New immunotherapy combo shows promise for advanced cancers

NCT ID NCT03369223

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called BMS-986249, either alone or combined with the immunotherapy nivolumab (Opdivo), in 356 people with advanced solid tumors. The main goals were to check safety and find the right dose. Researchers also looked at whether the tumors shrank. The trial has completed, and results will help guide future studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BMS-986249 (an experimental immunotherapy) and nivolumab (Opdivo)

What this could lead to

If successful, this could lead to a new treatment option for people with advanced solid tumors that have not responded to other therapies.

What could go wrong

This is an early-phase trial focused on safety, so it is not yet known if the drug combination works better than existing treatments. Side effects may be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED CANCER

Contacts and locations

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Locations

Local Institution - 0001

Hackensack, New Jersey, 07601, United States
Local Institution - 0002

New York, New York, 10032, United States
Local Institution - 0003

New York, New York, 10065, United States
Local Institution - 0004

Philadelphia, Pennsylvania, 19104, United States
Local Institution - 0005

Aurora, Colorado, 80045, United States
Local Institution - 0006

Denver, Colorado, 80218, United States
Local Institution - 0007

Norfolk, Virginia, 23502, United States
Local Institution - 0008

Greenville, South Carolina, 29605, United States
Local Institution - 0009

Dallas, Texas, 75246, United States
Local Institution - 0010

Austin, Texas, 78705-1165, United States
Local Institution - 0011

Tyler, Texas, 75702, United States
Local Institution - 0012

Leesburg, Virginia, 20176, United States
Local Institution - 0013

Eugene, Oregon, 97401, United States
Local Institution - 0014

Adelaide, South Australia, 5000, Australia
Local Institution - 0015

North Sydney, New South Wales, 2060, Australia
Local Institution - 0016

San Antonio, Texas, 78240, United States
Local Institution - 0017

Miami, Florida, 33176, United States
Local Institution - 0018

Vancouver, Washington, 98684, United States
Local Institution - 0020

Naples, 80131, Italy
Local Institution - 0021

Houston, Texas, 77030, United States
Local Institution - 0022

Madrid, Madrid, Comunidad de, 28027, Spain
Local Institution - 0023

Madrid, 28040, Spain
Local Institution - 0024

Baltimore, Maryland, 21287, United States
Local Institution - 0025

Frankston, Victoria, 3199, Australia
Local Institution - 0026

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0029

Cincinnati, Ohio, 45219, United States
Local Institution - 0030

Essen, 45147, Germany
Local Institution - 0031

Heidelberg, 69120, Germany
Local Institution - 0035

Hamburg, 20251, Germany
Local Institution - 0036

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0037

Buenos Aires, C1426ANZ, Argentina
Local Institution - 0038

Buenos Aires, Distrito Federal, 1121, Argentina
Local Institution - 0039

Helsinki, 00029, Finland
Local Institution - 0040

Warsaw, 02-781, Poland
Local Institution - 0041

Craiova, 200542, Romania
Local Institution - 0042

Badalona, Barcelona [Barcelona], 08916, Spain
Local Institution - 0043

Málaga, 29010, Spain
Local Institution - 0044

Barcelona, 08035, Spain
Local Institution - 0045

Bucharest, 022328, Romania
Local Institution - 0047

Heidelberg, Victoria, 3084, Australia
Local Institution - 0048

Milan, 20133, Italy
Local Institution - 0049

Siena, 53100, Italy
Local Institution - 0050

Madrid, 28041, Spain
Local Institution - 0052

CABA, Distrito Federal, C1430, Argentina
Local Institution - 0056

Ottawa, Ontario, K1H 8L6, Canada