Unc Lineberger Comprehensive Cancer Center

This study is for people with metastatic breast cancer (cancer that has spread). It aims to see if choosing treatments based on specific tumor markers (biomarkers) can help control the disease longer. About 700 participants will receive standard therapies matched to their biomark…

This early-stage study tests a new treatment for triple negative breast cancer that has come back or not responded to other therapies. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goal is to che…

This study tests a program called HomeGrown that helps families of young children with Down syndrome (ages 2-6) create healthier home environments. The goal is to improve eating habits and physical activity to prevent obesity. About 38 families will be randomly assigned to start …

This early-phase study tests a new treatment for advanced lung cancer that uses a person's own immune cells, modified to better recognize and attack cancer cells. The treatment, called iC9-GD2.CAR.IL-15 T cells, combines antibodies and T cells to target a protein (GD2) found on s…

This study tests whether lower doses of three drugs (isatuximab, lenalidomide, and dexamethasone) can safely and effectively treat newly diagnosed multiple myeloma in patients who are very likely to have severe side effects from standard treatment. The goal is to reduce side effe…

This early-stage study tests two drugs, ulixertinib and palbociclib, together in people with advanced solid tumors, including pancreatic cancer and certain melanomas. The main goal is to find the safest dose and check for side effects. About 45 adults whose cancer has not respond…

This study tests a new treatment for people with certain types of lymphoma or leukemia that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The main goal is t…

This study tests a shorter, 5-day radiation treatment for women aged 50 and older with early-stage breast cancer or DCIS. The goal is to see if this ultra-fast approach is as safe and effective as longer courses, with fewer side effects and less disruption to daily life. About 90…

This study tests a new treatment for people with a rare type of blood cancer (peripheral T-cell lymphoma) that has come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, modifying them in a lab to recognize and attack cancer ce…

This study tests a new gene therapy for people with pancreatic cancer that has returned after standard treatment. The therapy uses the patient's own immune cells, modified to target a protein called B7-H3 on cancer cells, and includes a safety switch to control side effects. The …

This study tests whether a mobile health program can help young adults (ages 18-39) who have survived cancer and are now overweight or obese lose weight. Participants will be randomly assigned to either a full mobile weight management program or a self-guided version with digital…

This early-phase study tests whether giving two drugs (XL092 and cemiplimab) before surgery can help remove a rare and fast-growing thyroid cancer called anaplastic thyroid cancer. The study includes 12 adults whose cancer has a specific gene change (BRAF V600E). The main goals a…

This early-phase study tests the safety of a new treatment for glioblastoma, an aggressive brain cancer that has returned or not responded to standard therapy. The treatment involves taking a patient's own immune cells (T cells), modifying them in a lab to recognize and attack ca…

This study is for people with a high-risk type of breast cancer (triple negative) who still have cancer after standard treatment and surgery. Researchers will use a simple blood test to look for tiny bits of cancer DNA that might be left in the body. If the blood test finds cance…

This early-phase study tests a new treatment for children whose neuroblastoma or osteosarcoma has come back or not responded to standard therapy. The treatment uses the patient's own T cells (a type of immune cell) that have been genetically modified to recognize and attack GD2, …

This study tests a new treatment for Hodgkin lymphoma that has returned or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells carrying a protein called CD30. About 31 participants will receive…

This early-stage study tests a new treatment for ovarian cancer that has come back after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goal is to find a safe dose and understand…

This study tests a new treatment called iC9.CAR-CSPG4 T cells for people with head and neck cancer that has returned after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goals ar…

This study is for people with operable, lymph node-positive triple negative breast cancer. It tests whether giving a low or high dose of radiation to the breast tumor along with immunotherapy (pembrolizumab) before standard chemotherapy can improve the chance of eliminating all c…

This study tests whether an online weight management program for child care teachers can improve the diet and physical activity of 2-5-year-old children in their care. About 84 child care centers and over 900 participants (directors, teachers, and children) will take part. Some c…

This study tests whether a special type of radiation called GRID, given before standard radiation and surgery, is safe and effective for people with soft tissue sarcoma in their arms or legs. The goal is to improve tumor removal and reduce the chance of the cancer coming back, wi…

This study looks at how the genetic makeup of pancreatic cancer affects response to FOLFIRINOX chemotherapy given before surgery. About 45 adults with non-metastatic pancreatic cancer will receive chemo, then have their tumors analyzed. The goal is to see if certain tumor types r…

This early-stage study tests the safety of combining two drugs, atezolizumab and ONC201, for women with advanced or recurrent endometrial cancer. The trial includes both obese and non-obese participants to see how body weight affects treatment. Researchers aim to find the best do…

