QUALITY OF LIFE

This study compares three ways to correct nearsightedness (myopia) in children aged 7-17: regular glasses, special glasses that blur side vision, and rigid contact lenses worn overnight. Researchers will track how each method affects quality of life, vision, and costs over one ye…

This study tests whether special air cleaners and ventilators can reduce indoor pollutants and mold, helping people with asthma breathe easier. About 80 children and adults with asthma from low-income households in the Dallas-Fort Worth area will receive either real or placebo de…

This study tests whether giving extra protein and activating muscles early can reduce muscle loss in critically ill patients in the intensive care unit (ICU). About 40 adults on breathing machines will be split into two groups: one gets standard care, the other gets extra protein…

This study tests whether adding the drug adebrelimab to standard chemotherapy before surgery can completely eliminate esophageal cancer in 25 patients with locally advanced disease. The main goal is to see how many patients have no cancer cells left in their removed tissue. Resea…

This study looks at whether a dual bronchodilator (a type of inhaler that opens airways) can improve both breathing and heart function in people newly diagnosed with moderate-to-severe COPD. Researchers will measure exercise capacity, quality of life, and lung function over 12 we…

This study tests a special vacuum dressing (negative pressure wound therapy) on the incision after emergency belly surgery. It aims to see if it reduces wound complications like infection or reopening compared to a regular bandage. About 720 adults with a midline incision longer …

This study tests whether a combination of chemotherapy and radiation before surgery (total neoadjuvant therapy) can help about half of rectal cancer patients achieve a complete response, allowing them to avoid surgery and preserve their rectum through a watch-and-wait strategy. T…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their blood pressure. Participants will use a medication reminder app and receive health tips. The goal is to see if these tools improve blood pressure cont…

This study tests whether a home blood pressure monitoring program with health coaching can help rural adults better control their high blood pressure. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bl…

This study looks at whether older adults (60+) with kidney failure who still produce some urine can safely start dialysis just twice a week instead of the usual three times. The goal is to see if fewer sessions lower hospital stays, falls, and other complications while maintainin…

This study is testing whether giving patients more oxygen (80%) during major surgery reduces wound infections compared to lower oxygen levels (30% or 50%). It will enroll 7,800 adults having planned surgeries lasting at least 2 hours. The goal is to see if extra oxygen helps peop…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, along with practical heat-safety advice, can reduce heat-related health problems and improve quality of life. Over 7,000 people in rural Pakistani villages will participat…

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections (pneumonia) and improve survival in ICU patients with severe brain injuries. About 3,300 adults on ventilators due to stroke, trauma, or lack of …

This study tests a coaching program for pregnant or new-mom doctors in training. About 48 participants will either get coaching (one-on-one and group sessions) or not. Surveys over 7 months will measure burnout, well-being, and confidence. The goal is to see if coaching helps the…

This study looks at whether a pulmonary rehabilitation program can help people with advanced non-small-cell lung cancer maintain muscle mass, improve lung function, and reduce inflammation. About 94 participants will take part while receiving standard cancer treatments like chemo…

This study tests whether a program called CAPABLE, when added to regular home-based primary care, can help older adults who feel lonely or isolated. About 450 participants will receive support to improve their ability to do daily activities and reduce pain and depression. The goa…

This study is testing a small, patient-controlled device that sends mild electrical pulses to acupoints on the body. The goal is to see if using it at home can improve quality of life for people with long-term cancer pain. Researchers will track pain levels, painkiller use, mood,…

This study tests a new digital follow-up program for people who had early-stage colorectal cancer. The program uses a smartphone app to monitor symptoms, fear of cancer returning, and late side effects, and provides personalized care. It compares this approach to standard follow-…

This study looks at whether a 16-week supervised aerobic exercise program, combined with a single session of pain education, can help women aged 18 to 48 who have migraines. Participants will be randomly assigned to either the exercise group or a control group that gets advice on…

