COGNITIVE IMPAIRMENT

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

This study tests whether adding choline to a peanut-based therapeutic food improves cognitive development in 1,500 Malawian children aged 6-59 months with severe acute malnutrition. Half get standard food, half get food with extra choline. All also receive amoxicillin. The goal i…

This study tests whether adding milk fat globule membrane (MFGM) to a standard therapeutic food helps brain development and reduces death or hospitalization in 1,600 severely malnourished children aged 6-59 months in Sierra Leone. Children receive either the MFGM-enriched food or…

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial dysfunction. Researchers will give 50 participants either MitoQ or a placebo daily for 12 weeks, alongside their usual med…

This study is testing whether blood tests can help screen for Alzheimer's disease in older adults during routine check-ups. Researchers will enroll 3,000 people aged 60-80 from communities and clinics. Participants will give blood samples, and those with abnormal results will tak…

This study tests a quick, 5-minute cognitive assessment called the 5-Cog to help primary care doctors identify older adults with undiagnosed dementia or mild cognitive impairment. The trial will involve 6,600 patients aged 65 and older across 22 clinics in the Bronx and Indiana. …

This study tests an app designed for primary care doctors to quickly screen older adults for early cognitive decline. The app includes risk questions, a symbol matching task, and voice tasks. Researchers will enroll 100 Spanish-speaking adults aged 60 and older to see if the tool…

This study is testing a new, smaller and mobile PET scanner called the Radialis PET Imager (RPI) to see if it can produce brain images as good as standard PET scanners for detecting amyloid plaques—a hallmark of Alzheimer's disease. Researchers will enroll 160 adults with cogniti…

This study tests whether a virtual reality (VR) platform called VIRADIA can accurately assess neurological and cognitive functions like memory, balance, and coordination. Researchers will compare VR test results with standard paper or in-person tests in 200 healthy volunteers and…

This study tests whether a program of group nutrition classes, physical activities like walking and gardening, and at-home cognitive training can help prevent cognitive decline in older adults at higher risk for dementia. Researchers will enroll 120 people aged 55-85 and track ch…

After surgery, many older adults experience confusion or memory problems, known as delirium. This study tests a program that identifies patients at high risk before surgery and then uses simple steps—like better sleep and hydration—to prevent delirium. The program also educates f…

This study tests whether a specially designed bright light can improve cognitive problems like memory and attention in people with major depressive disorder. 120 adults with depression and cognitive issues will receive either the bright light or a dim red placebo light for four w…

This study tests a twice-weekly, moderate-intensity exercise and coaching program for adults with mild-moderate cognitive impairment. Researchers want to see if the program is practical and enjoyable, and whether it can improve endurance, mobility, and thinking over 12 months. Th…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests whether playing brain-training games using a virtual reality (VR) headset can improve memory, attention, and thinking skills in adults who have recently been in the intensive care unit (ICU). About 51 participants will be split into three groups: VR games, tablet…

This study tests if playing on a maze balance board can improve how children with cognitive impairment walk and move. Twenty-two kids aged 6-10 will either do balance board exercises or standard physical therapy for 8 weeks. Researchers will measure changes in mobility and motor …

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking problems (often called 'chemo brain') in women with early-stage breast cancer undergoing chemotherapy. Ninety participants will be split into three groups: mem…

This Phase 3 trial tests whether metformin, a widely used diabetes drug, can improve memory and thinking in children and teens who have finished treatment for a brain tumor. About 140 participants aged 7 to 21 will take metformin or a placebo for 16 weeks. Researchers will measur…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This pilot study at St. Jude Children's Research Hospital is testing whether a daily dose of extended-release methylphenidate (Ritalin) can safely improve attention, thinking, and school performance in children aged 8 to 17 with sickle cell disease. The trial will enroll 72 parti…

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in adults who had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either start training right away or wait 12 weeks. The goal is…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests whether immersive virtual reality (VR) exercises can improve memory, attention, and thinking speed in people with cancer who have mental fogginess after chemotherapy. Sixty participants will either use VR-based cognitive, physical, and mindfulness training or do …

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This pilot study tests whether a 12-week sitting Tai Chi program can improve cognitive function, arm movement, balance, and mood in chronic stroke survivors who have memory or thinking problems. About 176 participants (88 stroke survivors and 88 caregivers) will be randomly assig…

This study compares two ways to help stroke survivors improve their thinking skills: doing cognitive exercises at home via video sessions (tele-rehabilitation) versus doing them in person at a clinic. Researchers will enroll 32 adults aged 50-80 who have mild to moderate cognitiv…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study tests whether 8 weeks of phone-based mindfulness training can improve self-care and thinking skills in 176 adults with heart failure and mild cognitive impairment. Participants practice techniques like breath awareness and body scanning for 20 minutes daily. The goal i…

This study tests a telehealth program called C-READY that helps teens with sickle cell disease improve thinking skills like planning and problem-solving. The goal is to prepare them to manage their own health care as they grow up. About 120 teens aged 10-18 will take part, and th…

This study tests a new virtual reality job training program for people with schizophrenia who want to work. About 40 adults aged 20 to 55 will practice job interviews and other skills in a safe VR environment. The goal is to see if this training helps improve symptoms and makes i…

This study tests whether a three-week virtual reality cognitive training program, combined with a daily supplement (sodium butyrate), can improve memory, attention, and thinking speed in 160 adults aged 50+ who have had depression or bipolar disorder but are currently stable. Par…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study tests whether a gentle brain stimulation technique called tDCS can improve motor and thinking skills in children aged 10-15 who have had a mild concussion. Ten participants will receive tDCS and be evaluated with balance, coordination, and brain imaging tests. The goal…