This study tests if adding a low-dose EGFR blocker (erlotinib) to standard chemotherapy works better for people with a specific type of advanced pancreatic cancer called 'basal-like.' Participants first get a test to classify their tumor. Those with basal-like cancer may receive …

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in obese patients with endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor samples taken before and a…

This study tests whether adding trilaciclib to the standard drug lurbinectedin can lower the risk of dangerous low white blood cell counts (neutropenia) in people with advanced small cell lung cancer that has stopped responding to initial treatment. About 30 adults will receive t…

This study compares a newer X-ray-based imaging method (contrast-enhanced digital breast tomosynthesis, or CE-DBT) with standard contrast-enhanced MRI for evaluating known breast lesions. About 20 women with suspicious breast findings will undergo both scans to see if CE-DBT prov…

This study is testing a new imaging method called Contrast Enhanced Super-Resolution (CESR) ultrasound to see if it can better find cancer in the breast, liver, and kidney. About 40 people will take part: 30 patients with known lesions and 10 healthy volunteers to help fine-tune …

This study tests whether combining three treatments—a spine-stabilizing procedure, radiofrequency ablation (using heat to destroy tumor tissue), and radiation therapy—can better relieve pain in people with cancer that has spread to the middle or lower back. All 70 participants wi…

This study tests whether taking short-chain fatty acid (SCFA) supplements can reduce stomach and bowel side effects caused by radiation therapy for cancers in the belly or pelvis. About 122 adults receiving such radiation will be randomly assigned to get either the supplement or …

This study is testing a remote program called PRISM that teaches stress management and resilience skills to people recently diagnosed with metastatic breast cancer. The goal is to see if it improves quality of life and possibly survival, especially for Black women who often have …

This study tests a new way to give radiation for head and neck cancer that may reduce dry mouth, a common and severe side effect. About 98 adults with oropharynx cancer will be randomly assigned to standard radiation or a technique guided by MRI that spares the saliva ducts. The …

This study is testing whether a personalized exercise and rehabilitation program given before cancer treatment (called prehabilitation) can improve how well patients function and their overall quality of life. Researchers will enroll 60 adults with cancer who are starting care at…

This study tests a program called enCompass Humana, designed to support family caregivers of people with both cancer and diabetes. The program offers coaching and help finding resources to reduce stress and improve coping skills. About 162 caregivers will take part to see if the …

This study tests whether a smartphone app that guides users through art therapy can help young adults (ages 18-25) who survived childhood cancer feel better emotionally. Participants use the app for 6 weeks, completing weekly art prompts and surveys about their mood and quality o…

This study looks at whether providing free, healthy frozen meals to families of children undergoing cancer treatment is practical and helpful. About 30 children aged 12-17 and their parents will take part. The goal is to see if families find the meal program easy to use and suppo…

This study is testing a values assessment tool for women with metastatic breast cancer and their caregivers. The goal is to see if the tool helps them feel less conflicted about treatment decisions and improves communication with their doctors. About 40 participants will use the …

This study looks at whether a community-based exercise program called Get Real and Heel can help people with metastatic breast cancer become more physically active. Researchers want to see if the program improves quality of life, physical function, and social support while reduci…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women undergoing chemotherapy for early-stage breast cancer. About 90 participants will be split into three groups: on…

This study tests a gel spacer placed between the cervix and rectum during radiation therapy for cervical cancer. The gel creates space to protect nearby organs like the bladder and rectum from radiation damage. Researchers want to see if this approach is safe and feasible in 14 p…

This study is creating a Spanish-language version of a decision aid called BREASTChoice to help Spanish-speaking Latina breast cancer survivors make informed choices about breast reconstruction after mastectomy. Researchers will work with 50 women to adapt the tool culturally and…

This study interviews 15 doctors and nurses who care for people with metastatic breast cancer. The goal is to find out if a new computer tool that predicts how the disease may progress is easy to use and helpful. The results will guide how to best bring this tool into everyday ca…

This study looks at whether giving doctors extra genetic information about a patient's metastatic breast cancer helps them choose better treatments. About 500 adults with metastatic breast cancer will join. Doctors will get a special test result (PAM50) that shows the tumor's mol…

This study tests a new tool that lets cancer patients report any issues that might delay their treatment. Researchers want to see if this tool can help identify and address problems sooner, especially for racial groups that often face longer delays. The study will enroll 240 adul…

This study is creating a large registry of lymphoma patients in Malawi to collect detailed information about the disease and its treatment. Researchers will enroll 800 people with suspected lymphoma, perform biopsies, and follow their health over time. The goal is to better under…

This study creates a registry of 500 children, teens, and young adults (up to age 39) diagnosed with cancer. Participants fill out surveys, do physical and thinking tests, and give blood or other samples at diagnosis, during treatment, and yearly after. The goal is to learn how c…