This study tests a new rehabilitation program that uses multiple senses (like touch and hearing) to help people with ultra low vision. The goal is to improve visual ability, hand-eye coordination, and quality of life. The program is for people with very low vision (20/1600 or wor…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in 120 women waiting for IVF treatment. Participants are split into three groups: one gets real lavender, one gets a placebo scent, and one gets no scent. The goal is to see if aroma…

This study aims to find out which ovarian stimulation method is more comfortable and satisfying for women undergoing IVF. About 60 women will try both a new approach (using CFA and PPOS) and the standard approach, then report their experiences. The goal is to improve quality of l…

This study looks at whether adding kinesiotaping (a special elastic tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks pregnant and aged 18-35 will take part. They wi…

This study compares three treatments—mirror therapy, brain stimulation (rTMS), and robotic hand therapy—added to standard rehab for stroke survivors. It aims to see which best improves arm movement, quality of life, and pain. About 120 adults aged 40-80 who had a stroke at least …

This study tests whether taking a collagen supplement for 8 days can improve quality of life, appetite, and blood sugar in overweight or obese adults aged 18-65. Participants will take the supplement or a placebo, fill out questionnaires about their mood and energy, and wear a co…

This study tests whether a 24-week Frame Running training program can improve physical function, daily activity, and quality of life in children aged 8-18 with cerebral palsy or similar conditions. Participants start with a low-intensity familiarization period, then progress to m…

This study is testing whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help Black teenagers and young adults with sickle cell disease cope with stress related to racism. About 30 participants aged 14-21 will take part in a 10-session group therapy…

This study tests if a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital and now face problems like memory trouble, anxiety, or depression. About 106 survivors will use a special app designed to support their mental and soc…

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat-related chest injuries. About 50 adults in Ukraine will be randomly assigned to one of the two treatments. The goal is to see…

This study tests whether regular, friendly phone calls can improve mental health and reduce loneliness in older adults who are homebound. About 400 people aged 65 and older who receive home services will be assigned to one of two types of supportive phone calls or a control group…

This study tests whether a non-invasive technique called Transcranial Magnetic Stimulation (TMS) can help people recover movement after brain tumor surgery. Six adults with recent or long-lasting motor problems will receive three daily TMS sessions. Researchers will measure muscl…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks and report how their symptoms and quality of life change. The goal …

This study looks at whether adding Brandt-Daroff exercises (simple head movements done at home) to the standard GANS maneuver can better reduce dizziness and improve quality of life in people with BPPV, a common inner-ear problem that causes brief spinning sensations. Researchers…

This study tests a special gel and mouthwash (XCM-OM118) in 63 head and neck cancer patients getting radiation, with or without chemo. The goal is to see if it lowers the chance of severe mouth sores (grade 3-4) and improves quality of life. Patients use the product during radiat…

This study tests a mobile app called Stappvoorstap for adults on mental health waiting lists in the Netherlands. Over 4 weeks, participants use the app to track stress, learn coping skills, and access relaxation exercises. The goal is to see if the app can reduce stress and impro…

This study tests whether Jing Si Herbal Tea can improve quality of life and sleep for people with dementia and their caregivers. Over three years, 400 participants will take the tea or a placebo twice daily for six months. Researchers will measure changes in well-being and daily …

This study tests whether a 12-week digital yoga program called MediYoga can improve quality of life, lower blood pressure, and reduce heart rate in 456 adults with paroxysmal atrial fibrillation. Participants use a smartphone app and get online support. The goal is to see if this…

This study looks at whether hearing aids can improve the quality of life for cancer patients who develop hearing problems from platinum-based chemotherapy. About 52 adults currently receiving such chemotherapy and experiencing hearing loss will be offered a hearing aid. Researche…

This study looks at how using a handheld breathing device (oscillating PEP) affects quality of life in people with bronchiectasis. Researchers will ask 60 children (ages 8+) and adults to fill out questionnaires before and after using the device. The goal is to see if the device …

This study looks at whether extending the nightly fasting period (not eating for a longer stretch at night) can improve sleep, thinking, and quality of life in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 60 female …

