New hope for Hard-to-Treat cancers: enhertu studied in 20+ tumor types

NCT ID NCT07124000

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study is testing the drug T-DXd (Enhertu) in 100 adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. The goal is to see how well the drug works in real-world settings, including how many patients respond and for how long. The study covers many cancer types, such as bladder, cervical, ovarian, and pancreatic cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Trastuzumab deruxtecan (Enhertu)

What this could lead to

If successful, this could show that T-DXd is an effective treatment option for many types of HER2-positive cancers that have stopped responding to other therapies.

What could go wrong

This is an observational study, not a controlled trial, so results may be less definitive. The drug may not work for all tumor types, and side effects like lung inflammation are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma anal carcinoma anus neoplasm cervical cancer digestive system neoplasm digestive system neuroendocrine neoplasm endometrial cancer endometrium neoplasm esophageal cancer Esophageal Neoplasms gallbladder cancer gallbladder neoplasm gastrointestinal stromal tumor head and neck cancer Head and Neck Neoplasms liver cancer Liver Neoplasms malignant pancreatic neoplasm melanoma Mouth Neoplasms nasopharyngeal carcinoma oral cavity cancer ovarian cancer pancreatic neoplasm prostate cancer renal cell carcinoma salivary gland cancer sarcoma small cell lung carcinoma testicular cancer thyroid cancer Thyroid Neoplasms urethra cancer Urethral Neoplasms urinary bladder carcinoma Urinary Bladder Neoplasms Uterine Cervical Neoplasms vaginal cancer vulva cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site

    RECRUITING

    Birmingham, Alabama, 35243, United States

  • Research Site

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    Bullhead City, Arizona, 86442, United States

  • Research Site

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    Casa Grande, Arizona, 85122, United States

  • Research Site

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    San Diego, California, 92123, United States

  • Research Site

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    Boulder, Colorado, 80309, United States

  • Research Site

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    Coral Springs, Florida, 33065, United States

  • Research Site

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    St. Petersburg, Florida, 33714, United States

  • Research Site

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    West Palm Beach, Florida, 33401, United States

  • Research Site

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    Decatur, Illinois, 62526, United States

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    Topeka, Kansas, 66604, United States

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    Durham, North Carolina, 27708, United States

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    Wilson, North Carolina, 27893, United States

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    Canton, Ohio, 44718, United States

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    Maumee, Ohio, 43537, United States

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    Philadelphia, Pennsylvania, 19104, United States

  • Research Site

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    Nashville, Tennessee, 37203, United States

  • Research Site

    RECRUITING

    Dallas, Texas, 75390, United States