METASTATIC CANCER

This is an early-stage study testing the safety of a new type of CAR-T cell therapy called PTC13 in adults with advanced solid tumors that have a marker called CEA. The therapy involves collecting a patient's own immune cells, genetically engineering them in a lab to better targe…

This is the first-ever study in people for an experimental pill called IDRX-42. It aims to find a safe dose and see if it can help control advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The study will enroll adults whose cancer h…

This study is for people with liver cancer (HCC) who need surgery to remove their tumor but currently don't have enough healthy liver tissue left to safely undergo the operation. Researchers are testing a treatment called Y90 radioembolization, where tiny radioactive beads are in…

This early-stage trial tests whether a patient's own immune cells can be genetically modified to recognize and attack their cancer. The study is for adults with advanced cancers that have spread and express a specific marker called NY-ESO-1. Researchers will first find the safest…

This early-stage study is testing whether using high-intensity focused ultrasound to break apart a tumor can make immunotherapy drugs work better for people with advanced cancer that has stopped responding to standard treatments. The trial will enroll 24 adults to receive one ult…

This is a first-in-human study testing a new experimental drug called 177Lu-SN201 in adults with advanced solid tumors that have progressed despite standard treatments. The drug is a radioactive nanoparticle designed to accumulate in tumors. The main goals are to find a safe and …

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This study is testing a new combination treatment for cancer that has spread to the liver. It combines a standard procedure (TACE) that delivers chemotherapy directly to the liver tumor with an added drug (bevacizumab) that aims to starve the tumor by blocking its blood supply. T…

This trial is testing if using a very precise, high-dose form of radiation on every visible tumor can help people with cancer that has spread to many places in the body. It will compare this aggressive radiation approach to standard care to see if it helps patients live longer, k…

This study is testing a new oral drug called ART0380 in people with advanced or metastatic solid tumors that have spread and are hard to treat. The main goals are to find the safest and most effective dose of ART0380 when given alone or combined with standard chemotherapy drugs, …

This study is comparing a new two-drug immunotherapy combination (botensilimab + balstilimab) against standard chemotherapy plus immunotherapy for adults with advanced stomach or esophageal cancer that has specific genetic features. The main goal is to see if the new combination …

This early-stage trial is testing a new oral drug called ALTA2618 for people with advanced cancers that have a specific genetic mutation called AKT1 E17K. The study aims to find the safest and most effective dose and see how well the drug works against cancers like breast and end…

This early-stage study is testing whether adding targeted, high-dose radiation to standard immunotherapy can better control advanced solid tumors that have spread to multiple sites. It will enroll about 28 patients whose cancer has spread to 3-10 locations and who are already on …

This is the first human study testing a new drug called IPH5301 for people with advanced cancers that have spread. The trial has two parts: first finding the safest dose of IPH5301 alone, then testing it combined with standard chemotherapy in breast cancer patients. It's for adul…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This early-stage trial is testing a new drug called FOG-001 for people with advanced or spreading cancers that have specific genetic mutations. Researchers want to find the safest dose and see if the drug can shrink tumors or slow cancer growth. The study will include 575 partici…

This early-stage study is testing whether adding a radioactive imaging agent called Y-NM600 can make standard immunotherapy drugs work better for people with metastatic cancer. The main goals are to find a safe dose and see if the combination helps control the cancer. About 60 pa…

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This study is testing two different dosing schedules of the drug adagrasib to see which one works better for people with advanced lung cancer that has a specific genetic change called KRAS G12C. It is for patients whose cancer has continued to grow after trying standard chemother…

This is a first-in-human study to find a safe and effective dose of a new drug called ONM-501. The drug is injected directly into tumors and is being tested alone and in combination with an approved immunotherapy drug (cemiplimab) in adults with advanced cancers that have stopped…

This is a first-in-human study to find a safe dose of a new experimental treatment for advanced cancers that produce a protein called CEA. The treatment is an antibody attached to a radioactive particle (Actinium-225) designed to seek out cancer cells and deliver radiation direct…

This study allows patients with advanced or metastatic cancer who are benefiting from certain experimental drugs to continue receiving them after their original trial ends. It aims to provide continued treatment access while closely monitoring for any long-term side effects. The …

This study is testing a new gene therapy for people with advanced cancers caused by HPV. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack HPV-infected cancer cells, and then infuse them back into the patient. The goal is to see if thi…

