ADVANCED CANCER

This study aims to understand how well the drug trastuzumab deruxtecan works and what side effects patients experience in real-world medical settings in China. It will follow 800 adults with advanced breast cancer that has spread and is difficult to remove surgically. Researchers…

This study is testing a new antibody drug called TST001 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how well the body handles the drug. Researchers will also check if the drug helps shrink t…

This study is testing whether a three-month course of strong chemotherapy before surgery works as well as the current standard approach of chemotherapy followed by radiation for locally advanced rectal cancer. It will involve 540 patients across France who have rectal cancer that…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a personalized cancer vaccine made from the unique mutations found in a patient's own tumor. The goal is to see if this custom vaccine, given with other immune-boosting drugs, is safe and can help control advanced or high-risk cancers. It is for adults with …

This study is testing a new oral medication called Alintegimod, given alongside the immunotherapy drugs ipilimumab and nivolumab. It aims to see if this combination is safe and can help control advanced cancers that have spread or returned after other treatments. The study will e…

This study is testing an inhaled therapy called KB707 for adults with advanced solid tumors in the lungs that have stopped responding to standard treatments. The therapy uses a modified, harmless virus designed to stimulate the immune system to fight the cancer directly in the lu…

This study is testing whether adding a new oral drug called CVM-1118 to an existing immunotherapy (nivolumab) can better control advanced liver cancer that cannot be surgically removed. It is for about 95 adults whose cancer has progressed after standard treatments. The main goal…

This is the first time a new drug called ALK201 is being tested in people. The study aims to find a safe dose and see if it can help shrink tumors in adults with advanced solid cancers that have spread. Researchers will also check how the drug moves through the body and look for …

This study is testing a new oral drug called ART0380 in people with advanced or metastatic solid tumors that have spread and are hard to treat. The main goals are to find the safest and most effective dose of ART0380 when given alone or combined with standard chemotherapy drugs, …

This early-stage study is testing a new combination of two oral drugs, BMS-986504 and olaparib, in adults with advanced solid tumors that have a specific genetic change called MTAP loss. The main goal is to find a safe and tolerable dose. Researchers will also check how the drugs…

This is the first study in people testing a new cancer drug called AGX101. It aims to find a safe and effective dose for patients with advanced solid tumors that have spread or cannot be removed by surgery, and who have no other standard treatment options left. The drug is given …

This is the first study in humans testing an experimental drug called AWT020 for people with advanced cancer that has spread and no longer responds to standard treatments. The main goals are to find a safe dose and see how the drug behaves in the body. About 60 participants will …

This study is comparing a new two-drug immunotherapy combination (botensilimab + balstilimab) against standard chemotherapy plus immunotherapy for adults with advanced stomach or esophageal cancer that has specific genetic features. The main goal is to see if the new combination …

This is an early-stage study to find a safe dose and see if a new drug combination can help the immune system fight advanced cancers. It will test the experimental drug ASTX660 together with the immunotherapy pembrolizumab in up to 61 adults with solid tumors that have stopped re…

This is the first study in people for a new drug called OKI-219, designed to target a specific genetic mutation (PI3KαH1047R) found in some advanced cancers. The main goals are to find a safe dose and see how the body handles the drug, both alone and combined with other cancer tr…

This study is testing a new three-drug combination for people newly diagnosed with advanced clear cell kidney cancer. The goal is to see if adding a targeted radiation drug to two existing cancer drugs is safe and can help control the disease. Researchers will enroll about 100 pa…

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This study is testing two different dosing schedules of the drug adagrasib to see which one works better for people with advanced lung cancer that has a specific genetic change called KRAS G12C. It is for patients whose cancer has continued to grow after trying standard chemother…

This study is testing a two-part treatment for advanced bile duct cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. It combines chemotherapy delivered directly to the liver (HAIC) with immunotherapy drugs (Durvalumab or Pembrolizumab). The main goal is t…

This is a first-in-human study to find a safe dose of a new experimental treatment for advanced cancers that produce a protein called CEA. The treatment is an antibody attached to a radioactive particle (Actinium-225) designed to seek out cancer cells and deliver radiation direct…

This study allows patients with advanced or metastatic cancer who are benefiting from certain experimental drugs to continue receiving them after their original trial ends. It aims to provide continued treatment access while closely monitoring for any long-term side effects. The …

This study is testing if adding an experimental drug called givastomig to standard immunotherapy and chemotherapy works better for controlling advanced stomach or esophageal cancer. About 180 adults whose cancer has spread and who have not yet received treatment for their advance…

This is the first time researchers are testing the experimental drug TQB3122 in people. The study aims to find the safest dose and check for side effects in 86 adults with advanced cancers that have stopped responding to standard treatments. Researchers will also gather early inf…

This is an early-stage study testing a new oral drug called RBS2418, both by itself and combined with an existing immunotherapy (pembrolizumab), in people with advanced cancers that have spread or returned. The main goals are to find safe doses and see how the body processes the …

