Dementia

This Phase 1 trial tests an experimental vaccine called AV-1980R that targets tau protein, a key player in Alzheimer's disease. The study enrolls 48 cognitively healthy adults aged 65-80 who have biological signs of early Alzheimer's. Researchers will check if the vaccine is safe…

This study tests an investigational drug called KarXT to see if it can prevent the return of psychosis (like hallucinations or delusions) in people with Alzheimer's disease. About 410 participants aged 55-90 will receive either KarXT or a placebo for 38 weeks. The main goal is to…

This study tests whether listening to a specific 40 Hz sound for one hour a day, five days a week over 12 weeks, can improve memory, brain activity, sleep, and quality of life in older adults with mild cognitive impairment or mild dementia. Half of the participants will receive t…

This trial is testing whether huperzine A, given as a controlled-release tablet, can improve thinking and daily living skills in people with mild-to-moderate Alzheimer's dementia. Participants will receive either huperzine A, a placebo, or an existing Alzheimer's drug (donepezil)…

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This study tests an experimental drug called MK-2214 in 340 people with early Alzheimer's disease. The goal is to see if it can slow the buildup of a harmful protein called tau in the brain, which damages brain cells. Participants will receive either the drug or a placebo, and re…

This early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This phase 2 trial tests whether an oral drug called SAR448851 can slow the progression of early Alzheimer's disease. It includes people with mild cognitive impairment or mild dementia due to Alzheimer's, who have brain amyloid plaques. Participants receive either the drug or a p…

This trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This study tests donanemab, an experimental drug, against a placebo in 140 Chinese adults who show early signs of Alzheimer's risk. Participants receive the drug intravenously every few weeks for up to 3 years. The goal is to see if donanemab can delay memory loss and help mainta…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This Phase 3 trial tests trontinemab, an antibody given by IV, in 800 people with early Alzheimer's (mild cognitive impairment to mild dementia). Half get the drug, half get a placebo, for 72 weeks. The goal is to see if it slows decline in memory, thinking, and daily activities.

This Phase 3 trial tests whether trontinemab can slow down Alzheimer's in people with early symptoms like mild memory problems. About 800 volunteers will receive either the drug or a placebo by IV for 72 weeks. The study measures changes in thinking, daily function, and safety.

This study tests an experimental drug called NIO752 in 300 people with progressive supranuclear palsy (PSP), a rare brain disorder that affects movement and balance. Participants are randomly assigned to receive either the drug or a placebo. After the main study, everyone can rec…

This study tests the drug acoramidis in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart, weakening it. Over 36 months, researchers measure whether acoramidis improves heart function and structure using cardiac …

This study tests whether combining a daily oral diabetes medication (semaglutide) with a nasal insulin spray can improve memory, thinking, and blood flow in the brain. The trial enrolls older adults with mild cognitive impairment and metabolic syndrome, a group at high risk for d…

This phase 2 trial investigates whether ozanimod, an oral drug that regulates the immune system, can reduce brain amyloid plaques and inflammation in people with moderate Alzheimer's disease. Forty participants aged 55 to 80 will receive either ozanimod or standard Alzheimer's me…

This Phase 3 trial is testing whether two existing drugs—atomoxetine, typically used for ADHD, and metformin, a diabetes medication—can slow cognitive and functional decline in people with Alzheimer's disease. Around 1,200 participants aged 55 and older with mild to moderate Alzh…

This study tests whether a non-invasive brain stimulation technique called closed-loop transcranial alternating current stimulation (tACS) can improve memory and brain activity in people with mild cognitive impairment likely due to Alzheimer's disease. Participants receive four d…

This study tests whether a drug called CORT108297, which blocks a stress hormone, can improve memory and thinking in people with mild cognitive impairment or those at risk for Alzheimer's disease. Participants take the drug or a placebo for two weeks, then complete memory and att…

