COGNITIVE IMPAIRMENT

This study is testing whether a three-week virtual reality brain training program, combined with a daily pill (sodium butyrate), can improve thinking skills like memory and focus in middle-aged and older adults who have had depression or bipolar disorder but are currently stable.…

This study is testing if adding a nutrient called choline to the special food given to treat severe malnutrition helps children's brain development. Researchers in Malawi will give 1500 malnourished children, aged 6-59 months, either the standard therapeutic food or the food with…

This study has two main goals. First, it aims to find out how common memory and thinking problems are in older adults with type 2 diabetes. Second, it will test a 2-year personalized health program designed to slow down cognitive decline. The program combines medication managemen…

This study is testing whether metformin, a medication commonly used for diabetes, can help children and young adults recover thinking skills and brain health after treatment for brain tumors. Researchers will give 140 participants either metformin or a placebo pill for 16 weeks t…

This study is testing whether a gentle, non-invasive brain stimulation technique, when combined with standard thinking-skills therapy, can help improve memory and thinking in people who have had a recent stroke. About 70 participants who are having trouble with thinking after a s…

This study is testing whether a home-based brain training program, delivered on a tablet, can help reduce thinking and memory problems after a stroke. It will involve 100 adults who recently had a stroke. One group will do 40 hours of brain exercises over 8 weeks, while the other…

This study is testing if a daily antioxidant supplement called MitoQ can improve thinking skills like memory and focus in people with early schizophrenia. Researchers will enroll 100 people, but only 50 with a specific blood marker of 'mitochondrial dysfunction' will take either …

This study is testing whether a newer schizophrenia medication called Xanomeline/Trospium (XT) can improve thinking, memory, and concentration over one year of treatment. It involves 171 adults with schizophrenia who are already stable on their current antipsychotic medication. T…

This study is testing if adding a special milk-derived ingredient (MFGM) to the standard therapeutic food given to children with severe malnutrition can improve their brain development and reduce the worst outcomes like death or hospitalization. Researchers in Sierra Leone will c…

This study is testing whether a gentle, non-invasive brain stimulation technique can help children recover from lingering effects of mild concussions. Researchers will work with 10 children aged 10-15 who still have symptoms like balance problems or thinking difficulties weeks af…

This study is testing whether a safe, mild form of brain stimulation (tDCS) can boost the benefits of computer-based brain training for people who have trouble with memory and thinking after a minor stroke. About 60 participants will be randomly assigned to receive either the rea…

This study is testing whether adding acupuncture to the standard Alzheimer's medication donepezil can better help patients with mild to moderate symptoms. It will involve 180 people who will either receive the medication alone or the medication plus acupuncture three times a week…

This study is testing a new, automated tool designed to help primary care doctors easily screen older adults for early signs of memory or thinking problems. The tool runs on an iPad and is being tested specifically with 100 Spanish-speaking adults aged 60 and older. The goal is t…

This study is testing a new, brief iPad-based tool called MyCog to help primary care doctors detect early signs of memory loss and dementia more effectively. It focuses on helping older adults from Black, Hispanic/Latino, and low-income communities who often face delays in diagno…

This study is checking if a new virtual reality (VR) system can accurately test brain function and movement, just like standard paper or face-to-face exams. Researchers will have 200 participants—some healthy and some with neurological conditions—take the same tests in both VR an…

This study aims to find the best bedside test to predict which unconscious patients in the intensive care unit (ICU) with low blood pressure will improve after receiving IV fluids. Researchers will compare several simple, low-cost methods, like leg raising, against more complex m…

This study is testing a new, smaller, and more portable type of brain scanner called the Radialis PET Imager. Researchers want to see if it can detect the amyloid plaques linked to Alzheimer's disease as accurately as the standard, larger PET scanners currently in use. The goal i…

This study is testing whether a 6-month program focused on nutrition education, healthy cooking classes, and at-home brain exercises can help prevent cognitive decline in adults at higher risk for dementia. Researchers will enroll 120 adults aged 55-85 and randomly assign them to…

This study is testing a program designed to prevent delirium, a common and serious state of confusion after surgery in older adults. Researchers will first test patients' memory before surgery to identify those at highest risk. Those patients and their care teams will then receiv…

This study is testing whether a 12-month exercise and coaching program can help adults with mild to moderate cognitive impairment. Fifty participants in South Carolina will exercise twice weekly, either in-person with a coach or remotely with support, for up to a year. Researcher…

This study is testing whether a 4-month supervised exercise program can help improve memory and thinking skills in older adults living with HIV. Researchers will compare high-intensity interval training to moderate continuous exercise in 110 sedentary participants. The goal is to…

This study is testing a new virtual reality (VR) training program designed to help people with schizophrenia improve their job interview skills and problem-solving abilities. Researchers will recruit 40 participants to complete the VR training and measure changes in their intervi…

This study is testing a telehealth program called C-READY, designed to help teenagers with sickle cell disease build the skills they need to manage their own healthcare as they become adults. Over 120 teens will participate in one-on-one video sessions with a therapist to learn a…

This study is testing whether a 6-week exercise program is practical and helpful for older adults who have just finished home health care. The program combines strength training with everyday movement tasks. Researchers want to see if it improves participants' physical mobility a…

