University Of Alabama At Birmingham

This study tests whether two different pneumonia vaccines can create antibodies that kill newly discovered types of pneumococcal bacteria. Researchers will give each vaccine to healthy adults and measure the immune response. The goal is to see if current vaccines can offer cross-…

This study is for people newly diagnosed with multiple myeloma. It uses a sensitive test to measure tiny amounts of cancer left after initial treatment. For those with a deep response, the study tests if they can safely skip a stem cell transplant and take fewer treatments. For o…

This early-stage trial tests whether two vaccines, given as a shot, are safe for people with a long-lasting HPV16 infection that has caused mild cervical cell changes. About 30 adults will receive the vaccines to find the best dose and check for side effects. The goal is to help …

This early-phase study tests a combination of two drugs, mogamulizumab and brentuximab vedotin, in people with a rare type of skin lymphoma (CTCL or MF) that has been treated before. The main goal is to find a safe dose and understand side effects. About 10 adults with advanced d…

This study tests if adding a special growth factor (rhPDGF) to donated bone particles helps rebuild jawbone better than using just salt water. About 44 adults who need dental implants but have thin jawbone will take part. Researchers will measure new bone growth after 4 months us…

This study looks at whether a blood test can detect leftover cancer cells after kidney cancer surgery. Patients with no signs of cancer in the blood will skip standard immunotherapy, while those with signs will receive it. The goal is to see if this approach helps people live lon…

This study tests whether combining three drugs—tacrolimus, methotrexate, and a new dosing schedule of anti-thymocyte globulin—can prevent acute graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers like leukemia. About 29 adults aged 18-60 w…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure will stick with and find helpful. About 50 women aged 40 and older will take part. The goal is to see if the program is easy to follow and if it hel…

This study tests whether wearing special soft contact lenses for a short time each day can slow the progression of nearsightedness (myopia) in children. About 80 kids who already wear contacts will use either one type of lens or two types at different times for one year. Research…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests a combination program to improve HIV testing, linkage to care, and rapid treatment in coastal Alabama. Researchers will work with local health departments to direct testing to high-need areas, help people connect to care right after diagnosis, and start antiretro…

This study aims to find the best combination of strategies to help people maintain weight loss after losing weight. Over 500 adults with obesity will first lose weight through a 16-week program, then try different support methods—like limiting food variety, home strength training…

This study tests whether a special dental gel, used at home, can help reduce deep gum pockets more than standard deep cleaning alone. It involves 76 adults with moderate to severe gum disease. Participants will use the gel or a regular toothpaste for 6 months, and researchers wil…

This study tests whether a newer extrafine inhaler (Trimbow) works better than a standard one (Trelegy) for people with moderate to severe asthma that is not well controlled. Researchers will use special MRI scans to see how well the medicine reaches the lungs and measure breathi…

This study tests a new breast biopsy marker (HydroMARK Plus) to see if surgeons can find and remove it more easily than the current marker. About 150 adults with breast cancer who need surgery will take part. The goal is to improve how well the marker is retrieved and how satisfi…

This study looks at whether giving young women (ages 15-24) living with HIV a long-acting injectable HIV treatment along with their birth control is safe and effective. Researchers will compare this approach to standard daily pills. The goal is to see if combining these long-acti…

This study looks at whether different oxygen levels can help preterm infants who have both a chronic lung disease (bronchopulmonary dysplasia) and high blood pressure in the lungs (pulmonary hypertension). About 39 infants born extremely early will be enrolled. Researchers will m…

This study tests whether metformin, a standard diabetes medicine, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants will take metformin or a placebo for 16 weeks …

This study tests whether a medicine called IVIG (made from donated blood) can help people with a rare muscle disease that causes weakness and damage. About 12 adults with active disease will receive either IVIG or a placebo every 4 weeks for 3 doses. The main goal is to see if IV…

This study tests whether a new EDTA mouth rinse helps gums heal better after a tooth is pulled and bone grafted, compared to standard rinses like chlorhexidine and essential oil. About 40 adults who need a single tooth removed and bone grafting for a future dental implant will us…

This study compares a low-carbohydrate diet to a standard diet in 40 adolescents aged 12-18 with type 2 diabetes over 24 weeks. The goal is to see if the low-carb approach improves blood sugar control and insulin sensitivity. Participants must have stable diabetes and not be on i…

