PROSTATE CANCER

This study tests a single, high-dose radiation session aimed only at the tumor inside the prostate, not the whole gland, for early-stage prostate cancer. Some participants also receive a very short course of hormone therapy to boost effectiveness. For higher-risk patients, the si…

This study tests a new type of radiation (SBRT) that targets only the tumor in the prostate, not the whole gland. The goal is to cure early-stage prostate cancer while reducing side effects like incontinence and impotence. About 42 men with low- or intermediate-risk cancer that h…

This study is testing a new way to deliver radiation for prostate cancer that hasn't spread. Instead of the usual 5 sessions, doctors will give 3 high-dose sessions. They want to see if this shorter course causes fewer long-term side effects in the bladder and bowel. About 175 me…

This study compares two modern treatments for men with low-to-intermediate risk prostate cancer that hasn't spread: a robotic partial prostatectomy (removing part of the prostate through a single port) and high-intensity focused ultrasound (HIFU), which uses sound waves to destro…

This study is for men whose prostate cancer has returned in the same area after previous radiation and surgery. It tests a precise, high-dose radiation treatment (SBRT) combined with the diabetes drug metformin to see if it can control the cancer longer. About 44 participants wil…

This early-stage study tests a new treatment for prostate cancer that hasn't spread. It uses a special light-sensitive drug and laser fibers placed into the prostate to destroy cancer cells. About 43 men will take part, and researchers will check safety and how well the treatment…

This early-phase trial tests a new radiation method for men with low-to-intermediate risk prostate cancer. Instead of many sessions, it uses just two high-precision radiation treatments, with an extra boost to the main tumor seen on MRI. The goal is to see if this approach is saf…

This study tests whether giving a mix of hormone therapy (ADT), a targeted drug (darolutamide), and an immunotherapy (pembrolizumab) before prostate removal surgery, followed by more immunotherapy after surgery, can reduce or eliminate cancer in high-risk prostate cancer patients…

This study tests a new type of radiation therapy for prostate cancer that uses an MRI machine to guide the beam. It aims to deliver high doses of radiation more precisely, reducing damage to healthy tissue and side effects. The trial includes 50 men with either localized or limit…

This study tests a new medicine called PRL-02 depot, given as a shot into the muscle every 12 weeks, to lower testosterone in men with advanced prostate cancer. The goal is to find a safe dose and see if it works alone or with another drug, enzalutamide. About 174 men whose cance…

This study tests whether advanced scans (PSMA PET/CT) and a genetic test (Decipher) can help doctors choose the right treatment for high-risk prostate cancer. For some patients, treatment may be intensified to better control the cancer; for others, it may be reduced to improve qu…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This study tests whether a single, precise dose of radiation can safely control prostate cancer in men with intermediate or high-risk disease. About 58 participants will receive one targeted treatment session, along with standard hormone therapy. The goal is to see if this shorte…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors that have spread and are not responding to other treatments. About 100 people will be followed to see if their tumors shrink and how long that lasts. The goal is to provide a trea…

This study looks at whether a detailed heart CT scan can help doctors better prevent heart disease in prostate cancer patients who are on or about to start hormone therapy. About 100 participants will either get the scan or standard care. The goal is to see if the scan finds hidd…

This study is for men with high-risk prostate cancer that hasn't spread. It tests how well a short course of hormone therapy (ADT) shrinks the cancer before surgery. Researchers use a special PET scan (PSMA PET/CT) to measure changes in the cancer. The goal is to see if this appr…

This study tests a new drug called AAA817 against standard treatments for men with a specific type of advanced prostate cancer (PSMA-positive) that has worsened after prior therapies, including a targeted radiation drug. About 443 adult participants will be randomly assigned to r…

This study tests whether adding an immune-boosting treatment (Sipuleucel-T) to ongoing hormone therapy can better control metastatic prostate cancer that has started to progress. About 26 adults with asymptomatic or mildly symptomatic cancer will receive Sipuleucel-T either with …

This study looks at how well ablation treatments work for men with prostate cancer that hasn't spread. It will track cancer control, side effects, and quality of life like urinary and erectile function. About 225 men will take part, either as their first treatment or after a prev…

This study tests whether using a special PET scan (PSMA-PET) to guide radiation can safely reduce the dose and side effects in men whose prostate cancer has returned after surgery. About 54 men will receive a lower amount of radiation to the pelvis plus a focused boost to the can…

This early-phase study tests a new drug called AMG 509 in people with a type of advanced prostate cancer that no longer responds to standard hormone therapy. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. About 479 participant…

This study is for men with a certain type of advanced prostate cancer that has spread to many places in the body. It tests a treatment plan that combines hormone therapy, a drug called darolutamide, chemotherapy, and a focused ultrasound procedure on the prostate. The goal is to …

This early-phase study tests a new drug, CLSP-1025, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have a specific genetic change called p53 R175H and a certain immune type (HLA-A*02:01). The goal is to find a safe dose and see if the drug can …

This study looks at whether a genetic test can help decide the best treatment for men with prostate cancer. Instead of treating the whole prostate, doctors may only treat the cancerous spots (focal therapy) to reduce side effects. The trial will check if men with certain genetic …

This study tests whether giving the drug enoblituzumab for 12 weeks before prostate removal surgery can help prevent prostate cancer from coming back in men with high-risk localized disease. About 219 men will be randomly assigned to receive either the drug or standard care. The …

This study tests a new radioactive drug (177Lu-rhPSMA-10.1) in men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to find the safest and most effective dose to shrink tumors or lower PSA levels. About 82 men will take part acr…

This study looks at whether proton therapy can safely treat tumors that have come back after standard radiation. Proton beams are more precise than X-rays, so they may deliver a stronger dose to the tumor while sparing healthy tissue. The study will enroll 1,800 adults with vario…

This study tests a new drug called ACE-86225106 in adults with advanced solid tumors (like ovarian, breast, or prostate cancer) that are hard to treat or no longer respond to standard therapy. The goal is to see if the drug is safe, tolerable, and can shrink tumors. About 298 par…

This study is tracking 100 men with prostate cancer who choose to receive a treatment called high-intensity focused ultrasound (HIFU). HIFU uses sound waves to heat and destroy cancer cells in a targeted area. The goal is to see how well the treatment works at removing the cancer…

This study tests whether giving a targeted drug (olaparib) plus hormone therapy for 6 months before prostate removal can eliminate or shrink tumors in men with aggressive prostate cancer. Participants must have specific gene changes (HRR alterations). After surgery, doctors will …

This study is testing a new way to deliver radiation for high-risk prostate cancer. Doctors will use advanced PSMA PET/MR scans to precisely target tumors and give a stronger dose to the most aggressive areas. The goal is to improve the chance of staying cancer-free for at least …

This study tests whether adding lymph node radiation to standard salvage radiotherapy helps men whose prostate cancer has returned after surgery. About 374 men with low but rising PSA levels will be randomly assigned to receive either standard radiation or standard radiation plus…

This study tests a natural compound from licorice root (glycyrrhizin) in 60 men with prostate cancer who are scheduled for surgery. Participants take the extract daily before their operation to see if it lowers PSA levels and is safe. The goal is to learn if this supplement can h…

This study tests whether adding omeprazole (a common heartburn drug) to chemotherapy (cabazitaxel or docetaxel) can help control advanced prostate cancer that has stopped responding to standard treatments. About 50 men with castration-resistant prostate cancer that progressed aft…

This study tests whether adding the drug homoharringtonine to standard hormone therapy before prostate removal can improve outcomes for men with high-risk or advanced prostate cancer. About 93 participants will receive the combination before surgery. The goal is to see if this ap…

This study tests whether a new drug (AAA817) given with hormone therapy can slow the growth of advanced prostate cancer that no longer responds to standard hormone treatment. About 940 adults with PSMA-positive metastatic castration resistant prostate cancer will be randomly assi…

This study tests a new medicine called ifinatamab deruxtecan (I-DXd) against standard chemotherapy (docetaxel) in people with metastatic castration-resistant prostate cancer (mCRPC), a type of prostate cancer that has spread and no longer responds to hormone therapy. About 1,440 …

This trial is for men with prostate cancer that has spread to nearby lymph nodes but not further. It compares giving a higher radiation dose to the prostate only versus to both the prostate and the affected lymph nodes. All participants also receive hormone therapy. The goal is t…

This study compares a new treatment called irreversible electroporation (IRE) to the standard radiation boost for men with intermediate-risk prostate cancer. IRE uses electrical pulses to destroy cancer cells. About 224 participants will receive standard radiation therapy plus ei…

This study compares two ways to give high-dose radiation for men with unfavorable-risk prostate cancer that has not spread. One method uses a special machine to deliver radiation in fewer, stronger sessions (SBRT). The other combines standard external radiation with a temporary r…

This study tests whether adding immunotherapy (pembrolizumab) and a PARP inhibitor (olaparib) to standard radiation can better control high-risk prostate cancer. About 64 men with localized but aggressive prostate cancer will receive these treatments. The goal is to see if the co…

This study tests a new drug, HRS-1167, combined with two standard treatments (abiraterone and prednisone) in men with metastatic prostate cancer that has spread. The goal is to find the best dose and see if the combination is safe and helps control the disease. About 66 men aged …

