METASTATIC CANCER

This study tested whether combining three different cancer drugs was safe and could help control advanced solid tumors that had stopped responding to other treatments. It involved 70 people with cancers like advanced lung cancer and colorectal cancer. The goal was to see if this …

This is an early-stage study to test the safety and find the right dose of a new drug called BGB-B3227 for people with advanced or metastatic solid tumors. The drug will be tested both by itself and in combination with another cancer drug, tislelizumab. The main goals are to see …

This study tested a combination of two drugs, futibatinib and pembrolizumab, for people with a specific type of advanced endometrial (uterine) cancer that had spread and was not responding well to standard chemotherapy. The goal was to see if this new combination could shrink tum…

This early-phase study tested a new treatment called BT-001, which is injected directly into tumors. It was given alone and combined with an existing immunotherapy drug (pembrolizumab) to people with advanced cancers that had spread. The main goals were to find a safe dose and se…

This was an early-stage study testing a new gene therapy for advanced cancer that had spread. Doctors took a patient's own white blood cells, genetically modified them in a lab to recognize a specific protein found on cancer cells, and then infused them back into the patient. The…

This was the first human study testing an experimental drug called DS-9606a in people with advanced solid tumors, including ovarian, lung, and pancreatic cancers. The main goals were to find a safe dose and understand how the body processes the drug. The study was terminated earl…

This study tested whether the drug niraparib could help control advanced solid tumors in patients whose cancer has a specific genetic change called a PALB2 mutation. It involved 22 adults with various cancers (like breast, lung, or pancreatic) that had spread or were locally adva…

This early-stage study tested the safety of an experimental treatment called VAXINIA, which is a modified virus designed to infect and kill cancer cells. It was given to 66 adults with advanced solid tumors that had spread and stopped responding to other treatments. The virus was…

This early-stage study tested a new drug called OC-001, both by itself and combined with an existing immunotherapy drug, in people with various advanced cancers that had stopped responding to standard treatments. The main goal was to check the safety of the drug and see how the b…

This study tested an oral medication called ART0380 for people with advanced or metastatic solid tumors that have specific weaknesses in their DNA repair system. It aimed to see if the drug could shrink tumors and was safe. The trial was designed for 36 participants, including th…