This study looks at whether treating mild high blood pressure (stage 1) in pregnant women can lead to healthier birth weights for their babies. About 74 pregnant women with blood pressure between 130-139/80-89 mmHg will be split into two groups: one that gets medication to keep b…

This study tests a new treatment for people with aggressive brain tumors like glioblastoma. It combines a genetically modified virus (M032) that attacks tumor cells and boosts the immune system, with the immunotherapy drug pembrolizumab. The goal is to see if this combination is …

This study looks at two ways of giving focused radiation (radiosurgery) to people with brain metastases that are 4 cm or smaller. One method uses a 0mm margin around the tumor, the other uses a 2mm margin. The goal is to find out which approach better controls the tumor while cau…

This study tests a new automated method to select specific stem cells (CD34+) for patients with blood cancers who need a stem cell boost or second transplant. The goal is to lower the risk of graft-versus-host disease (GVHD), a serious complication where donor cells attack the pa…

This study tests a drug called pirfenidone, currently used for lung disease, to see if it can safely reduce repeat attacks of pancreatitis. About 60 adults who have had two or more pancreatitis attacks will receive either the drug or a placebo. Researchers will track side effects…

This study is for people with a type of advanced lung cancer that lacks the PD-L1 marker. It compares standard treatment (one immunotherapy drug plus chemo) to a stronger approach (two immunotherapy drugs plus chemo). The goal is to see if the double therapy clears cancer DNA fro…

This study is for people with advanced ovarian, fallopian tube, or peritoneal cancer that has a specific marker called folate receptor alpha. Participants will receive a combination of chemotherapy (carboplatin) and a targeted drug (mirvetuximab) before and after surgery. The goa…

This study tests whether people with newly diagnosed multiple myeloma or amyloidosis who achieve a very deep response to initial drug therapy can safely postpone a stem cell transplant. About 40 participants will receive 6 cycles of a powerful drug combination (Dara-VRD). Those w…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems keep their daily living skills and delay dementia. About 1,300 participants aged 55–89 will try different combinations of cognitive training or general mental stimulation…

This study tests whether using a home pulse oximeter (like a smart sock) to monitor oxygen levels in high-risk infants after they leave the NICU can reduce emergency room visits and hospital readmissions. About 700 babies will be randomly assigned to receive the monitor or standa…

This study tests whether the antibiotic azithromycin can help children with severe RSV infection who need breathing support in the ICU. Researchers want to see if it shortens hospital stays and reduces time on oxygen. About 370 children will take part, receiving either azithromyc…

This study tests three custom-designed stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce hospital stays, lung problems, and death. About 410 participants will be enrolled at one center.

This study tests if a 24-week live online exercise program with music can improve heart health in 132 adult wheelchair users. The program focuses on reducing risk factors like waist size, blood sugar, and cholesterol. Participants will be compared to those doing standard exercise…

This study tests a lower daily dose of the chemotherapy drug capecitabine in 40 patients aged 60 or older, or those who are frail, with advanced HER2-negative breast cancer. The goal is to see if this gentler approach can still shrink tumors or slow the disease while reducing har…

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural day-night blood pressure rhythm in people with obesity. Obese individuals often have high nighttime blood pressure, which increases heart risks. Researchers will co…

This study tests whether keeping blood pressure below 140/90 mmHg in pregnant women with preeclampsia or gestational hypertension can safely prolong pregnancy. About 132 women between 23 and 35 weeks pregnant will be randomly assigned to either tighter blood pressure control or u…

This study tests whether giving a special fat called DHA early to very premature babies who are small at birth can help their heads grow better. About 152 babies will receive either DHA or a placebo to see if it improves head size without adding too much body fat. The goal is to …

This study tests a three-drug chemotherapy and immunotherapy combination given before surgery, followed by maintenance therapy after surgery, in 20 people with newly diagnosed stage III or IV ovarian cancer. The goal is to see if this approach delays cancer progression. Participa…

This study looks at whether eating only during the early part of the day (early time-restricted eating) can help improve heart health and daily body rhythms in older adults with high blood pressure. Researchers will monitor blood sugar, heart rate variability, and blood pressure …

This study tests a two-step method of giving an anti-rejection drug (ATG) along with standard medications to prevent severe graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 56 adults aged 18-75 will participate. The goal is to …

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study tests a 24-week church-based program for Black men aged 18 and older who are at risk for heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get one-on-one support from a community health worker, and use smart d…