This study tests whether a personalized physical activity program, combined with support from a trained peer (another prostate cancer patient who is already active) and a doctor's prescription, can help inactive prostate cancer patients become and stay more active. The goal is to…

This study tests whether adding a radiation drug (225Ac-J591) to standard immunotherapy (pembrolizumab) and hormone therapy can better control advanced prostate cancer that has spread and stopped responding to treatment. About 52 men with this type of cancer will receive either t…

This study tests a treatment called bipolar androgen therapy (BAT) for men with prostate cancer that has not spread but is showing signs of progression on standard therapy. About 69 men will receive testosterone injections along with their current medication to see if it can dela…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced or spreading solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and works against these cancers. About 300 adults (and some teens after …

This study tests whether adding a DNA vaccine (pTVG-AR) and/or an immunotherapy drug to standard hormone therapy can help the immune system fight high-risk prostate cancer more effectively. About 60 men scheduled for prostate removal will receive these treatments before surgery. …

This study tests whether adding the drug saruparib to standard radiation and hormone therapy can delay or prevent the spread of prostate cancer in men with high-risk disease and BRCA gene mutations. About 700 participants will receive either saruparib or a placebo alongside their…

This study tests an experimental drug called AZD6621 for men with metastatic prostate cancer that has spread. The drug is designed to help the immune system attack cancer cells. The trial has two parts: first, finding the safest dose, then testing that dose in more people to see …

This study tests a new approach for men with a tough-to-treat form of prostate cancer that has spread and stopped responding to standard hormone therapy. Instead of continuing hormone blockers, participants get a precise type of radiation to all visible tumors plus a radioactive …

This early-phase trial tests a new drug called STM-416p, which is given directly into the prostate area during surgery to remove the prostate (radical prostatectomy) in men with prostate cancer. The main goals are to check the drug's safety and find the best dose. About 18 men wi…

This study tests whether adding a short course of the oral hormone drug Relugolix to precise radiation (SBRT) works better than radiation alone for men with a certain type of prostate cancer. About 60 men will be randomly assigned to one of the two treatments. The goal is to see …

This study tests whether adding an experimental drug (SHR-1701) to targeted radiation (SBRT) can slow the growth of metastatic castration-resistant prostate cancer. About 66 men aged 18-80 whose cancer has spread and stopped responding to hormone therapy will participate. The mai…

This study compares a newer, nerve-sparing prostate surgery to the standard approach in 600 men with localized prostate cancer. The goal is to see if the newer method controls cancer just as well while improving urinary function, reducing penile shortening, and lowering the risk …

This study tests whether adding an injected drug (PDS01ADC) to a daily pill (enzalutamide) can better control prostate cancer that has returned after initial treatment. About 65 men with rising PSA and positive PET scans will be enrolled. The goal is to see if the combination kee…

This study tests a procedure called irreversible electroporation (IRE) using the NanoKnife system to treat intermediate-risk prostate cancer. The goal is to destroy cancer cells with fewer side effects than standard treatments like surgery or radiation. About 100 men aged 50 and …

This early-phase study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer) that have not responded to other treatments. The main goals are to check safety, find the right…

This study tests whether a short, focused radiation treatment called SBRT can safely boost the effectiveness of standard radiation for prostate cancer, without using needles. About 150 men with unfavorable localized prostate cancer will receive this boost. Researchers will track …

This study tests whether freezing just the part of the prostate that contains cancer (focal cryotherapy) can effectively control intermediate-risk prostate cancer. About 30 men with a single area of cancer will receive this targeted treatment. The goal is to reduce side effects w…

This study looks at two treatments for men with intermediate-risk prostate cancer that hasn't spread. One group gets proton beam radiation alone (28 sessions), and the other gets the same radiation plus hormone therapy. The goal is to see if adding hormones helps keep the cancer …

This study looks at whether eating a Mediterranean-style diet before prostate cancer surgery can lower insulin levels and improve other health measures. Twenty men scheduled for prostate removal will follow a controlled diet for a short time. The goal is to see if diet changes ca…

This study is for people with a certain type of prostate cancer that is not too advanced but has features that make it more likely to come back. It tests whether adding a short course of the drug darolutamide to standard radiation therapy can better control the cancer. The main g…

This study looks at the long-term safety of enzalutamide, a drug for prostate cancer. It is for people who have already been helped by enzalutamide in a previous study. About 900 participants will continue their treatment and be monitored for side effects.

This study tests whether combining a targeted radiation drug (177Lu-PSMA-617) with liver-directed therapy is safe for men with advanced prostate cancer that has spread to the liver. About 30 participants will receive both treatments to see how well they tolerate the combination a…

This study tests whether a new drug (BMS986365) combined with hormone therapy (degarelix) can safely shrink or eliminate high-risk prostate cancer before surgery. About 30 adults with localized high-risk prostate cancer will receive the drug combo for a few months, then have thei…

This study is collecting information from 300 men with early-stage prostate cancer who choose to be treated with high-intensity focused ultrasound (HIFU). The goal is to understand how well the treatment controls cancer and what side effects it may cause, including effects on uri…

This is a single-patient program for someone with advanced prostate cancer who has run out of standard treatments. The experimental therapy, X-PACT, combines a drug called methoxsalen with a special device that activates it using X-rays, injected directly into the tumor. The goal…

This study tests whether adding a drug called relacorilant to standard hormone therapy and enzalutamide can better shrink high-risk prostate cancer before surgery. About 90 men with advanced, localized prostate cancer that hasn't spread will take the combination for 24 weeks, the…

This study tests a new injectable radioactive drug, Actinium-225 rhPSMA-10.1, in men with advanced prostate cancer that has spread and no longer responds to standard treatments. The drug aims to find and destroy cancer cells with radiation. About 60 men will receive up to 6 doses…

This study looks at men whose prostate cancer has come back after surgery, with new spots found on only one side of the pelvis using a special scan (PSMA PET). Doctors want to see if removing lymph nodes only on that one side works as well as removing them on both sides, which ca…

This early-phase trial tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part.

This early-stage trial tests a new drug called 225Ac-LNC1011 in 9 men with a type of advanced prostate cancer that no longer responds to hormone therapy. The drug delivers radiation directly to cancer cells using a targeting molecule (PSMA). The main goals are to find the safest …

This study tests two experimental drugs (HS-20093 or SHR2554) taken as pills alongside standard hormone therapy for men with metastatic prostate cancer that has spread. About 218 men aged 18 to 80 will participate. The goal is to see if these combinations can lower PSA levels and…

This early-stage study tests a new drug, DXC008, for safety and the right dose in people with prostate cancer or other solid tumors like Ewing sarcoma. About 110 adults who have not responded to standard treatments will take part. The goal is to see if the drug is safe and to get…

This study tests a new drug called 2141-V11 that helps the immune system find and kill prostate cancer cells. It is given as an injection directly into the tumor, either alone or with standard hormone therapy. The goal is to see if this approach can completely eliminate cancer or…

This study tests whether adding a targeted radiation drug (Lu-PSMA) to standard stereotactic radiotherapy can better control prostate cancer that has spread to 1-3 small spots. About 70 men with asymptomatic metastases will be randomly assigned to receive either the combination o…

This study tests a new drug called INR102 in people with a specific type of advanced prostate cancer (PSMA-positive) that no longer responds to hormone therapy. The goal is to see if the drug is safe, how it moves through the body, and whether it can shrink tumors or lower PSA le…

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This early-phase trial tests a new drug called ZM008, alone and with another drug (toripalimab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 100 adults with canc…

This study compares a focused ultrasound treatment (HIFU) that targets only the tumor to complete surgical removal of the prostate in men with intermediate-risk prostate cancer. The goal is to see which approach offers better value for money and quality of life over two years. Ab…

This study tests a new drug called LY4052031 in people with advanced or spreading solid tumors, including bladder, breast, lung, and other cancers. The goal is to see if the drug is safe and works against these cancers. About 420 participants will take part, and the study will la…

This study is for men whose prostate cancer has spread to a few spots (up to 5) in the bones or soft tissues. It tests whether adding precise, high-dose radiation to those spots, along with standard radiation to the prostate and hormone therapy, can keep the cancer from growing b…

This study tests a new way to give radiation to men with high-risk or advanced prostate cancer. It combines two modern techniques to deliver stronger doses to the tumor while sparing healthy tissue. The goal is to see if this approach is safe and works better than standard radiat…

This study tests a drug called REGN5678 in men with high-risk prostate cancer before they have surgery to remove the prostate. The goal is to see if the drug is safe and how it affects the cancer. About 42 men will take part in this early-phase trial.

This study looks at whether a very precise, high-dose radiation treatment (SBRT) alone can control prostate cancer as well as the standard approach of SBRT plus 6 months of hormone therapy. About 392 men with unfavorable intermediate-risk prostate cancer will choose either SBRT a…

This study tests whether two common, low-cost drugs—aspirin and atorvastatin (a cholesterol-lowering statin)—can help men with advanced prostate cancer that no longer responds to hormone therapy live longer. About 1,210 men will be randomly assigned to take one or both drugs or a…

This study tests a surgical nerve grafting technique to help men who have had persistent erectile dysfunction for over 18 months after prostate cancer surgery. The procedure aims to reconnect nerves to restore natural erectile function. One hundred participants will be followed f…

This early-phase study tests a new drug called JANX007 in men with advanced prostate cancer that has stopped responding to standard treatments. The main goals are to check the drug's safety and find the right dose. About 272 men will take part in this first human study.