This study tests whether virtual cycling — pedaling a stationary bike while watching an interactive video — can improve quality of life for older adults with cognitive impairment living in nursing homes. Researchers will compare a group that does virtual cycling with a control gr…

This study tests whether a painless brain stimulation technique called tDCS, combined with cognitive therapy, can improve thinking and memory in people who recently had a stroke. About 70 adults who had a stroke within the past month and have trouble thinking will receive either …

This study tests a six-week exercise program for older adults (ages 65-90) who recently finished home health care and have trouble moving or thinking. Participants will do task-oriented resistance exercises at home with some remote coaching. The goal is to see if the program is p…

This study tests whether adding acupuncture to the standard Alzheimer's drug donepezil can improve memory, daily living skills, and quality of life. Researchers will compare two groups of 90 patients each: one gets acupuncture plus donepezil, the other gets donepezil alone. The t…

This study tests whether a skin patch called ALTO-101 can improve cognitive function in people with schizophrenia who have thinking problems. About 82 participants will receive either the active patch or a placebo, then switch after a period. The main goal is to see changes in br…

This study tests whether combining a modified ketogenic diet (using a meal replacement drink) with online brain training can improve memory and thinking in blood cancer survivors. About 80 adults with mild to moderate cognitive issues will either get the combined program for 12 w…

This study tests whether high-intensity interval training (HIIT) or moderate continuous exercise can improve thinking, memory, and daily function in 110 older adults with HIV who are sedentary and fatigued. Participants will exercise three times a week for four months. The goal i…

This study tests whether a personal sound amplifier, along with hearing training, can reduce troubling symptoms like agitation and distress in older adults with Alzheimer's or related dementias who also have hearing loss. Researchers will enroll 300 people aged 60-100 and their c…

This study is testing whether a wearable robotic exoskeleton can improve both walking and thinking in people with multiple sclerosis who have trouble walking. Ten participants will either use the robotic suit or receive standard walking therapy for eight sessions. Researchers wil…

This study tests whether butylphthalide, a drug already used for stroke in China, can improve cognitive function in 220 elderly patients (ages 60-85) who have both focal epilepsy and mild cognitive impairment. Participants take the drug or a placebo for 48 weeks while continuing …

This study tests whether a gentle electrical current applied to the scalp (tDCS) combined with computer-based cognitive training can improve memory, attention, and thinking in people who had a mild stroke. About 60 participants will receive either real tDCS or a sham (fake) versi…

This study tests whether a non-invasive brain stimulation technique called iTBS can improve memory and thinking in people with cerebral small vessel disease, a common cause of cognitive decline. 58 adults aged 45-80 will receive either real or sham stimulation daily for 15 days. …

This study is testing whether a mild electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare the effects of real tDCS versus a sham (fake) version in 110 participants aged 60-95. The …

This study looks at how different amounts and types of exercise can improve thinking and memory in Veterans aged 65 and older. Researchers will measure changes in cognitive skills and blood markers related to brain health. The goal is to understand which exercise habits work best…

This study tests whether soaking in hot spring water helps teenage rowers recover from central fatigue and maintain mental sharpness during high-altitude training. Twenty-seven athletes aged 12-16 will either rest normally, bathe in plain warm water, or bathe in sodium bicarbonat…

This study looks at how memory, attention, and other thinking skills change in people who have surgery to remove a meningioma (a type of brain tumor) from the front or side of the brain. Researchers will test cognitive function before surgery and one year later in about 50 adults…

This study looks at how endocrine therapy, a common breast cancer treatment, affects thinking and brain function in 120 survivors aged 35-65. Researchers will use brain scans and memory tests to compare survivors on therapy with healthy women. The goal is to understand if menopau…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This observational study seeks to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function in 20 participants to develop a vis…

This observational study looks at 300 adults with new-onset cognitive impairment to see how often certain immune system markers (neuronal synaptic antibodies) are present. Researchers aim to develop a scoring system to help diagnose autoimmune dementia more accurately. The study …

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and talk about it with doctors. Researchers …

This study looks at different methods to predict whether giving IV fluids will help raise blood pressure in patients with impaired consciousness. Researchers will compare tests like ultrasound of the vena cava, leg raising, and fluid challenges in 222 ICU patients. The goal is to…

This study looks at why some people's thinking and memory get worse as they get older. Researchers will use brain scans and memory tests in 300 healthy adults aged 60 and older to find early signs of Alzheimer's disease. The goal is to better understand how the brain changes over…

This study is creating a registry of 50 people aged 50 and older who have cerebral small vessel disease (CSVD), a condition that affects small blood vessels in the brain and can cause thinking problems. Researchers will track changes in memory tests, brain scans, and other health…

This study looks at how common memory problems are in older adults (65+) with type 2 diabetes. It then tests a program that combines several lifestyle changes to see if it can prevent or slow down memory loss. About 420 people will take part, and their thinking skills will be com…

This study follows 100 people with severe narrowing of brain arteries to understand why some develop memory and thinking problems. Participants receive either standard medications or a procedure to open the artery. Researchers will track changes in memory and stroke risk over tim…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This study looks at two types of radiation therapy for a slow-growing brain tumor near the cavernous sinus. Researchers want to see if proton therapy causes less long-term harm to thinking and memory than standard photon radiation. About 160 adults aged 18 to 70 will be followed …

This study is working to create and improve tests that measure thinking skills, memory, and social understanding. Researchers will test these tools on 300 people, including healthy volunteers and patients with conditions like dementia or psychiatric disorders. The goal is to make…

This study follows 65 adults with obstructive sleep apnea to see how three weeks of CPAP therapy changes their thinking skills, blood markers of brain health, and emotional well-being. Participants complete memory and attention tests, give blood samples, and fill out questionnair…