This early-stage trial tests whether adding decitabine and venetoclax to a standard stem cell transplant is safe for people with high-risk blood cancers like leukemia. About 20 adults aged 18-75 with a matching donor will take part. The goal is to find the best dose that limits s…

This study tests a bundle of services—telehealth check-ins, a peer support specialist, the medication buprenorphine, and help connecting to addiction treatment—for people who have had an opioid overdose and are leaving the emergency department. The goal is to see if this approach…

This study tests a program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults who had a confirmed gout flare in…

This study tests whether a dye called panitumumab-IRDye800 can make head and neck cancer cells glow during surgery, helping surgeons see exactly where the cancer is and remove it completely while sparing healthy tissue. About 25 adults with squamous cell carcinoma of the head and…

This study explores whether a tampon can collect samples to detect endometrial (uterine) and ovarian cancer early. Researchers will analyze DNA and proteins from tampons used by 1,500 women before surgery. The goal is to develop a simple, non-invasive screening tool that could ca…

This study tests whether using an AI tool to screen for glaucoma and other eye conditions at community health centers works better than usual care. About 1,800 adults at higher risk for eye disease will get a quick eye screening. If the AI finds a problem, patients are referred t…

This study compares self-collected Pap smears to traditional doctor-collected ones for cervical cancer screening. About 250 women aged 21-65 in rural Alabama will participate. The goal is to see if self-sampling is accurate enough to boost screening rates in underserved communiti…

This study tests a new way to diagnose biliary atresia, a serious liver condition in newborns where bile ducts are blocked. Infants with jaundice will receive a safe dye (ICG) through an IV, and their diapers will be checked for a glow that shows bile is flowing. The goal is to s…

This study explores a new ultrasound technique called Shear Wave Elastography to detect acute kidney injury early after vascular surgery. Researchers will compare results from 50 healthy volunteers and surgery patients to see if the test can identify kidney damage sooner than sta…

This early-phase study tests whether a PET scan using a radioactive tracer (89Zr-trastuzumab) can show which HER2-positive breast cancer patients are likely to benefit from targeted therapy. Ten newly diagnosed adults will receive the tracer and undergo PET/MRI imaging. The goal …

This is a small, early-stage study to see if a new type of imaging scan can more accurately find and measure head and neck cancer tumors before surgery. Researchers will compare the new scan, which uses a special tracer drug, to the standard scan that is already used. The study i…

This study looks at whether spending extra time in a kangaroo mother care (KMC) ward—where mothers hold their babies skin-to-skin—can help prevent postpartum depression. About 1,900 mothers of low birthweight infants in Zambia will be randomly assigned to either standard KMC or e…

This study tests a new data dashboard to help clinics in Alabama better track and improve HIV prevention services (PrEP). Researchers will work with seven clinics to see if the dashboard helps more Black and other at-risk people get PrEP prescriptions. The study involves clinic s…

This study looks at whether telling people their genetic risk for high blood pressure can help them make healthier choices and lower their blood pressure. Researchers will give some participants a special genetic test result plus counseling, while others get standard care. The go…

This study tests whether a medication called misoprostol can help doctors see the cervix more clearly during cancer screening. About 420 non-pregnant women aged 25 and older with a hard-to-examine cervix will receive either misoprostol or a placebo. The goal is to see if the drug…

This study tests whether a patient navigator—a personal health coach—can help older adults prevent another broken bone after a fragility fracture. About 2,634 people aged 50 and older who recently broke a bone will be assigned to either get this extra support or just standard edu…

This study tests if teaching people how to use mobility devices like crutches or walkers before foot or ankle surgery can lower their risk of falling after the operation. About 250 adults having elective foot or ankle surgery will be enrolled. The goal is to see if this simple tr…

This study tests a simple program to help Black and Latinx adults with rheumatic diseases get the updated COVID-19 vaccine. Participants will receive guidance and support during their regular rheumatology visits. The goal is to see if this approach increases vaccination rates in …

This study looks at whether a healthy DASH-style diet can lower the risk of forming kidney stones. Researchers will provide all meals for one week to 48 adults with a history of kidney stones, comparing the DASH diet to a typical Western diet. The goal is to see if the DASH diet …