This study is testing if adding an experimental drug called givastomig to standard immunotherapy and chemotherapy works better for controlling advanced stomach or esophageal cancer. About 180 adults whose cancer has spread and who have not yet received treatment for their advance…

This study is testing whether a lower dose of radiation can effectively treat metastatic tumors that have a specific genetic change called an ATM mutation. Researchers are recruiting 40 patients to find the minimum radiation dose needed to control these tumors while potentially r…

This early-stage study is testing a new drug called JZP815 in people with advanced or metastatic solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to find a safe dose, understand how the drug works in the body, and look for early signs that i…

This study is testing if two cancer drugs (nivolumab and pembrolizumab) can be given less often while still working effectively. It will compare the standard dosing schedule to a new, less frequent schedule in adults with advanced or metastatic cancer. The main goal is to see if …

This study is testing whether a new immunotherapy drug called MGD019 can help control advanced cervical cancer that has spread or returned. It's for patients who haven't yet received chemotherapy for their advanced disease. Researchers will measure how well the drug controls the …

This is a first-in-human study to test the safety and find the right dose of a new drug called TJ033721 (givastomig) for people with advanced or metastatic solid tumors. It will enroll about 330 patients whose cancer has progressed despite standard treatments or who have no other…

This early-stage study is testing a new oral medication called INX-315 in people with advanced cancers that have spread or stopped responding to standard treatments. It aims to find a safe dose and see if the drug can help control cancers like certain types of breast and ovarian …

This is the first study in people to test a new drug called AU-007 for advanced cancers that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug shows early signs of helping. It will be tested alone and in combination with other…

This study is testing a smartphone app called ApricityCare that helps patients report treatment side effects quickly. The goal is to see if catching problems early helps manage them better, so patients can stay on their cancer therapy longer. It is enrolling 425 adults with metas…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced prostate cancer that has spread and no longer responds to standard hormone treatments. It will involve about 47 men who have already tried other therapies. The main goa…

This early-stage study is testing a new two-step method for patients whose cancer has spread. First, a special imaging scan helps find tumors that might respond to a new targeted radiation treatment. Then, a single dose of that treatment is given to see if it's safe and if it hel…

This study is testing whether adding a new drug called azeliragon to a precise form of radiation therapy is safe and more effective at controlling brain tumors that have spread from other cancers. It will involve about 46 adult patients with small brain tumors. The main goal is t…

This is the first study in people to test a new drug called NTX-1088, an antibody designed to target a protein found on many cancer cells. The main goals are to find safe doses and see how the body processes the drug, both by itself and when combined with an existing immunotherap…

This early-stage trial is testing a new imaging tracer called FAP-2286 to see if it can better detect cancer that has spread (metastasized) in people with solid tumors. The study will enroll about 191 adults with cancers like breast, prostate, pancreatic, and colon cancer. Resear…

This study is testing two different counseling programs designed to help parents who have advanced cancer communicate better with their teenage and young adult children about the disease. Researchers are comparing a shorter, education-focused program with a longer program that in…

This early study is testing a specialized form of proton radiation called 'GRID' for patients with large, inoperable, or metastatic tumors that need treatment to relieve symptoms. The technique delivers radiation in a precise 'peaks and valleys' pattern, which researchers hope wi…

This study is testing whether a monthly check-in about money problems can help people with advanced cancer. It aims to connect 1,000 eligible patients to financial support resources. The goal is to see if this reduces financial worry, improves quality of life, and helps people st…

This study is creating a registry to collect information about short-term side effects in patients receiving targeted, high-dose radiation for cancer that has spread. It will enroll 300 adults with metastatic cancer who are planning to receive, currently receiving, or have comple…

This study is testing a new type of PET scan to see if it can help doctors predict which chemotherapy drugs might work best for a patient's metastatic cancer. A small number of participants with advanced cancer will receive an injection of an experimental imaging agent and then h…

This study is testing whether cancer patients receiving palliative radiation therapy can wear a special smart shirt to monitor their health. Researchers want to see if the shirt can help detect treatment side effects earlier by tracking things like heart rate, breathing, and acti…

This study is testing a tool that uses lab results and other health information to predict how long patients with advanced cancer might live after starting palliative radiation therapy. Researchers will give patients a score and then track their survival and quality of life over …