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New prostate cancer trial aims to tailor treatment with Cutting-Edge imaging and DNA tests

NCT ID NCT06282588

Recruiting now Disease control Sponsor: Cancer Research Antwerp Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

The THUNDER trial is testing whether using advanced PET scans and a genetic test (Decipher) can help doctors choose the right treatment for high-risk prostate cancer. About 493 men will either get stronger treatment if their scans or genetic score show high risk, or less intense treatment if they appear lower risk. The goal is to improve survival and quality of life by personalizing care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Darolutamide, goserelin, radiotherapy
What this could lead to
If successful, this could lead to more personalized treatment for high-risk prostate cancer, potentially improving survival and reducing side effects.
What could go wrong
This is an early-phase trial with a long follow-up (7-8 years), so results are uncertain. The treatments have known side effects like fatigue, hot flashes, and sexual dysfunction.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AZ Delta

    RECRUITING

    Roeselare, 8800, Belgium

  • AZ Groeninge

    RECRUITING

    Kortrijk, 8500, Belgium

  • AZ Sint-Jan

    RECRUITING

    Bruges, 8000, Belgium

  • AZORG

    RECRUITING

    Aalst, 9300, Belgium

  • CHU Liège

    RECRUITING

    Liège, 4000, Belgium

  • Saint Luc

    RECRUITING

    Brussels, 1200, Belgium

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • VITAZ

    RECRUITING

    Sint-Niklaas, 9100, Belgium

  • ZAS Sint-Augustinus

    RECRUITING

    Wilrijk, Antwerp, 2610, Belgium

    Contact Email: •••••@•••••

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