ADVANCED CANCER

This study tests a personalized vaccine made from your tumor's unique mutations. It aims to train your immune system to attack cancer cells. The trial includes 10 adults with advanced or high-risk solid tumors. Participants receive the vaccine plus immune-boosting drugs over seve…

This study tests an inhaled treatment called KB707 for people with advanced solid tumors that have spread to the lungs. KB707 is a modified virus designed to trigger the immune system to attack cancer cells. The trial involves 250 adults who have not responded to standard treatme…

This early-phase trial tests a new drug, ASTX660, combined with the immunotherapy pembrolizumab in people with advanced solid tumours, including cervical and triple-negative breast cancer. The goal is to see if blocking certain proteins can make cancer cells die in a way that tri…

This early-stage study tests a new drug called IMC-002 in about 62 adults with advanced solid tumors that no longer respond to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers will also measure how the drug moves through the body…

This study tests a new experimental drug called CVM-1118 combined with the immunotherapy nivolumab in people with advanced liver cancer that cannot be surgically removed. The goal is to see if the combination shrinks tumors or slows cancer growth. About 95 adults aged 18 and olde…

This early-stage study tests a new oral drug, TQB3122, in about 86 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety, find the best dose, and get a first look at whether it can shrink tumors or slow dis…

This study tests a drug called toripalimab, which helps the immune system fight cancer. It is for adults with advanced solid tumors that have specific gene changes (POLE or POLD-1) but not high microsatellite instability. The goal is to see if the drug can shrink tumors and contr…

This study is for children and young adults with advanced or spreading solid tumors. It tests a new drug called repotrectinib combined with two chemotherapy drugs (irinotecan and temozolomide). The goal is to find the safest dose and see if the combination helps shrink tumors. Ab…

This study tests an experimental oral drug called Alintegimod combined with standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, or liver cancer who have already tried other treatments. The goal is to see if the com…

This study tests whether adding the experimental drug givastomig to standard immunotherapy and chemotherapy helps people with advanced stomach or esophageal cancer live longer without their cancer growing. About 180 adults whose tumors have certain proteins (CLDN18.2 and PD-L1) w…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This early-phase study tests the safety of combining two drugs (BMS-986504 and olaparib) in adults with advanced solid tumors that have lost a gene called MTAP. These cancers have not responded to standard treatments. The goal is to find safe doses and understand side effects. Ab…

This early-stage study tests a new drug, TQB3002, in 150 adults with advanced cancers that have not responded to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also measure how the drug moves through the body. This is …

This study will follow 800 Chinese adults with advanced HER2-positive or HER2-low breast cancer who are taking trastuzumab deruxtecan (T-DXd). Researchers will track how long the drug keeps the cancer from getting worse and note any side effects. The goal is to see how well the t…

This early-stage trial tests a new drug, AWT020, in about 60 adults with advanced solid tumors or lymphoma that has not responded to standard treatments. The main goals are to check the drug's safety at different doses and to see how the body processes it. This study is a first s…

This study tests an experimental pill called INX-315 in 150 people with advanced cancers, including certain breast and ovarian cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can shrink or control tumors. The study has three…

This early-phase study tests an experimental drug called RBS2418, which works by helping the body's immune system fight cancer more effectively. It is given alone or with another immunotherapy (pembrolizumab) to adults with advanced solid tumors that have not responded to standar…

This study tests a new drug called AGX101 in people with advanced solid tumors that have not responded to standard treatments. The drug is given through a vein and aims to shrink or control tumors. The main goals are to find the safest dose and understand side effects. About 80 p…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with other chemotherapy drugs like gemcitabine or irinotecan. About 442 participants wi…

This study tests a new drug called TST001 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug targets a protein called Claudin18.2 found on some cancer cells. The main goals are to check safety, find the best dose, and see if it helps s…

This study is testing an experimental drug called NUC-7738, given alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have not responded to other treatments. The goal is to find the safest dose and see if it can shrink tumors or slow …

This early-stage study tests an experimental drug called TJ033721 (givastomig) in people with advanced or metastatic solid tumors, including stomach, pancreatic, and bile duct cancers. The main goals are to check the drug's safety, find the best dose, and see how the body process…

This early-stage study tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancers that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly to tumor cells. The m…

This study gives people with advanced or metastatic cancer continued access to experimental drugs they are already benefiting from in earlier studies. The main goal is to monitor long-term safety, including side effects. About 50 participants will join this Phase 3 rollover study…

This study tests whether chemotherapy alone works as well as chemotherapy followed by radiation for people with advanced rectal cancer that can be surgically removed. About 540 adults with mid or low rectal cancer will be randomly assigned to one of two treatment groups. The goal…

This early-phase study tests a new drug called JZP815 in adults with advanced or spreading solid tumors that have specific changes in the MAPK pathway. The main goals are to find a safe dose and see if the drug can shrink tumors. About 332 participants who have tried all other tr…

This study is testing an experimental drug called MGC026 in about 250 adults with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the right dose. Participants receive the drug by IV and are closely monitore…

This study tests a combination of three drugs—177Lu girentuximab, cabozantinib, and nivolumab—in people with advanced clear cell kidney cancer who have not had treatment before. The goal is to see if this mix can help control the cancer. About 100 adults will take part, and the s…

