Could testosterone shots keep prostate cancer at bay?

NCT ID NCT06594926

Recruiting now Disease control Sponsor: Australian and New Zealand Urogenital and Prostate Cancer Trials Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether giving testosterone injections (bipolar androgen therapy) can delay the time it takes for prostate cancer to spread in men whose cancer is progressing despite standard treatment. About 69 men with non-metastatic castrate-resistant prostate cancer will receive testosterone every 8 weeks along with their usual darolutamide. The goal is to see if this approach extends metastasis-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: testosterone enanthate (a form of testosterone)
What this could lead to: If successful, this could offer a new way to delay cancer spread in men with prostate cancer that is resistant to standard hormone therapy.
What could go wrong: This is a small, early-phase trial with only 69 participants, so results may not apply broadly. Testosterone therapy can also cause side effects like increased PSA or tumor growth in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Cabrini Health
RECRUITING

Malvern, Victoria, 3144, Australia
Eastern Health - Box Hill
RECRUITING

Box Hill, Victoria, 3128, Australia
GenesisCare North Shore
RECRUITING

St Leonards, New South Wales, 2065, Australia
Grampians Health
RECRUITING

Ballarat, Victoria, 3350, Australia
ICON Cancer Centre
RECRUITING

Chermside, Queensland, 4032, Australia
Mater Misericordiae Ltd - QLD
RECRUITING

South Brisbane, Queensland, 4101, Australia
Northeast Health Wangaratta
RECRUITING

Wangaratta, Victoria, 3677, Australia
Royal Adelaide Hospital
RECRUITING

Adelaide, South Australia, 5000, Australia
St Vincents Hospital
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
Sydney Adventist Hospital
RECRUITING

Wahroonga, New South Wales, 2076, Australia
The Border Cancer Hospital
TERMINATED

Albury, New South Wales, 2640, Australia
The Canberra Hospital
RECRUITING

Garran, Australian Capital Territory, 2605, Australia

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