments by collecting blood samples from patients. Researchers will analyze the genetic material in the blood to look for differences that might explain why the disease becomes more aggressive …

This study aims to understand how specific gene mutations affect the course of prostate cancer over a person's lifetime. Researchers will follow 2,000 men who have prostate cancer and certain gene changes to see how their disease progresses and responds to treatments. The goal is…

This study is testing whether easy-to-understand educational materials can help newly diagnosed African American prostate cancer patients better comprehend their treatment options and potential side effects. Researchers will interview 210 patients to see if these materials reduce…

This study is testing whether a short educational video can be a good alternative to standard genetic counseling for patients with certain cancers. Researchers want to see if the video helps people understand their risk for hereditary cancers and makes genetic testing information…

This study aims to understand how two common surgical conditions—tilting the patient head-down and inflating the abdomen with gas—affect pressure inside the skull during robotic prostate cancer surgery. Researchers will use a simple, non-invasive ultrasound scan on the eye to mea…

This study is creating a database of health information and blood samples from cancer patients receiving targeted radiation therapy. Researchers will collect data from 350 adults with thyroid, prostate, or neuroendocrine cancers to better understand how these treatments work and …

This study aims to understand how major surgeries for bladder, prostate, and kidney cancers, as well as procedures for kidney stones, affect patients' ability to return to their jobs and their overall quality of life. Researchers will survey 2000 adult patients in Poland about th…

This study is creating a large database of 1,500 men with prostate cancer to serve as a testing ground for future treatments. It will track patients' quality of life, side effects, and survival over many years. The goal is to efficiently compare new interventions against standard…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand why people react differently to cancer drugs. Researchers will collect blood or cheek swab samples from about 1,100 cancer patients already enrolled in treatment trials at the National Cancer Institute. By analyzing genes, they hope to learn which ge…

This study is testing a new software tool called TRAQinform Theranostics that analyzes medical scans. Researchers want to see if the information from this software would make doctors change their minds about which treatment to use for men with advanced prostate cancer. The study …

This study aims to understand how genetic risk factors affect prostate cancer progression in men who are being monitored rather than immediately treated. Researchers will follow 200 men with low-risk prostate cancer who are on active surveillance, comparing those with higher gene…

This large Swedish study aims to collect detailed molecular and health information from 5500 men with prostate cancer. It will analyze tumor samples, blood, and urine, and track patient outcomes to identify biomarkers that predict treatment response. The goal is to build a knowle…

This study aims to understand how prostate cancer is diagnosed and treated in Algeria by tracking 2000 patients. Researchers will collect information about patients' backgrounds, symptoms, tests, treatments, and outcomes. The goal is to create a detailed picture of current care p…

This study aims to understand how prostate cancer responds to standard radiation treatment by tracking changes in blood tests and imaging scans over time. Researchers will follow 144 patients undergoing radiation therapy or surgery to see if certain markers in blood and scans can…

This study is testing a new, simpler way to monitor drug levels in men with prostate cancer. Instead of a standard blood draw, researchers are checking if a small finger-prick blood sample dried on a card works just as well. The goal is to make it easier for patients to have thei…

This study aims to understand how a cancer diagnosis impacts the health, needs, and quality of life of both patients and their family members over time. Researchers will follow 240 Danish patients with certain cancers and their caregivers for 18 months, using surveys and intervie…

This study aims to understand how doctors in Russia treat men with aggressive, spreading prostate cancer that is still sensitive to hormone therapy. Researchers will observe 400 patients to see what treatments they receive in real-world practice and compare genetic test results f…

This study is testing a new, highly sensitive blood test to see if it can detect tiny traces of cancer DNA in men with high-risk prostate cancer before they have surgery to remove the prostate. The goal is to learn if finding this cancer DNA in the blood can help doctors better p…

This study aims to see if a person's inherited genetic risk score can help predict who is more likely to have prostate cancer found during a biopsy. It will observe 1,000 men from diverse racial backgrounds who are already scheduled for a prostate biopsy. The goal is to gather ev…

