Unc Lineberger Comprehensive Cancer Center

This early-stage trial is testing a new type of immune cell therapy called CAR-T cells that target a protein called B7-H3 on triple-negative breast cancer cells. The cells also have a safety switch to stop them if needed. Up to 42 adults whose cancer has returned or not responded…

This study tests a 6-month family-based program called HomeGrown, designed to help parents of young children (ages 2-6) with Down syndrome create healthier home environments. Families get online tools, resources, and monthly coaching calls to improve nutrition and physical activi…

This early-phase study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses a patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side eff…

This phase 2 study tests a combination of three drugs—isatuximab, lenalidomide, and dexamethasone—at lower doses than usual for people newly diagnosed with multiple myeloma who are at high risk for side effects. The goal is to see if the treatment can still control the cancer whi…

This study is for women aged 65 and older with low-risk breast cancer who have had a lumpectomy. It compares two follow-up treatments: a short course of targeted radiation (5 sessions) versus 5 years of hormone pills. The main goal is to see which approach gives a better quality …

This early-phase trial is testing a new treatment for ovarian cancer that has returned after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The main goal is to find a safe dose and see what side…

This phase 2 trial is testing whether adding low or high dose radiation to standard chemotherapy and the immunotherapy drug pembrolizumab can improve treatment for people with node-positive triple negative breast cancer. Thirty-two participants will be randomly assigned to receiv…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This early-stage study tests whether a new type of immune cell therapy (CAR T-cells) is safe for people with glioblastoma, a fast-growing brain cancer that has come back or not responded to standard treatment. The therapy is given directly into the fluid around the brain. The mai…

This study tests whether adding a low dose of erlotinib to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and effective for people with advanced pancreatic cancer. Participants are grouped by tumor type: those with 'basal-like' tumors get the new combo, while thos…

This study is for people with a high-risk type of breast cancer (triple-negative) who still have cancer cells left after standard treatment and surgery. Researchers will use a special blood test (ctDNA) to look for tiny traces of cancer DNA that scans might miss. If the test find…

This study tests a new, ultra-short radiation schedule for early-stage breast cancer. Instead of the usual 3 weeks, patients receive 5 radiation sessions over one week, with an extra boost to the tumor site given at the same time. The goal is to see if this approach is safe, redu…

This Phase 2 trial tests whether adding trilaciclib to the chemotherapy drug lurbinectedin can reduce severe neutropenia (a dangerous drop in white blood cells) in people with small cell lung cancer that has spread. About 30 participants will receive both drugs intravenously. The…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has come back or not responded to standard therapy. The treatment uses the patient's own T-cells, which are modified in a lab to better recognize and attack cancer cells. The main goals …

This study tests a mobile health program designed to help young adults (ages 18-39) who have survived cancer and are now overweight or obese. Participants will either get a full weight management program through their phone or receive basic digital tools and support. The goal is …

This study tests whether an online weight management program for child care providers can improve the diet and physical activity of 2-5-year-old children in their care. About 84 child care centers and 924 participants (directors, teachers, and children) will take part. Some cente…

This study tests a new treatment called iC9-CAR.CSPG4 T cells for people with head and neck cancer that has come back after standard treatments. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The main goals are to fin…

This early-phase study tests a new treatment for people with advanced lung cancer that has not responded to standard therapies. The treatment uses a patient's own immune cells (T cells) that are modified in a lab to better recognize and attack cancer cells. The main goal is to fi…

This early-stage trial tests the safety of combining two drugs, ONC201 and atezolizumab, in 58 women with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see if body weight affects treatment. The goal is to find the best dose …

This study tests a new treatment for people with certain types of lymphoma or leukemia that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The main goal is t…

This study looks at how the genetic makeup of pancreatic cancer affects response to a chemotherapy called FOLFIRINOX given before surgery. About 45 adults with non-metastatic pancreatic cancer will receive the chemo, then have their tumors analyzed to see if genetic subtypes (lik…

This early-phase trial is testing whether giving a combination of two drugs (XL092 and cemiplimab) before surgery can help people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer. The study will enroll 12 participants to see if the treatment is safe an…

This pilot study tests a special radiation technique called GRID therapy given before standard radiation and surgery for people with soft tissue sarcoma in their arms or legs. The goal is to see if GRID can safely increase the radiation dose to the tumor without causing more woun…

This study tests a new type of immunotherapy called CAR-T cells, which are specially engineered to recognize and attack CD30, a protein found on Hodgkin lymphoma cells. The trial enrolls up to 31 adults whose cancer has returned or not responded to standard treatments. Participan…

This study tests a new approach for people with peripheral T-cell lymphoma that has come back or not responded to standard treatments. Researchers take a patient's own immune T-cells, modify them in the lab to recognize and attack cancer cells carrying the CD30 protein, and infus…

