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Preventive radiation may stop bone metastases from causing fractures

NCT ID NCT07146074

Recruiting now Disease control Sponsor: Cancer Research Antwerp Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving radiotherapy early to high-risk bone metastases that are not yet causing symptoms can prevent future bone complications like fractures. About 120 adults with solid tumors and at least three bone metastases will be randomly assigned to either standard care (medication or observation) or standard care plus radiotherapy. Researchers will track how long it takes for a bone complication or death to occur, and compare hospitalization rates and quality of life between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiotherapy
What this could lead to
If it works, this could reduce fractures and other bone complications in cancer patients with bone metastases, improving quality of life.
What could go wrong
This is a relatively small Phase 3 trial (120 participants) and the benefit of early radiotherapy over observation alone is not yet proven. Side effects from radiation are possible.

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Conditions

The condition(s) this trial relates to.

metastatic carcinoma in the bone metastatic malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASYMPTOMATIC OR MINIMALLY SYMPTOMATIC BONE METASTASES HIGH RISK FOR SKELETAL EVENTS SOLID NEOPLASMS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AZ Delta

    RECRUITING

    Roeselare, 8800, Belgium

  • AZ Groeninge

    RECRUITING

    Kortrijk, 8500, Belgium

  • AZ Turnhout

    RECRUITING

    Turnhout, 2300, Belgium

  • AZORG

    RECRUITING

    Aalst, 9300, Belgium

  • Jessa Ziekenhuis

    NOT_YET_RECRUITING

    Hasselt, 3500, Belgium

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven Gasthuisberg

    NOT_YET_RECRUITING

    Leuven, 3000, Belgium

  • ZAS Augustinus

    RECRUITING

    Wilrijk, Antwerp, 2610, Belgium

    Contact Email: •••••@•••••

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