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Lung cancer pill study aims to find best dose for shrinking tumors

NCT ID NCT05853575

Ongoing Disease control Sponsor: Mirati Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 26 times

Summary

This study tests two different doses of the targeted drug adagrasib in 200 adults with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants take either 600 mg twice daily without food or 400 mg twice daily with food. The main goal is to see which dose shrinks more tumors, while also tracking survival and side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Local Institution - 100

    Durham, North Carolina, 27705, United States

  • Local Institution - 101

    Santa Rosa, California, 95403, United States

  • Local Institution - 102

    São Paulo, 01509-900, Brazil

  • Local Institution - 105

    Kansas City, Missouri, 64128, United States

  • Local Institution - 106

    Dallas, Texas, 75216-7167, United States

  • Local Institution - 125

    Toluca, 50090, Mexico

  • Local Institution - 127

    Colonia Roma, Mexico City, 06760, Mexico

  • Local Institution - 129

    Colonia Nápoles, Mexico City, 3810, Mexico

  • Local Institution - 175

    São Paulo, 01509-900, Brazil

  • Local Institution - 177

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Local Institution - 178

    Belo Horizonte, São Paulo, 30360-680, Brazil

  • Local Institution - 179

    Taichung, Taichung, 404327, Taiwan

  • Local Institution - 181

    Salvador, Estado de Bahia, 41950-640, Brazil

  • Local Institution - 182

    Itajaí, Santa Catarina, 88301-220, Brazil

  • Local Institution - 325

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 6351, South Korea

  • Local Institution - 326

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, 08308, South Korea

  • Local Institution - 327

    Goyang-si, Gyeonggido [Kyonggi-do], 10408, South Korea

  • Local Institution - 328

    Seoul, Seoul Teugbyeolsi [Seoul-T'ukp, 06273, South Korea

  • Local Institution - 350

    Taichung, Taichung, 404327, Taiwan

  • Local Institution - 352

    Kaohsuing City, Kaohsiung, 833401, Taiwan

  • Local Institution - 353

    Taichung, Taichung, 402306, Taiwan

  • Local Institution - 375

    Khon Kaen, 40002, Thailand

  • Local Institution - 376

    Muang, Chiang Mai, 50200, Thailand

  • Local Institution - 377

    Bangkok, Krung Thep Maha Nakhon [Bangko, 10700, Thailand

  • Local Institution - 378

    Songkhla, 90110, Thailand

  • Local Institution - 400

    Osaka, Ôsaka [Osaka], 541-8567, Japan

  • Local Institution - 401

    Tōon, Ehime, 791-0295, Japan

  • Local Institution - 402

    Kashiwa, Tiba [Chiba], 277-8577, Japan

  • Local Institution - 403

    Nishinomiya, Hyôgo [Hyogo], 663-8501, Japan

  • Local Institution - 527

    Zagreb, City of Zagreb, 10000, Croatia

  • Local Institution - 529

    Rijeka, Primorje-Gorski Kotar County, 51000, Croatia

  • Local Institution - 550

    Saint-Mandé, 94163, France

  • Local Institution - 551

    Marseille, Rhône, 13915, France

  • Local Institution - 552

    Lorient, Morbihan, 56322, France

  • Local Institution - 553

    Saint-Herblain, Loire-Atlantique, 44800, France

  • Local Institution - 554

    Angers, Maine-et-Loire, 49933, France

  • Local Institution - 555

    Nantes, Pays de la Loire Region, 44093, France

  • Local Institution - 556

    Pessac, Gironde, 33604, France

  • Local Institution - 557

    Poitiers, Poitou-Charentes, 86000, France

  • Local Institution - 558

    Quimper, 29000, France

  • Local Institution - 559

    Grenoble, Auvergne-Rhône-Alpes, 0, France

  • Local Institution - 560

    Villefranche-sur-Saône, Rhône, 69655, France

  • Local Institution - 561

