QUALITY OF LIFE

This study is testing whether giving patients more oxygen (80%) during major surgery reduces wound infections compared to lower oxygen levels (30% or 50%). It will enroll 7,800 adults having planned surgeries lasting at least 2 hours. The goal is to see if extra oxygen helps peop…

This study tests whether adding the drug adebrelimab to standard chemotherapy before surgery can completely eliminate esophageal cancer in 25 patients with locally advanced disease. The main goal is to see how many patients have no cancer cells left in their removed tissue. Resea…

This study looks at whether a dual bronchodilator (a type of inhaler) can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. About 80 adults aged 40 and older who smoke or used to smoke will take the medication for 12 weeks. Research…

This study tests whether a vacuum-sealed dressing (negative pressure wound therapy) can reduce wound problems like infection or reopening after emergency abdominal surgery. About 720 adults with a large belly incision will be randomly assigned to get either the special dressing o…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their high blood pressure. About 208 participants will use a mobile health app to track medications and receive reminders. The goal is to see if this techno…

This study looks at three ways to correct nearsightedness in children: regular glasses, special glasses that blur side vision, and hard contact lenses worn overnight. Researchers will track how each method affects kids' quality of life, how well they work, and how much they cost …

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, along with practical heat-safety advice, can reduce heat-related health problems and improve quality of life. Over 7,000 people in rural Pakistani villages will participat…

This study looks at whether giving ICU patients extra protein and activating their muscles early (with movement and electrical stimulation) can prevent severe muscle loss. About 40 critically ill adults will take part, with half receiving the extra protein and muscle therapy and …

This study tests a home blood pressure monitoring program combined with health education and coaching for rural adults with uncontrolled hypertension. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bl…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This study tests a new digital follow-up program for people who had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, check for cancer return with a blood test, and provide personalized care. Researchers want to see if this approach improves qu…

This study looks at whether extending the overnight fasting period (prolonged nightly fasting) can improve sleep, thinking, and quality of life in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 60 female survivors who…

This study tests a new rehabilitation program that uses multiple senses (like hearing and touch) to help people with ultra low vision. The goal is to improve visual ability, hand-eye coordination, and quality of life. The program is designed for people whose vision is 20/1600 or …

This study looks at how a health and wellness product affects digestion and quality of life in adults, including those taking GLP-1 medications for weight loss. About 133 people in the U.S. will use the product and report their symptoms through surveys and biomarker tests. The go…

This study looks at children with congenital melanocytic nevi (CMN), a common type of birthmark, to see if surgical removal improves their quality of life and reduces feelings of stigma. About 100 children aged 9 months to 16 years will be followed before and after surgery. The g…

This study tests whether regular, caring phone calls from trained volunteers can reduce loneliness, depression, and thoughts of suicide in older adults who are homebound. About 400 people aged 65 and older who receive home-delivered meals or other community services will be rando…

This study looks at whether a single dose of the anti-inflammatory drug dexamethasone, given during hip replacement surgery, can help people recover better and feel better up to three months later. About 224 adults aged 60 and older having a hip replacement will be randomly assig…

This study is testing if cannabidiol (CBD) suppositories can reduce pain during sex and improve well-being. Researchers will give different doses to 50 adults who experience sexual pain. The study lasts one month, with a follow-up after 12 weeks. Results will help decide if large…

This study looks at how a precise radiation treatment called stereotactic radiosurgery affects quality of life and tremor severity in people with essential tremor or Parkinson's disease. About 60 adults whose tremors are not well controlled by medication will fill out questionnai…

This study compares giving a single high-dose radiation treatment versus several smaller doses for people whose cancer has spread to a few places (up to 5 spots). The goal is to see which approach causes fewer side effects, better controls the cancer, and improves quality of life…

This study is testing a device that uses mild electrical pulses on specific points on the skin (similar to acupressure) to help people with long-term cancer pain feel better. The goal is to see if using this device at home can improve overall quality of life, reduce pain, and les…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, combined with practical heat-safety advice, can reduce heat-related illnesses and improve quality of life. Over 7,000 people in low-income neighborhoods of Karachi, Pakist…

