Unc Lineberger Comprehensive Cancer Center

This study tests whether a self-applied cream (5-fluorouracil) after a standard heat procedure can help clear HPV infections in women with HIV in Kenya. About 140 women will use the cream or a placebo every two weeks for six months. The goal is to see if the cream improves HPV cl…

This study tests whether giving a combination of two drugs (XL-092 and pembrolizumab) before surgery can shrink tumors in people with a type of mouth cancer called oral cavity squamous cell carcinoma. The trial will include 26 adults whose cancer has not spread too far and is HPV…

This study tests whether tirzepatide, a diabetes and weight-loss drug, can slow or stop the growth of early endometrial cancer or its precursor (EIN) in women with obesity. About 40 women will be randomly assigned to receive tirzepatide or no drug for 4 weeks before their schedul…

This study looks at whether people with chronic lymphocytic leukemia (CLL) who have been in remission for at least two years can safely stop taking their BTK inhibitor medication. Researchers will track how long patients stay cancer-free without treatment, and whether stopping le…

This study looks at whether a virtual support platform can improve emotional well-being and quality of life for men who have had testicular cancer. About 360 men in North Carolina will be split into two groups: one gets access to the virtual support platform, the other gets educa…

This study tests an online tool called Let's Talk to help people with Lynch syndrome encourage their relatives to get screened for cancer. Researchers will work with 20 participants (15 patients and 5 genetic counselors) to see if the tool is easy to use and improves knowledge. T…

This study aims to make cervical cancer screening easier for women with HIV in the United States. Researchers will talk to patients and doctors to find out what makes it hard to get screened and will test a self-testing option for HPV. The goal is to help more women get the care …

This study tests if wearable health trackers (like a Fitbit) can be easily used in a cancer clinic to monitor patients getting chemotherapy and radiation. About 20 adults with cancer will wear a device during their treatment and for 4 weeks after. The goal is to see if patients a…

This study tests whether trained community health workers and local organizations can help more women in rural North Carolina get screened for cervical cancer. About 112 women who haven't had a recent Pap or HPV test will receive a self-collection kit at home. The goal is to see …

This study looks at how much mental effort doctors put into writing case reports about rare tumors. It tests whether using an AI tool can make this task easier. About 10 doctors, medical students, or postdocs will write two case reports—one with AI help and one without—in a singl…

This study will test an artificial intelligence (AI) tool designed to help doctors and physicists review radiation treatment plans for prostate cancer before treatment starts. The AI highlights differences in how doctors plan treatments and flags potential errors, aiming to reduc…

This study tests whether showing patients a short educational video before they sign consent for Whipple surgery (a complex pancreas cancer operation) improves their understanding and satisfaction compared to the usual verbal discussion alone. About 60 adults scheduled for Whippl…

This study looks at whether offering colorectal cancer screening kits through community pharmacies makes it easier for people to get screened. About 1,500 patients and pharmacy staff will take part. The goal is to see if this approach increases screening rates and is practical fo…