This study tests whether giving selumetinib early to children with NF1 (ages 1 to 8) can prevent nerve tumors from growing and causing serious problems like blindness or nerve damage. About 200 children with no current symptoms but tumors in risky locations will either receive se…

This study looks at the best time to place a small mesh sling to treat stress urinary incontinence (leaking urine when coughing or laughing) during robotic surgery for pelvic organ prolapse. Doctors want to know if placing the sling before or after lifting the vagina works better…

This study tests whether a personalized exercise program using motion exergames (like Nintendo Switch) can help head and neck cancer survivors reduce fatigue and pain after treatment. About 150 participants who have finished radiation or chemotherapy will be assigned to either th…

This study is testing a 5-session radiation treatment for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and causes fewer side effects than standard longer radiation. About 40 participants aged 50 and old…

This study compares two types of brain training programs for 30 adults with long COVID who have mild to moderate brain fog. One program uses computer games and real-life tasks to improve thinking speed and work skills, while the other focuses on relaxation and healthy habits. Bot…

This study tests if a simple injection near a nerve in the neck can reduce chronic cough. 50 adults with a cough lasting 8 weeks or more will receive a local anesthetic and steroid shot. The goal is to see if this treatment improves cough frequency and quality of life.

This study aims to help young people with Down syndrome (age 12 and older) and their caregivers sleep better and feel better. Researchers will adapt a virtual mindfulness program for insomnia and test it in a small trial with 20 participants. The goal is to see if the therapy imp…

This study tests whether a gentle, non-invasive nerve stimulation called taVNS can improve how the body controls heart rate and blood pressure in people with Parkinson's disease. About 24 participants will receive the stimulation while performing simple physical tasks. The goal i…

This study tests a program to help cancer survivors and their caregivers in low-income areas eat healthier and be more active. About 100 adults aged 18-89 who have had cancer or are close to a survivor can join. The program adapts proven health tips to fit each person's life and …

This study tests whether morning bright light therapy can improve sleep and brain health in 105 adults recovering from opioid use disorder. Participants on stable medication will receive either bright or dim light for 30 minutes daily over two weeks. Researchers will measure slee…

This study tests whether a 10-week online writing program, guided by a coach, can help adults with spinal cord injury process grief and improve emotional well-being. About 60 participants will write about their feelings and complete surveys on grief, stress, sleep, and mood. The …

This study tests whether sitting ARDS patients upright in bed helps them breathe better compared to standard head-of-bed elevation. Researchers will measure changes in lung function. The study involves 40 adults with ARDS who would normally be placed on their stomach (proning).

This study tests if a type of talk therapy called acceptance and commitment therapy (ACT) can help people with religiously focused obsessive-compulsive disorder (OCD). Ten adults will receive the therapy and report changes in their symptoms. The goal is to see if ACT reduces dist…

This study tests whether adding sensory training to standard Constraint-Induced Movement (CI) therapy can help stroke survivors with mild-to-severe arm and hand weakness. Researchers will enroll 15 adults who are at least 6 months post-stroke. Participants will receive intensive …

This study tests a therapy called ReACT for teens aged 11-18 who have psychogenic non-epileptic seizures (PNES), which look like seizures but aren't caused by epilepsy. The therapy focuses on changing thoughts and behaviors to improve the teen's sense of control and reduce fear o…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help reduce pain, fatigue, and other symptoms in women with fibromyalgia. About 30 participants will receive the treatment and report changes in pain severity and quality of life. The g…

This study tests whether a mobile app can reduce memory and thinking problems (often called 'chemobrain') caused by chemotherapy in women with gynecologic cancers. About 64 participants will use the app and have their brain function tested. The goal is to see if this simple, at-h…

This study tests if a 12-week program combining a special diet supplement with online brain exercises can improve memory and thinking in blood cancer survivors. About 80 adults who have mild to moderate thinking problems after treatment will be randomly assigned to either start t…

This study explores whether watching virtual reality nature scenes can help lower stress in adults with mobility impairments. Researchers will measure stress levels using surveys and saliva samples from 30 participants. The goal is to find a simple, accessible way to improve well…

This study tests whether special tinted contact lenses can reduce light sensitivity in people who have had a mild concussion. Researchers will enroll 60 adults who have had a concussion within the past two years and currently experience light sensitivity. Participants will try th…

This study tests a new mind-body treatment called ReACT for teenagers aged 11-18 who have functional seizures (seizures not caused by epilepsy). Participants will be randomly assigned to either ReACT or a comparison therapy for 12 sessions. The goal is to see if ReACT is practica…