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, and blood sugar control in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires about their mood and energy, and w…

This study looks at whether combining Swiss ball exercises with deep breathing can reduce stress urinary incontinence (leaking urine when coughing, sneezing, or exercising) in pregnant women. About 42 pregnant women with mild to moderate leakage will be split into two groups: one…

This study tests a mobile app called Stappvoorstap designed to help adults in the Netherlands manage stress while they wait for mental health treatment. Over 4 weeks, 54 participants will use the app to track stress, learn coping skills, and do relaxation exercises. The goal is t…

This study tests whether a procedure called alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women with ovarian endometriomas. About 288 women aged 18 to 45 will be randomly assigned to either the procedure or watchful waiting. The main goal is to see i…

This study tests two types of air cleaning devices—energy recovery ventilators and portable air cleaners—to see if they can reduce mold and pollutants in homes and improve asthma symptoms. About 80 children and adults with asthma from low-income households in the Dallas-Fort Wort…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks. Researchers will measure changes in symptoms and quality of life u…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related negative thinking in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. The goal is to see if t…

This study looks at whether a workout program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play games at least one hour per week. The goal is to see…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again. It focuses on solving barriers like frailty, depression, and lack of support. About 43 adults will join to see if the program improves waitlist status and qu…

This study tests whether a structured 24-week Frame Running (a special running bike) training program can improve physical function, daily activities, and quality of life in 35 children and teens aged 8-18 with cerebral palsy or similar physical disabilities. Participants start w…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will measure changes in depression, anxiety, PTSD…

This study looks at whether hearing aids can improve quality of life for cancer patients who develop hearing loss or tinnitus from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing problems will be offered a hearing aid. T…

This study looks at whether adding Brandt-Daroff exercises to the standard GANS maneuver can further reduce dizziness and improve quality of life in people with BPPV, a common cause of vertigo. Thirty adults with BPPV will be split into two groups: one gets the GANS maneuver alon…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study offers a free 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce symptoms of anxiety, depression, and stress while improving quality of life and healthy coping skills. Participants will complete surveys before and af…

This study compares two types of weight-loss surgery—robotic and laparoscopic sleeve gastrectomy—to see which causes less pain the day after surgery. About 91 adults who qualify for weight-loss surgery will be randomly assigned to one of the two procedures. The main goal is to me…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study tests whether a tailored physical activity program can help lymphoma and breast cancer patients maintain their exercise ability, heart function, memory, and quality of life during cancer treatment. About 110 adults aged 18-85 with certain lymphomas or breast cancers wi…

This study compares underwater exercise to regular aerobic exercise in 100 adults with muscle weakness and low quality of life. Participants will be assigned to one of the two exercise programs to see which better improves muscle power, reduces pain, and boosts well-being. The go…

This study tests whether drinking Jing Si Herbal Tea twice a day can improve quality of life and sleep for people with dementia and their caregivers. Over three years, 400 participants will take the tea or a placebo and be followed for six months. The goal is to see if this simpl…

This study looks at how using a handheld breathing device (oscillating PEP) affects quality of life for 60 children (ages 8+) and adults with bronchiectasis. Participants will use the device and answer questionnaires about their daily life before and after. The goal is to see if …

This study looks at two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see which meth…

This study compares a modified double-J ureteral stent with a thinner loop at the bladder end to a standard stent in 40 adults with kidney or ureteral stones. The goal is to see if the new design reduces common side effects like pain, blood in urine, and discomfort, which affect …

This study compares two surgical techniques (Parks and Bacon) for ultra-low rectal cancer to see which one results in better anal function and quality of life one year after surgery. About 256 adults with rectal cancer will be randomly assigned to one of the two procedures. The g…

This study tests whether a 12-week digital yoga program called MediYoga can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online support. The goal is to see if this…

This study tests a wellness program for 50 residents of a transitional housing estate. Participants will do light exercise, gardening, and attend health talks. The goal is to see if the program improves quality of life, happiness, and daily activities.