This study aims to understand the biological effects of two investigational drugs, saruparib and darolutamide, given alone and in combination to men newly diagnosed with prostate cancer who are scheduled for surgery. The main goal is to see how these treatments change specific ma…

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study is creating a large database to track the long-term results and side effects of prostate ablation, a minimally invasive treatment for prostate cancer. It will follow 3,000 men who have had or will have this procedure as part of their regular care. The goal is to gather…

This study is testing whether advanced MRI scans can improve how doctors monitor men with low-risk prostate cancer who are on 'active surveillance' (watchful waiting). Researchers want to see if these scans can accurately track the cancer over time and possibly reduce the need fo…

This study aims to understand how well patients with advanced breast or prostate cancer take their prescribed oral medications and what factors might make it harder to follow their treatment plan. Researchers will enroll 200 patients to complete questionnaires and provide a blood…

This study aims to understand how a new, more sensitive type of prostate cancer scan (PSMA-PET) affects patients' anxiety, decision-making, and quality of life. Researchers will follow 350 men with prostate cancer who are getting this scan for the first time, collecting surveys a…

This study aims to understand how prostate cancer that returns after initial treatment changes over time. Researchers will use a new type of PET scan on up to 350 men to track the cancer's progression for up to five years. The goal is to gather knowledge about the disease's behav…

This study aims to collect blood and other samples from adults with cancer to help scientists better understand how cancer affects the immune system and tumor biology. Participants provide samples for lab analysis, but this is not a treatment study. The goal is to gather knowledg…

This study is testing whether two new tools—a special PET scan and a blood test that looks for tumor DNA—can detect if prostate cancer is getting worse earlier than the standard PSA blood test. It will involve 50 men with prostate cancer that has spread to a few spots, who are ge…

This international study is creating a large registry to track the treatment journeys and health outcomes of over 5,000 men with advanced prostate cancer. Participants will be followed for at least five years across multiple countries to understand how care differs and what treat…

This study aims to create and test an online educational program designed with community input to help African American cancer survivors learn about and access genetic counseling and testing. Researchers will work with 85 eligible survivors from Detroit to see if the program incr…

This study aims to find substances in urine that might predict how well prostate cancer treatments work and what side effects patients might experience. Researchers will collect urine samples from 360 men with prostate cancer before they start treatment. The goal is to develop fu…

This study aims to find out if a high-support patient navigation program helps more people with prostate or kidney cancer join clinical trials compared to a low-support program. Patient navigators help participants overcome barriers to healthcare access. About 90 eligible patient…

This study aims to create better educational materials about genetic testing for cancer patients who speak different languages and come from diverse cultural backgrounds. Researchers will work with 445 patients who have breast, ovarian, prostate, pancreatic, or colorectal cancer …

This study aims to understand if hormone therapy for prostate or breast cancer affects sleep quality. Researchers will monitor 60 patients' sleep patterns before starting treatment and again at 6 and 12 months. The goal is to gather information to plan future studies on how to he…

This study aims to see if a simple blood test can predict which hormone therapies will work for men with advanced prostate cancer that has spread. Researchers will follow 120 men receiving standard treatment, checking their blood for cancer cells to look for genetic clues linked …

This study is testing whether visual tools help surgeons explain prostate and kidney cancer surgery options more clearly to patients. Researchers will record conversations between 20 surgeons and 200 patients before and after surgeons use the visual aids. They'll measure if discu…

This study is a large registry that will track 5,000 men in Germany with recurrent or metastatic prostate cancer. Its purpose is to observe and document the real-world treatments doctors choose, how the disease progresses, and how patients' quality of life is affected. It does no…

This study aims to understand how different Mediterranean-style diets affect the body's metabolism in men with early-stage prostate cancer who are on active surveillance. Researchers will provide controlled meals to 30 participants and measure changes in prostate tissue, blood ma…

Due to the subject's lack of conventional treatment options, a treatment plan using X-PACT administered intra-tumorally is proposed. X-PACT (X-ray Psoralen Activated Cancer Therapy) is comprised of a phosphor device (an energy modulation agent), methoxsalen sterile solution (a p…