ADVANCED CANCER

This study tests whether giving the drug lenvatinib before surgery can help doctors more completely remove advanced thyroid cancer that has spread outside the gland. About 30 adults with this type of cancer will receive lenvatinib for a short time before their operation. The main…

This study tests whether adding ramucirumab to the standard drug osimertinib can delay cancer growth in people with advanced EGFR-mutant non-small cell lung cancer. About 160 participants who have not had prior targeted therapy will be randomly assigned to receive either the comb…

This early-stage study tests a new treatment for people with advanced colorectal or other cancers that make a protein called CEA. The treatment, Ac225-DOTA-M5A, is an antibody that seeks out CEA on cancer cells and delivers a radioactive payload to kill them. The main goals are t…

This study tests whether combining a cancer vaccine (DPX-Survivac) with an immunotherapy drug (pembrolizumab) and low-dose chemotherapy can shrink tumors in people with advanced ovarian, fallopian tube, or primary peritoneal cancer. The vaccine trains the immune system to attack …

This study tests a drug called adagrasib (MRTX849) in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drug is safe, how the body processes it, and whether it can shrink tumors. About 731 participants with various cancers (e.g.,…

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This early-phase study tests a new drug called DS-1055a in about 40 adults with advanced solid tumors (like head and neck, stomach, or lung cancer) that have not responded to standard treatments. The main goal is to check the drug's safety and find the right dose. Participants re…

This early-phase study tests the safety and best dose of combining vorinostat with one of three mTOR inhibitors (sirolimus, everolimus, or temsirolimus) in people with advanced cancer that hasn't responded to standard treatments. The goal is to find a tolerable dose that might sl…

This study tests two different doses of the targeted drug adagrasib in 200 adults with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants have already tried chemotherapy and immunotherapy. The goal is to see which dose works bett…

This early-phase trial tests a new drug called TST001, an antibody that targets a protein (CLDN18.2) found on some cancer cells. It is being studied alone or with other treatments in about 150 people with advanced stomach, esophageal, or pancreatic cancers that have not responded…

This early-phase study tests the safety of a new drug called AB598, given alone or with other treatments, in about 40 people with advanced solid tumors (e.g., lung, bladder, breast, or ovarian cancer). The main goal is to see if the drug is safe and tolerable. Participants must h…

This early-phase study tests whether combining two drugs—tepotinib and pembrolizumab—can help treat advanced non-small cell lung cancer (NSCLC) that doesn't respond to standard immunotherapy. The trial includes 19 adults with NSCLC, some with a specific MET gene mutation. The goa…

This study tests whether high doses of a radioactive sugar called FDG can safely shrink tumors in people with advanced stage IV cancers that no longer respond to standard treatments. FDG is taken up by cancer cells because they use a lot of sugar, and the radiation inside the FDG…

This early-phase study tests a new drug (RP-6306) combined with two standard chemotherapies for people with recurrent ovarian or uterine cancer that has a specific gene change (TP53 mutation). The main goals are to find the safest dose and see if the combination can shrink tumors…

This early-phase study tests two experimental immunotherapy drugs (botensilimab and balstilimab) in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety and find the best dose. About 499 participants with various can…

This phase 2 trial tests the drug avelumab in 25 people with advanced penile cancer who cannot have standard platinum chemo or whose cancer worsened after it. Avelumab works by blocking a protein called PD-L1, which may help shrink or stop tumor growth. The main goal is to see ho…

This study tests a new drug called AB801, alone or with other treatments, in about 91 people with advanced cancers like lung, colon, breast, or ovarian cancer that have not responded to standard therapies. The main goal is to check the drug's safety and find the best dose. This i…

This early-stage trial aims to find the safest highest dose of a two-drug combination (bevacizumab and temsirolimus) when given with one of three other drugs (carboplatin, paclitaxel, or sorafenib) for people with advanced cancer that hasn't responded to standard treatments. Abou…

This study looks at whether a special decision-making tool can help doctors and patients with advanced non-small cell lung cancer choose wisely about continuing or stopping cancer treatments. The goal is to reduce the use of chemotherapy and other treatments in the last month of …

This study looks at whether support from community health workers can help African American patients with advanced cancer feel better and have a higher quality of life. About 160 patients will either get standard care or standard care plus extra help from a community health worke…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who are losing weight. About 98 patients will receive either mirtazapine or a placebo for 15 to 29 days. The goal is to see if it helps with appetite, sl…

This study tests whether a mobile app called SUPPORT+ can help adults with advanced cancer who are receiving palliative care feel better and stay out of the hospital. Participants use the app to report symptoms weekly, get self-care tips, and receive nurse follow-up for severe is…

This study adapts a type of counseling called Meaning-Centered Psychotherapy for Chinese immigrants with advanced cancer. The goal is to help patients maintain a sense of meaning and purpose in life despite their illness. Researchers will interview and test the adapted program wi…

This study looks at whether draining fluid from the chest every day helps people with advanced cancer breathe better compared to draining it three times a week. About 257 adults with cancer-related fluid buildup around the lungs will have a small tube placed and be assigned to on…

This study tests a 5-session telehealth program called CASA, designed to help advanced cancer patients (stage III or IV) and their caregivers cope with emotional and spiritual challenges. About 30 patient-caregiver pairs will participate. The goal is to see if the program improve…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with advanced cancer feel less anxious and more connected. Fifteen adults with stage IV cancer will receive the treatment and be followe…

This study looks at whether a new care planning method, called ABC123, is practical and acceptable for people over 60 with advanced, incurable cancer. The framework combines geriatric, oncology, and palliative care into the initial treatment discussion. Researchers will track how…

This study tests whether artificial intelligence (AI) can accurately summarize conversations between doctors and patients with advanced cancer about their care goals. About 60 patients from Dana-Farber Cancer Institute will have their serious illness talks summarized by an AI pro…