This study tests if dry needling—inserting thin needles into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will compare three different dry needling sessions in 42 adults aged 18 to 65. The goal is to see if the appr…

This study compares four types of mouthwash (Bone Bioactive Liquid, Hyaluronic Acid, Chlorhexidine, and Warm Saline) to see which one helps gums heal best after wisdom tooth removal. About 100 adults will use one of the rinses after surgery. The goal is to find which mouthwash im…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two doses of LSD or a very low dose as a placebo.…

This study tests if a precise radiation treatment called stereotactic radiosurgery can reduce tremors and improve quality of life for people with essential tremor or Parkinson's disease whose medications aren't working well enough. About 60 adults will receive the treatment and t…

This study tests a program called CAPABLE Transplant to help people on the kidney transplant waitlist become active again. It focuses on solving barriers like frailty, depression, or lack of support. The study includes 43 adults and will see if the program improves waitlist statu…

This study enrolls 120 women with ovarian cancer who have finished their initial treatment. It tests a special survivorship care program (POSTCare-O) designed to provide support during the transition after treatment. Participants are randomly assigned to receive the program or us…

This study looks at whether a fermented whey and fiber supplement can improve digestive comfort in recreational athletes. About 114 participants will be split into two groups: those without stomach issues and those with them. Researchers will measure breath hydrogen and symptom s…

This study compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by combat injuries in Ukraine. Fifty adults with moderate to severe pain from neuromas will be randomly assigned to one treatment. The go…

This study compares two types of exercise training—Dynamic Neuromuscular Stabilization (DNS) and Pelvic Floor Muscle Training (PFMT)—in women with stress urinary incontinence (leaking urine when coughing, sneezing, or exercising). About 51 women will be randomly assigned to one o…

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This study looks at whether doing Swiss ball exercises along with deep breathing can help pregnant women who leak urine when they cough, sneeze, or exercise. About 42 pregnant women with mild to moderate stress urinary incontinence will be split into two groups: one doing ball ex…

This study compares a modified double-J ureteral stent with a thinner loop to a standard stent in 40 adults with kidney or ureteral stones. The goal is to see if the new design reduces common side effects like pain, blood in urine, and discomfort, which can lower quality of life.…

This study looks at children with large birthmarks (congenital melanocytic nevi) who choose to have them surgically removed. The goal is to see if removal improves their quality of life and reduces feelings of being stigmatized. About 100 children aged 9 months to 16 years will b…

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study compares giving a single high-dose radiation treatment versus several smaller doses for people whose cancer has spread to a few places (up to 5 spots). The goal is to see which approach causes fewer side effects, better controls the cancer, and improves quality of life…

This study looks at how a health and wellness product affects digestion and quality of life in adults, including those taking GLP-1 medications for weight loss. About 133 people in the U.S. will use the product and report their symptoms through surveys and biomarker tests. The go…

This study looks at whether a single dose of the anti-inflammatory drug dexamethasone, given during hip replacement surgery, can help people recover better and feel better up to three months later. About 224 adults aged 60 and older having a hip replacement will be randomly assig…

This study is testing if cannabidiol (CBD) suppositories can reduce pain during sex and improve well-being. Researchers will give different doses to 50 adults who experience sexual pain. The study lasts one month, with a follow-up after 12 weeks. Results will help decide if large…

This study looks at whether combining pain education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. Researchers will track how well participants stick with the program and any side effects like incr…

This study tests whether affordable home improvements like shade, reflective roof paint, and better airflow, combined with practical heat-safety advice, can reduce heat-related illnesses and improve quality of life. Over 7,000 people in low-income neighborhoods of Karachi, Pakist…

This study tests whether a procedure called alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women with ovarian endometriomas. About 288 women aged 18 to 45 will be randomly assigned to either the procedure or watchful waiting. The main goal is to see i…

This study looks at whether a workout program can help recreational video game players react faster and click more accurately. Researchers will measure changes in reaction time and mouse accuracy in 15 college students who play games at least one hour per week. The goal is to see…