This early-stage trial tests an investigational drug called SSGJ-716, given as an injection, to see if it is safe and tolerable. The study first enrolls healthy adults to test a single dose, then moves to people with moderate-to-severe atopic dermatitis (a type of eczema) who rec…

This study tests whether very low doses of radiation delivered to the whole brain are safe and can help preserve thinking and memory in people with Alzheimer's disease or certain dementias with inflammation. Participants receive an initial course of 10 radiation sessions, followe…

This study tests a single intravenous dose of an experimental drug called CGB3002 in healthy adults aged 18 to 55. The main goal is to see if the drug is safe and how the body processes it. This is a first step toward possibly developing a treatment for Alzheimer's disease.

This phase 4 trial tests lecanemab, an antibody treatment for Alzheimer's disease, in 100 people with mild cognitive impairment or mild Alzheimer's dementia. Participants receive lecanemab infusions every two weeks for 18 months. The study also evaluates a new blood test that use…

This study tests whether people with Alzheimer's who already took the drug donanemab benefit from getting it just once a year. About 550 volunteers who finished a previous donanemab study will receive either the drug or a placebo for up to 2.5 years. Researchers will track change…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This study explores whether personalized exercise and music-based therapy can help prevent dementia in older veterans who show early warning signs. Participants have motoric cognitive risk syndrome, meaning they walk slowly and have memory or concentration concerns. The study tes…

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This early-stage trial is testing whether stem cells taken from donated fat tissue are safe when given through an IV to people with mild to moderate Alzheimer's disease. Nine participants will receive increasing doses of the cells and be monitored for side effects over six months…

This trial tests a gene therapy for metachromatic leukodystrophy (MLD), a rare and life-threatening genetic disorder that damages the nervous system. The treatment uses a lentivirus to deliver a working copy of the ARSA gene directly into the spinal fluid and bloodstream. Up to 1…

This study tests an experimental oral drug called KDS2010 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease. Participants take either a low dose, a higher dose, or a placebo daily for 24 weeks. Researchers measure changes in memory, thinking, an…

This early-phase trial tests whether combining interleukin-2 (IL-2) with semaglutide (a diabetes drug) can safely reduce harmful inflammation in the brains of people with Alzheimer's disease. The study will enroll 30 adults aged 50–86 with mild-to-moderate Alzheimer's. Participan…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This study tests whether taking silkworm pupa powder daily for four months can improve thinking, daily living, and nutrition in people with Alzheimer's disease. About 300 participants will receive either the powder or a placebo. Researchers will track changes in memory, frailty, …

This study tests whether adding a single infusion of human stem cells to standard antibody therapy can slow memory and thinking decline in people with mild Alzheimer's or mild cognitive impairment. Ten participants aged 55-90 who are already on antibody treatment will receive one…

This early-stage trial is testing whether a nasal spray containing exosomes from umbilical cord stem cells is safe and might help people with mild to moderate Alzheimer's. The study involves 33 participants and will first test different doses, then compare the best dose to a plac…

This study tests a drug called lecanemab in 200 people with early-stage Alzheimer's. Participants receive either lecanemab or standard care for 24 months. Researchers use eye and brain scans along with memory tests to see if the drug slows the disease and to check for side effect…

This study tests whether a drug called leronlimab is safe for people with mild Alzheimer's or mild cognitive impairment. Twenty volunteers over age 50 will receive weekly injections for 12 weeks. Researchers will use brain scans and blood tests to see if the drug lowers brain inf…

This study tests a device called HiDO-ALZ that uses facial recognition and video to help people with dementia take their daily medications correctly. About 50 participants will use the device at home, and a study partner will get alerts if doses are missed. Researchers will measu…

This study explores whether daily mindfulness practice, combined with heart rate biofeedback, can improve attention and memory in adults aged 50-70. Participants will practice breathing patterns that either increase or decrease heart rate swings. Researchers will measure changes …