This early-phase study tests a new treatment called IDOV-Immune, a virus designed to infect and kill cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatm…

This early study tests whether a diabetes medicine called dapagliflozin is safe and tolerable when taken for four weeks before prostate cancer surgery. About 24 men with intermediate or high-risk localized prostate cancer will take the drug daily before their operation. Researche…

This study tests the drug Enhertu in 60 men with a specific type of advanced prostate cancer (HER2-positive) that has stopped responding to standard hormone therapy and chemotherapy. The goal is to see if Enhertu can shrink tumors or slow the cancer's growth. Participants must ha…

This study is for men with prostate cancer that has spread to pelvic lymph nodes only detectable by a special PSMA-PET scan. It compares standard hormone therapy plus radiation to a stronger combination that includes abiraterone and prednisone. The goal is to see if the stronger …

This early-phase study tests a new drug called OCT-598 in about 51 adults with advanced solid tumors (breast, lung, prostate, head/neck, or stomach cancer). The main goal is to find the safest dose and check for side effects when given alone or with standard treatments. Participa…

This study is testing a new drug called DXC014 in people with advanced solid tumors, including small cell lung cancer, melanoma, and prostate cancer. The main goals are to check the drug's safety, find the best dose, and see if it can help shrink tumors. About 150 participants wi…

This study tests whether taking curcumin (a compound found in turmeric) after prostate removal surgery can help prevent prostate cancer from returning. About 650 men who had their prostate removed for early-stage cancer will take curcumin or a placebo. The main goal is to see if …

This study tests whether a single, very high dose of precisely targeted radiation can safely control intermediate-risk prostate cancer. About 200 men will receive one 24 Gray dose to the whole prostate, with some getting an extra boost to the main tumor. The goal is to reduce sid…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The trial includes 740 participants with 13 different cancer types, such as lung, breast, and prostate cancer. The goal is to see if the …

This early-stage study tests a new drug called ASP5541 in about 12 Chinese men with advanced prostate cancer. The drug is given as a shot in the hip, along with standard treatments (prednisone and hormone therapy). The main goals are to see if the drug is safe and how it is proce…

This early-phase study tests a new drug called BG-68501 in people with advanced solid tumors (like breast, lung, or ovarian cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors, either alone or combined with ot…

This study tests a highly targeted radiation therapy for men with intermediate-risk prostate cancer. Using real-time MRI guidance, doctors deliver a stronger dose to the main tumor while giving a lower dose to the rest of the prostate. The goal is to improve tumor control and red…

This early-phase study tests a new radioactive drug called [225Ac]Ac-AKY-2519 in people with a hard-to-treat type of advanced prostate cancer (metastatic castration-resistant prostate cancer). The drug targets a protein (B7-H3) on cancer cells to deliver radiation directly to tum…

This study is testing whether using MRI scans to guide radiation therapy can lower the dose to healthy parts of the prostate while giving a higher dose to cancer spots. The goal is to reduce bowel-related side effects and preserve quality of life. About 60 men with intermediate- …

This study is for people with metastatic prostate cancer that has spread and is no longer controlled by hormone therapy. It tests a new drug called [212Pb]Pb-ADVC001, which delivers a precise dose of radiation directly to cancer cells. The goal is to find the safest and most effe…

This early-phase study tests a new treatment called A-CAR032 for men with advanced prostate cancer that has stopped responding to standard hormone therapy. The treatment uses specially engineered immune cells to attack the cancer. The main goal is to check safety, but researchers…

This study is for men whose prostate cancer has returned after surgery, shown by rising PSA levels. It compares a standard few weeks of radiation to a much shorter course (just a few days) to see if the shorter option works just as well with fewer side effects. The goal is to mak…

This study tests whether adding talazoparib to standard hormone therapy and enzalutamide can help shrink prostate cancer that has spread to lymph nodes. About 30 men will receive the drug combination before having their prostate removed. The main goal is to check safety and how w…

This study tests a sequence of three drugs—DFMO, high-dose testosterone, and enzalutamide—in 50 men with metastatic prostate cancer that has stopped responding to standard hormone therapy. The goal is to see if this approach can lower PSA levels and delay cancer growth. Participa…

This study tests a new drug called HRS-5041, given as a tablet alongside other cancer treatments, for men with advanced prostate cancer. The goal is to see if the combination is safe and helps lower PSA levels, a key marker of cancer activity. About 100 men aged 18 to 80 with goo…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have run out of standard options. The goal is to find a safe dose and see if the drug can shrink tumors. About 27 adults will take part in this …

This study tests if axelopran, a drug typically used for opioid-induced constipation, can help slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran capsules dai…

This study tests whether simvastatin, a common cholesterol medication, can help the immune system better attack prostate cancer. Men with localized prostate cancer who are planning to have surgery will be randomly assigned to take simvastatin for 8 weeks before their operation or…

This study tests a new two-drug combination (gedatolisib plus darolutamide) in men with metastatic castration-resistant prostate cancer, a type that has spread and stopped responding to standard hormone therapy. The goal is to find the safest, most effective dose and see if the c…

This early-stage study tests two types of targeted radiation therapy (177Lu-PSMA-617 and 225Ac-PSMA-617) in 45 men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see which therapy delivers more radiation to the tumor and how it affec…

This study tests a more precise type of radiation therapy for men with early-stage prostate cancer. Instead of treating the whole prostate, doctors use special scans to find only the aggressive parts of the tumor and target those with radiation seeds. The goal is to control the c…

This study tests a new drug called pocenbrodib, either by itself or combined with other treatments, in people with a type of advanced prostate cancer that no longer responds to hormone therapy. The goal is to find the safest dose and see if it helps shrink tumors or lower PSA lev…

This study tests a personalized approach to radiation therapy for men whose prostate cancer has returned after prostate removal surgery. Instead of giving everyone the same treatment, doctors will use PSA blood tests to decide who needs additional radiation and hormone therapy. T…

This study looks at people with lung, colorectal, or prostate cancer that has spread to up to 10 spots in the body. It compares starting treatment right away versus waiting 6 months to see which approach helps people live longer and maintain quality of life. About 800 participant…

This study tests whether blocking nerve signals to the prostate can slow or stop the spread of high-risk prostate cancer. Twenty-one men scheduled for prostate removal surgery will receive one or two injections of a nerve-blocking agent. Researchers will measure changes in nerve …

This study compares standard systemic therapy alone versus standard therapy plus PET-directed local therapy in 464 veterans with prostate cancer that has returned in a few spots (oligorecurrence). The goal is to see if adding targeted local treatment can delay the cancer from bec…

This early-phase study tests a new drug called BL-M14D1 in people with advanced small cell lung cancer or other neuroendocrine cancers that have spread. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. About 120 adults will take part.

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed, localized prostate cancer. The goal is to see how the drugs affect tumor cells and check for side effects. About 120 men will take part.

This study tests a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. It aims to improve tumor control and reduce side effects for people with cancers of the pancreas, lung, kidney, prostate, liver, and others. About 400 particip…

This study tests whether a personalized diet and exercise program is practical for men with metastatic prostate cancer who are already receiving hormone therapy. Researchers will enroll 30 participants to see how many stick with the program. The goal is to improve disease control…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This study tests a new drug called xaluritamig, given alone or with hormone therapy, before prostate removal surgery in men with intermediate or high-risk prostate cancer. The goal is to see if the drug is safe and if surgery afterward is still possible. About 40 men will take pa…

This study tests whether a 16-week exercise program designed for Black men can lower heart disease risk in those receiving hormone therapy for prostate cancer. Participants are randomly assigned to either the exercise group or usual care. The goal is to see if exercise improves h…

This study looks at whether men with low-volume, hormone-sensitive prostate cancer that has spread can safely stop a specific hormone therapy after 12 months instead of taking it indefinitely. About 400 men will be randomly assigned to either continue the therapy or stop it, with…

This study is testing whether giving a higher dose of radiation directly to the prostate (called HDR brachytherapy) can better control early-stage prostate cancer. About 36 men with low- or favorable intermediate-risk prostate cancer will receive one of three dose levels. Researc…

This study tests an herbal supplement called INM176 (made from Angelica gigas Nakai root) in 45 men with prostate cancer whose PSA levels are rising after prior treatment or who are on active surveillance. The goal is to find a safe dose and see if the supplement can stabilize or…

This study tests a new drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their growth. About …

This study tests a new, shorter radiation treatment for men with intermediate- to high-risk prostate cancer. The experimental treatment delivers 5 high-dose radiation sessions with a targeted boost to the tumor, compared to the standard 20 sessions. The goal is to see if the shor…

This study tests whether aggressively lowering cholesterol with a common FDA-approved drug (Vytorin or ezetimibe) can increase cancer-fighting immune cells inside the prostate. It involves 140 men with prostate cancer who are under active surveillance and planning a biopsy in 3-6…

This study tests a new way to give radiation for prostate cancer that has a higher risk of coming back. It combines two types of radiation: one from outside the body and one from a small tube placed inside the tumor. The main goal is to see if this treatment is safe and tolerable…

This early-stage study tests a new drug called JANX014 in about 43 men with a hard-to-treat type of prostate cancer that has spread and no longer responds to hormone therapy. The main goals are to check the drug's safety and find the right dose, while also looking for any signs t…

This study tests whether adding a new drug called tinengotinib to standard hormone therapy (abiraterone or enzalutamide) is safe and effective for men with metastatic castration-resistant prostate cancer (mCRPC). About 50 participants will receive the combination to find the best…

This early-phase trial tests TJ101, an experimental antibody-drug conjugate, in adults with advanced solid tumors (lung, prostate, esophageal, and others) who have no standard treatment options left. The main goals are to find a safe dose and see if the drug can shrink tumors. Ab…

This study tests a new drug called SHR-4394 combined with other anti-tumor treatments for prostate cancer. It involves about 100 men aged 18 to 85. The goal is to find the safest dose and see if the combination helps control the cancer by lowering PSA levels.