This early-phase study tests two drugs—ulixertinib and palbociclib—together in people with advanced solid tumors, including pancreatic cancer and certain melanomas. The main goal is to find a safe dose and check for side effects. About 45 adults whose cancers have not responded t…

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study is testing a new ultrasound imaging method called Contrast Enhanced Super-Resolution (CESR) to see if it can better detect and tell apart cancerous and non-cancerous lesions in the breast, liver, and kidney. It involves 40 participants: 10 healthy volunteers to fine-tu…

This study is testing a new, non-invasive ultrasound method to see if it can tell the difference between benign and malignant breast tumors. Researchers will also check if it can measure how well breast cancer responds to chemotherapy. Up to 250 women with breast lumps or breast …

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This pilot study compares contrast-enhanced digital breast tomosynthesis (CE-DBT) to standard MRI in 20 women with known breast lesions. Researchers want to see if CE-DBT can give doctors similar confidence in identifying suspicious areas. If it works, it might offer a quicker or…

This study tests a personalized program combining exercise and nutrition advice to help reduce fatigue in people with indolent (slow-growing) lymphomas, such as chronic lymphocytic leukemia and follicular lymphoma. Participants receive an individualized exercise plan and dietary …

This study tests whether taking a short chain fatty acid supplement can reduce gut-related side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 adults will be randomly assigned to receive either the supplement or a placebo. The goal i…

This study tests a remote coaching program called PRISM for people recently diagnosed with metastatic breast cancer. The program teaches stress management, goal setting, and coping skills through video sessions. Researchers want to see if it improves resilience and quality of lif…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: mem…

This study tests whether combining three treatments—kyphoplasty (spine stabilization), radiofrequency ablation (heat to destroy tumor tissue), and standard radiation—can better reduce pain from spine tumors. About 70 adults with cancer that has spread to the middle or lower back …

This study tests a program called enCompass Humana, which provides coaching and resources to unpaid caregivers of adults with both cancer and diabetes. The goal is to see if the program is practical and helpful for caregivers, improving their coping skills and reducing loneliness…

This pilot study is testing whether a personalized exercise and rehabilitation program given before cancer treatment (called prehabilitation) can help adults with cancer maintain their function and quality of life. Sixty participants will be randomly assigned to either receive th…

This early study tests whether a gel spacer, already used in prostate cancer, can be safely placed between the cervix and rectum in 14 women with cervical cancer receiving standard chemoradiation. The goal is to see if the gel creates enough space to reduce radiation exposure to …

This Phase 2 trial tests whether using MRI to map saliva ducts before radiation therapy can reduce dry mouth in people with oropharyngeal cancer. About 98 participants will be randomly assigned to standard radiation planning or a new approach that spares the parotid ducts. The ma…

This study looks at whether a 16-week exercise program called Get Real and Heel can increase physical activity and improve well-being in people with metastatic breast cancer. Researchers will enroll 50 participants to see if the program is feasible and helps with symptoms, qualit…

This study looks at whether providing free, healthy frozen meals to families of children with cancer is practical and helpful. About 30 children aged 12-17 and their parents will receive meals for 12 weeks during chemotherapy. The goal is to see if families find the meals easy to…

This study tests whether a digital art therapy app called ARTCan is practical and acceptable for young adults aged 18-25 who survived childhood cancer. Participants use the app for 6 weeks to create art and complete mood surveys. The goal is to see if at least 10 out of 15 partic…

This research study creates a registry of older adults with cancer to collect information about their health, treatments, and outcomes. Participants complete a geriatric assessment and allow researchers to follow their medical records. The goal is to better understand how cancer …

This study tests an artificial intelligence (AI) tool designed to help doctors and physicists review radiation treatment plans for cancer patients before therapy begins. The AI highlights differences in how providers plan treatments and flags potential warning signs, aiming to re…

This study looks at how words like 'all natural' or 'zero sugar' on beer, hard seltzer, and flavored malt drinks change what people think about the drink and whether they want to try it. About 1,500 adults in the US who drink alcohol will answer questions after seeing different l…

This study collects tumor tissue and blood samples from 10,000 women with breast cancer to build a large biorepository. Researchers will analyze these samples to find molecular markers that may predict how well a patient responds to therapy. The goal is to better understand breas…

This study tests whether specially designed ads can help people who use both cigarettes and e-cigarettes quit. Over 5 weeks, 90 participants will receive these ads and answer surveys about their interest in quitting. The goal is to see if the ads increase quit intentions and atte…

This study is for people with metastatic breast cancer, including estrogen receptor-positive and triple-negative types. It uses biomarkers from tumors and blood to guide treatment choices, comparing how long the cancer stays controlled on the new therapy versus the previous one. …

This study is developing and testing a mobile app designed to help Black people with pancreatic cancer learn about and discuss clinical trials with their doctors. The goal is to increase their participation in these trials, which is currently much lower than for White patients. R…

