Can precision protons spare the bowel in prostate cancer?

NCT ID NCT05350475

Ongoing Disease control Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether proton therapy, a more precise form of radiation, causes fewer long-term bowel side effects than standard photon therapy in men with high-risk prostate cancer. Participants receive the same radiation dose and schedule, but one group gets protons and the other photons. The study tracks bowel, urinary, and sexual side effects over two to five years to see if protons improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton therapy compared to standard photon radiation therapy
What this could lead to: If protons reduce long-term bowel side effects, this could establish proton therapy as a better standard for high-risk prostate cancer, improving quality of life.
What could go wrong: The trial is relatively small and early, and results may not show a significant difference. Proton therapy may not be widely available or cost-effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer radiation injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER RADIOTHERAPY SIDE EFFECT

Contacts and locations

Locations

Department of Oncology, Aarhus University Hospital

Aarhus, Central Region, 8200, Denmark
Department of Oncology, Copenhagen University Hospital Herlev

Herlev, Capital Region, DK-2730 Herlev, Denmark
Department of Oncology, Odense University Hospital

Odense, Region South, 5000, Denmark
Department of Oncology, Vejle Hospital, Denmark

Vejle, Region South, Denmark
Dept. of Oncology, Aalborg University Hospital

Aalborg, Region North, Denmark
Dept. of Oncology, Rigshospitalet, Denmark

Copenhagen, Capital Region, Denmark
Dept. of Oncology, Zealand University Hospital, Denmark

Næstved, Region Sjælland, Denmark

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