New prostate cancer trial aims to tailor treatment with Cutting-Edge imaging and DNA tests
NCT ID NCT06282588
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
The THUNDER trial is testing whether using advanced PET scans and a genetic test (Decipher) can help doctors choose the right treatment for high-risk prostate cancer. About 493 men will either get stronger treatment if their scans or genetic score show high risk, or less intense treatment if they appear lower risk. The goal is to improve survival and quality of life by personalizing care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Darolutamide, goserelin, radiotherapy
What this could lead to
If successful, this could lead to more personalized treatment for high-risk prostate cancer, potentially improving survival and reducing side effects.
What could go wrong
This is an early-phase trial with a long follow-up (7-8 years), so results are uncertain. The treatments have known side effects like fatigue, hot flashes, and sexual dysfunction.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AZ Delta
RECRUITINGRoeselare, 8800, Belgium
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AZ Groeninge
RECRUITINGKortrijk, 8500, Belgium
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AZ Sint-Jan
RECRUITINGBruges, 8000, Belgium
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AZORG
RECRUITINGAalst, 9300, Belgium
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CHU Liège
RECRUITINGLiège, 4000, Belgium
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Saint Luc
RECRUITINGBrussels, 1200, Belgium
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UZ Gent
RECRUITINGGhent, 9000, Belgium
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VITAZ
RECRUITINGSint-Niklaas, 9100, Belgium
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ZAS Sint-Augustinus
RECRUITINGWilrijk, Antwerp, 2610, Belgium
Contact
Contact Email: •••••@•••••