This study looks at whether adding a cocoa supplement to regular exercise helps older adults with slow walking speed improve their physical performance and muscle strength more than exercise alone. About 36 people aged 55 and older will take part. The goal is to find a simple, en…

This study tests a therapy called ReACT for children aged 11-18 who have psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on changing thoughts and behaviors to help children feel more in control and reduc…

This pilot study tests Constraint-Induced Movement Therapy for adults who had a stroke at least 6 months ago and have mild weakness in one arm. The therapy involves daily training over consecutive weekdays to improve how much and how well they use their weaker arm in everyday act…

This study tests whether taking oral tranexamic acid for a short time after total shoulder replacement can reduce pain and improve early recovery. Researchers will enroll 60 adults aged 18-79 who are having their first shoulder replacement. Participants will be randomly assigned …

This study tests a new training program designed to help smokers quit by teaching them how to manage withdrawal symptoms and negative feelings. Researchers will enroll 400 adult smokers who want to quit. The program focuses on handling early withdrawal to improve the chances of s…

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in people who have had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either use the program or wait. The goal is to see if the…

This study compares carbon dioxide gas versus regular air for inflating the belly during endoscopy in children. The goal is to see if CO2 causes less abdominal pain, bloating, and gas afterward. About 350 children aged 6 months to 18 years will take part. The study is currently r…

This study tests a program that gives cancer patients free help with legal problems like health insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will receive legal navigation and be followed for 6 months. Researchers want to see if t…

This early study tests if ivacaftor, a drug that helps the lungs clear mucus, can also help people with chronic sinusitis that hasn't improved with standard treatments. The trial will include 20 adults who have a sinus infection with certain hard-to-treat bacteria. Researchers wi…

This study tests whether a 6-week online magic trick training program can help adolescents with autism improve their social and emotional skills. Researchers will measure changes in social knowledge, self-esteem, loneliness, and friendship quality. The goal is to see if learning …

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during and after deep brain stimulation surgery. The goal is to understand the brain's role in movement p…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, for several years. Researchers track how the liver and immune system change over time, especially when standard antiviral treatments are started. The goal is to better understand the disease, not to tes…

This study tests whether an augmented reality (AR) headset can help doctors place IVs and catheters more successfully. About 50 patients who need ultrasound-guided vascular access will take part. Researchers will compare success rates, number of needle sticks, and time needed whe…

This study uses special PET scans to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will compare scans taken at the start, after 12 months, and after 24 months to see how inflammation changes over time. The …

This study looks at tiny particles called exosomes released from the placenta that may cause preeclampsia, a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these particles in…

This study looks at how to set the breathing machine (ventilator) for preterm babies born before 34 weeks. The goal is to find the pressure that helps their lungs work best without hurting their heart. Researchers will use ultrasound and a special imaging tool to check heart func…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity in cisgender and transgender individuals. Researchers will recruit 120 participants across six groups and use heat, cold, and pressure tests to measure pain responses. Blood samples will a…

This study looks at how spinal cord stimulators change nerve signals and symptoms in people with restless leg syndrome (RLS) and chronic pain. Researchers will use brain and nerve tests to measure these changes. The study includes 50 adults with RLS, chronic pain, or both, and ai…

This study looks at brain activity while people perform thinking tasks like memory and attention exercises. Researchers hope to learn how the brain works in conditions like dementia, ADD, and depression. About 30 adults with epilepsy who are already scheduled for brain monitoring…

This study looks at how vision loss from glaucoma affects the ability of older adults to move around and go places. Researchers will measure participants' usual range of activities and test their vision in dim light. The goal is to understand the link between glaucoma-related vis…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study explores how a financial navigation program helps cancer patients deal with money problems caused by their treatment. Researchers will look at patient surveys and medical records to see if the program reduces financial hardship, improves quality of life, and eases emot…

This study looks at whether a ketogenic diet can increase the number of calories your body burns each day and help manage hunger during weight loss maintenance. Researchers will enroll 20 adults with obesity who have lost weight. Participants will stay in a special room that meas…

This study uses a special PET scan to measure a protein called tau in the brains of 160 people with Alzheimer's disease. The goal is to see how tau buildup relates to memory, thinking, race, and heart health risks. Participants are already part of a larger Alzheimer's research pr…

This study aims to find out if people with alpha-1 antitrypsin deficiency (AATD) also have nearby gene changes that weaken their immune system and lead to more lung infections. Researchers will compare immune responses to a pneumonia vaccine in 30 adults who have one abnormal AAT…

This study looks at lymphoma patients who also develop a serious immune condition called HLH. Researchers will collect data from 2,000 participants to see which treatments and factors help patients live longer. The goal is to find better ways to treat this rare complication.

