LIVER CANCER

This study is testing a new type of cell therapy for people with advanced solid tumors that have stopped responding to standard treatments. Doctors will analyze a patient's tumor to select a specific target, then infuse specially engineered immune cells (CAR-NK cells) from a heal…

This study is testing whether a new temperature-sensitive embolic agent works as well as the standard gelatin sponge for controlling liver cancer during TACE procedures. TACE is a minimally invasive treatment that delivers chemotherapy directly to the tumor and blocks its blood s…

This study tests whether combining a non-invasive ultrasound treatment called histotripsy with standard chemotherapy works better for people with advanced colorectal cancer that has spread to the liver. About 100 participants will receive both treatments to see if this combinatio…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing whether an immunotherapy drug called pembrolizumab (KEYTRUDA®) can help control liver cancer that has come back or hasn't responded to other treatments in children and young adults. The trial will enroll up to 18 participants under age 30 to see if the drug …

This early-stage trial is testing a new drug called SON-DP in people with advanced solid tumors that have not responded to standard treatments. The drug works by trying to reprogram cancer cells in the body, turning them back into normal tissue cells instead of killing them. The …

This is the first study in people testing a new cancer drug called AGX101. It aims to find a safe and effective dose for patients with advanced solid tumors that have spread or cannot be removed by surgery, and who have no other standard treatment options left. The drug is given …

This study compares two ways of injecting a fluorescent dye to guide surgeons during minimally invasive liver cancer removal. It aims to see if injecting the dye into an artery is better than the standard method of injecting it into a vein at preventing the cancer from coming bac…

This early-stage trial is testing a new type of mRNA vaccine designed to help the immune system fight advanced liver cancer. It is for patients whose cancer has continued to grow despite standard treatments. The main goals are to check if the vaccine is safe and to see if it can …

This study is testing a new drug called BI 765049, given alone and with another drug called ezabenlimab, for Asian adults with advanced cancers that have stopped responding to standard treatments. The main goals are to find safe doses and see if the treatment can shrink tumors by…

This study is developing a computer-based planning tool to make a common liver cancer treatment more precise. The treatment involves injecting tiny radioactive beads into the liver's blood vessels to attack tumors. Researchers will use patient scans to create digital models, hopi…

This study is testing a new, faster way to deliver precise radiation treatment for liver cancer. It uses real-time MRI scans to guide the radiation beam and aims to complete the entire treatment in a single session, without needing a separate planning scan. The main goal is to se…

This study is testing if using a radiofrequency device to heat the cut edge of the liver after removing a tumor helps stop the cancer from growing back in that same spot. It will involve 720 adults with liver cancer from colorectal cancer or primary liver cancer (HCC). Patients w…

This early-stage trial is testing a new way to deliver radiation to liver tumors that cannot be surgically removed. The goal is to find the highest dose of this targeted radiation that is safe for patients. After the radiation, participants will receive a standard immunotherapy d…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing if a special type of ultrasound, called contrast-enhanced ultrasound (CEUS), can better check if a liver cancer treatment is working. It will compare CEUS to the standard CT or MRI scans that patients already get. The goal is to see if CEUS can give doctors …

This study is testing whether adding a quick, 10-minute MRI scan to the standard 6-month ultrasound check can help find liver cancer at its earliest, most treatable stage in people with cirrhosis who are at high risk. Researchers will compare the two approaches in about 944 patie…

This study is testing new radioactive tracer chemicals for PET/CT scans to see if they can better detect and monitor cancers of the digestive system, including stomach, colon, liver, and pancreatic cancer. About 400 adults with confirmed or suspected digestive cancer will receive…

This study is testing new, advanced ultrasound techniques to improve the detection and diagnosis of liver cancer. It aims to see if these new methods can find small tumors that standard ultrasound often misses, especially in patients at high risk. Finding cancer earlier is critic…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing a new fluorescent dye that makes liver cancer cells glow under special imaging. Researchers will apply the dye to liver tissue removed during standard cancer surgery to see if it can help identify the exact edges of tumors. The goal is to improve surgical ac…

This study is testing a new diagnostic platform that uses artificial intelligence to analyze small pieces of a patient's tumor. The goal is to predict whether a patient's cancer will respond to immunotherapy drugs before they start treatment. Researchers will compare the AI's pre…

This large national trial aims to find the best method for early liver cancer detection in people at high risk. It will compare the current standard approach (an ultrasound plus a blood test) against a newer blood test alone. The goal is to see which method is more effective at f…

This study is testing whether a drug called riluzole can help prevent the memory and thinking problems often called 'chemo brain' in people receiving chemotherapy for various cancers. About 24 adult patients will be randomly assigned to receive either riluzole or a placebo pill w…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study is comparing two different non-surgical treatments for liver cancer to see which one helps patients maintain a better quality of life. It's for people with small liver tumors who cannot have surgery. Researchers will measure how patients feel physically and emotionally…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study is creating a large collection of blood, saliva, stool, and other samples from people with rare liver diseases and healthy volunteers. The goal is to help researchers better understand diseases like Primary Sclerosing Cholangitis (PSC) and Primary Biliary Cholangitis (…

This study aims to understand why some liver cancer patients respond to immunotherapy while others do not. Researchers will collect blood, tissue, and health data from 500 adults with liver cancer who have had or will have immunotherapy. By analyzing this information over time, t…

This study aims to collect blood and tissue samples from 800 patients with various chronic liver diseases and liver cancer. Researchers will use these samples to create better laboratory models, like mini-tumors in dishes and mice, to study how these diseases progress and to test…

This study aims to use artificial intelligence (AI) to make a minimally invasive liver cancer treatment called thermal ablation more effective and accessible. Researchers will collect data from 1500 patients to develop AI tools that help doctors better select patients, plan treat…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study is testing a new type of CT scanner called HyperSight, which is built into a radiation therapy machine. Researchers want to see if the clearer pictures it takes can help doctors plan and deliver radiation treatment more accurately for various cancers. They will compare…

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study is creating and testing an educational website to help people understand how to prevent liver cancer. Researchers will work with 40 participants to make sure the website is easy to understand and use. The goal is to develop a tool that clearly explains liver cancer ris…

This study aims to find out if simple blood tests can predict how well patients with advanced cancers respond to immunotherapy drugs. Researchers will track 50 patients with late-stage lung, breast, colorectal, liver, or stomach cancer who are starting immunotherapy. They will co…

This study aims to find biological markers in blood and tumor tissue that can predict how well patients with advanced liver cancer respond to immunotherapy. Researchers will collect samples from 50 patients before and during their treatment to analyze genetic and immune system ch…

This study aims to collect blood and other samples from adults with cancer to help scientists better understand how cancer affects the immune system and tumor biology. Participants provide samples for lab analysis, but this is not a treatment study. The goal is to gather knowledg…

This study aims to understand if anxiety or depression (emotional distress) affects how well immunotherapy works for people with liver cancer. It will follow 651 patients receiving standard immunotherapy to see if their mental health influences how long the treatment keeps the ca…

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …