University Of Alabama At Birmingham

This study tests whether two different pneumococcal vaccines can create antibodies that kill newly discovered types of pneumonia bacteria. Researchers will give healthy adults one of the vaccines and measure how well their immune system fights these bacteria. The goal is to see i…

This study offers a free 3-month diabetes education program at a local faith-based organization for adults with diabetes or prediabetes in Jefferson County, Alabama. Participants attend group sessions on diet, exercise, and coping, and are paired with a community health worker fo…

This study compares continuous glucose monitoring (CGM) to standard fingerstick testing for pregnant women with type 2 diabetes. Researchers want to see if CGM leads to better blood sugar control and fewer complications for both mother and baby. Participants wear a CGM device or …

This phase 2 trial is testing a combination of three drugs (carboplatin, paclitaxel, and pembrolizumab) given before surgery to shrink tumors in women with newly diagnosed stage III or IV ovarian cancer. After surgery, participants receive two maintenance drugs (olaparib and pemb…

This study tests a new drug, asciminib, as the first treatment for adults newly diagnosed with chronic myeloid leukemia (CML). If the drug alone does not achieve a deep response within 2 to 3 years, a low dose of another targeted therapy is added. The goal is to see if this appro…

This study tests whether giving caffeine citrate to moderately preterm infants for 28 days after hospital discharge can prevent apnea (breathing pauses) that lead to sick visits. About 340 babies in Zambia will receive either caffeine or a placebo daily. Researchers will also che…

This study tests whether eating only between about 6:30 am and 2:30 pm (an 8-hour window) for 6 days a week can improve blood pressure, blood sugar, and heart rate in adults aged 60 and older with high blood pressure. Participants will follow this pattern for 12 weeks. The goal i…

This study tests whether different oxygen targets (higher vs. lower) improve outcomes in 39 preterm infants with bronchopulmonary dysplasia and pulmonary hypertension. Each infant will experience both oxygen levels in a crossover design. The goal is to see which level reduces dan…

This study tests a program that combines community health worker visits with a smartphone app to help low-income women stop smoking. About 344 women in Brazil will either get the app plus health worker support or just a referral to a standard quit-smoking clinic. The goal is to s…

This study tests whether giving DHA (a type of omega-3 fat) early to very preterm infants who are small at birth can improve head growth without causing too much fat gain. The trial will include 152 infants and measure head size and body fat at 36 weeks adjusted age. If successfu…

This Phase 2 trial is testing whether using two immune therapy drugs together with chemotherapy works better than one immune drug plus chemo for people with advanced non-small cell lung cancer that lacks the PD-L1 marker. Researchers will track changes in tumor DNA in the blood t…

This study compares two common tendon grafts used in ACL knee reconstruction: the quadriceps tendon and the patellar tendon. Researchers want to see which one gives better knee stability and function after surgery. The trial will enroll 100 people who need ACL surgery and follow …

This study tests a prescription eye drop called Vevye (cyclosporine 0.1%) in 48 adults with meibomian gland dysfunction (MGD), a common cause of dry, burning eyes. Participants use the drops twice daily for 24 weeks, and researchers measure changes in eye symptoms, gland function…

This early-phase trial tests siplizumab, a drug given as a shot under the skin, in 12 adults with moderate-to-severe hidradenitis suppurativa (painful boils) that hasn't improved with standard treatments. The main goal is to see if the drug safely reduces the number of inflamed l…

This study tests a personalized approach for people newly diagnosed with multiple myeloma. After initial treatment, patients are grouped based on whether their cancer is deeply suppressed (MRD-negative) or not. Those with deep response may receive extra drug cycles instead of a s…

This study tests whether giving people a live gut bacterium called Oxalobacter formigenes can lower the amount of oxalate in their urine. High urinary oxalate is a major risk factor for calcium oxalate kidney stones. Forty adults with a history of such stones who lack this bacter…

This study tests whether using a pressurized, pulsed antibiotic wash during breast reconstruction surgery reduces complications like infection, bleeding, fluid buildup, or implant failure. Researchers will compare this method to the standard wash using a bulb syringe. The trial e…

This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by…

This study compares a standard metal rod (nail) used to fix shinbone fractures with a new 'micromotion' nail that allows a tiny amount of movement at the break. Researchers want to see if the new nail helps bones heal faster and with fewer problems. About 100 adults with stable s…

This study is testing whether a 24-week live telehealth exercise program, set to music and tailored to individual abilities, can improve cardiometabolic health in 132 adult wheelchair users. The program focuses on reducing risk factors like waist size, blood sugar, and cholestero…

This study looks at whether a simple breathing test (spirometry) can help doctors decide the right dose of immunoglobulin therapy for people with common variable immune deficiency (CVID). Researchers will enroll 22 adults with CVID who already take a stable dose of Hizentra. Half…

This study tests whether metformin, a common diabetes drug, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants take metformin or a placebo for 16 weeks and receive…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women with recurrent gynecologic carcinosarcoma, a rare and aggressive cancer. The goal is to see if the combo can keep the cancer from growing for at least 6 months. Participants must have had at le…

This study looks at whether giving young women (ages 15-24) in Kenya a long-acting injectable HIV medication along with a birth control implant is safe and works well. Researchers will check hormone levels and HIV viral suppression in 700 participants. The goal is to simplify car…

This early-phase study tests a new automated method (CliniMACS Prodigy) to select CD34 stem cells for patients with blood cancers who need a stem cell boost or second transplant. The goal is to reduce the risk of severe graft-versus-host disease (GVHD) while improving blood cell …

This study aims to see which of two triple-combination inhalers works better for people with moderate to severe asthma that is not well controlled. About 20 adults will try both Trimbow and Trelegy Ellipta in a crossover design, and researchers will use special MRI scans to measu…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study tests whether treating mild high blood pressure (stage 1 hypertension) during pregnancy can improve baby birth weight. 74 pregnant people with blood pressure between 130-139/80-89 mmHg will be randomly assigned to either active treatment with blood pressure medication …

This study tests whether a new EDTA mouth rinse helps wounds heal better after tooth extraction and bone grafting compared to standard chlorhexidine rinse. Forty adults who need a single tooth pulled and bone grafting will use one of two rinses for 12 weeks. Researchers will meas…

This study tests a new program to help people quit smoking by teaching them how to handle withdrawal symptoms and negative feelings. Researchers will enroll 400 adult smokers who want to quit. The goal is to see if this training helps more people stay smoke-free compared to stand…

This early-stage trial is testing whether adding two drugs, decitabine and venetoclax, to a standard reduced-intensity stem cell transplant can safely help control high-risk myeloid cancers like acute myeloid leukemia. About 20 adults aged 18-75 with a matched donor will receive …

This phase 2 trial tests whether intravenous immunoglobulin (IVIG) can help people with a rare autoimmune muscle disease called anti-HMGCR immune-mediated necrotizing myopathy. Twelve participants will receive either IVIG or a placebo every 4 weeks for 12 weeks, then all may rece…

This study tests a combination of telehealth, peer support, buprenorphine medication, and connections to addiction treatment programs for people who have had an opioid overdose and visited the emergency department. The goal is to help participants stay in treatment and prevent fu…

This study tests whether the antibiotic azithromycin can help children with severe RSV infection who need breathing support in the ICU. About 370 children will receive either azithromycin or a placebo for three days. The main goal is to see if the drug shortens the time they need…

This early-phase trial is testing a combination of two treatments for people with recurrent or newly diagnosed glioblastoma and other aggressive brain cancers. The first treatment is pembrolizumab, an immunotherapy that helps the immune system attack cancer cells. The second is M…

This study tests a 24-week church-based program called FELLAship for Black men at risk of heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get coaching, and use a smartwatch to track progress. The goal is to see if the …

This study tests a new program to help people with gout get the follow-up care they need after an emergency room visit for a flare-up. The goal is to improve both short-term treatment and long-term management of gout. The study will enroll 200 adults and also aims to increase par…

This study tests whether a DASH-style diet (rich in fruits, vegetables, and low-fat dairy) can reduce the risk of kidney stones compared to a typical Western diet. Forty-eight adults with a history of kidney stones will eat specially prepared meals for one week. Researchers will …

This study tests three custom-made stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce deaths, lung problems, and hospital stays. About 410 adults with certain types of aortic aneurysms will take part.

This study aims to find the best combination of strategies to help people maintain weight loss after losing at least 5% of their body weight. Over 500 participants will first lose weight through a 16-week program, then be assigned to different packages of four methods: eating few…

This study tests a lower daily dose of the chemotherapy drug capecitabine in 40 patients aged 60 or older, or those who are frail, with advanced breast cancer. The goal is to see if this gentler dose can still shrink tumors while causing fewer side effects. Participants will take…

This phase 2 trial is testing whether a powerful four-drug combination can achieve such deep cancer remission that newly diagnosed multiple myeloma and amyloidosis patients can safely delay or avoid a stem cell transplant. Forty participants will receive six cycles of the drug co…

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study tests whether adding a growth factor (rhPDGF) to a standard bone graft helps rebuild jawbone better than using saline alone. About 44 adults who need dental implants but have thin jawbone will receive one of the two treatments. Researchers will measure new bone formati…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

The ACHIEVE trial is testing whether giving pregnant women with preeclampsia or high blood pressure medication to keep their blood pressure below 140/90 mmHg can safely prolong their pregnancy. The study will enroll 132 women between 23 and 35 weeks of pregnancy who have mild for…

This study is testing different combinations of computerized brain exercises (cognitive training) to see which works best to delay dementia in older adults with mild cognitive impairment. About 1,300 participants aged 55–89 will complete 40 sessions of either cognitive training o…

This study looks at whether a low-carbohydrate diet helps teenagers with type 2 diabetes control their blood sugar better than a standard diet. About 40 teens aged 12-18 will follow one of the two diets for 24 weeks. Researchers will measure changes in blood sugar, insulin resist…

This study is testing a 5-session radiation treatment (stereotactic body radiotherapy) for people with early-stage breast cancer who have already had a lumpectomy. The goal is to see if this shorter course is safe and has fewer side effects than standard longer radiation. About 4…

This study is for people with high-risk kidney cancer that has been surgically removed. It uses a blood test to look for tiny bits of cancer DNA (molecular residual disease). If no DNA is found, patients skip standard immunotherapy (pembrolizumab); if DNA is found, they receive i…

This study tests whether using a 0mm or 2mm margin around brain metastases during radiosurgery leads to better tumor control with fewer side effects. Radiosurgery delivers a high dose of radiation to kill tumors. The trial will enroll 180 adults with brain metastases up to 4 cm i…

This study tests a drug called pirfenidone, currently used for lung disease, to see if it can safely reduce repeat attacks of pancreatitis. About 60 adults who have had two or more pancreatitis episodes will receive either the drug or a placebo. The goal is to lower the number an…

This phase 2 trial tests whether a new way of giving anti-thymocyte globulin (ATG) along with standard drugs tacrolimus and methotrexate can prevent acute graft-versus-host disease (GVHD) after a stem cell transplant. The study enrolls 29 adults aged 18-60 with blood cancers who …

This phase 2 trial tests a two-step dosing schedule of anti-thymocyte globulin (ATG) combined with standard drugs (tacrolimus and mini methotrexate) to prevent severe graft-versus-host disease (GVHD) in 56 adults with blood cancers like acute leukemia. Participants receive ATG on…

This study tests whether wearing specialized soft contact lenses for short periods each day can slow the progression of nearsightedness (myopia) in children. Eighty kids who already wear contacts will use one of two lens types daily for a year. Researchers will measure changes in…

This study tests whether giving high-risk infants an Owlet smart sock monitor after NICU discharge can reduce emergency room visits and hospital readmissions. The device tracks heart rate and oxygen levels and alerts caregivers to problems. 700 babies will be enrolled to see if r…

This study compares a new breast biopsy marker, HydroMARK Plus, with the standard marker to see if it is easier for surgeons to find and remove during breast cancer surgery. About 150 patients scheduled for surgery with SCOUT localization will take part. The main goal is to measu…

This phase 2 trial is testing a combination of the targeted drug mirvetuximab soravtansine and the chemotherapy carboplatin as a first treatment for women with advanced ovarian, fallopian tube, or primary peritoneal cancer that has a specific marker (folate receptor alpha). About…

This pilot study tests whether placing ARDS patients in an upright position in bed can improve their breathing while on a ventilator. Forty adults with ARDS will be randomly assigned to either upright positioning or standard head-of-bed elevation. The main goal is to see if uprig…

This early-phase study tests a new type of PET/MRI scan that uses special radioactive tracers to detect leftover high grade glioma (a fast-growing brain cancer) after standard radiation therapy. About 20 patients aged 10 and older will receive up to three imaging sessions. The go…

This study is testing whether a self-administered Pap smear is as accurate as the traditional one done by a healthcare provider. Researchers will recruit 250 women in rural Alabama who need routine cervical cancer screening. Each woman will do a self-collected sample right before…

This study tests a simple method to diagnose biliary atresia, a serious liver condition in newborns. Infants with suspected cholestasis receive a dye called indocyanine green (ICG) through an IV. Doctors then check the baby's diaper for the dye, which would indicate bile is flowi…

This early-phase study aims to see if a special PET scan using 89Zr-trastuzumab can predict how well HER2-positive breast cancer patients will respond to targeted therapy. Ten newly diagnosed adults will receive the imaging agent and undergo PET/MRI scans. The goal is to improve …

This study is testing whether an AI-based eye screening program can help detect glaucoma and other eye conditions in people visiting community health centers. About 1,800 adults at higher risk for glaucoma will get a quick eye scan using an AI tool called AI-RONA. If the screenin…

This study tests whether a dye called panitumumab-IRDye800 can make head and neck cancer cells glow during surgery, helping surgeons see and remove all cancer while sparing healthy tissue. About 25 adults with head and neck cancer scheduled for surgery will receive the dye before…

This early-phase study tests whether a special tracer called 89Zr panitumumab, used with PET/MRI scans, can show head and neck tumors more clearly than the standard FDG tracer. Fourteen newly diagnosed patients scheduled for surgery will receive both scans. The results are for re…

This study is testing a new ultrasound technique called Shear Wave Elastography to see if it can detect acute kidney injury early after vascular surgery. Researchers will compare results from 50 healthy volunteers and surgery patients. The goal is to find a quick, non-invasive wa…

This study explores whether a tampon can collect DNA samples from the vagina to detect endometrial and ovarian cancer early. Researchers will compare tampon samples with tissue and blood from 1,500 women undergoing surgery. The goal is to develop a simple, non-invasive screening …

This study tests if teaching people how to use mobility devices like crutches or walkers before foot or ankle surgery can lower their risk of falling after the operation. About 250 adults having elective foot or ankle surgery will take part. The goal is to see if this simple trai…

This study tests whether adding folic acid to iodized salt can raise folate levels in women of childbearing age in Zambia, a country without mandatory folic acid fortification. Two hundred fifty non-pregnant, non-lactating women aged 18–45 will use the fortified salt instead of r…

This study tests a quick digital toolkit that teaches cisgender women about PrEP, a daily pill that prevents HIV. About 125 women at clinics in Alabama and Mississippi will use the toolkit on a tablet and then talk with a healthcare worker about starting PrEP. Researchers want to…

This study tests whether giving selumetinib early to children with NF1, before nerve tumors cause symptoms, can prevent tumor growth and related problems. About 200 children aged 1 to 8 years with no known tumors will either receive the drug or be observed. The goal is to see if …

This study tests whether a patient navigator—someone who contacts you after a fracture and connects you to a bone health specialist—can help older adults avoid future fractures. Over 2,600 people aged 50 and older who recently had a fragility fracture will be assigned to either t…

This study is testing a new data dashboard to help clinics in Alabama track and improve how they provide PrEP, a daily pill that prevents HIV. The dashboard shows real-time data on PrEP prescriptions and patient needs, aiming to reduce racial gaps in HIV prevention. Researchers w…

This study tests whether early time-restricted eating (eating only during a set morning window) helps postpartum women with overweight lose weight and improve heart health. Sixty women 6-16 weeks after a healthy pregnancy will either follow this eating schedule or eat normally fo…

This early study tests whether a gentle, non-invasive nerve stimulation device placed in the ear (taVNS) can improve how the body regulates heart rate and blood pressure in people with Parkinson's disease. Researchers will measure changes during simple physical tasks like deep br…

This study tests whether daily disposable tinted contact lenses can reduce light sensitivity in people who have had a mild concussion. Researchers will measure symptom improvement using a standard questionnaire. The goal is to help participants return to work or school more comfo…

This study tests two types of smell training in 80 adults aged 40+ with HIV. Participants will sniff scents at home twice a day for 8 weeks. The goal is to see if the training is easy to do and if it improves smell and thinking abilities.