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can slow cognitive decline in people with early Alzheimer's disease. The treatment targets a key brain region affected by Alzheimer's. Fifty-five partici…

This early-stage study tests whether it is safe to combine a drug called etanercept with repeated ultrasound sessions to temporarily open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more of the drug reach the brain to reduce inflammation. O…

This Phase 2 trial tests whether ambroxol, a common cough medicine ingredient, can slow cognitive decline and improve symptoms in people with early dementia with Lewy bodies. 180 participants will receive either ambroxol or a placebo for 18 months. The study measures changes in t…

This Phase 2 trial tests whether fasudil, a drug already used in Japan and China for brain blood vessel spasms, can improve memory and brain function in people with early Alzheimer's disease. Two hundred participants will receive either fasudil or a placebo for 12 months, with re…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

This study will follow 3,000 South Korean Alzheimer's patients taking LEQEMBI for up to 6 years to monitor safety, especially brain swelling or bleeding. Researchers will use real-world data from a national registry. The goal is to understand how often these side effects occur in…

This study tests whether stem cells taken from a person's own fat can reduce brain inflammation and slow memory decline in adults aged 60–80 with early Alzheimer's. Participants receive four stem cell infusions over 12 weeks and are monitored for a year. The goal is to see if thi…

This study tests whether a clinical pharmacist calling a patient's general practitioner 90 days after hospital discharge can reduce readmissions and emergency visits. It includes 800 patients aged 65 and older who take at least seven medications. The goal is to improve communicat…

This study is testing a new version of a gut antibiotic called rifaximin in 20 people with mild-to-moderate Alzheimer's or vascular dementia. The goal is to see if changing the bacteria in the gut can improve brain function and reduce inflammation. Participants will take the drug…

This study tests whether a device that flashes light and plays sound at a specific frequency (40Hz) can help people with mild Alzheimer's. Sixty participants will use the device at home for an hour each day over six months. Researchers will check brain waves, memory, and blood ma…

This study tests whether an 8-week home-based breathing exercise called Inspiratory Muscle Strength Training (IMST) can reduce dementia risk in adults aged 60-80. Researchers will measure changes in blood pressure, thinking skills, mood, and sleep quality. The goal is to see if t…

This Phase 2 trial tests whether adding an antioxidant to an NMDA-enhancing drug (DAOIB) improves thinking and memory more than the drug alone in people with early Alzheimer's or mild cognitive impairment. Eighty participants will take the combination or a placebo for 24 weeks. R…

This phase 2 trial is testing a drug called DAOIB in 123 people with mild Alzheimer's disease or mild cognitive impairment. Participants take DAOIB for 24 weeks, with dose adjustments every 8 weeks. Researchers will measure changes in thinking and memory, and look at blood marker…

This Phase II trial tests whether siponimod, a drug already approved for multiple sclerosis, can safely slow brain atrophy in people with mild Alzheimer's disease. Over 18 months, 105 participants will receive either the drug or a placebo. Researchers will measure brain volume ch…

This study tests a nasal spray called foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray aims to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and have brain scan…

This study tests whether a daily dose of flaxseed oil (alpha-linolenic acid) can slow memory loss and protect brain blood vessels in older adults with mild cognitive impairment and the APOE4 gene, which raises Alzheimer's risk. Twenty participants will take either the oil or a pl…

This early-stage trial tests a drug called NIO752, given via spinal injection, to see if it can reduce production of tau protein in the brain. Tau buildup is linked to Alzheimer's damage. Ten people with mild to moderate Alzheimer's will receive either NIO752 or a placebo, and re…

This Phase 2 trial tests bumetanide, a diuretic used for decades, in 40 people with early Alzheimer's. Researchers want to see if it is safe and might help slow cognitive decline. The study is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets…

This early study tests a surgical procedure that reroutes lymphatic vessels in the neck to help the brain drain waste proteins linked to Alzheimer's. Ten people with mild-to-moderate Alzheimer's will undergo the operation and be followed for two years. The main goals are to check…