This early-phase study tests a new drug, OKI-219, designed to block a specific cancer-driving mutation (PI3KαH1047R) found in some advanced solid tumors and breast cancers. About 200 adults whose cancer has this mutation will receive OKI-219 alone or combined with other anti-canc…

This phase 3 study compares a new two-drug immunotherapy (botensilimab + balstilimab) against the current standard treatment (chemotherapy plus nivolumab) in people with advanced or metastatic stomach or esophageal cancer that has a specific genetic feature (MSI-H/dMMR). The goal…

This study tests a new treatment for people with advanced pancreatic cancer whose tumors have a specific genetic change (KRAS G12V) and a certain immune type (HLA-A*11:01). The treatment uses the patient's own immune cells, modified in a lab to recognize and attack cancer cells. …

This study tests a treatment for people with advanced bile duct cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. The treatment combines chemotherapy delivered directly to the liver (HAIC) with immunotherapy drugs. The goal is to shrink tumors enough to …

This study tests a new drug called ALK201 in people with advanced solid tumors that have not responded to other treatments. The main goals are to check the drug's safety and find the best dose. About 202 adults will take part in this early-phase trial.

This study tests a new program where chaplains and doctors work together to provide spiritual care for people with advanced cancer. The goal is to see if this approach is practical and helpful for patients whose faith influences their medical choices. About 60 adults with advance…

This study tests a program called BOLSTER designed to support people with advanced gynecologic or gastrointestinal cancers and their caregivers. Participants will receive extra help managing complex care needs like ostomies or feeding tubes. The goal is to see if the program impr…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce anxiety, depression, and fear of death in people with advanced cancer. About 200 adults with stage 3 or 4 cancer will receive either psilocybin or…

This study is testing whether regular electronic surveys can help people with advanced cancer report their symptoms and care needs, so their doctors can connect them to palliative (supportive) care services more quickly. About 90 adults with incurable solid tumors will participat…

This study tests a program called ALIGN, which provides virtual palliative care visits for older adults with advanced cancer who are moving to a skilled nursing facility. The goal is to see if this approach is practical and helps patients and their family caregivers feel supporte…

This study tests whether a care coach-led program that combines palliative care and rehabilitation can improve quality of life for 770 adults with advanced cancer who are undergoing major surgery. Participants will receive extra support from trained coaches, surgical teams, and r…

This study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. Researchers want to see if this program is practical and can improve emotional, social, and overall well-being. 70 participants will be randomly assign…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help relieve severe pain that doesn't respond to opioids in people with advanced cancer. Fifteen adults with advanced cancer and persistent pain will receive psilocybin-assisted therapy. The…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in people with advanced cancer. About 30 adults whose cancer has not responded fully to standard treatments will receive the therapy.…

This study tests a short counseling program called Focused ACT (FACT) to help people with advanced cancer feel less anxious about death. About 70 adults who have advanced cancer and are already receiving supportive care will take part. The goal is to see if FACT is safe, acceptab…

This study tests whether spiritual care interventions can improve spiritual well-being and readiness to plan future care in Black patients with advanced cancer. About 64 participants will be recruited from outpatient clinics. The goal is to see if a larger trial is possible.

This study aims to understand how cancer therapies cause nerve pain by testing how patients feel heat, cold, and touch. Researchers will also take small skin samples to see if nerve endings have pulled back. The goal is to learn more about this type of pain, not to treat it. Adul…

This study looks at whether changes in a blood marker called ctDNA can help doctors tell early on if immunotherapy is working for people with advanced cancers like lung, breast, colorectal, stomach, or liver cancer. Researchers will also check other markers like PD-L1 and TMB to …

This study looks at whether special tests can predict which off-guideline drugs (FDA-approved for other cancers but not listed for a patient's specific cancer) will work for people with advanced cancer. About 300 participants will have their tumors tested, and doctors will try a …

This study looks at how SPECT imaging can help doctors better understand where radiation therapy goes in the body and how much reaches healthy organs. Researchers will scan 80 people with advanced prostate or other cancers who are already receiving standard radiation treatments. …

This study looks at whether a quick, practical geriatric assessment can help doctors better tailor cancer treatments for adults aged 70 and older with advanced cancer. About 150 participants will be tracked to see how often the assessment is completed and whether it leads to safe…

This study enrolls 400 people with advanced or rare cancers to test personalized treatments based on their tumor's genetic profile. Doctors use each patient's unique genetic information to select a targeted therapy, then track how well the cancer responds. The goal is to improve …

This study tests whether a special clinic that checks your genes and all your medications can lower the risk of harmful drug interactions. About 1,300 adults with cancer or mental health conditions who take multiple drugs will get a consultation. The goal is to help doctors presc…

This study looks at whether asking people with advanced or metastatic cancer about their financial worries every month can improve their quality of life and reduce stress. About 1,000 adults who are getting cancer treatment that is not meant to cure them will take part. The goal …

This study is creating a simple guide (called TA-DA) for people with advanced cancer who have already tried at least two treatments. The guide helps them prepare for conversations with their doctors about whether to try more therapy. About 155 patients and their doctors will help…