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes/diabetes, or high blood pressure. Participants will do strength training at home using their own equipment or bodywei…

This study looks at whether a single dose of a ketone drink can improve thinking, coordination, and driving skills in 45 adults aged 19 to 55. Participants include people who are obese and sedentary, lean and sedentary, or lean and very active. Each person will take the drink or …

This study looks at whether a fast genetic test can help doctors choose the best antiplatelet medication for people who have had a minor stroke or a high-risk transient ischemic attack (TIA). About 200 adults admitted to the hospital will provide a cheek swab for genetic testing.…

This study tests a telehealth program called C-READY designed to help teens with sickle cell disease improve thinking skills and learn to manage their own health. About 120 participants aged 10-18 will be randomly assigned to the program or usual care. The goal is to see if the p…

This study follows 40 adults who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will test strength and mobility at several points, especially looking at how hospital readmissions affect recovery. The goal is to…

This study watches how hospitals in Latin America treat sudden kidney failure that needs dialysis. Researchers will track 1,000 ICU patients to see what care they get and how they recover. The goal is to find ways to improve treatment and outcomes across different countries.

This study looks at whether high-intensity exercise can improve thinking and memory in older adults living with HIV. Researchers will also explore what helps people stick with an exercise routine. The goal is to find better ways to prevent dementia in this group.

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and vascular risk factors. Participants are already part of a larger Alzheimer's study at the University of…

This study looks at whether a partial problem with a protein called CFTR (which helps move salt and water in the body) contributes to chronic sinusitis. Researchers will measure chloride levels in the nose of 20 people with sinusitis and healthy volunteers. The goal is to underst…

This study looks at how people with severe vision loss from macular degeneration can train their brains to use their remaining side vision more effectively. Researchers will measure changes in eye movements and focus after about 7 weeks of training. The goal is to understand brai…

This study looks at brain signals recorded during Deep Brain Stimulation (DBS) surgery for Parkinson's disease. Researchers want to understand how DBS changes brain activity and use that information to better target electrodes and program the device. About 36 adults with advanced…

This study explores whether special stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will take blood from 20 people with diabetes and healthy volunteers to create these stem cells in a lab. The …

This study looks at whether shining red light on the leg can change blood flow in healthy adults. About 40 people will get red light and a special dye to help see blood flow on ultrasound. The goal is simply to learn more, not to treat any disease.

This study uses a special PET scan to measure brain inflammation in people with Parkinson's disease compared to healthy volunteers. Researchers want to see if inflammation levels are higher in Parkinson's and how they relate to symptoms. About 205 participants will be scanned and…

This study tests a training program for doctors and nurses who care for older African American patients at the end of life. The training uses videos and guidelines to help clinicians understand patients' cultural values and recognize their own biases. The goal is to improve commu…

This study looks at whether activating a protein called LXR can help prevent diabetic retinopathy, a common eye problem in people with diabetes. Researchers will test blood samples from 104 adults with and without diabetes to see how LXR affects cholesterol and the function of ce…

This study looks at how much oxalate the body naturally makes in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver. About 28 adults with MASLD will eat a low-oxalate diet and provide urine samples to measure oxalate levels. The go…

This study aims to understand which inflammatory genes are active in psoriasis, a chronic skin condition. Researchers will measure specific genes from skin samples of 13 adults with psoriasis. The goal is to find better ways to track and manage the disease, not to test a new trea…

This study looks at how the brain processes language by recording brain activity in epilepsy patients who already have electrodes implanted for medical reasons. Participants read or listen to sentences and choose matching pictures, while researchers measure their brain signals an…

This study looks at whether using a special saw during a common jaw surgery changes the way the inner bone breaks. About 40 people having jaw surgery will be included. The goal is to find out if the saw leads to more predictable and favorable bone fractures, which could help surg…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers will test special light-sensitive cells in the eye that help control sleep and body rhythms. The goal is to find new ways to improve sleep and reduce relapse. About …

