New antibody TST001 targets Hard-to-Treat cancers in early trial
NCT ID NCT04495296
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called TST001, an antibody that targets a protein called Claudin18.2 found on some cancer cells. It is given alone or with chemotherapy to people with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to check safety, find the best dose, and see if it shrinks tumors. About 320 adults are being enrolled at multiple sites.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TST001 (a monoclonal antibody targeting Claudin18.2)
What this could lead to
If successful, this could lead to a new treatment option for advanced solid tumors like gastric or biliary tract cancer.
What could go wrong
This is an early phase trial (I/IIa) with a small number of participants, so safety and effectiveness are not yet proven. Side effects may occur, and the drug may not work for all tumor types.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100036, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Beijing Friendship Hospital, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, China
Contact
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First Affiliated Hospital of Zhejiang University
RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cance Center
RECRUITINGShanghai, Shanghai Municipality, China
Contact Email: •••••@•••••
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Fujian Cancer Hospital
RECRUITINGFuzhou, Fujian, China
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Fujian Medical University Union Hospital
RECRUITINGFuzhou, Fujian, China
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Hainan Provincial People's Hospital
RECRUITINGHaikou, Hainan, China
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Harbin Medical University Cancer Hospital
RECRUITINGHarbin, Heilongjiang, China
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Henan Cancer Hospital
RECRUITINGZhengzhou, Henan, China
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Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, China
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Hunan Cancer Hospital
RECRUITINGChangsha, Hunan, China
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Jilin Cancer Hospital
RECRUITINGChangchun, Jilin, China
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Jinan Central Hospital
RECRUITINGJinan, Shandong, China
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Liaoning Cancer Hospital & Institute
RECRUITINGShenyang, Liaoning, China
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Linyi Cancer Hospital
RECRUITINGLinyi, Shandong, China
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Peking Union Medical College Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, China
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Peking University International Hospital
NOT_YET_RECRUITINGBeijing, Beijing Municipality, China
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Sichuan Cancer Hospital
RECRUITINGChengdu, Sichuan, China
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Suzhou Municipal Hospital
RECRUITINGSuzhou, Jiangsu, China
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The Affiliated Hospital of Qingdao University
RECRUITINGQingdao, Shandong, China
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The First Affiliated Hospital of Bengbu Medical College
RECRUITINGBengbu, Anhui, China
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The First Affiliated Hospital of Chongqing Medical University
RECRUITINGChongqing, Chongqing Municipality, China
Contact
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The First Affiliated Hospital of Jinzhou Medical University
RECRUITINGJinzhou, Liaoning, China
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The First Affiliated Hospital of Xiamen University
RECRUITINGXiamen, Fujian, China
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Heibei, China
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The First Hospital of China Medical University
RECRUITINGShenyang, Liaoning, China
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The First Hospital of Jilin University
RECRUITINGChangchun, Jilin, China
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The People's Hospital of Guangxi Zhuang Autonomous Region
NOT_YET_RECRUITINGGuangxi, Guangxi, China
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The Second Affiliated Hospital of Nanchang University
RECRUITINGNanchang, Jiangxi, China
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The Second Affiliated Hospital of Soochow University
RECRUITINGSuzhou, Jiangsu, China
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The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, China
Contact
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The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, China
Contact
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Tianjin Medical University Cancer Institute & Hospital
RECRUITINGTianjin, Tianjin Municipality, China
Contact
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Tianjin Medical University General Hospital
RECRUITINGTianjin, Tianjin Municipality, China
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, China
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Xiangya Hospital, Central South University
RECRUITINGChangsha, Hunan, China
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Xuzhou Central Hospital
RECRUITINGXuzhou, Jiangsu, China
Contact
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Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, China
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Zhongnan Hospital of Wuhan University
RECRUITINGWuhan, Hubei, China
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Zhongshan Hospital Fudan University
RECRUITINGShanghai, Shanghai Municipality, China
Contact