New model aims to predict jaw bone disease before it strikes
NCT ID NCT07691892
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab for at least two years and are scheduled for invasive dental work. By combining clinical exams, imaging, and biological samples like saliva and blood, they hope to build a risk prediction model that could help prevent this painful complication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a tool that helps dentists and doctors identify patients at high risk of jaw bone damage before oral procedures, allowing for better preventive care.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly improve outcomes. The prediction model may not be accurate enough for widespread use.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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