Exercise and drug combo may fight chemo brain fog

NCT ID NCT06727773

Recruiting now Symptom relief Sponsor: UNC Lineberger Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: memantine plus exercise, memantine alone, or a placebo. The goal is to see if this approach is practical and helps protect brain function during treatment.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm cognitive disorder Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER BREAST CANCER STAGE I BREAST CANCER STAGE II BREAST CANCER STAGE III COGNITIVE CHANGE COGNITIVE DECLINE COGNITIVE IMPAIRMENT LOCALLY ADVANCED BREAST CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••

Contact