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teens and young adults (ages 14-21) with sickle cell disease cope with stress related to racism. About 30 participants will join a 10-session group therapy program o…

This study is testing three different dry needling sessions to see if they can reduce pain and improve quality of life for people with chronic low back pain. Dry needling uses very thin needles inserted into muscles to relieve pain and improve function. The study will include hea…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain science education, can reduce headache-related disability in women aged 18-48 with migraine. One hundred participants will either exercise three times a week or follow at-ho…

This study compares two home exercise programs—Dynamic Neuromuscular Stabilization (DNS) and Pelvic Floor Muscle Training (PFMT)—for women with stress urinary incontinence (leakage with coughing, sneezing, or exercise). About 51 women will be randomly assigned to one of three gro…

This study compares three add-on therapies—mirror therapy, brain stimulation, and robotic hand training—for stroke survivors who have arm weakness and pain. 120 adults aged 40-80 who had a stroke at least 3 months ago will receive one of these treatments alongside standard rehab.…

This study tests whether a non-invasive technique called transcranial magnetic stimulation (TMS) can help people recover movement after brain tumor surgery. Six adults with lasting motor problems will receive daily TMS sessions for three days. Researchers will measure muscle stre…

This study is testing whether a pulmonary rehabilitation program can help people with advanced non-small-cell lung cancer preserve muscle mass, improve lung function, and reduce inflammation. About 94 participants will take part in the program while receiving standard cancer trea…

This study tests if a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. Researchers will enroll 106 survivors who have memory, mood, or social problems. Participants use a web app designed to support healthy living and em…

This study tests a program to help veterans leaving the military manage pain and reduce risky substance use. About 1,800 veterans will take part. The program adds extra support for case managers to help veterans use non-drug pain treatments and safer pain management strategies.

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study is testing whether smelling lavender essential oil can help improve mental health and quality of life for women who are waiting to start IVF treatment. Researchers will compare 120 women split into three groups: one using real lavender oil, one using a fake scent, and …

This study is testing a support program designed to help women transition to life after ovarian cancer treatment. Researchers will enroll 120 women who have recently completed their initial treatment and randomly assign them to either receive this specialized survivorship care or…

This study is testing a new topical gel and mouthwash to see if it can reduce the occurrence of severe mouth sores in people receiving radiation treatment for head and neck cancer. It will involve about 63 participants and will also measure how the treatment affects their quality…

This study aims to find out which of two fertility treatment approaches causes less stress and provides better quality of life for women. 60 women undergoing IVF for either egg freezing or genetic testing will try both treatment methods. Researchers will compare how satisfied wom…

This study tests whether a digital dashboard can help home visitors in Rwanda deliver mental health support more effectively. The program, called Sugira Muryango, aims to improve family well-being and reduce violence. About 1,800 caregivers and officials will take part to see if …

This study is a large registry that will follow 8,000 cancer patients treated with a new type of radiation machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to see if this technology improves survival, tumor control, and quality of life …

This study follows 327 adults aged 65 and older who have surgery to remove gastrointestinal cancer. Researchers want to find out what factors lead to a decline in physical function and quality of life one year after surgery, and how these relate to cancer outcomes over five years…

This study follows women who already have Silimed breast implants to see how safe they are over 10 years and how satisfied the women are with the results. About 632 women who had breast augmentation for cosmetic or reconstructive reasons will be checked for side effects and quali…

This study looks at how a brief full-body cold-water bath changes the way people make decisions, their mood, and body signals like heart rate and stress hormones. Forty healthy adults will take both a cold and a warm bath on different days and then complete tasks measuring risk-t…

This study looks at how inner strengths like resilience, gratitude, and acceptance help older adults (60+) maintain a good quality of life and reduce loneliness, anxiety, and depression. Researchers will survey 110 people in Spain to understand these strengths and test a program …

This study translates the Parkinson's Disease Dyskinesia Scale (PDYS-26) into Turkish and checks if it is accurate and reliable. Researchers will ask 130 people with Parkinson's disease to complete the questionnaire along with other surveys. The goal is to provide a trusted tool …

This study looks at how anxiety levels and attitudes toward artificial intelligence relate to quality of life in women receiving infertility treatment. About 191 women aged 18-45 will fill out questionnaires. The goal is to understand these connections, not to test a new treatmen…

