Brain games put to the test: can they really stave off dementia?

NCT ID NCT04171323

Recruiting now Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing different combinations of computerized brain exercises (cognitive training) to see which works best to delay dementia in older adults with mild cognitive impairment. About 1,300 participants aged 55–89 will complete 40 sessions of either cognitive training or a control activity. The goal is to find the most effective training to improve daily function and reduce the risk of developing dementia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: computerized cognitive training exercises
What this could lead to: If successful, this could identify the most effective combination of brain exercises to delay dementia onset and improve daily function in older adults at risk.
What could go wrong: This is a large but early-stage adaptive trial; the best combination may not outperform the control, and benefits may be modest or not apply to all types of cognitive decline.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction dementia prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Active Mind Study
RECRUITING

Tampa, Florida, 33617, United States
Clemson University
RECRUITING

Greenville, South Carolina, 29607, United States
Clemson University
RECRUITING

Seneca, South Carolina, 29672, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Florida
RECRUITING

Gainesville, Florida, 32611, United States
University of Minnesota
ACTIVE_NOT_RECRUITING

Minneapolis, Minnesota, 55455, United States

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