BONE METASTASES

This phase 3 trial tests whether giving denosumab every 12 weeks is as effective as the standard every 4 weeks at preventing bone complications (like fractures or need for radiation) in people with metastatic breast or prostate cancer that has spread to the bone. About 1380 parti…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This study compares two common blood thinners, aspirin and low molecular weight heparin (LMWH), to prevent dangerous blood clots after orthopedic surgery for cancer. About 2,868 adults having surgery on the pelvis or leg for bone metastases or sarcoma will be enrolled. The goal i…

This study tests whether adding the drug durvalumab to targeted radiation therapy helps control prostate cancer that has come back in a few spots (up to 5). About 96 men with hormone-sensitive prostate cancer will receive either radiation alone or radiation plus durvalumab for 12…

This study tests whether adding a high-dose, precise type of radiation called SBRT to standard treatments (like hormone therapy or chemotherapy) can delay cancer progression in people with solid tumors that have spread to 1 to 5 spots in the bones. It includes adults up to age 75…

This small pilot study tested whether a special PET scan using a radioactive tracer can predict how well patients with advanced HER2-positive breast cancer respond to the drug ado-trastuzumab emtansine (T-DM1). Ten women with cancer that had spread to other parts of the body rece…

This study tests if using focused ultrasound (MR-HIFU) alone or with standard radiation can better relieve bone pain caused by cancer that has spread to the bones. About 216 adults with painful bone metastases will receive either ultrasound, ultrasound plus radiation, or radiatio…

This study looks at whether a structured, supervised exercise program is safe and doable for people who have had radiation for painful bone metastases (cancer that spread to bones, but not the spine). About 20 adults with good mobility and a life expectancy of at least 6 months w…

This study aims to improve how doctors estimate survival for people with cancer that has spread to their bones. Researchers will combine the doctor's assessment with the patient's own health report to create a more accurate prediction. The goal is to help guide treatment decision…

This study looks at whether a special PET scan can help doctors see how well hormone therapy is working in breast cancer that has spread to the bones. About 75 adults with ER+ breast cancer and bone metastases will get a PET scan before starting new hormone treatment, then again …