ADVANCED CANCER

This early-stage trial aims to find the safest and most effective doses of new drug combinations for people with advanced cancer that has not responded to standard treatments. Researchers are testing two core drugs (bevacizumab and temsirolimus) paired with one of three other can…

This study is testing whether the immunotherapy drug avelumab can help men with advanced penile cancer that has spread or cannot be removed by surgery. It is for patients who are not suitable for standard platinum-based chemotherapy or whose cancer has continued to grow despite t…

This trial is testing an experimental pill called MRTX849 (adagrasib) for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The study aims to find safe doses, see how the drug works in the body, and measure if it shrinks tumors. It includes 7…

This is the first human study testing the safety of an experimental drug called AB598 in people with advanced cancers. The trial will enroll 40 participants with various cancers including lung, stomach, bladder, and breast cancer to determine safe dosage levels and monitor side e…

This early-stage study is testing whether adding an experimental drug called RP-6306 to standard chemotherapy (carboplatin and paclitaxel) is safe for patients with recurrent ovarian or uterine cancer that has a specific genetic change (TP53 mutation). The main goal is to find th…

This study tested an immunotherapy drug called pembrolizumab in people with many different types of advanced solid tumors that had stopped responding to standard treatments. The main goal was to see if the drug could shrink tumors and to identify biological markers that might pre…

This is an early-stage safety study for a new drug called AB801, given alone or with other treatments, for people with advanced cancers that have stopped responding to available therapies. The main goal is to find a safe dose and understand the drug's side effects in about 91 par…

This study tests a decision-making tool designed to help doctors and patients with advanced lung cancer decide when to continue or stop aggressive treatments near the end of life. It compares usual care to using a structured checklist that guides conversations about treatment goa…

This study is testing if taking the drug lenvatinib before surgery can help control advanced thyroid cancer that has grown into nearby structures. The goal is to shrink the tumors, making them easier and safer to remove completely. About 30 adults with this specific type of invas…

This is the first study in humans testing a new drug called DS-1055a. It aims to find a safe dose and check for side effects in 40 adults with advanced solid tumors that have returned or stopped responding to available treatments. The main goal is to understand how the body handl…

This early-stage trial aims to find the safest, most effective doses of four different drug combinations for patients with advanced cancer that hasn't responded to standard treatments. Researchers are testing vorinostat paired with one of three other drugs (sirolimus, everolimus,…

This study is testing whether adding a second immunotherapy drug (relatlimab) to a standard one (nivolumab) works better for controlling advanced soft tissue sarcoma. It enrolled 67 adults whose cancer has spread and is no longer responding to other treatments. Patients were rand…

This study is testing whether a three-drug combination can help the body's immune system fight advanced ovarian, fallopian tube, or primary peritoneal cancer that has returned after initial treatment. The treatment includes an immunotherapy drug (pembrolizumab), an investigationa…

This is a very early study to see if a new experimental treatment called SXRN is safe for people with advanced solid tumors. The treatment uses a DNA-based technique. The main goal is to find the right dose and check for side effects in a small group of patients who have no other…

This study is for adults with a specific type of advanced lung cancer (non-small cell) that has a mutation in the EGFR gene. It aims to see if adding a drug called ramucirumab to the standard drug osimertinib can help control the cancer for a longer time without it getting worse.…

This early-stage study is testing whether a very high dose of a radioactive sugar molecule (FDG), commonly used in PET scans to find cancer, can be used to treat it. The trial is for adults with advanced cancer that has spread and is no longer responding to standard treatments. R…

This early-stage trial is testing a new drug called TST001 for people with advanced stomach, gastroesophageal junction, or pancreatic cancer. The main goals are to find a safe dose and see how well the body handles the drug, both alone and when combined with other standard cancer…

This study is testing whether adding a community health worker to standard care improves quality of life for African American patients with advanced cancer. Researchers will compare outcomes between patients receiving standard care alone and those who also get support from a trai…

This study is testing a new type of therapy that combines talk therapy with a single dose of psilocybin, the active compound in 'magic mushrooms.' It aims to help people with advanced cancer who are struggling with severe anxiety, depression, and fear related to their illness. Th…

This study is adapting a counseling therapy called 'Meaning-Centered Psychotherapy' to better meet the cultural and language needs of Chinese immigrant cancer patients. The goal is to help patients cope with the emotional burden of advanced cancer by finding a sense of purpose an…

This study aims to find the best schedule for draining fluid from the chest in advanced cancer patients. Researchers are comparing whether draining a chest catheter every day works better than draining it three times a week for relieving breathing problems. About 250 patients wit…

This study is testing whether a drug called mirtazapine, commonly used for depression, can help improve poor appetite and weight loss in people with advanced cancer. About 98 participants were randomly assigned to receive either mirtazapine or a placebo pill for two weeks, with r…

This study is testing whether summaries created by an artificial intelligence (AI) program can help doctors and patients with advanced cancer have better conversations about serious care goals. The AI reviews past medical records to create a summary of what's important to the pat…

This pilot study is testing whether a new care planning framework called ABC123 is practical and acceptable for older adults with advanced, incurable cancer. The framework combines expertise from geriatrics, oncology, and palliative care to help ensure treatment plans match what …