New cancer drug AGX101 enters human trials for advanced tumors
NCT ID NCT06440005
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the drug intravenously every 3 to 9 weeks. The main goals are to find the safest dose and check for side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AGX101 (an antibody-drug conjugate that targets TM4SF1 on cancer cells)
- What this could lead to
- If successful, this could lead to a new treatment option for patients with advanced solid tumors that have not responded to standard therapies.
- What could go wrong
- This is an early Phase 1 trial with only 80 participants, so safety and effectiveness are not yet established. The drug may cause side effects or fail to shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Florida Cancer Specialist
RECRUITINGSarasota, Florida, 34232, United States
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NEXT Oncology
RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT Oncology
RECRUITINGFairfax, Virginia, 22031, United States
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Sarah Cannon Research Center
RECRUITINGNashville, Tennessee, 37203, United States
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USC/Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
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