This study looks at whether taking creatine supplements while doing supervised resistance training for 12 weeks can help men with prostate cancer who are on hormone therapy (ADT) maintain or improve their muscle mass, strength, and physical function. ADT often causes muscle loss …

This study tests a new drug called APL-5125 in about 100 adults with advanced solid tumors, including colorectal, pancreatic, and ovarian cancers. The goal is to check safety and see if the drug can shrink tumors. Participants must have tried standard treatments first.

This early-phase study tests a new drug called EXS74539 in about 40 adults with advanced solid tumors, including lung, prostate, ovarian, and breast cancers. The main goal is to find a safe dose and check for side effects. Researchers will also watch for signs that the drug shrin…

This study is for men with prostate cancer that has just spread to a few other body parts. It tests whether giving radiation to those spread spots, on top of standard hormone therapy and prostate radiation, helps keep the cancer under control longer. About 200 men will take part,…

This study looks at whether metformin, a drug used for diabetes, can help prostate cancer patients who have high blood sugar or are overweight. About 100 men will either get metformin plus lifestyle advice or just lifestyle advice. The goal is to see if this approach is practical…

This study tests if adding the experimental drug mevrometostat to standard enzalutamide therapy works better than enzalutamide alone for men with metastatic castration-sensitive prostate cancer (cancer that has spread but still responds to hormone therapy). About 1,000 participan…

This study tests a new two-drug combination for men with advanced prostate cancer that has stopped responding to standard treatments. The drugs aim to help the immune system attack cancer cells more effectively. About 60 men will take part to find the safest dose and see if the t…

This study tests whether a 12-week exercise program can reduce the number of cancer cells in the blood of men with advanced prostate cancer. Twenty men on hormone therapy will participate. Researchers will measure changes in cancer cells and DNA before, during, and after the exer…

This study tests a new way to give radiation to men whose prostate cancer has come back after surgery. Using special scans, doctors will give higher radiation doses to the cancer spots and lower doses to healthy areas. The goal is to control the cancer while reducing side effects…

This study looks at how well proton radiation (and sometimes hormone therapy) works for prostate cancer that has come back or is at risk of coming back after surgery. About 70 men whose cancer has not spread will receive this treatment. The main goal is to measure short-term side…

This study tests a new drug, ADI-PEG20, combined with two standard chemotherapy drugs (carboplatin and cabazitaxel) in men with a fast-growing type of prostate cancer called aggressive variant prostate cancer (AVPC). The goal is to find the best dose and check for side effects. A…

This study tests a personalized approach to treating prostate cancer in men who still have detectable PSA after prostate removal surgery. Participants receive radiation therapy plus the drug apalutamide, with the goal of reducing fatigue and other side effects compared to standar…

This study compares two types of radiation therapy for men with low- or intermediate-risk prostate cancer. One uses precise external beams (SBRT), the other uses tiny radioactive seeds placed inside the prostate (brachytherapy). The goal is to see which causes fewer urinary and b…

This study compares a targeted radiation treatment (SBRT) to standard care for men whose prostate cancer returns after surgery. About 284 participants will receive either SBRT or usual treatments to see which better controls the cancer and reduces side effects. The goal is to man…

This early-stage study tests a new drug, QXL138AM, for safety in about 100 people with advanced solid tumors (like ovarian, pancreatic, lung, or breast cancer) or multiple myeloma. Participants must have tried other treatments without success. The study will find the right dose a…

This study tests a new way to treat early-stage prostate cancer using heat from ultrasound waves guided by MRI. About 21 adults with localized prostate cancer will receive the procedure, where a small device is placed in the urethra to destroy cancer cells. The goal is to see if …

This study tests whether eating 2 ounces of walnuts daily for 4-10 weeks can slow prostate cancer growth in 50 men who are scheduled for prostate removal surgery. Participants are randomly assigned to either add walnuts to their usual diet or continue their normal eating habits. …

This study tests a new injectable form of the hormone therapy abiraterone (ASP5541) in men with advanced prostate cancer that has spread. The shot is given every 12 weeks, instead of daily pills. The goal is to see if it works as well as or better than the standard pill, and to c…

This study tests whether men with advanced prostate cancer can safely take breaks from hormone therapy instead of staying on it continuously. The goal is to see if intermittent treatment works just as well for survival while reducing side effects and improving quality of life. Ab…

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and 177Lu-PSMA-617 (a targeted radiation therapy)—can slow or stop the growth of advanced prostate cancer that has spread and no longer responds to hormone therapy. About 48 men with this type of cancer…

This study tests whether adding fasudil hydrochloride to immunotherapy can help control metastatic castration-resistant prostate cancer in patients who have already tried standard treatments. About 30 adults aged 18 to 85 will receive the combination therapy. Researchers will mea…

This study is testing a shorter, more intense course of targeted radiation therapy for men with high-risk or aggressive intermediate-risk prostate cancer. It combines two radiation techniques—proton therapy to the pelvis and a high-dose internal boost—to try to better control the…

This study tests a new imaging agent called copper Cu 64 PSMA I&T, used with a PET/CT scan, to see if it can more accurately find cancer that has spread to lymph nodes in men with newly diagnosed, aggressive prostate cancer. About 439 men who are scheduled for prostate removal su…

This study aims to see if a type of PET-CT scan called FCH-PET-CT is better than standard scans (bone scan and MRI/CT) at finding cancer that has spread outside the pelvis in men with prostate cancer who have certain inherited gene mutations (like BRCA). About 50 men with these m…

This study is testing a new radioactive tracer called PSMA-T4 to see if it can safely and accurately find prostate cancer tumors during a special type of scan (SPECT/CT). About 80 adults with prostate cancer will receive the tracer and then have scans to compare with standard ima…

This study tests whether an upright MRI can better detect prostate cancer compared to the standard PSA blood test and traditional MRI. About 550 men at risk for prostate cancer will get both types of MRI scans and answer comfort questionnaires. The goal is to see if the upright M…

This study compares two prostate biopsy techniques—cognitive-targeted and MRI-ultrasound fusion—to see which detects prostate cancer more accurately. About 80 men with elevated PSA and suspicious MRI findings will participate. Results may help doctors choose the best method for d…

This study is testing a special MRI technique that uses a substance called hyperpolarized pyruvate to help doctors find aggressive prostate cancer. The goal is to see if this scan can tell the difference between high-grade and low-grade cancer, as well as normal tissue. About 80 …

This study involves 30 men with advanced prostate cancer who are already scheduled for a standard treatment called 177Lu-PSMA therapy. Researchers want to see if a newer type of PET scan (18F-DCFPyL) can detect cancer spots as well as the current standard scan (68Ga-PSMA-11). The…

This study tests whether a new PET-CT scanner (RefleXion X1) can detect prostate cancer as well as standard scanners. About 25 men with prostate cancer who are already scheduled for a standard PSMA-PET scan will get an extra scan on the new machine the same day. The goal is to se…

This study tests a new type of MRI scan for prostate cancer that does not require a coil placed in the rectum. The goal is to see if this method can accurately detect aggressive prostate cancers while reducing unnecessary biopsies. About 258 men with intermediate- or high-risk pr…

This study compares two ways to use MRI scans to guide prostate biopsies: one uses computer software to merge MRI and ultrasound images, the other relies on the doctor's visual estimate. The goal is to see which method finds more clinically significant prostate cancers. About 1,3…

This study is testing a new type of MRI scan to see if it can find prostate cancer more accurately than current methods. About 2000 men with suspected prostate cancer will get this special MRI, and the results will be checked against standard biopsies. The goal is to develop a be…

This study aims to find out if prostate MRI is better than a set of lab tests (like PSA) at detecting serious prostate cancer in men who have not been diagnosed yet. About 950 men scheduled for a biopsy will get both an MRI and lab tests, and researchers will compare which method…

This study tests a special PET/CT scan that uses a radioactive tracer to find prostate cancer that has spread to nearby lymph nodes. It involves 380 men with newly diagnosed high-risk prostate cancer who are planning to have their prostate removed. The goal is to see how accurate…

This study tests a new type of PET scan using a radioactive tracer called 64Cu-SAR-bisPSMA to see if it can better detect prostate cancer that has spread to nearby lymph nodes. About 383 men with high-risk prostate cancer who are planning to have their prostate removed will get t…

This study tests a new contrast agent called Gadopiclenol (Elucirem) to see if it improves MRI scans for finding aggressive prostate cancer. About 150 men scheduled for a prostate MRI with contrast will receive this agent. The goal is to see if it provides clearer images and bett…

This study tests a new imaging agent, 68Ga-P16-093, against the standard 68Ga-PSMA-11 for detecting prostate cancer. About 50 men with untreated prostate cancer will receive both PET scans within a week. The goal is to see which agent finds more tumors and gives clearer images.

