ADVANCED CANCER

This early-stage trial tested adding an approved lung fibrosis drug, pirfenidone, to standard first-line chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe combined dose and get early signs of whether the combination could help sh…

This study looked at whether combining newer immunotherapy drugs with palliative radiation is safe for people with advanced cancer. Researchers followed 42 patients who received both treatments to manage cancer symptoms like pain or breathing problems. The main goal was to check …

This early-stage study tested a new drug called BMS-986288, both by itself and combined with an existing immunotherapy (nivolumab), in people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find safe doses and see if the treat…

This early-stage study aimed to find safe doses for several different combinations of cancer drugs in patients with advanced or metastatic solid tumors, including lung cancer. The 60 participants were divided into groups to test combinations of chemotherapy, immunotherapy, and ta…

This early-stage study tested a new drug called AGEN1777, both by itself and combined with an existing immunotherapy drug, in 25 patients with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find a safe dose and understand how the bo…

This early-stage study tested whether a personalized vaccine, made from a patient's own tumor, could be safely created and given to people with advanced cancers that no longer respond to standard treatments. The vaccine was combined with an immunotherapy drug (pembrolizumab) to t…

This first-in-human study tested a new oral medication called MRX-2843 in adults with advanced solid tumors that had returned or stopped responding to standard treatments. The main goals were to find the highest safe dose and understand how the drug moves through the body. Resear…

This early-stage study tested a new drug called PTX-100 in 25 patients with advanced cancers that had stopped responding to standard treatments. The main goals were to check the drug's safety, how the body processes it, and its initial effects on cancer-related proteins. Patients…

This early-stage study tested a new oral drug called ART4215 in people with advanced or metastatic solid tumors, including breast cancer. The main goals were to find a safe dose for the drug when taken alone and when combined with other cancer drugs, and to check for early signs …

This large, completed Phase 3 trial tested whether the immunotherapy drug nivolumab could help prevent cancer from returning in patients who had surgery for esophageal or gastroesophageal junction cancer. The study involved 794 patients who had already completed chemotherapy and …

This study tested the safety and effectiveness of combining two drugs, lenvatinib and eribulin, for treating advanced liposarcoma and leiomyosarcoma. It involved 30 patients whose cancer could not be surgically removed or had spread, and who had received up to two prior chemother…

This study tested whether a video visit with a cancer nurse practitioner a few days after leaving the hospital helps patients with advanced cancer. The goal was to see if this extra support made patients feel more confident managing their health, improved communication with their…

This early-stage study tested a new drug called BMS-986249, both by itself and combined with an existing immunotherapy (nivolumab), in people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check if the treatments were safe, f…

This study tested a new oral drug called RP-6306, given alongside standard chemotherapy, for people with advanced cancers that had stopped responding to other treatments. Researchers wanted to see if the drug was safe and if it helped shrink tumors, especially in patients whose c…

This early-stage trial tested a new oral medication called Q702 in patients with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose and understand how the drug moves through the body. Researchers enrolled 51 adults …

This study tested whether a communication skills training program could help couples where one partner has advanced cancer. 440 couples were randomly assigned to receive either the communication training or general health information. Researchers measured if the training improved…

This study looked back at the medical records of 1,250 patients with advanced cancer who visited a hospital emergency department. The goal was to find common factors—like lab test results, overall health, and nutrition—that are linked to a higher risk of dying within 90 days of t…

This study aimed to understand if patients with advanced cancer would engage in structured discussions to plan their future care if their illness worsened. Researchers offered 71 patients two interviews to assess their wishes and begin these sensitive conversations. The goal was …