This study tests whether an 8-week virtual reality adventure exergaming program can improve physical activity, mood, and thinking in women veterans aged 18-45. Participants will play VR games that involve movement, and researchers will measure changes in depression, anxiety, PTSD…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study offers a free 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce symptoms of anxiety, depression, and stress while improving quality of life and healthy coping skills. Participants will complete surveys before and af…

This study compares two types of weight-loss surgery—robotic and laparoscopic sleeve gastrectomy—to see which causes less pain the day after surgery. About 91 adults who qualify for weight-loss surgery will be randomly assigned to one of the two procedures. The main goal is to me…

This study compares underwater exercise to regular aerobic exercise in 100 adults with muscle weakness and low quality of life. Participants will be assigned to one of the two exercise programs to see which better improves muscle power, reduces pain, and boosts well-being. The go…

This study compares two surgical techniques (Parks and Bacon) for ultra-low rectal cancer to see which one results in better anal function and quality of life one year after surgery. About 256 adults with rectal cancer will be randomly assigned to one of the two procedures. The g…

This study tests a wellness program for 50 residents of a transitional housing estate. Participants will do light exercise, gardening, and attend health talks. The goal is to see if the program improves quality of life, happiness, and daily activities.

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study looks at how immunotherapy for advanced cancer changes a person's physical fitness and quality of life. About 67 adults will do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers will also track their health for up…

This study looks at how small-fiber neuropathy (nerve damage causing pain, burning, and tingling) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's, comparing those with and without nerve pain. The …

This study looks at how sleep problems impact thinking skills and quality of life in 75 women treated for breast cancer. Researchers will track sleep patterns using a wrist monitor and ask participants about their memory and mood. The goal is to better understand these links and …

This study explores how depression and other mental health issues impact the severity of symptoms in people with graft-versus-host disease (GvHD), a complication after bone marrow transplant. Researchers will follow 200 adults and use questionnaires to measure mood, symptoms, and…

This study looks at how well treatments for a fast heart rhythm called ventricular tachycardia (VT) work by asking patients about their quality of life. About 70 adults with an implanted defibrillator (ICD) will fill out questionnaires before and after treatment, either with a ca…

This study follows 250 people with chronic diverticular disease to see if elective surgery improves their quality of life compared to those who continue with non-surgical care. Participants complete questionnaires about their symptoms, bowel function, and overall well-being. The …

This study is translating and testing a questionnaire called AQUAREL, which measures quality of life in people with pacemakers. The goal is to create a reliable Turkish version that doctors can use to assess how patients feel and function. The study will involve 120 adults who ha…

This study follows 160 men with good prognosis metastatic testicular cancer to see if surgery (RPLND) causes fewer side effects than chemotherapy. Participants choose or are assigned to either surgery or 3-4 rounds of chemo. Researchers track quality of life, fatigue, and other o…

This study looks at how getting a full set of fixed dental implants changes people's daily lives and well-being. Researchers will follow 100 adults who need implants in their upper or lower jaw. The goal is to understand the social and emotional impact of this treatment, not just…

This study looks at what helps older adults in nursing homes in Hanoi, Vietnam, have a better quality of life. Researchers will interview 176 residents aged 60 and older to see how things like health, independence, and support from others affect their well-being. The goal is to u…

This study follows 327 adults aged 65 and older who have surgery to remove gastrointestinal cancers. Researchers track their physical function, quality of life, and cancer outcomes for up to 5 years. The goal is to identify factors that predict decline, helping doctors better sup…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1,800 veterans who recently left service and have a back, neck, knee, or shoulder condition will take part. The program includes s…

This study is testing a smartphone app called Empower My Congenital Health (EmpowerMyCH) designed to help adults with congenital heart disease feel more confident managing their health. Researchers will enroll 1000 adults aged 18 and older to use the app and provide feedback on i…

This study follows 800 adults who spent at least 48 hours in the ICU to learn why some develop long-lasting pain. Researchers will track pain, sleep, mood, and quality of life at 90 and 180 days after leaving the ICU. A smaller group will get extra tests to understand how pain fe…

