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Promising prostate cancer combo trial stalls after just 7 patients

NCT ID NCT03869762

Terminated Disease control Sponsor: Cancer Trials Ireland Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tested two drugs—denosumab and enzalutamide—together in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could slow cancer growth better than enzalutamide alone. However, the study was stopped early and only enrolled 7 people, so we cannot draw strong conclusions from it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Denosumab (Xgeva) and Enzalutamide (Xtandi)
What this could lead to
If it worked, this combination might slow cancer growth and reduce bone complications in men with advanced prostate cancer.
What could go wrong
The trial was terminated early with only 7 participants, so results are very limited. It is unclear if the combination is better than enzalutamide alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic carcinoma in the bone metastatic malignant neoplasm metastatic prostate carcinoma Neoplasm Metastasis prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE METASTASES CASTRATION-RESISTANT PROSTATE CANCER METASTATIC CANCER

Contacts and locations

Locations

  • Adelaide and Meath incorporating National Children's Hopsital

    Dublin, Leinster, Ireland

  • Cork University Hospital

    Cork, Munster, Ireland

  • Galway University Hospital

    Galway, Connacht, Ireland

  • Sligo University Hospital

    Sligo, Connacht, Ireland

  • St. Vincent's Hospital

    Dublin, Leinster, Ireland

  • University Hospital Limerick

    Limerick, Munster, Ireland

  • University Hospital Waterford

    Waterford, Munster, Ireland

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