This early-stage study is testing a new drug called JZP815 in people with advanced or metastatic solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to find a safe dose, understand how the drug works in the body, and look for early signs that i…

This early-stage trial is testing a new treatment for advanced pancreatic cancer. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack cancer cells with a specific KRAS G12V mutation, and then infuse them back into the pati…

This is a first-in-human study to test the safety and find the right dose of a new drug called TJ033721 (givastomig) for people with advanced or metastatic solid tumors. It will enroll about 330 patients whose cancer has progressed despite standard treatments or who have no other…

This early-stage study is testing a new oral medication called INX-315 in people with advanced cancers that have spread or stopped responding to standard treatments. It aims to find a safe dose and see if the drug can help control cancers like certain types of breast and ovarian …

This is the first study in people testing a new experimental cancer drug called PHN-012. It aims to find a safe dose and see if it can shrink tumors in patients with advanced colon, lung, or pancreatic cancer who have no other standard treatments left. The study will enroll about…

This study is testing a practical health assessment tool designed to help doctors personalize cancer treatment for adults aged 70 and older. The goal is to see if using this tool in community cancer clinics helps doctors better adjust treatment doses to reduce severe side effects…

This early-stage study is testing a new drug called NUC-7738 in adults with advanced cancers that have not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors, either by itself or combined with another immunotherapy drug.…

This study aims to see if custom, precision treatments can help control advanced cancer in patients who have exhausted all standard options. It will enroll 400 participants. Doctors will use each patient's unique tumor genetics to design a personalized treatment plan, then track …

This study is testing whether a new drug called repotrectinib, when given with standard chemotherapy, is safe and effective for children and young adults (up to age 30) whose solid tumors have come back or stopped responding to other treatments. Researchers will first find the sa…

This is a first-in-human study to test the safety and find the right dose of a new drug called TQB3002 for people with advanced cancers. It is for adults whose cancer has continued to grow despite standard treatments or who have no other effective options. The main goals are to s…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychotherapy, can help reduce depression and anxiety in people with advanced cancer. It will involve 30 participants who are receiving ongoing cancer treatment. Researchers will mea…

This study is testing whether spiritual care services can help improve emotional and spiritual well-being for Black patients with advanced cancer. Researchers want to see if these services also help patients feel more ready to discuss their future medical care wishes. The study i…

This study is testing whether electronic symptom surveys can help patients with advanced cancer report their needs so doctors can connect them to supportive care services faster. The goal is to see if this approach makes it easier for 90 participants to get help managing symptoms…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with therapy can help reduce severe pain in people with advanced cancer when standard opioid painkillers are not effective enough. About 15 participants will receive one dose of psilocybi…

This study is testing a new support program for people with advanced cancer who are having major surgery. The program provides a dedicated care coach and rehabilitation team to help manage symptoms, improve function, and support quality of life throughout the cancer journey. Rese…

This study is testing a new telehealth support program called BOLSTER for people with advanced gastrointestinal or gynecologic cancers who have complex care needs, like feeding tubes or drains. The program aims to improve patients' quality of life, ease symptoms, and reduce the b…

This study is testing whether a monthly check-in about money problems can help people with advanced cancer. It aims to connect 1,000 eligible patients to financial support resources. The goal is to see if this reduces financial worry, improves quality of life, and helps people st…

This study is testing a new counseling program called Focused Acceptance and Commitment Therapy (FACT) to see if it helps people with advanced cancer manage their fear and anxiety about death. The researchers want to know if the program is practical, acceptable to patients, and i…

This study is testing whether a single dose of psilocybin, the active compound in 'magic mushrooms,' given alongside supportive therapy, can help people with advanced cancer. It aims to reduce severe anxiety, depression, and the deep distress that can come from facing a serious i…

This study is testing a spiritual support program called PEACE, led by a chaplain and a clinician, for people with advanced cancer. The goal is to see if the program is practical and helpful for patients, and if it can help them manage how their spiritual or religious beliefs aff…

This study aims to improve how doctors use radiation-based cancer drugs. Researchers will use a special type of scan (SPECT) to see exactly where these drugs go in the body and how much radiation they deliver. The goal is to gather information that could help doctors personalize …

This study is creating an educational tool to help patients with advanced cancer, their caregivers, and doctors have better conversations about treatment options. It focuses on patients who have already tried at least two rounds of therapy and are considering more. The goal is to…

This study aims to find better ways to predict which FDA-approved cancer drugs might work for patients when those drugs aren't listed in standard treatment guidelines for their specific cancer type. Researchers will analyze genetic tests and drug sensitivity results from 300 adva…

This study aims to test whether specific sensory tests and skin biopsies can reliably measure nerve pain caused by cancer treatments like chemotherapy. Researchers will enroll 450 people, including cancer patients with treatment-related pain, those starting treatment, and healthy…

This study aims to find out if simple blood tests can predict how well patients with advanced cancers respond to immunotherapy drugs. Researchers will track 50 patients with late-stage lung, breast, colorectal, liver, or stomach cancer who are starting immunotherapy. They will co…