New antibody TST001 targets Hard-to-Treat cancers in early trial

NCT ID NCT04495296

Recruiting now Disease control Sponsor: Suzhou Transcenta Therapeutics Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called TST001, an antibody that targets a protein called Claudin18.2 found on some cancer cells. It is given alone or with chemotherapy to people with advanced solid tumors that cannot be removed by surgery or have spread. The main goals are to check safety, find the best dose, and see if it shrinks tumors. About 320 adults are being enrolled at multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TST001 (a monoclonal antibody targeting Claudin18.2)
What this could lead to: If successful, this could lead to a new treatment option for advanced solid tumors like gastric or biliary tract cancer.
What could go wrong: This is an early phase trial (I/IIa) with a small number of participants, so safety and effectiveness are not yet proven. Side effects may occur, and the drug may not work for all tumor types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary tract neoplasm cancer colorectal cancer gastric adenocarcinoma gastroesophageal junction adenocarcinoma lung adenocarcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CANCER

Contacts and locations

Locations

Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100036, China
Beijing Friendship Hospital, Capital Medical University
RECRUITING

Beijing, Beijing Municipality, China
First Affiliated Hospital of Zhejiang University
RECRUITING

Hangzhou, Zhejiang, China
Fudan University Shanghai Cance Center
RECRUITING

Shanghai, Shanghai Municipality, China
Fujian Cancer Hospital
RECRUITING

Fuzhou, Fujian, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, Fujian, China
Hainan Provincial People's Hospital
RECRUITING

Haikou, Hainan, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, Heilongjiang, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, Henan, China
Hubei Cancer Hospital
RECRUITING

Wuhan, Hubei, China
Hunan Cancer Hospital
RECRUITING

Changsha, Hunan, China
Jilin Cancer Hospital
RECRUITING

Changchun, Jilin, China
Jinan Central Hospital
RECRUITING

Jinan, Shandong, China
Liaoning Cancer Hospital & Institute
RECRUITING

Shenyang, Liaoning, China
Linyi Cancer Hospital
RECRUITING

Linyi, Shandong, China
Peking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Peking University International Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, China
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, China
Suzhou Municipal Hospital
RECRUITING

Suzhou, Jiangsu, China
The Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, Shandong, China
The First Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, Anhui, China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, China
The First Affiliated Hospital of Jinzhou Medical University
RECRUITING

Jinzhou, Liaoning, China
The First Affiliated Hospital of Xiamen University
RECRUITING

Xiamen, Fujian, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, Heibei, China
The First Hospital of China Medical University
RECRUITING

Shenyang, Liaoning, China
The First Hospital of Jilin University
RECRUITING

Changchun, Jilin, China
The People's Hospital of Guangxi Zhuang Autonomous Region
NOT_YET_RECRUITING

Guangxi, Guangxi, China
The Second Affiliated Hospital of Nanchang University
RECRUITING

Nanchang, Jiangxi, China
The Second Affiliated Hospital of Soochow University
RECRUITING

Suzhou, Jiangsu, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, China
The Sixth Affiliated Hospital of Sun Yat-sen University
RECRUITING

Guangzhou, Guangdong, China
Tianjin Medical University Cancer Institute & Hospital
RECRUITING

Tianjin, Tianjin Municipality, China
Tianjin Medical University General Hospital
RECRUITING

Tianjin, Tianjin Municipality, China
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, China
Xiangya Hospital, Central South University
RECRUITING

Changsha, Hunan, China
Xuzhou Central Hospital
RECRUITING

Xuzhou, Jiangsu, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, Zhejiang, China
Zhongnan Hospital of Wuhan University
RECRUITING

Wuhan, Hubei, China
Zhongshan Hospital Fudan University
RECRUITING

Shanghai, Shanghai Municipality, China

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