This study surveys 400 Danish men undergoing ICSI due to low sperm quality. It aims to understand their emotional experiences, social burden, and testosterone levels, and compare these to a similar study from 2008. No treatment is given; the goal is to gather updated knowledge to…

This study looks at how a heart condition called ventricular tachycardia affects quality of life in people with an implanted defibrillator. Researchers want to see if asking patients to fill out regular questionnaires can help compare two treatments: a procedure called catheter a…

This study looks at how small fiber neuropathy (nerve damage causing pain, burning, and tingling) impacts the daily life and medical costs of people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure quality of life using standard surveys and tr…

This study observes 200 adults with graft-versus-host disease (GvHD) to see how depression and other mental health issues relate to their physical symptoms and quality of life. Researchers will use surveys and psychiatric assessments to gather data. The goal is to understand if t…

This study looks at the long-term health of children (age 16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's transplant medications. Abou…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers will track their physical and emotional distress, financial struggles, care needs, and quality of life over one year. The goal is to develop a tool that can predict which patients are …

This study follows 160 men with good-prognosis metastatic testicular cancer to see whether surgery (RPLND) causes fewer side effects than chemotherapy. Researchers will measure quality of life, fatigue, and other outcomes over time. The goal is to help doctors and patients choose…

This study looks at what makes life better for people aged 60 and older living in nursing homes in Hanoi, Vietnam. Researchers will interview 176 residents to see how things like health, daily independence, and support from others affect their quality of life. The goal is to use …

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their own healthcare. The app includes a digital medical passport, educational information, community suppor…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study is for women who have had the first stage of implant-based breast reconstruction and have surgical drain tubes in place. The goal is to see if showering 48 hours after surgery increases the risk of infection or affects quality of life. About 100 participants will be fo…

This study follows 1500 women for 5 years after breast cancer surgery to understand how their quality of life changes. Participants fill out questionnaires about their physical and emotional well-being. No new treatments are tested—the goal is simply to learn from patients' real …

This study watches 67 adults with advanced solid cancers to see how immunotherapy changes their physical fitness and daily life. Participants do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers also collect blood samples an…

This study follows 384 women who receive Silimed smooth breast implants for cosmetic reasons. Researchers will track any short- and long-term side effects over 10 years and measure how satisfied patients are with the results. The goal is to confirm the implants are safe and work …

This study follows 800 adults who spent at least 48 hours in the ICU to see how many develop ongoing pain after leaving the hospital. Researchers will call participants at 90 and 180 days to ask about pain, sleep, mood, and quality of life. A smaller group will also have a detail…

This study looks at how the daily abilities of young children with rare genetic disorders affect their families' mental health and quality of life. Researchers will assess 45 children aged 0-4 and their caregivers using questionnaires. The goal is to help doctors provide better s…

This study tests a coaching program for pregnant doctors or those who recently gave birth. About 48 participants will be randomly assigned to receive coaching or not. The goal is to see if coaching reduces burnout and improves well-being. Researchers will use surveys and intervie…

This study follows 260 adults newly diagnosed with cancer who had no prior sleep issues. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand how sleep problems emerge and what factors—like treatments or emotional distress—m…

This study is testing a program called CAPABLE, which is added to regular home-based primary care for older adults who are homebound and may feel socially isolated or lonely. The goal is to see if this combined approach can improve their daily function, reduce pain and depression…

This study looks at how sleep issues impact memory, thinking, and quality of life in women treated for breast cancer. Researchers will track sleep patterns and mental function in 75 patients aged 39 to 69. The goal is to understand the link between sleep and cognition to develop …

This study looks at how a pilonidal cyst coming back affects the quality of life of people who were already treated with surgery or laser. Researchers will ask 100 participants about pain, discomfort, and how long they needed care or time off. The goal is to better understand the…

This study looks at how nerve pain (neuropathic pain) impacts the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain severity and quality of life in 128 adults with type 2 diabetes. The goal is to better understan…

This study aims to understand how two mental practice techniques—imagining movements and watching others perform movements—affect muscle activity in stroke survivors. Researchers will measure electrical signals in arm and hand muscles of 28 participants during these exercises to …