This study is testing a new type of PET scan that uses a special tracer to find a protein called Trop2 on cancer cells. The goal is to see if this scan can detect and monitor many types of solid tumors more accurately than current methods. About 400 adults with or suspected of ha…

This study is testing whether a special type of PET scan (PSMA-PET CT) can accurately rule out dangerous prostate cancer in men who are already on active surveillance (watchful waiting). Researchers will compare scan results with yearly biopsies in 200 men with low- or favorable …

This study tests a new approach for men with a moderate risk of prostate cancer. Instead of getting an immediate biopsy, participants will be monitored with regular PSA tests and MRI scans. The goal is to see if this strategy can safely avoid unnecessary biopsies and overdiagnosi…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including breast, lung, and colon cancer. Researchers want to see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before symptoms appear. About …

This study is testing new types of MRI scans to see if they can more accurately find and grade prostate cancer without using a contrast dye. About 300 men with suspected prostate cancer will get both standard and new MRI scans. The results will be checked against biopsy or surger…

This study is testing a new imaging tracer called 18F-PSMA-1007 for PET/CT scans to see if it can better detect where prostate cancer has spread in the body. About 2800 adults who have already had treatment for prostate cancer (such as surgery or radiation) and have signs that th…

This study tests a new way to decide who needs a prostate biopsy. Instead of relying only on MRI, it adds a blood test called Prostate Health Index (PHI) to better tell which men have dangerous prostate cancer. The goal is to safely skip biopsies in men who don't need them, reduc…

This study tests whether a special PET/CT scan (PSMA PET/CT) can more accurately find cancer spread to lymph nodes in men with intermediate- or high-risk prostate cancer before they have surgery. Current scans often miss this spread, leading to incomplete treatment. About 159 par…

This study looks at whether adding a special PET/CT scan (rhPSMA-7.3) to the usual MRI can better find aggressive prostate cancer in men with low-risk cancer who are monitoring their disease. About 120 men will get both scans before a confirmatory biopsy. The goal is to see if th…

This study tests whether combining two types of scans (PSMA PET and MRI) can find prostate cancer better than the usual methods. About 204 men with suspected prostate cancer will get the combined scan, and results will be checked against tissue samples. The goal is to see if this…

This study aims to see if a new type of PET scan, called 68Ga-XACP3 PET/CT, can find prostate cancer tumors as well as or better than the current standard scan (68Ga-PSMA PET/CT). About 60 adults with newly diagnosed, suspected recurrent, or previously treated prostate cancer wil…

This study is testing whether a special type of MRI (called bpMRI) can help find prostate cancer earlier in men who are at high risk. The study includes 100 men with slightly elevated PSA levels who are Black, have a family history of prostate cancer, or have certain genetic risk…

This early-stage study tests whether a special imaging tracer, made of tiny silica nanoparticles, can safely help surgeons find prostate cancer cells before and during surgery. About 16 men with high-risk prostate cancer will receive the tracer and then have PET/MRI scans and a s…

This study tests a new MRI platform that adds about 15 minutes to a standard prostate scan. Researchers want to see if it is safe and can collect detailed images to help find prostate cancer. About 75 men aged 40-90 with elevated PSA levels will take part.

This early-stage study tests a new imaging drug called Flotufolastat F-18 in 6 healthy Chinese adults. The drug is a radioactive tracer that helps spot prostate cancer cells on PET scans. The goal is to check its safety, how it spreads in the body, and the radiation dose received…

This early-stage study tests a new radioactive tracer called 68Ga-FC516 for PET/CT scans. It includes 10 participants—healthy adults and prostate cancer patients—to check safety, how the tracer spreads in the body, and how well it spots tumors compared to existing tracers. The go…

This study tests a robot-assisted ultrasound biopsy to improve how prostate cancer is detected. About 483 men who need their first prostate biopsy will take part. The robot aims to make biopsies more precise and reduce the chance of missing dangerous cancers.

This study aims to see if a special scan (PSMA PET/MRI) can better find aggressive prostate cancer than standard biopsies in men whose MRI looks normal but still have a high suspicion of cancer. About 100 men will get both the new scan-guided biopsies and standard biopsies. The g…

This study tests a special probe that measures electrical signals to see if any prostate cancer tissue remains after the prostate is removed. About 200 men having prostate cancer surgery will take part. The goal is to help surgeons remove all cancer in one operation.

This study tests a new radioactive tracer called 64Cu-GRIP B that lights up immune activity in PET scans. It aims to see if the tracer is safe and can help detect which advanced cancers (like prostate, kidney, or bladder) are more likely to respond to immunotherapy. About 91 adul…

This study looks at whether a person's inherited genetic risk can help predict if they have prostate cancer. About 1,000 men aged 40 to 69 who are scheduled for a prostate biopsy will have their genetic risk scored as high, medium, or low. Researchers will then compare how often …

This study tests a computer program developed at the University of Chicago that creates risk maps from MRI scans of the prostate. The goal is to see if this tool helps doctors decide where to biopsy more accurately than current methods. About 180 adults with known or suspected pr…

This study is testing a special type of PET scan to see if it can accurately find prostate cancer that has come back after a patient has received targeted focal therapy. Researchers will compare the scan results to biopsy results taken one year after treatment to check its accura…

This study is testing whether a genetic test can help doctors better screen men for prostate cancer. Current screening methods often lead to false alarms and unnecessary biopsies. The trial will enroll 5,000 male Veterans aged 55-69 to see if genetic risk information can identify…

This study tests different ways to help Black or African American men aged 40 and older get screened for prostate cancer. Participants will receive either passive navigation, active navigation, or community-based screening to see which method works best. The goal is to increase t…

This study tests a precise radiation technique for men with low- to intermediate-risk prostate cancer. The treatment adjusts daily to avoid the urethra, the tube that carries urine out of the body. The goal is to reduce short-term urinary side effects compared to standard radiati…

This study tests a new technique called 'Spot Delete' in proton therapy for low- and intermediate-risk prostate cancer. The goal is to reduce side effects like diarrhea, rectal bleeding, and bladder problems by preventing proton beams from stopping in the bowel and rectum. The st…

This study looks at whether intermittent fasting (with or without a plant-rich diet) is practical for men with prostate cancer who are receiving hormone therapy. Researchers will track how many patients join, stick with the diet, and follow it correctly. The goal is to see if thi…

This study tests a program called MyCarePulse and ASCENT that helps cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either get the program or standard care. Researchers will check if the program improves food securit…

This study tests a digital exercise program designed to help prostate cancer patients on hormone therapy stick with physical activity. Side effects like weight gain, muscle loss, and fatigue are common, and exercise can help, but many patients struggle to keep it up. The trial wi…

This study tests whether men recovering from robotic prostate surgery can manage pain without automatically receiving opioid painkillers. Participants are counseled on pain management and then randomly assigned to either receive a standard opioid prescription plus other pain medi…

This study tests if a home-based exercise program can improve heart and lung fitness in men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy). The study will compare 60 men who exercise at home to those who receive only healthy living education…

This pilot study tests if brodalumab, a drug approved for autoimmune diseases, can safely reduce severe side effects caused by cancer immunotherapy. About 11 adults with various solid tumors who have immune-related side effects will receive brodalumab. The goal is to see if it lo…

This study compares two radiation therapy methods for prostate cancer: adaptive radiotherapy, which adjusts daily to changes in the body, and conventional radiotherapy. The goal is to see if adaptive treatment reduces side effects like digestive and urinary problems. About 188 me…

This study compares two types of radiation therapy for localized prostate cancer: a newer ultra-short course versus a standard shorter course, both combined with a precise internal radiation boost. Researchers want to see if the ultra-short approach causes fewer urinary and bowel…

This study looks at whether daily text message reminders to do pelvic floor exercises can help men recover bladder control faster after prostate surgery. About 132 men who are scheduled for prostate surgery will be split into two groups: one gets the text reminders, the other doe…

This study looks at two types of radiation therapy (proton and photon) given after prostate cancer surgery. The goal is to see if proton therapy causes fewer bowel side effects and improves quality of life. About 900 men who need radiation after their prostate removal will take p…

This study tests a new, technology-supported care plan for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) along with other health problems. The goal is to see if this approach improves their quality of life after 6 months. About 720 participants …

This study tests a precise radiation technique for prostate cancer that aims to protect the nerves and blood vessels needed for erections. About 200 men will get either standard or this 'neurovascular-sparing' radiation. The goal is to see if the new method reduces sexual side ef…

This study is for men with intermediate-risk prostate cancer. It compares standard radiation given in two sessions to a lower-dose version, both using advanced MRI-guided technology. The goal is to see if the lower dose causes fewer urinary side effects while still controlling th…

This study tests a highly precise radiation therapy for men with low- or intermediate-risk prostate cancer. The goal is to deliver radiation to the tumor while carefully avoiding areas important for erections, such as nerves and blood vessels. 70 men will receive 5 sessions of MR…

This study looks at whether adding neuromuscular electrical stimulation to a physical activity program can help men on hormone therapy for prostate cancer keep their leg muscle strength. About 48 men who have been on hormone therapy for at least 26 weeks will take part. Researche…

This study tests a device that uses mild electrical pulses to calm bladder nerves in men with overactive bladder. About 150 men will use the device for up to a year. The goal is to reduce sudden urges to urinate and improve quality of life.