This study is testing whether HPV DNA found in blood and urine can be used as a simple, non-invasive way to detect cervical cancer and monitor how well treatment is working. Researchers will collect samples from 30 women newly diagnosed with cervical cancer before and after their…

This study is building a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Participants will complete physical and mental function tests, surveys, and provide blood samples over time. The goal is to learn how cancer and its treatments affect agi…

This registry is collecting information from 2,000 people with metastatic cancer who are receiving radiation therapy as part of their standard care. Researchers will gather clinical data and patient-reported outcomes to better understand how radiation affects cancer outcomes. The…

This study looks at whether chemotherapy speeds up aging in the body's organs. Researchers will take blood samples from 80 women with early-stage breast cancer before and after treatment to measure markers of cellular aging. The goal is to find out if these markers can predict wh…

This study looks at 220 people with HPV-related oropharynx cancer to see if certain gene mutations (TRAF3 and CYLD) and levels of HPV DNA in the blood can predict if the cancer will come back after treatment. Participants give blood samples and fill out quality-of-life questionna…

This study watches how people with gastrointestinal or sarcoma cancers do during and after their standard treatments, including radiation. It aims to learn more about side effects and how well the treatments control the cancer. The results will help doctors improve future treatme…

This study tests a decision aid called BREASTChoice in 20 breast cancer patients who had breast surgery. Participants use the tool on their phones and share their thoughts in interviews. Researchers measure how much patients learn about reconstruction options using a knowledge su…

This study looks at a blood test that measures tiny bits of tumor DNA floating in the blood. Researchers will enroll 50 adults with head and neck cancer who are planning surgery. They want to see how these DNA levels change after surgery and whether they can help predict if the c…

This study asks 200 women who have finished treatment for non-metastatic breast cancer about their willingness and ability to eat healthier foods. Participants complete online surveys and review an educational flyer about diet and cancer. The goal is to understand what helps or h…

This study looks at whether giving doctors the molecular subtype of a patient's metastatic breast cancer helps them pick more effective treatments. It involves 500 adults with metastatic breast cancer who are starting or have had one prior treatment. The main goal is to see how o…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like leukemia or lymphoma. The tool helps patients clarify their values and shares that information with their doctors. The goal is to see if using PRIME leads to treatment decis…

This study looks at whether adding an oncology research navigator (ORN) to standard cancer navigation helps patients with cancer. About 686 adults with new cancer appointments will take part. Some will get the usual navigation, while others also get an ORN who helps them find sup…

This study looks at whether a blood test can find tiny bits of tumor DNA left after breast cancer surgery. It includes 100 women with early-stage breast cancer that spread to 1-3 lymph nodes. The goal is to see if this test can help predict which patients are more likely to have …

This study is creating a large registry of 800 lymphoma patients in Malawi to collect detailed information about the disease. Researchers will perform biopsies and track patients over time to understand how lymphoma affects people in sub-Saharan Africa. The goal is to gather data…

This study tests whether showing surgeons a visual decision-support tool before they meet with patients improves how they discuss risks and benefits of surgery. Up to 20 urologists and 200 patients with prostate or kidney cancer will take part. Researchers will compare conversati…

This study is creating a Spanish-language version of a decision aid called BREASTChoice to help Spanish-speaking Latina women make informed choices about breast reconstruction after mastectomy. Researchers will work with 50 women to adapt the tool culturally and linguistically. T…

This study creates a registry for adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Researchers will collect health information and optional blood samples to better understand these conditions. The goal is to gather data that could support future resear…

This pilot study looks at whether showing educational videos about genetic testing can increase the number of patients with ovarian or endometrial cancer who get tested. About 30 participants will watch a short video relevant to their cancer type and then fill out a satisfaction …

This study collects blood, tissue, and body fluid samples from up to 15,000 people with blood cancers or related disorders. The samples are stored in a central lab for future research on diagnosis, prognosis, and immune monitoring. Participants do not receive any treatment as par…

This study surveys 100 young adults (ages 18-39) receiving cancer treatment at a North Carolina hospital to compare their satisfaction in two different infusion spaces. Participants fill out surveys and may join interviews about their experience with the room design and mental he…

This study collects pleural fluid (fluid around the lungs) and medical information from patients with known or suspected lung cancer or lung infections. The goal is to build a registry of samples that researchers can use to develop better tests and treatments in the future. Parti…

This study enrolls 3,300 women with invasive breast cancer living in 59 North Carolina counties. It aims to understand how tumor biology, healthcare access, and patient behavior together affect outcomes. All participants receive a structured program to improve communication with …

This study asks 15 doctors, nurses, and physician assistants about a new computer tool that estimates how long patients with metastatic breast cancer might live. The goal is to see if the tool is easy to use and helpful for discussing end-of-life care. Researchers will interview …