METASTATIC CANCER

This study tested a new drug called OC-001, given alone or with an immunotherapy drug (Avelumab), in people with advanced cancers that had spread. The goal was to check safety and how the drug moves through the body. The study was stopped early and involved 73 participants with v…

This early-phase study tested a new treatment called VAXINIA (a virus designed to attack cancer cells) in 66 adults with advanced solid tumors that had spread. The virus was given alone or with an immunotherapy drug (pembrolizumab), either as a shot into the tumor or through an I…

This study tested the drug niraparib in 22 adults with advanced solid tumors (like breast, lung, or pancreatic cancer) that have a specific PALB2 gene mutation. The goal was to see if the drug could shrink tumors or slow cancer growth. The study was stopped early, so results are …

This study tested an experimental drug called ART0380 in 36 people with advanced or metastatic solid tumors, including endometrial cancer. The goal was to see if the drug could shrink tumors. The trial was terminated early, so results are limited. Participants had to have stopped…

This study tested a combination of two drugs, futibatinib and pembrolizumab, in people with advanced endometrial cancer that had spread and was not responding to standard treatments. The goal was to see if the combination could shrink tumors or slow the disease. Only 9 people too…

This early-phase study tested a gene therapy approach for people with metastatic cancer that makes a protein called CEA. Researchers took patients' own immune cells, added a new gene to help them attack CEA-positive tumors, and infused them back after chemotherapy. Only 3 patient…

This study tested a combination of three drugs (azacitidine, pembrolizumab, and epacadostat) in people with advanced solid tumors, including lung and colorectal cancers that had stopped responding to standard treatments. The goal was to see if the combination was safe and could s…

This study tested a combination of two drugs, denosumab and enzalutamide, in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could delay cancer growth longer than historical results w…

This early-stage study tested a new drug, BGB-B3227, alone or with another drug (tislelizumab) in 35 people with advanced solid tumors. The goal was to check safety and find the right dose. The study was terminated early, so results are limited.

This early-phase study tested a new drug, BT-001, injected directly into tumors of people with advanced solid cancers (like melanoma or lung cancer). Some participants also received the immunotherapy pembrolizumab. The goal was to check safety and find the right dose. The study w…

This early-stage study tested a new drug, DS-9606a, in 88 adults with advanced solid tumors that have a specific protein called Claudin-6. The main goal was to check safety and find the right dose. The trial was stopped early, so results are limited.