This study is testing a new type of talk therapy called Process-Based Therapy (PBT) for people with anxiety. Unlike standard treatments, PBT adapts techniques from different therapies to target each person's specific struggles. Ten adults with moderate-to-severe anxiety will try …

This study tests whether a type of counseling called Acceptance and Commitment Therapy (ACT) can reduce minority stress—the internalized stigma from social marginalization—in LGBTQ+ individuals. Researchers will compare ACT to standard counseling in 80 non-heterosexual adults. Th…

This study tests a new type of talk therapy called ReACT for adults with functional seizures (also called psychogenic non-epileptic seizures). The therapy aims to help people regain control over their body by changing thoughts and behaviors that trigger seizures. Fifty participan…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study tests if a simple injection near a nerve in the neck can help people with a chronic cough that won't go away. About 50 adults with a cough lasting 8 weeks or more will receive the injection and report how their cough affects their daily life. The goal is to see if this…

This study looks at whether adding a cocoa supplement to a regular exercise program helps older adults (55+) with slow walking speed improve their physical performance and muscle strength more than exercise alone. Participants will be randomly assigned to receive either cocoa or …

This study is testing whether taking oral tranexamic acid after total shoulder replacement surgery can reduce pain and improve short-term outcomes. Sixty adults aged 18-79 having shoulder replacement will be randomly assigned to receive either the drug or a placebo. The goal is t…

This early study tests whether ivacaftor, a drug used for cystic fibrosis, can help people with chronic sinusitis caused by hard-to-treat bacteria. Twenty adults will receive either ivacaftor plus standard care or standard care alone for 14 days. Researchers will check safety, sy…

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in adults who had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either start training right away or wait 12 weeks. The goal is…

This study compares two cognitive rehab programs for adults with long COVID who have mild to moderate brain fog. Both programs include computer games, in-lab training, and a mild nerve stimulation device worn on the ear. One group focuses on processing speed and work-related task…

This study is testing whether adding sensory training to a proven arm therapy (Constraint-Induced Movement therapy) can help stroke survivors with mild-to-severe arm and hand weakness. Researchers will enroll 15 adults who are at least 6 months post-stroke. The goal is to see if …

This study tests a mindfulness-based therapy designed to improve sleep in people with Down syndrome (age 12+). The program is adapted with visual aids, shorter meditations, and caregiver support. Researchers will compare it to a brief behavioral therapy in 20 participants, measur…

This study tests whether acceptance and commitment therapy (ACT) can help adults with religiously oriented obsessive-compulsive disorder (OCD). Ten participants will receive ACT and be assessed for changes in their OCD symptoms and avoidance behaviors. The goal is to see if this …

This study tests a new cognitive behavioral therapy called ReACT for teens aged 11-18 with psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but are not caused by epilepsy. The therapy focuses on helping teens regain a sense of control over their body a…

This study tests a behavioral therapy called ReACT for teens aged 11-18 with functional seizures (non-epileptic). The therapy involves 12 sessions with a therapist to help manage seizures. Researchers want to see if a larger study is possible by checking how many teens join, stic…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help reduce pain, fatigue, and other symptoms in people with fibromyalgia. Researchers will enroll 30 women aged 25-65 who have had widespread pain for at least a year. The goal is to s…

This study tests a telehealth program called C-READY that helps teens with sickle cell disease improve thinking skills like planning and problem-solving. The goal is to prepare them to manage their own health care as they grow up. About 120 teens aged 10-18 will take part, and th…

This study tests a therapy called Constraint-Induced Movement (CI) Therapy for adults who had a stroke at least 6 months ago and have mild weakness in one arm. The therapy involves daily training to improve arm and hand use, along with strategies to encourage using the weaker arm…

This study compares two ways of doing a common surgery for pelvic organ prolapse and stress incontinence. Doctors want to know if placing a small mesh sling before or after lifting the vagina leads to better bladder control and happier patients. About 110 women having robotic sur…

This study tests whether a 6-week virtual magic trick training program can improve social and emotional skills in adolescents with autism. Sixty teens aged 11-18 will learn tricks from a magician and practice presenting them. Researchers will measure changes in social knowledge, …

This study tests a program that helps cancer patients deal with legal problems like insurance denials, disability benefits, and financial aid. About 50 adults with advanced cancer will get free legal navigation and be followed for 6 months. Researchers want to see if this support…

This study compares carbon dioxide gas to regular air for inflating the bowel during endoscopy in children. The goal is to see if CO2 reduces belly pain, bloating, and gas after the procedure. About 350 children aged 6 months to 18 years will take part.

