Unc Lineberger Comprehensive Cancer Center

This early study is testing whether the weight-loss medication tirzepatide can slow the growth of endometrial cancer tumors. Twenty obese women with this type of cancer will take the drug for four weeks before their scheduled surgery. Researchers will compare tumor samples taken …

This study is testing whether giving two drugs, XL-092 and pembrolizumab (Keytruda), before surgery can better shrink tumors in people with a specific type of oral cavity cancer that is not linked to HPV. The goal is to see if this combination leads to more patients having little…

This study aims to find better treatments for advanced breast cancer by matching therapies to specific tumor characteristics. It will enroll 700 patients whose cancer has progressed after initial treatment. Doctors will analyze tumor markers and assign standard treatments accordi…

This study aims to find the best dose of radiation to combine with standard chemotherapy and immunotherapy before surgery for an aggressive type of breast cancer that has spread to lymph nodes. It will enroll 32 patients who will be randomly assigned to receive either a low or hi…

This study is testing if a medication called tirzepatide, which is used for weight loss and diabetes, can slow the growth of abnormal cells in the uterus before a patient's scheduled surgery. It will involve 40 women with obesity who have been diagnosed with a pre-cancerous condi…

This is a first-in-human safety study for a personalized cancer vaccine called PANDA-VAC. It will be given alongside the immunotherapy drug pembrolizumab to 6 patients with advanced squamous cell lung cancer or head and neck cancer. The vaccine is custom-made for each patient bas…

This study is testing an online tool designed to help people with Lynch syndrome talk to their family members about getting genetic screening. Lynch syndrome is an inherited condition that increases the risk of several cancers. The goal is to see if this digital tool makes it eas…

This study is testing if getting colorectal cancer screening kits through community pharmacies helps more people complete this important preventive test. About 1,500 adults who are behind on their recommended screenings will be randomly assigned to either receive the pharmacy-bas…

This study is testing a family program called HomeGrown, designed to help prevent obesity and promote healthy growth in young children with Down syndrome. It works by supporting families to make changes at home related to nutrition and physical activity. The study will first chec…

This study aims to make cervical cancer screening more accessible for women in rural North Carolina by using community organizations to distribute at-home HPV test kits. Local health workers will help women through the testing process and guide those with positive results to foll…

This study is testing whether combining three treatments works better to relieve moderate-to-severe back pain in adults with cancer that has spread to the middle or lower spine. All participants will receive a spine stabilization procedure, a heat-based tumor treatment, and radia…

This study aims to see if a virtual support platform can improve the emotional well-being and quality of life for men who have had testicular cancer. It will enroll 360 men in North Carolina within five years of their diagnosis. Participants will be randomly assigned to either us…

This study aims to see if using artificial intelligence (AI) can make it easier for doctors to write detailed reports about rare tumor cases. Ten physicians or medical trainees will try writing reports with and without AI help during a single 2-hour session. The main goal is to m…

This study is testing a new computer tool that uses artificial intelligence (AI) to help doctors and medical physicists review radiation treatment plans for prostate cancer. The tool highlights potential errors and differences in how doctors plan treatments, aiming to catch mista…

This study aims to improve how patients learn about a major pancreas cancer surgery called a Whipple procedure. Researchers will test if adding an educational video to the standard consent process helps patients understand the surgery better and feel more satisfied. The goal is t…

This study is testing whether wearable health trackers (like smart watches) can be easily used to monitor patients during combined chemotherapy and radiation treatment for cancer. Researchers want to see if collecting daily health data (like heart rate and activity) helps doctors…