Exercise may sharpen aging minds in HIV patients

NCT ID NCT06013579

Recruiting now Symptom relief Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether high-intensity interval training (HIIT) or moderate continuous exercise can improve thinking, memory, and daily function in 110 older adults with HIV who are sedentary and fatigued. Participants will exercise three times a week for four months. The goal is to see if exercise can lower dementia risk and help build long-term exercise habits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: high-intensity interval training (HIIT) and continuous moderate exercise (CME)
What this could lead to: If successful, this could show that structured exercise programs help preserve brain function and build lasting exercise habits in older adults with HIV.
What could go wrong: This is a small, early-stage study (110 participants) without a placebo control, so results may not apply broadly. Exercise adherence and individual health differences could affect outcomes.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction HIV infectious disease Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT HIV INFECTIONS

Contacts and locations

Locations

University of Alabama at Birmingham
NOT_YET_RECRUITING

Birmingham, Alabama, 35294, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States

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