This study tests whether a 10-week online expressive writing program can help adults with spinal cord injury work through feelings of grief and loss. Participants will write about their emotions with guidance from a coach and share reflections with others. The goal is to see if t…

This study tests whether combining a modified ketogenic diet (using a meal replacement drink) with online brain training can improve memory and thinking in blood cancer survivors. About 80 adults with mild to moderate cognitive issues will either get the combined program for 12 w…

This study tests whether high-intensity interval training (HIIT) or moderate continuous exercise can improve thinking, memory, and daily function in 110 older adults with HIV who are sedentary and fatigued. Participants will exercise three times a week for four months. The goal i…

This study tests whether a mobile cognitive training app can reduce 'chemobrain'—memory and thinking problems caused by chemotherapy—in people with gynecologic cancers. Sixty-four participants will use the app on their own phones while undergoing chemotherapy and complete thinkin…

This study tests whether morning bright light therapy can improve sleep and brain function in 105 adults recovering from opioid use disorder. Participants on stable medication will receive either bright or dim light for 30 minutes daily over two weeks. Researchers will measure sl…

This study tests a 6-week program called PAfitME that uses motion-controlled exergames (like Nintendo Switch) to help head and neck cancer survivors manage fatigue and pain after finishing treatment. 150 participants will be randomly assigned to either the exergaming program or a…

This study tests whether the drug misoprostol, given before a cervical exam, can help doctors see the cervix more clearly. 420 women with a hard-to-examine cervix (called Type 3 transformation zone) will receive either misoprostol or a placebo. The goal is to see if the drug make…

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their …

This study tests a program called VISACT that uses visual aids, provider coaching, and organizational training to help surgery patients with low health literacy. The goal is to improve recovery and reduce complications. The study will enroll 1050 patients and providers at the Uni…

This study looks at how spinal cord stimulators affect nerve signals and symptoms in people with Restless Leg Syndrome (RLS). Researchers will measure brain and nerve activity using EEG, EMG, and other tests while the stimulator is on or off. The study includes 50 participants, s…

This study looks at whether CFTR modulators (ETI) help control blood sugar in people with cystic fibrosis-related diabetes (CFRD). Researchers will compare 30 adults with CFRD who take ETI to those who cannot take it. The goal is to see if the drug improves how the body handles s…

This study looks at how the brain processes emotions by using tiny electrical pulses in people with epilepsy who already have electrodes implanted for surgery. Researchers will measure brain activity and physical responses like sweat to understand how certain brain areas control …

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This study looks at whether giving very preterm babies (born 27-31 weeks) a higher or lower volume of human milk helps them grow healthier. About 486 infants will be tracked to see how their body composition and gut health respond. The goal is to find the best feeding plan for th…

This study is testing whether a special PET/MRI scan using an investigational tracer called [18F]FMISO can help monitor how well chemotherapy works in people with HER2-positive breast cancer. The study involves 25 patients and is for imaging purposes only—it will not change their…

This study will create and test a team-based treatment program for people with Functional Neurological Disorder (FND), a condition that causes symptoms like seizures, dizziness, and tics without a clear physical cause. Researchers will enroll 1,100 adults and children at the Univ…

This study follows 6,000 people with histiocytic disorders (like Langerhans cell histiocytosis) to understand long-term health problems, pain, mental health, and causes of death. Researchers compare participants to healthy controls to identify factors that lead to new health issu…

This study tests whether two types of PET/CT scans can show inflammation and scarring in the lungs of people with idiopathic pulmonary fibrosis (IPF). Ten adults aged 40-85 with IPF will receive the scans. The goal is to help doctors better understand the disease and guide future…

This pilot study tests whether a special type of PET/MRI scan can monitor how triple-negative breast cancer responds to immunotherapy. Twenty patients will get three scans over their first two treatment cycles. The results won't change their care but could help design larger stud…

This study uses a special PET scan tracer called [18F]DPA-714 to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will scan participants at the start, after 12 months, and after 24 months to see how inflammati…

This study uses a special PET scan to look for inflammation in the brains of people with long COVID who have neurological symptoms like brain fog or headaches. Researchers will compare these scans with those from healthy volunteers to better understand how the virus may affect th…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study uses a special PET scan to measure a harmful protein called tau in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau buildup relates to a person's thinking abilities, race, and heart health risks. Participants are already part of a larg…

This study aims to find out if people who get calcium oxalate kidney stones produce more oxalate in their bodies than healthy people. Researchers will compare 80 adults—some with a history of stones and some without—after they eat a special low-oxalate diet and take small amounts…