This study tests a simple, low-cost method: placing ice inside the rectum before a prostate biopsy to see if it lowers pain, anxiety, stress hormone levels, and complications like bleeding. About 84 adults having their first prostate biopsy will take part. The goal is to make the…

This study compares two radiation schedules for men whose prostate cancer has returned after surgery. One schedule uses fewer, higher-dose sessions (ultra-hypofractionated), while the other uses a standard moderate approach. The goal is to see which one leads to better quality of…

This study tests whether placing a special cord tissue graft during robotic prostate surgery helps men regain bladder control and erections faster. About 100 men with early prostate cancer will be randomly assigned to receive the graft or standard surgery alone. The goal is to im…

This study tests a program called PC-PEP in 400 men who have had prostate cancer. The program teaches life skills and healthy habits to improve mental health, fitness, and quality of life, and to reduce side effects from treatment. Participants will complete online surveys to tra…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. The study will involve 172 participants…

This study tests a nationwide virtual clinic called SHAReClinic that provides education and counselling to help prostate cancer patients and their partners manage sexual health after treatment. About 575 people will take part, using online modules and surveys to track changes in …

This study is testing a mobile health app designed to help Black men who have had prostate cancer feel better and track their quality of life. About 248 participants will use the app and share feedback on how easy it is to use and how it affects their physical, emotional, and soc…

This study tests a 12-week home-based rehabilitation program for men with advanced prostate cancer living in rural areas. The program includes exercise and support to help manage side effects from hormone therapy and improve quality of life. About 30 participants will use video c…

This study looks at whether a new robotic surgery system that gives surgeons a sense of touch (force feedback) helps them learn faster and operate more safely. About 60 men with localized prostate cancer will have their prostate removed by robot. Half of the surgeries will use th…

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The goal is to see if the program is safe and feasible. About 30 men will take par…

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR only, aromatherapy only, both, or standard car…

This study tests whether a 16-week supervised exercise program (circuit training with resistance, functional, and aerobic exercises) can improve frailty, muscle loss, and inflammation in men with metastatic prostate cancer who are on hormone therapy. The study will include 80 men…

This study tests whether adding acupuncture to standard anti-nausea medicine can better control nausea caused by chemotherapy. About 90 adults with various cancers who still feel sick despite medication will either receive acupuncture plus medicine or medicine alone. Researchers …

This study tests a new way to give radiation for prostate cancer. Instead of treating the whole prostate, doctors will focus the radiation only on the tumor. The goal is to see if this causes fewer short-term side effects like bladder or bowel problems. About 150 men with interme…

This study tests whether a structured nurse-led education session and direct referral to pelvic floor physiotherapy before prostate removal surgery can reduce urine leakage afterward. About 80 men scheduled for prostate cancer surgery will be randomly assigned to either standard …

This study tests whether a drug called 4-aminopyridine can help men recover faster from nerve damage caused during prostate cancer surgery. The trial includes 70 men aged 45-75 who are having robotic prostatectomy. The goal is to see if the drug improves bladder control and sexua…

This study tests if fezolinetant, a drug used for hot flashes in women, can reduce hot flashes in men with prostate cancer who are on hormone therapy. About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency, severity, and …

This study tests whether a telehealth exercise program can reduce cancer-related fatigue in rural breast and prostate cancer survivors. About 134 participants will receive personalized virtual exercise coaching and collect small blood samples at home to track changes. The goal is…

This early-phase study tests whether lisinopril, a blood pressure medicine, can reduce urinary side effects in men receiving radiation for prostate cancer. About 30 men will take lisinopril during and after treatment, and researchers will track their urinary symptoms and biomarke…

This study compares two different approaches to help men regain erectile function after prostate cancer surgery. About 224 men who had surgery within the past 9 months will participate. The goal is to see which method leads to better sexual rehabilitation outcomes.

This study compares two different radiation schedules for men with low- or favorable-risk prostate cancer. The standard approach uses 5 treatments, while the experimental approach uses just 2. The goal is to see if the shorter course can maintain sexual quality of life just as we…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at why some prostate cancers do not respond to a type of targeted radiation therapy called PSMA radioligand therapy. Researchers will use scans and tumor samples from 125 people to measure radiation doses and check gene activity. The goal is to learn more about r…

This study looks at whether a new telehealth program can safely reduce the number of in-person visits for people with breast or prostate cancer. About 1,750 patients will be assigned to either standard care or enhanced telehealth. The goal is to see if telehealth can save time an…

This study looks at whether a blood test can find tiny bits of tumor DNA in men with high-risk prostate cancer before they have surgery to remove the prostate. About 24 men will give blood samples, and researchers will check if the DNA test can help predict if the cancer might co…

This study looks at whether a special blood test can find tiny bits of cancer DNA left behind after prostate removal surgery in men with high-risk prostate cancer. The goal is to see if this test can better predict if the cancer will come back early. About 50 men will provide blo…

This study follows 200 men with prostate cancer who are on active surveillance (monitoring instead of immediate treatment). It compares those with higher genetic risk to those with average risk to see how their cancer changes over time. The goal is to learn whether genetic factor…

This study tests a special needle that uses light and sound to check prostate tissue during a standard biopsy. The goal is to see if it can reliably tell the difference between healthy and cancerous areas without taking extra samples. About 50 men scheduled for a prostate biopsy …

This study aims to improve how doctors choose treatments for aggressive prostate cancer. Researchers will grow 3D mini-tumors from patient samples and test different therapies on them to see which works best. The goal is to find the most effective lab technique for predicting ind…

This study looks at how hormone treatments for prostate and breast cancer affect sleep quality. Researchers will track 60 patients using sleep tests, questionnaires, and activity monitors before treatment starts, at 6 months, and again at 12 months. The goal is to see if these tr…

This study looks at how different Mediterranean-style diets affect the body's metabolism in men with early-stage prostate cancer who are not yet receiving treatment. Researchers will provide special meals to 30 men and measure changes in their prostate tissue and blood. The goal …

This study is testing new MRI techniques to see if they can detect prostate cancer more accurately than current scans. Researchers will compare different mathematical models of MRI images with detailed tissue analysis. The study involves 300 men with prostate cancer who are sched…

This study is observing how doctors in Russia treat a specific type of advanced prostate cancer (metastatic hormone-sensitive) and what biological markers (biomarkers) are present. It will involve 400 men and will not test any new treatments—it simply collects information from me…

This study looks at whether a special type of PET scan (PSMA-PET) can find early signs of prostate cancer that has spread to other parts of the body. It involves 60 men who had a high genetic risk score from a previous study. The goal is to see how well the genetic test matches w…

This study checks if a few drops of blood on paper (dried blood spots) can accurately measure levels of certain prostate cancer drugs. About 100 patients on these medications will provide both standard blood samples and dried blood spots for comparison. If successful, this could …

This study aims to create a better way to screen for prostate and bladder cancer using artificial intelligence (AI). Researchers will test this new screening system in 3,000 men aged 50 and older who live in Beijing. The goal is to catch cancer earlier and improve the entire proc…

This study looks at men with high-risk prostate cancer that appears on only one side of the prostate. It compares removing lymph nodes from just that side versus both sides during robotic prostate surgery. The goal is to see if the less extensive surgery causes fewer complication…

This study follows over 4,000 men with prostate cancer to see if those with rare gene mutations (like BRCA) have different outcomes than those without. Researchers collect medical records and tumor samples to compare survival and cancer progression. The goal is to learn how these…

This study creates a database to record how well freezing therapy (cryotherapy) works for men with early-stage prostate cancer that hasn't spread. Researchers will track 1,000 participants over time to see how long they live without their PSA levels rising. The goal is to better …

This study follows 106 men who have had surgery for prostate cancer to see how their bladder control, sexual function, and overall health improve over time. Participants receive standard care resources and are monitored for physical activity, fitness, and quality of life. The goa…

This study looks at whether artificial intelligence (AI) can help doctors find prostate cancer on MRI scans. About 150 men aged 55 to 80 who are scheduled for a prostate biopsy will take part. Researchers will compare how well radiologists detect cancer with and without AI assist…

This study aims to map the genetic makeup of breast and prostate cancers in patients treated through Brazil's public health system. Researchers will analyze tumor and normal DNA from 882 participants to build a national database for future precision medicine. The goal is to under…

This study gathers medical records and scan results from 10,000 men with prostate cancer or high risk. Researchers aim to find patterns in imaging that could lead to better diagnosis and treatment. No new drugs or procedures are tested; it is purely an observational data-collecti…

