Sound waves vs. bone pain: can ultrasound replace radiation?
NCT ID NCT04307914
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether MR-guided focused ultrasound (MR-HIFU), alone or with standard radiotherapy, can better relieve pain from bone metastases than radiotherapy alone. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if this non-invasive heat treatment can improve pain response and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MR-guided high-intensity focused ultrasound (MR-HIFU)
What this could lead to
If it works, this could offer a non-invasive, drug-free option to reduce severe bone pain from cancer that has spread, improving quality of life without surgery.
What could go wrong
This is a mid-stage trial, not yet proven in large populations. The ultrasound procedure may not work for all tumor locations, and pain relief may vary. Risks include tissue heating or nerve damage.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CSSP
Roma, Italy
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IOR
Bologna, Italy
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Isala Klinieken Zwolle
Zwolle, Netherlands
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TUCH Turku
Turku, Finland
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University Hospital Cologne
Cologne, Germany
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University Medical Center Utrecht
Utrecht, Utrecht, 3508GA, Netherlands