This study aims to find out if people who get calcium oxalate kidney stones absorb more oxalate from food than healthy people. Researchers will compare stone formers and healthy volunteers by having them eat special diets and measuring oxalate in urine, blood, and stool. The goal…

This study works with cancer survivors and their loved ones living in poor areas to improve their diet and physical activity. Researchers will adapt existing health programs to fit the community's needs. About 100 participants from the Birmingham area will track their eating, exe…

This study is testing a program to help more people in coastal Alabama get tested for HIV, quickly connect to care, and start treatment right away. The program uses data to find areas with high need, helps people link to care when diagnosed, and offers rapid antiretroviral therap…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and immune system change over time. Participants join when diagnosed or starting standard antiviral treatment and are monitored for years. The goal is to learn more about the dise…

This study aims to understand how oxalate, a substance found in many foods, contributes to kidney stone formation and affects the body's immune system. Researchers will enroll 88 healthy volunteers and people with calcium oxalate kidney stones. Participants will follow a controll…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study trains palliative care doctors and nurses to better understand and respect the cultural values of older African American patients. The goal is to improve communication and reduce the impact of racism in end-of-life care. Researchers will test if the training helps pati…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers think special light-sensitive cells in the eye might be involved. They will measure pupil responses, brain waves during sleep, and daily sleep patterns in 200 adults…

This study tests whether watching videos about COVID-19 vaccination experiences and receiving phone support can increase vaccine uptake among Black and Latinx adults with rheumatic diseases. Researchers will enroll 1,170 participants from rheumatology clinics. The goal is to find…

This study looks at whether shining red light on the leg can increase blood flow in healthy adults. Forty participants will receive red light and a contrast agent called Definity to measure blood flow with ultrasound. The goal is to learn more about how light affects circulation.

This study is testing whether shining a red light (670 nm) on the calf muscle for 5 minutes can increase blood flow in people with peripheral artery disease (PAD). Forty adults with PAD will receive the light treatment and an ultrasound contrast injection to measure blood flow. T…

This study uses a special PET scan tracer called DPA-714 to measure brain inflammation in people with Parkinson's disease compared to healthy volunteers. Researchers want to see if Parkinson's patients have higher levels of inflammation and how that relates to their symptoms. The…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study looks at whether a fast genetic test can help doctors pick the best blood-thinning medication for people who have had a minor stroke or a high-risk mini-stroke (TIA). The test checks a gene called CYP2C19, which affects how the body processes certain antiplatelet drugs…

This study looks at how a heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will test 200 adults with different genetic versions of ANP to see how their bodies respond to exercise and sugar. The goal is to understand why some p…

This study looks at whether a ketogenic diet can help people with obesity maintain weight loss by increasing the calories their body burns and reducing appetite. Twenty adults will first lose weight on a low-calorie diet, then follow a keto diet for six weeks while researchers me…

This study looks at inflammatory genes in people with psoriasis to better understand the disease. Researchers will take skin samples from 13 adults with psoriasis and measure genes linked to inflammation. The goal is to find markers that could help manage psoriasis in the future.

This study looks at how childhood trauma and stress affect tiny genetic molecules called microRNAs in the blood. Researchers will compare people with major depression and healthy volunteers to see if these molecules can help explain the link between early life stress and suicidal…

This study looks at whether pumping breast milk every 2 hours instead of every 3 hours helps mothers of preterm babies produce more milk. About 70 mothers will be assigned to one of two pumping schedules and record their daily milk volume for the first 28 days after birth. The go…

This study looks at whether a partial problem with a salt channel (CFTR) in the nose contributes to chronic sinusitis. Researchers will measure how well the nose clears mucus in 20 people with sinusitis and healthy volunteers. The goal is to understand the disease better, not to …

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory loss or depre…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity in cisgender and transgender individuals. Researchers will test pain responses to heat, cold, and pressure, and analyze blood samples for hormone levels and immune markers. The goal is to …

This study is observing 1,000 critically ill adults in Latin American ICUs who need dialysis for severe acute kidney injury. Researchers will track treatments, outcomes, and country differences to understand what works best. The goal is to gather data that can improve care and gu…

This study looks at how the brain makes sense of sentences. Researchers will record brain activity from electrodes already placed in the brains of people with epilepsy for medical reasons. Participants read or listen to sentences word by word and pick a picture that matches. In s…

This study tests whether using an augmented reality headset (Microsoft HoloLens 2) can help doctors place IVs and central lines with ultrasound guidance. About 50 patients who need these procedures will take part. The goal is to see if the technology improves success rates, reduc…