This study is testing whether a drug called butylphthalide can help improve memory and thinking problems in older adults who have epilepsy. 220 participants aged 60-85 with epilepsy and mild to moderate memory issues will take either the drug or a placebo pill for 48 weeks, while…

This study is testing whether a 6-session video support program can help older adults who have cancer and mild memory problems, along with their spouse or caregiver. The program aims to reduce distress, improve communication, and enhance quality of life for both people in the pai…

This study is testing if a daily ADHD medication called methylphenidate is practical, safe, and acceptable for children with sickle cell disease who struggle with attention, memory, and thinking. About 30 children, aged 8 to 18, will take the medication once a day for four weeks.…

This study is testing a phone-based training program called PICT for family caregivers of people with Alzheimer's or related dementias. The program teaches caregivers how to spot signs of pain in their loved ones and how to talk about it effectively with healthcare providers. Res…

This study is testing whether providing hearing aids and communication support to older adults with both Alzheimer's disease and hearing loss can reduce distressing symptoms like agitation and improve their relationship with their caregiver. Researchers will enroll 300 participan…

This study is testing if a virtual cycling activity can improve the quality of life for older adults with dementia living in nursing homes. About 60 participants will either use a stationary bike with interactive films or continue their usual care. Researchers will measure change…

This study is testing if a drug called memantine, combined with a supervised exercise program, can help reduce memory and thinking problems ('chemo brain') during breast cancer chemotherapy. It will involve 90 women with early-stage breast cancer who are already reporting mild co…

This study is testing whether mindfulness training delivered over the phone can help people who have both heart failure and mild memory problems. Researchers want to see if learning mindfulness improves participants' ability to manage their heart health day-to-day and if it affec…

This study is testing whether a wearable robotic exoskeleton suit can help people with multiple sclerosis (MS) walk farther and improve their memory and thinking skills. Researchers will compare the results of 10 participants who use the robotic device during therapy to those who…

This study is testing whether a non-invasive brain stimulation technique can improve thinking and memory in people with cognitive impairment from cerebral small vessel disease. Researchers will compare a real magnetic stimulation treatment to a fake (sham) treatment in 58 partici…

This study is testing whether eating more fermented foods like yogurt, kimchi, and sauerkraut can help people recover mentally and emotionally after a life-threatening illness like severe COVID-19. Researchers want to see if this diet improves gut health, reduces inflammation, an…

This study is testing whether a new skin patch called ALTO-101 can help improve thinking and memory problems in people with schizophrenia. Researchers will measure changes in brain wave activity and thinking tests in about 82 participants. The study compares the active patch to a…

This study is testing if a special diet drink and online brain games can help blood cancer survivors who are struggling with memory and thinking. For 12 weeks, one group will use both the diet drink and the games, while another group waits. Researchers want to see if this combina…

This study aims to create and test new tools to assess brain function, especially for conditions like dementia and psychiatric disorders. Researchers will develop phone-based and in-person tests to measure memory, reasoning, and social skills. The goal is to provide doctors with …

This study aims to understand how a mild, non-invasive electrical brain stimulation technique might temporarily improve working memory in older adults with mild cognitive impairment. Researchers will compare 55 adults with memory concerns to 55 healthy peers, giving each person b…

This study aims to understand why some people experience memory and thinking problems after a stroke caused by a narrowed brain artery. Researchers will follow 100 stroke survivors for a year, giving them memory tests, brain scans, and blood tests to see how their brain function …

This study is testing whether a simpler, easier-to-use version of a puzzle test can work at a patient's bedside in a hospital. Researchers want to see if using 9 larger blocks instead of 27 small ones is practical for staff and still gives useful information about a person's abil…

This study is creating a patient registry to collect detailed information from 50 people with cerebral small vessel disease, a common cause of memory and thinking problems in older adults. Researchers will track changes in thinking skills, walking ability, brain scans, and even g…

This study aims to understand the long-term impact on thinking skills and daily function for people with a specific brain tumor (cavernous sinus meningioma) treated with radiation. It will compare two modern radiation techniques—proton therapy and standard photon therapy—to see i…

This study aims to define a new concept called 'visual frailty' and create a tool to measure it. Researchers will gather information from 20 Scottish adults aged 60+ with advanced age-related macular degeneration (AMD). They will look at vision, reading ability, daily function, m…

This study aims to understand how a standard sleep apnea treatment (ventilotherapy) affects patients' thinking skills, brain health markers, and overall well-being. Researchers will observe 65 adults with sleep apnea, measuring their memory, attention, mood, and blood markers bef…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study aims to understand how often certain immune system antibodies are found in people with new memory problems and whether these antibodies play a role in causing or worsening dementia. Researchers will follow 300 adults aged 40-90 with recent cognitive decline to measure …

This study aims to understand the early brain changes that happen before noticeable memory problems begin. Researchers will use MRI and PET brain scans, along with memory tests, to track 300 older adults with normal thinking skills over time. The goal is to find the best combinat…

This study aims to understand if using cannabis with lower THC (the main psychoactive compound) can improve memory and thinking skills in young adults who use it frequently. Researchers will recruit 110 participants aged 21-25 in San Francisco, provide incentives for them to swit…