This study tests different ways to help people with advanced chronic kidney disease and their caregivers work together when making health decisions. Researchers will compare coaching sessions and training to see which combination works best. The goal is to improve how patients an…

This study looks at how early childhood experiences—like breastfeeding, stress, and social factors—affect children with sickle cell disease. Researchers will work with 20 mothers of infants with sickle cell disease in Birmingham, Alabama, to see if a community-based breastfeeding…

This study looks at whether a common breathing test (spirometry) can help doctors decide the best dose of immunoglobulin replacement therapy for people with common variable immune deficiency (CVID) who also have mild airway blockage. About 22 adults on a stable dose will be split…

This study looks at how childhood trauma and stress might change tiny genetic molecules called microRNAs in the blood. Researchers will compare 450 adults with depression or suicidal thoughts to healthy volunteers. The goal is to better understand the biological links between ear…

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key ingredient in kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to underst…

This study looks at whether giving very preterm babies (born 27-31 weeks) a higher volume of human milk helps them grow better and have healthier guts. About 486 babies will be randomly assigned to receive either 180 or 200 mL of milk per kilogram of body weight each day. Researc…

This study looks at brain activity related to non-motor symptoms like depression and attention problems in people with Parkinson's disease. Researchers will record brain surface signals during routine deep brain stimulation (DBS) surgery. About 140 participants who are already sc…

This study looks at whether pumping breastmilk every 2 hours produces more milk than pumping every 3 hours for mothers of premature babies. About 70 mothers will be assigned to one of two pumping schedules and record their daily milk volume for the first 28 days after birth. The …

This study tests whether a single 5-minute exposure to a specific type of light (670 nm) can increase blood flow in the calf muscles of people with peripheral artery disease (PAD). Researchers will measure blood flow using ultrasound and take blood samples to check for nitric oxi…

This study uses a special PET scan to look for inflammation in the brains of people with long COVID who have neurological symptoms like brain fog or memory problems. Researchers will compare these scans with those from healthy volunteers to see if inflammation is linked to ongoin…

This study looks at how a natural heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will compare people with a common genetic variation that lowers ANP levels to those with normal levels. Participants will undergo exercise and …

This study looks at how approved seasonal flu vaccines affect the body's immune response in younger adults (ages 18-50) and older adults (ages 65-80). Researchers will measure antibodies and memory B cells in the blood to see how age and past vaccination history change the way th…

This study looks at the best ways to help people with physical disabilities stay active using home exercise videos and health coaching. Over 32 weeks, 257 participants will try different support options, like one-on-one coaching or group classes, based on how well they are doing.…

This study looks at how the brain manages emotions, especially fear, in people with epilepsy who already have electrodes implanted for surgery. Researchers will record brain activity and use mild electrical stimulation to see how certain brain areas talk to each other during emot…

This study tests whether a special PET/MRI scan can help doctors see how well immunotherapy is working in people with triple negative breast cancer. About 20 patients will get the scan before and during their standard treatment. The results will not change their care but may help…

This study tests whether a special play activity using finger puppets can help preterm infants develop better. Caregivers will use the puppets to get the baby's attention and encourage communication, alongside standard developmental care. The study will enroll 188 preterm babies …

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory or mood chang…

This early study tests a new type of PET/MRI scan to see if it can find active high-grade glioma (a serious brain cancer) after standard radiation therapy. About 20 children and adults will get this special scan. The goal is to see if the scan can detect leftover tumor and help d…

This study is building a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will track frailty and other age-related health issues using surveys and simple physical tests. The goal is to learn more about this group to gui…

This study looks at whether a continuous glucose monitor can measure blood sugar changes after eating a starchy vegetable (potato) with or without herbs and spices. Ten healthy adults will wear a glucose monitor for at least 10 days and eat test meals. The goal is to see how well…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. The goal is to see if those with pain and fatigue have higher levels of brain inflammation. Researchers will compare…

This study follows 35 people with a recent spinal cord injury (within 6 weeks) for one year. Researchers will collect blood and stool samples and ask about bowel function to see how gut bacteria and body metabolism change over time. The goal is to understand the link between gut …

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…

This study aims to see if a special coaching program for parents, focused on early literacy and numbers, helps improve their baby's learning and development scores by age 2. It will compare babies whose parents receive this extra coaching plus shared reading training to babies wh…