This study explores how a program that helps cancer patients with money problems (like paying for treatment or basic needs) affects their stress, quality of life, and emotional health. Researchers will look at data from about 40 patients and staff at a cancer clinic. The goal is …

This study looks at whether adding a coach-led early literacy and numeracy program to regular shared reading can improve developmental test scores in infants at 24 months old. About 188 babies born at 35 weeks or later will take part. All families get reading training, and half a…

This study follows 40 adults who survived sepsis in the ICU to understand how their physical function changes after leaving the hospital. Researchers will test strength and mobility at several points, especially looking at how hospital readmissions affect recovery. The goal is to…

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This study looks at whether special vision training can improve how people with central vision loss from macular degeneration see and move their eyes. Researchers will train 60 adults aged 18 to 89 with severe vision loss to better detect and discriminate visual patterns. The goa…

This study looks at how early childhood experiences—like breastfeeding, stress, and social factors—affect children with sickle cell disease. Researchers will test a community-based breastfeeding support program for mothers and track health outcomes like asthma and chest pain epis…

This study looks at whether using a special saw during a common jaw surgery (called sagittal ramus osteotomy) helps the bone break in a cleaner, more predictable way. About 40 adults having jaw surgery will be checked with CT scans to see the fracture pattern. The goal is simply …

This study tests different coaching sessions to help people with stage 4 chronic kidney disease and their caregivers work together on health decisions. 128 patient-caregiver pairs will try one or more training components, like extra coaching or communication practice. The goal is…

This study is observing 2,000 lymphoma patients who also develop hemophagocytic lymphohistiocytosis (HLH), a severe immune overreaction. Researchers will collect data on which treatments patients receive and how they respond, aiming to identify factors that improve survival at 18…

This early-stage study explores whether stem cells made from a person's own blood can help repair damaged blood vessels in the eye caused by diabetic retinopathy. Researchers will create these stem cells in a lab and test them in animals to see if they can grow new, healthy blood…

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during deep brain stimulation surgery. The goal is to understand the brain's role in movement problems, w…

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This study is testing different combinations of recorded exercise videos, health coaching, and live training sessions to see which approach helps people with physical disabilities stay physically active over 32 weeks. About 257 participants will wear a Fitbit to track their steps…

This study looks at whether a special ketone drink can quickly improve thinking skills in adults aged 19 to 55. Researchers will test three groups: people with obesity who are inactive, lean inactive people, and lean active athletes. Participants will take either the ketone drink…

This study tests whether teaching parents of preterm infants to use finger puppets during play can improve their baby's development. 188 preterm babies born before 34 weeks will be split into two groups: one gets standard care plus finger puppet training, the other gets standard …

This study will follow 35 people who recently had a spinal cord injury to see how their gut bacteria change over the first year. Researchers will collect blood, stool samples, and bowel function surveys at the start, 6 months, and 12 months. The goal is to understand how the gut …

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and heart health risks. Participants are already part of a larger Alzheimer's study at the University of Al…

This study creates a registry of 5,000 adults aged 50 and older with blood cancers like multiple myeloma and lymphoma. Researchers will track frailty, muscle loss, and other age-related health issues to better understand this group's needs. The goal is to gather information that …

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants…

This study aims to understand why some people with alpha-1 antitrypsin deficiency (AATD) get more respiratory infections. Researchers will compare immune responses to a pneumonia vaccine (PCV20) in 30 adults who carry one abnormal copy of the SERPINA1 gene. Half have had frequent…

This study is looking at how deep brain stimulation (DBS) affects brain activity in people with Parkinson's disease. Researchers will record brain signals during DBS surgery to better understand which areas to stimulate and how to set the device for each person. The goal is to ma…

This study looks at how a cholesterol-regulating protein called LXR might protect the eyes in people with diabetic retinopathy. Researchers will take blood samples from 104 adults with or without diabetes to test how certain blood cells function. The goal is to understand the bio…

This study looks at how vision loss from glaucoma affects how often and how far older adults get out and about, known as 'life space.' Researchers will use questionnaires and vision tests to compare people with glaucoma to those without. The goal is to understand the real-world i…

This study tests whether giving young and middle-aged adults with high blood pressure a personalized genetic risk score helps them lower their blood pressure and adopt healthier habits. 300 participants will either receive standard care or get their genetic risk results along wit…