This study tests whether special PET scans can better find where prostate cancer has spread in the body. About 300 men with progressive prostate cancer will receive two types of radiotracers before imaging. The goal is to see if these scans are more accurate than standard tests l…

This study is looking at whether a blood test that finds prostate cancer cells can give similar information as a special PET scan. About 80 men with prostate cancer will give a blood sample before their PET scan. Researchers will compare the results to see if the blood test can h…

This study aims to create and improve educational materials about genetic testing for people with breast, ovarian, prostate, pancreatic, or colorectal cancer. Researchers will interview 445 participants from diverse cultural and language backgrounds to get their feedback. The goa…

This pilot study looks at whether a simple educational session can increase the number of Black men with high-risk prostate cancer who complete genetic testing. Researchers will enroll 50 men who identify as Black or multiracial, provide a brief teaching session on genetic testin…

This study collects blood samples from 1,000 men with prostate cancer to look for genetic differences that may explain why some cancers stop responding to hormone therapy. Participants give blood during clinic visits, and researchers analyze DNA and other genetic material. The go…

This study is creating a culturally tailored online program to help African American cancer survivors understand and decide about genetic counseling and testing. About 85 participants from Detroit who have had breast, prostate, or colorectal cancer will try the program and answer…

This study is looking for substances in urine that might help doctors predict how well prostate cancer treatments will work. Researchers will collect urine samples from 360 men with prostate cancer who are receiving standard treatments like surgery, radiation, chemotherapy, or ho…

This study is a large international registry that will follow at least 5,000 men with advanced prostate cancer for five years. Researchers will collect information on treatments, side effects, and quality of life to understand what works best in real-world settings. Participants …

This study uses special PET/CT scans to see how advanced prostate cancer tumors become resistant to newer hormone therapies like enzalutamide or abiraterone. About 25 men with advanced prostate cancer who are starting or already on these treatments will get multiple scans over 9 …

This study aims to prove that a gene test can identify oxygen-starved (hypoxic) tumours in real time for bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, plus undergo MRI scans. If successful, doctors could tailor stronger treatme…

This study looks at two standard treatments for high-risk prostate cancer that hasn't spread: robot-assisted surgery and radiation therapy (often with hormone therapy). The goal is to see which one offers better quality of life, fewer side effects, and better cancer control. Abou…

This study compares three surgical methods for removing the prostate in men with prostate cancer: robot-assisted, standard laparoscopy, and open surgery. It will enroll 2,000 participants to measure which technique leads to better urinary function after surgery. The goal is to pr…

This study follows 120 men with advanced prostate cancer to see if markers in their blood can predict how well they respond to hormone therapy. Researchers will collect blood samples and compare markers from those who respond well to those who don't. The goal is to develop a test…

This study is testing whether an artificial intelligence (AI) model can accurately predict if high-risk prostate cancer has spread to nearby lymph nodes. Researchers will analyze MRI scans, tissue samples, and clinical data from 2,000 men aged 50 and older with aggressive prostat…

This study is developing and testing an educational tool to help men aged 65 and older with prostate cancer decide with their doctors whether to reduce the frequency of monitoring tests like biopsies or scans. The goal is to see if the tool is easy to use and helpful for making i…

This study is creating and testing a simple, patient-friendly tool to help Black or African American men with metastatic prostate cancer understand genetic testing for their tumors. Researchers want to see if the tool makes it easier for patients to learn about testing options an…

This study follows 2000 men with prostate cancer who have certain gene changes. Researchers want to learn how these genes affect the cancer's growth and response to treatment. Participants are contacted every 6 months and provide medical records, blood, urine, and tumor samples. …

This study collects blood, urine, saliva, and tumor tissue from men with or suspected to have prostate cancer. Researchers will analyze these samples to learn how cell and gene changes cause prostate cancer to develop and grow. The goal is to find new ways to treat the disease. U…

This study is a long-term registry that will follow 5000 men with prostate cancer that has come back or spread. It includes four groups: men with a rising PSA after initial treatment, those whose cancer resists hormone therapy but hasn't spread, those with newly spread cancer, an…

This study will collect and analyze tumor samples from 5,500 men with high-risk or advanced prostate cancer. Researchers will use genetic and imaging tests to find markers that predict how well different treatments work. The goal is to learn more about the disease, not to test a …

This study is testing whether an artificial intelligence (AI) tool can automatically measure the amount of prostate cancer seen on special PET-CT scans. Researchers want to see if these AI measurements can predict how long patients will live or when the cancer might come back. Th…

This study is looking for markers in the blood that might help doctors predict how well a prostate cancer patient will respond to treatment. Researchers will collect blood samples from 600 men at different stages of prostate cancer and analyze them for certain biomarkers. The goa…

This study looks at whether giving cancer patients more personalized help (high-intensity navigation) makes them more likely to join a clinical trial compared to standard help (low-intensity navigation). About 90 adults with prostate or kidney cancer will take part. The goal is t…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. It does not provide any treatment. Up to 1,750 participants will give blood samples, and some may also provide tissue, urine, or stool. The …

This study looks at whether a blood test can detect tiny cancer cells shed by prostate tumors. Researchers will compare the number of these cells before and after surgery in 200 men with early-stage prostate cancer. The goal is to see if the test can help predict how the cancer b…

This study looks at tumor samples from 150 Native American patients with prostate cancer. Researchers will compare their genetic profiles to those of Caucasian patients to find differences that may affect treatment and outcomes. The goal is to better understand how genes influenc…

This study aims to develop a computer model that uses MRI scans and patient information to predict whether a man has clinically significant prostate cancer (csPCa). Researchers will analyze data from 3,000 men who had an MRI and a prostate biopsy. The goal is to create a tool tha…

This study follows men with metastatic prostate cancer who are receiving standard treatment with abiraterone and prednisone. Researchers want to see if a person's race or ethnicity affects how well the treatment works. The study will track PSA levels and genetic differences for u…

This study is for men with high-risk prostate cancer who will receive treatment before surgery. It tests a special type of MRI scan that looks at how cancer cells use energy. The goal is to see if this scan can detect early signs that the treatment is working, helping doctors mak…

This study looks at a radioactive treatment called 177Lu-PSMA-617 for men with advanced prostate cancer that has spread. Researchers want to measure how much radiation the tumor and healthy organs receive, and see if that affects how well the treatment works or causes side effect…

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, it checks their health once a year for 15 years to watch for any long-term side effects. Up to 750 participants with various cance…

This study is testing a new way to screen for dangerous prostate cancer. It combines a person's genetic risk score with a special MRI to find higher-grade cancers that could be life-threatening. About 1,500 men aged 40-69 with no prior prostate cancer will get a PSA blood test, a…

This study looks at whether giving breast, prostate, and colorectal cancer survivors a personal referral to a nutrition and exercise program helps them eat better and move more. About 306 survivors and their healthcare providers will take part. The goal is to see if survivors agr…

This study looks at how a new, more sensitive type of PET scan (PSMA PET) affects the anxiety, decision-making, and quality of life of 350 men with prostate cancer. Researchers will survey participants at three time points over a year to understand their experiences. The goal is …

This study looks at how well African American men newly diagnosed with early-stage prostate cancer understand what their doctor tells them about treatment options and side effects. Researchers will give some patients an easy-to-read educational handout after their doctor visit an…

This study compares two imaging methods—micro-ultrasound and MRI—for monitoring prostate cancer in men on active surveillance. About 210 men with low-risk prostate cancer will receive both types of scans and biopsies to see which method better detects cancer progression. The goal…

This study is testing a special MRI scan that uses a substance called hyperpolarized pyruvate to see how well it can monitor prostate cancer in men who have chosen active surveillance (no immediate treatment). The goal is to see if this scan can detect changes in tumor cells more…

This study looks at how SPECT imaging can help doctors better understand where radiation therapy goes in the body and how much reaches healthy organs. Researchers will scan 80 people with advanced prostate or other cancers who are already receiving standard radiation treatments. …

This study looks at whether watching a video before genetic testing helps people with certain cancers understand their hereditary risk better. About 1020 adults with breast, ovarian, pancreatic, prostate, colorectal, renal, melanoma, or sarcoma cancers will take part. Researchers…

This study follows 1,500 men newly diagnosed with prostate cancer to see how different treatments affect their quality of life and side effects over time. Researchers will collect health data and patient surveys to compare standard treatments like surgery and radiation with newer…

This study observes 400 men with aggressive, high-volume metastatic hormone-sensitive prostate cancer in Russia. It tracks which treatments doctors choose and tests blood for genetic changes. No new treatment is given; the goal is to learn about current care patterns and genetic …

This study is testing a special MRI technique that uses a substance called hyperpolarized 13C-Pyruvate to take detailed pictures of prostate cancer before, during, and after radiation therapy. The goal is to see if this imaging method can show how the cancer is responding to trea…

This study looks at a community-based program to help adults who often miss cancer screenings get tested for lung, breast, and prostate cancers at local resource spots. About 200 adults who meet screening guidelines will take part. The goal is to see if this approach increases sc…

This study is for people already in the SYNERGY-201 trial for prostate cancer. It aims to find out if a biomarker called CXCR2 can predict who will benefit from the study drugs. Researchers will collect blood samples and optional tumor biopsies to track changes over time. The goa…