    Nice, Provence-Alpes-Côte d'Azur Region, 06000, France

  • Local Institution - 562

    Paris, 75014, France

  • Local Institution - 575

    Athens, Attica, 11528, Greece

  • Local Institution - 576

    Thessaloniki, 54639, Greece

  • Local Institution - 577

    Pátrai, Achaïa, 265 04, Greece

  • Local Institution - 579

    Haidari - Athens, Pella, 12462, Greece

  • Local Institution - 580

    Thessaloniki, North Aegean, 552 36, Greece

  • Local Institution - 581

    Thessaloniki, 56429, Greece

  • Local Institution - 625

    Jerusalem, Jerusalem, 9103102, Israel

  • Local Institution - 626

    Tel Aviv, 6423906, Israel

  • Local Institution - 627

    Haifa, 3109601, Israel

  • Local Institution - 628

    Tel Aviv, Tel Aviv, 64239, Israel

  • Local Institution - 629

    Haifa, Tel Aviv, 31048, Israel

  • Local Institution - 650

    Krakow, Lesser Poland Voivodeship, 30-727, Poland

  • Local Institution - 651

    Gdynia, Pomeranian Voivodeship, 81-519, Poland

  • Local Institution - 653

    Lublin, 20-064, Poland

  • Local Institution - 675

    Madrid, 28007, Spain

  • Local Institution - 676

    Oviedo, Principality of Asturias, 33011, Spain

  • Local Institution - 677

    Valencia, 46010, Spain

  • Local Institution - 678

    Málaga, Andalusia, 29010, Spain

  • Local Institution - 679

    Madrid, 28033, Spain

  • Local Institution - 680

    Santiago de Compostela, A Coruña, 15706, Spain

  • Local Institution - 681

    Barcelona, 08035, Spain

  • Local Institution - 682

    Seville, 41009, Spain

  • Local Institution - 683

    Barcelona, 08025, Spain

  • Local Institution - 685

    Palma de Mallorca, Balearic Islands, 07120, Spain

  • Local Institution - 687

    Barcelona, 08028, Spain

  • Local Institution - 688

    Madrid, 28040, Spain

  • Local Institution - 700

    Edirne, 22030, Turkey (Türkiye)

  • Local Institution - 701

    Ankara, 06680, Turkey (Türkiye)

  • Local Institution - 702

    Ankara, Etlik/Ankara, 06010, Turkey (Türkiye)

  • Local Institution - 704

    Ankara, 06200, Turkey (Türkiye)

  • Local Institution - 705

    Ankara, Ankara/Cankaya, 06520, Turkey (Türkiye)

  • Local Institution - 706

    Ankara, 06800, Turkey (Türkiye)

  • Local Institution - 707

    Istanbul, 34722, Turkey (Türkiye)

  • Local Institution - 708

    Izmir, 35100, Turkey (Türkiye)

  • Local Institution - 709

    Istanbul, Samsun, 34214, Turkey (Türkiye)

  • Local Institution - 710

    Istanbul, Samsun, 34846, Turkey (Türkiye)

  • Local Institution - 725

    Sibiu, 550245, Romania

  • Local Institution - 728

    Suceava, 720214, Romania

  • Local Institution - 729

    Craiova, Dolj, 200385, Romania

  • Local Institution - 730

    Timișoara, Timiș County, 300166, Romania

  • Local Institution - 731

    Ovidiu, Constanța County, 905900, Romania

  • Local Institution - 732

    Cluj-Napoca, Cluj, 400641, Romania

  • Local Institution - 733

    Iași, 700106, Romania

  • Local Institution - 734

    Craiova, Dolj, 200746, Romania

  • Local Institution - 752

    Kragujevac, Šumadijski Okrug, 34000, Serbia

  • Local Institution - 754

    Nis, Vojvodina, 11000, Serbia

  • Local Institution - 775

    Perugia, 6132, Italy

  • Local Institution - 776

    Roma, 00144, Italy

  • Local Institution - 777

    Novara, Piedmont, 28100, Italy

  • Local Institution - 778

    Pesaro, Pesaro E Urbino, 61122, Italy

  • Local Institution - 779

    Milan, 20141, Italy

  • Local Institution - 780

    Candiolo, Torino, 10060, Italy

  • Local Institution - 800

    Amsterdam, North Holland, 1066 CX, Netherlands

  • Local Institution - 801

    Utrecht, 3543 AZ, Netherlands

Conditions

Explore the condition pages connected to this study.

ADVANCED CANCER MALIGNANT NEOPLASM OF LUNG METASTATIC CANCER