This study looks at a blood test that measures tiny bits of tumor DNA floating in the bloodstream. Researchers will enroll 50 adults with head and neck cancer who are scheduled for surgery. They want to see how these DNA levels change after surgery and whether they can help predi…

This study looks at why some women with breast cancer have worse outcomes than others, especially African American and American Indian women. Researchers will collect medical and genetic information and also teach participants how to better communicate with their healthcare team.…

This study looks at whether a blood test can find tiny bits of tumor DNA left after surgery in women with early-stage breast cancer. The goal is to see if this test can help identify patients who are more likely to have their cancer come back. The study includes a special focus o…

This study tests a decision-support tool called PRIME for adults aged 60 and older with blood cancers like lymphoma, leukemia, or multiple myeloma. The tool helps patients clarify their personal values and shares that information with their doctors. The goal is to see if using PR…

This study follows 180 adults with gastrointestinal or sarcoma cancers who are receiving standard treatments like radiation. Researchers will monitor how long patients live without cancer returning and track any side effects. The goal is to learn how newer treatments are affectin…

This study looks at whether showing educational videos about genetic testing helps more people with ovarian or endometrial cancer get tested. About 30 participants will watch a short video and may fill out a satisfaction survey. Researchers will compare testing rates before and a…

This study uses special MRI scans to see how radiation treatment for brain tumors affects thinking and memory. Researchers will follow 15 people with newly diagnosed brain metastases who are getting stereotactic radiosurgery. The goal is to better understand the brain changes tha…

This study is building a registry of 2,000 adults with plasma cell disorders, such as multiple myeloma and amyloidosis. Participants fill out health questionnaires and may give a blood sample to study aging markers. The goal is to gather information to help future research, not t…

This study is a registry that collects medical information and patient feedback from 2,000 adults with metastatic cancer who are receiving radiation therapy as part of their standard care. The goal is to build a large dataset to help researchers understand how radiation affects o…

This study tests whether visual decision aids help urologists better discuss risks and benefits of surgery with patients who have prostate or kidney cancer. About 20 doctors and 200 patient visits will be recorded and analyzed. The goal is to see if these tools improve communicat…

This study collects blood, bone marrow, and tissue samples from up to 15,000 people with blood cancers or related disorders. The samples are stored and used for future research to better understand these diseases. Participants do not receive any treatment as part of this study. T…

This study looks at how words on alcohol cans and bottles change what people think about the drink and whether they want to try it. About 1,500 adults in the US who drink alcohol will view different product images and answer questions. The goal is to understand if marketing claim…

This study is testing whether HPV DNA found in blood and urine can be used to detect cervical cancer and track how well treatment is working. Researchers will collect samples from 30 women newly diagnosed with cervical cancer before and after their treatment. The goal is to see i…

This study surveys 100 young adults (ages 18-39) receiving cancer treatment at North Carolina Basnight Cancer Hospital to compare their satisfaction with two different infusion spaces. Participants fill out surveys and may join interviews about the environment and mental health s…

This study collects fluid from around the lungs (pleural fluid) from people with lung cancer, breast cancer, or lung infections. The goal is to build a registry of samples and health information for future research. No treatments or new procedures are involved—samples are taken d…

This study looks at whether chemotherapy for early-stage breast cancer speeds up aging in organs like the heart and brain. Researchers will measure specific proteins and cell changes in blood samples from 80 women before and after treatment. The goal is to identify patients at hi…

This study is testing a mobile decision aid for breast cancer patients who have had surgery. Twenty participants will use the tool on their phones and share their thoughts out loud. Researchers will measure how much the tool improves knowledge about reconstruction options. The go…

This study looks at which features of vaping prevention ads are most effective for teens and young adults aged 13-20 who either vape or are open to trying it. Participants will watch a few short ads online and rate how convincing each one is. The goal is to learn what makes an ad…

This study follows 220 people with HPV-related throat cancer to see if a simple blood test for HPV DNA and changes in two genes (TRAF3 and CYLD) can predict if the cancer will come back after treatment. Participants will give blood samples and fill out quality-of-life questionnai…

This study looks at whether adding a special helper called an oncology research navigator (ORN) to standard cancer care helps patients access support services and join clinical trials. About 686 adults with new cancer appointments at UNC Medical Center will take part. The goal is…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus also providing HPV self-collection kits through community health workers. About 2,900 women will take part to see if the community approach increases s…

This study looks at how willing and able women with non-metastatic breast cancer are to make healthier food choices. About 200 women who have finished their main cancer treatment will fill out online surveys and review an educational flyer about diet and cancer. The goal is to un…