BONE METASTASES

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with cancers that have not responded to standard treatments. The goal is to see if the drug is safe and can help control the disease. About 350 people with various advanced cancers, including…

This phase II trial tests whether adding the immunotherapy drug durvalumab to precise radiation (SBRT) can better control prostate cancer that has returned and spread to a few spots (oligometastases). About 96 men with hormone-sensitive prostate cancer will be randomly assigned t…

This phase 3 trial tests whether giving denosumab every 12 weeks instead of every 4 weeks can still prevent bone complications (like fractures or spinal cord compression) in people with metastatic breast or prostate cancer. About 1,380 participants with bone metastases will be ra…

This study looks at whether adding a high-precision type of radiation called SBRT to usual cancer treatments (like hormone therapy or chemo) can delay cancer growth in people with breast, lung, or prostate cancer that has spread to 1 to 5 bones. About 168 adults aged 18-75 with g…

This study compares two common blood thinners—aspirin and enoxaparin (Lovenox)—to see which works better at preventing dangerous blood clots after surgery for bone cancer or cancer that has spread to the bone. About 2,868 adults having pelvic or leg surgery for these conditions w…

This study tested whether a special PET scan using a radioactive tracer can predict how well patients with advanced HER2-positive breast cancer respond to the drug T-DM1. Ten women with cancer that had spread to other parts of the body received the scan before treatment. The goal…

This study looks at whether a special type of PET/CT scan (called FDG PET/CT) can help doctors see how well hormone therapy is working in breast cancer that has spread to the bones. About 75 adults with estrogen receptor-positive breast cancer and bone metastases will get the sca…

This study tests whether a structured, supervised exercise program is safe and feasible for people with painful non-spine bone metastases who have just had palliative radiotherapy. Twenty participants will follow an 8-week exercise plan plus a short maintenance period. Researcher…

This study tests whether MR-guided focused ultrasound (MR-HIFU), alone or with standard radiotherapy, can better relieve pain from bone metastases than radiotherapy alone. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to …

This study collects medical information from patients whose cancer has spread to the bone. The goal is to learn more about how cancer affects bones and how to prevent complications like fractures and pain. No extra tests or visits are needed—just data from regular care. The study…

This study involves 230 adults with cancer that has spread to their bones who need surgery. Researchers want to improve how doctors estimate survival by combining the patient's own health assessment with the doctor's evaluation. The goal is to create a more accurate prediction to…