This study looks at whether exposure to chlordecone, a pesticide used in the French West Indies until 1993, is linked to prostate cancer. Researchers will compare 3600 men in Martinique—half with prostate cancer, half without—measuring chlordecone levels in blood and through ques…

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance (monitoring the cancer instead of treating it right away). Researchers will use remote check-ins and build a tissue and data bank to better understand which cancers progress. The …

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial help. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it reduces financial stress a…

This study tests whether visual decision aids help urologists better discuss risks and benefits of surgery with patients who have prostate or kidney cancer. About 20 doctors and 200 patient visits will be recorded and analyzed. The goal is to see if these tools improve communicat…

This study collects blood or cheek swab samples from people with cancer who are already in treatment at the National Cancer Institute. Researchers will analyze the DNA to find genetic differences that may affect how the body processes cancer drugs and whether side effects occur. …

This study creates a large database of men with prostate cancer who choose prostate ablation (a minimally invasive treatment) instead of active surveillance or more aggressive therapies. Researchers will collect medical records from up to 3,000 participants to see how well ablati…

This study looks at whether patient navigators—people who guide and support patients through their care—can help more African American, Native American, and Hispanic patients complete radiation therapy for breast or prostate cancer. About 420 adults will take part. The goal is to…

This study looks at whether elderly men (70+) with prostate cancer who have been on hormone therapy for over 3 years can stop taking it. The idea is that their bodies may already be permanently unable to produce testosterone, so the shots may no longer be needed. Researchers will…

This study compares regular MRI scans to the usual monitoring for men with low-to-medium risk prostate cancer who choose active surveillance. Over 5 years, researchers will see if MRIs catch cancer progression earlier and reduce the need for biopsies and clinic visits. About 1,26…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study looks at how well African American and rural White men understand genetic information related to prostate cancer. Researchers will use educational videos and surveys to measure genetic literacy and knowledge. The goal is to help men make more informed treatment decisio…

This study looks at whether a new imaging analysis tool, called TRAQinform Theranostics, can help doctors make better treatment decisions for people with metastatic prostate cancer. About 32 participants will have their treatment plans compared with and without the tool's report.…

This study looks at how cancer impacts not just the patient, but their entire family. Researchers will survey 240 Danish patients with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. The goal is to understand family health, needs, and emotional well…

This study is testing a new saliva-based DNA test called i4i PRODICT® to see how well it can estimate a person's future risk of prostate cancer. The test looks at both common and rare genetic changes. Researchers aim to recruit 1,000 men aged 40-55 from Black, South Asian, and Wh…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study is creating a large database of clinical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid cancer, prostate cancer, or neuroendocrine tumors. The goal is to provide researchers with valuable data to better understand these treat…

This study tests whether giving doctors AI-powered feedback on how they discuss treatment risks helps men with prostate cancer make better decisions. About 259 men and 24 doctors will take part. Doctors in the experimental group receive a report within 72 hours of each visit, gra…

This study tests whether a special PET scan (PSMA-PET) and a blood test for tumor DNA can detect prostate cancer progression earlier than the usual PSA blood test. About 50 men with prostate cancer that has spread to a few spots will get targeted radiotherapy. Researchers will th…

This study looks at whether a special type of scan (PSMA PET/MRI) is better than a standard MRI at finding prostate cancer that has come back one year after a treatment called High-Intensity Focused Ultrasound (HIFU). About 60 men who have already had HIFU for their prostate canc…

This study compares two ways to check for dangerous prostate cancer in men with elevated PSA: an upfront MRI or a risk calculator that uses machine learning. The goal is to see if the calculator is just as good at finding serious cancers while reducing unnecessary biopsies, MRIs,…

This study tests a new FDA-approved scanner that gives doctors a quick, high-resolution view of the prostate surface during surgery to find leftover cancer cells. The goal is to see if this method saves at least 20 minutes compared to the usual approach. About 78 men with interme…

This study follows 64 men with localized prostate cancer who are having keyhole surgery to remove their prostate. The goal is to track any complications that happen from the day of surgery up to 30 days later. The results will help doctors understand how safe this outpatient surg…

This study tests a new imaging method that uses sound waves to monitor proton radiation treatment in real time for prostate cancer patients. The goal is to see if this technique can accurately track where the radiation dose is delivered inside the body. 30 participants will recei…

This study looks at how to help veterans with advanced prostate cancer make informed decisions about precision oncology tests, which use genetic information to guide treatment. Researchers will develop and test a decision support tool to reduce confusion and improve understanding…

This study looks at how standard radiation treatment for prostate cancer changes MRI and PET scans, and how those changes relate to tumor cells in the blood. About 144 men with prostate cancer will have scans and blood tests before, during, and up to 2.5 years after treatment. Th…

This study compares two ways to take prostate biopsies in men with suspicious MRI findings: one where the doctor mentally fuses the MRI with live ultrasound, and another using special software to overlay the images. The goal is to see which method more accurately detects aggressi…

This study looks at how urological diseases and their treatments impact patients' work life. Researchers will survey 2000 adults admitted to a hospital in Poland, focusing on those who have major cancer surgeries or stone procedures. Participants will report their job status and …

This study looks at whether a genetic test can help doctors better assess prostate cancer risk in men who either have the disease or are at high risk. Researchers will analyze DNA from 3,000 men to find rare and common genetic changes linked to prostate cancer. The goal is to see…

This study is building a collection of prostate tissue samples from 200 people who have genetic mutations that raise their risk for aggressive prostate cancer, along with samples from people without those mutations. Researchers will compare the samples to learn how these genes af…

This study looks at whether men with prostate cancer who get hot flashes from hormone therapy will wear a smartwatch to track their symptoms. For 4 weeks, participants log hot flashes on the watch and complete daily surveys. The goal is to see if the watch data matches the survey…

This study looks at how the head-down position and gas used during robotic prostate surgery affect pressure inside the eye, which can reflect pressure in the brain. Researchers will measure the optic nerve sheath diameter using ultrasound in 50 men undergoing either robotic or op…

This study looks at whether advanced MRI scans can improve how doctors monitor prostate cancer in men who choose active surveillance (watching the cancer instead of treating it right away). About 500 men with low-risk prostate cancer will get regular MRIs alongside standard tests…

This study compares two advanced imaging techniques—PSMA PET/CT and MRI-RSI—against the current standard MRI for finding and outlining prostate tumors in 50 men with newly diagnosed, intermediate- to high-risk prostate cancer. The goal is to see if these newer methods improve tum…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study enrolls 222 men with low- to intermediate-risk prostate cancer to see if adding MRI and a genetic test helps them stick with active surveillance (monitoring the cancer instead of treating it right away). The goal is to improve safety and reduce unnecessary biopsies and…

This study looks at anxiety levels in men with low-risk prostate cancer who choose active surveillance (regular check-ups instead of immediate treatment) and their partners. Researchers will use questionnaires to measure anxiety and find out what factors contribute to it. The goa…

This study tests a smartphone app called Connect2Care to see if it helps African American men learn about prostate cancer and feel ready to get a PSA screening test. About 266 Black men aged 45 to 69 in Oklahoma who haven't been screened recently will use either the Connect2Care …

This study looks at the best times to send messages that encourage physical activity to older adults (65+) who have survived certain cancers and still have chronic pain. Researchers will track activity with a wearable device and ask participants to rate their pain four times a da…

This study aims to understand the genetic and molecular causes of breast and prostate cancer in people of African ancestry. Researchers will collect blood and tumor samples from 1,500 participants across nine countries and the US, along with information about lifestyle and social…

This study aims to use advanced PSMA-PET scans combined with artificial intelligence to discover new imaging biomarkers that can predict how prostate cancer will progress and respond to treatment. Researchers will collect scan data and follow-up information from 1000 men with pro…

This study looks at why some prostate cancers return after radiation treatment. Researchers will use detailed MRI scans and tissue samples to see how tumors respond to radiation. The goal is to better understand treatment failures and help doctors choose the best next steps for e…

This study aims to see if specially trained radiographers can make decisions about prostate MRI scans as well as radiologists. Currently, a shortage of radiologists means patients often get unnecessary contrast injections and extra scans. The study will compare decisions made by …

This study is testing whether short educational videos can help Spanish-speaking Latinx patients with breast or prostate cancer better understand radiation therapy and feel more comfortable about joining clinical trials. About 194 participants will watch a video or read a brochur…

This study is testing whether a special PET/CT scan using a radioactive tracer called 18F-DCFPyL can find prostate cancer that has come back after initial treatment. About 350 men whose cancer has returned will be scanned and followed for up to 5 years. The goal is to see how wel…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…

This study collects information about how well different focal therapies work for prostate cancer. Researchers will track 200 patients who receive treatments like ultrasound, freezing, or laser therapy. The goal is to understand treatment patterns, side effects, and quality of li…

This study aims to understand the real-world picture of prostate cancer in Algeria. Researchers will observe 2,000 patients to learn about their backgrounds, how they were diagnosed, and what treatments they receive. The goal is to gather information to help improve future care, …

This study aims to learn from the real-world experiences of over 500 patients with advanced prostate cancer. It looks back at medical records to see how well three different types of modern drug treatments worked in everyday practice. The goal is to gather knowledge that can help…