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Radiation may offer better quality of life than hormone pills for older breast cancer patients

NCT ID NCT05472792

Recruiting now Disease control Sponsor: UNC Lineberger Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for women aged 65 and older with low-risk breast cancer who have had a lumpectomy. It compares two follow-up treatments: a short course of targeted radiation (5 sessions) versus 5 years of hormone pills. The main goal is to see which approach gives a better quality of life after one year. The researchers hope radiation might be easier to tolerate while still keeping the cancer from coming back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiation (accelerated partial breast irradiation) or hormone therapy (tamoxifen, anastrozole, exemestane, letrozole, fulvestrant, toremifene)
What this could lead to
If successful, this could show that a short course of radiation after lumpectomy offers better quality of life than years of hormone pills, while still controlling the cancer.
What could go wrong
This is a small, early-phase study (90 people) and only looks at 1-2 year outcomes. It may not prove long-term safety or apply to all older women with breast cancer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER QUALITY OF LIFE

Contacts and locations

Locations

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

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