This study follows 632 women who received Silimed breast implants (textured or polyurethane-coated) for augmentation. Researchers will track side effects and patient satisfaction over 10 years. The goal is to better understand the long-term risks and how happy women are with thei…

This study follows 200 adults with advanced cancer who are receiving immunotherapy. Researchers will track their physical and emotional distress, financial burden, care needs, and quality of life over one year. The goal is to develop a tool that can predict who is at high risk fo…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep problems. Researchers will track insomnia symptoms over the first year using questionnaires. The goal is to understand when and why sleep issues start and what factors—like treatment type or emotion…

This study follows 1500 people for 5 years after breast cancer surgery to see how their quality of life changes. Participants will fill out questionnaires about their physical and emotional well-being. The goal is to better understand the long-term effects of surgery and help imp…

This study follows 100 people whose pilonidal cyst came back after either surgery or laser treatment. Researchers will use questionnaires to measure how the recurrence impacts their quality of life, pain, and daily activities. The goal is to better understand the long-term effect…

This study looks at how nerve pain (neuropathic pain) impacts the ability to care for oneself and overall quality of life in people with type 2 diabetes. Researchers will measure pain severity and quality of life in 128 adult volunteers using standard questionnaires. The goal is …

This study looks at how women's feelings about artificial intelligence (AI) relate to their anxiety and quality of life while going through infertility treatment. About 191 women aged 18-45 who are currently receiving treatment will fill out surveys. The goal is to understand if …

This study looks at whether providing meal kits and nutrition education can improve food security, diet quality, mental health, and heart health in adults aged 40 and older with low income. About 120 participants will either receive meal kits and classes or just general nutrition…

This study follows 384 women who receive Silimed smooth breast implants for breast augmentation. Researchers will track any side effects or complications over 10 years and measure how satisfied patients are with the results. The goal is to better understand the long-term safety a…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study tests whether an 8-week online education program based on logotherapy (finding meaning in life) can increase physical activity and improve quality of life in middle-aged adults with desk jobs. Researchers will recruit 200 participants aged 35-60 in Croatia, randomly as…

This study aims to find blood markers that can predict serious complications after high-risk surgeries like heart, lung, or colon operations. Researchers will collect blood samples from about 5,000 patients before and after surgery and track their recovery. The goal is to create …

This study looks at how personal strengths like resilience, gratitude, and acceptance help older adults (60+) maintain a good quality of life and feel less lonely or anxious. Researchers will survey 110 people living in Spain to understand these strengths and test a program that …

This study looks at how the daily abilities of young children with rare genetic disorders affect their families' mental health and quality of life. Researchers will assess 45 children aged 0-4 and their caregivers using questionnaires. The goal is to help doctors provide better s…

This study translates and tests a questionnaire called PDYS-26 for Turkish-speaking people with Parkinson's disease. The questionnaire measures how involuntary movements (dyskinesia) affect daily activities. About 130 participants will fill out the form along with other surveys t…

This study surveys 400 Danish men undergoing ICSI due to low sperm quality. It aims to understand their emotional experiences, social burden, and testosterone levels, and compare these to a similar study from 2008. No treatment is given; the goal is to gather updated knowledge to…

This study tests whether a digital dashboard can help home visitors in Rwanda deliver mental health support more effectively. The program, called Sugira Muryango, aims to improve family well-being and reduce violence. About 1,800 caregivers and officials will take part to see if …

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study is for women who have had the first stage of implant-based breast reconstruction and have surgical drain tubes in place. It aims to see if showering 48 hours after surgery increases the risk of infection or affects quality of life. Half of the 100 participants will be …

This study looks at how a brief full-body cold-water bath changes the way people make decisions, their mood, and body signals like heart rate and stress hormones. Forty healthy adults will take both a cold and a warm bath on different days and then complete tasks measuring risk-t…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study aims to understand how two mental practice techniques—imagining movements and watching others perform movements—affect muscle activity in stroke survivors. Researchers will measure electrical signals in arm and hand muscles of 28 participants during these exercises to …