BONE METASTASES

This phase 2 trial tests whether adding the drug narlumosbart and precise radiation therapy to standard first-line treatment can help people with advanced non-small cell lung cancer that has spread to the bones. The study will enroll 27 adults who have not had prior systemic ther…

This study is testing a highly precise radiation method called SBRT for people with cancer that has spread to the spine. The goal is to deliver strong radiation doses while protecting nearby healthy tissue. Researchers will track side effects and how well the treatment controls t…

This study tests whether giving radiotherapy early to high-risk bone metastases that are not yet causing symptoms can prevent future bone complications like fractures. About 120 adults with solid tumors and at least three bone metastases will be randomly assigned to either standa…

This study is tracking 50 people with cancer that has spread to the bones (bone metastases) to see if freezing those tumors with a special probe (cryoablation) can control them. The goal is to prevent local tumor growth, ease pain, and improve quality of life. Participants have l…

This phase 2 trial tests whether a higher dose of radiation (40-50 Gy over 10 sessions) can better relieve pain from cancer that has spread to bones or other areas. Researchers hope to double the complete pain response rate at one month compared to standard doses. The study invol…

This study looks at whether a procedure called arterial embolization can reduce pain and improve quality of life in people with bone metastases (cancer that has spread to the bones). The procedure blocks blood flow to the tumor, which may shrink it and ease symptoms. Researchers …

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medication can reduce the amount of opioids needed after preventive femur surgery. The study includes 60 adults with bone lesions from cancer who are getting a metal rod placed in the thig…

This study tests a newer, more precise radiation method called SBRT against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goa…

This study tests whether a single, quick radiation session can treat painful bone metastases without the usual planning visit. About 40 adults with cancer and one or two painful bone spots will get one dose of radiation in a single trip to the hospital. The goal is to see if this…

This study looks back at 600 patients who had surgery for a broken or about-to-break upper thigh bone caused by cancer that spread from elsewhere. Researchers will compare two surgical methods—a metal rod inside the bone or a replacement joint—to see which one leads to fewer comp…

This study collects health information from 500 adults with painful bone metastases that have spread from other cancers. Researchers aim to better understand the disease and track survival over time. No new treatments are given; participants simply share their medical data.

This study will follow 2500 cancer patients with bone metastases to better understand why some respond to radiation therapy and others do not. Researchers will collect data to build tools that predict pain relief and survival, and to create a platform for testing new treatments. …

Researchers are gathering medical records, scans, and lab results from 250 patients with bone metastases that spread from other cancers. They will use this data to create a dataset called RAW, which will help develop computer models to predict fracture risk and life expectancy. T…