This study tracks 50 children and adults with non-malignant disorders like immune deficiencies and anemias who receive a stem cell transplant after a reduced-intensity chemotherapy regimen. The goal is to see if this approach improves survival and reduces severe graft-versus-host…

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzh…

This phase III trial is evaluating whether an experimental PET imaging agent, [18F]Fluorbetazine, can accurately detect amyloid-beta plaques in the brain—a hallmark of Alzheimer's disease. The study will include about 400 adults aged 40 and older with normal cognitive function, m…

This study tests whether a small, home-use lancet device can collect blood samples that accurately measure p-tau217, a key Alzheimer's biomarker, compared to standard blood draws. Researchers will enroll 1,000 adults aged 40–90, including those with confirmed Alzheimer's, healthy…

This study tests whether a special imaging agent called 18F-FPyCO/SMBT-1 can help diagnose Parkinson's disease and related conditions by detecting a brain enzyme called MAO-B. About 200 adults with suspected or confirmed Parkinson's will receive a single injection of the agent an…

This study looks at whether measuring certain proteins in the blood (p-tau217 and neurofilament light) can help doctors diagnose Alzheimer's disease more quickly and confidently in people with memory problems. About 550 participants visiting a memory clinic will have their blood …

This study is testing whether a blood test that measures specific proteins (pTau217) can help primary care doctors diagnose Alzheimer's disease in people with memory concerns. Researchers will compare the test's accuracy against standard evaluations and track how it changes docto…

This study tests a new radioactive tracer called 18F-Fluselenamyl for PET scans to safely detect amyloid plaques in the brain, a hallmark of Alzheimer's disease. Researchers will compare it to an existing tracer in 60 healthy volunteers and people with mild cognitive impairment o…

This study explores whether a simple test of naming and identifying famous landmarks can tell apart healthy older adults from those with Alzheimer's disease. Researchers will compare the performance of 220 participants (half with Alzheimer's, half without) on this monument-based …

This early-stage study tests a radioactive tracer called [18F]Flortaucipir, used during a PET scan to detect tau protein tangles in the brain—a hallmark of Alzheimer's disease. Researchers will enroll 18 Chinese adults aged 50-85 with normal cognition, mild cognitive impairment, …

This study is testing whether blood tests can help screen for Alzheimer's disease in older adults during routine check-ups. Researchers will enroll 3,000 people aged 60-80 from communities and clinics. Participants will give blood samples, and those with abnormal results will tak…

This study is testing a new, non-invasive way to detect Alzheimer's disease by looking for specific proteins (amyloid and tau) in stool samples. The goal is to see if these proteins can serve as early warning signs, potentially allowing for earlier diagnosis and treatment. Resear…

This study is testing a non-invasive eye camera that takes pictures of the retina using different colors of light. Researchers want to see if these images can help detect signs of Alzheimer's, Parkinson's, and other neurodegenerative diseases. About 930 adults over age 30 with or…

This study tests a quick, 5-minute cognitive assessment called the 5-Cog to help primary care doctors identify older adults with undiagnosed dementia or mild cognitive impairment. The trial will involve 6,600 patients aged 65 and older across 22 clinics in the Bronx and Indiana. …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study is testing whether new blood tests can accurately diagnose the cause of memory loss or dementia, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If success…

This study aims to make it easier for family doctors to detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using blood tests and brain scans. The goal is to see if these tools can accurately identify who has …

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study aims to find the best cutoff values for key Alzheimer's-related proteins in spinal fluid and blood to improve diagnostic accuracy. Researchers will compare results from Alzheimer's patients, those with mild memory problems, people with other dementias, and healthy olde…

This study aims to find early warning signs of Alzheimer's disease by analyzing body fluids, genes, and brain images in 6,000 older adults in China. Researchers hope to create a diagnostic kit and a risk prediction model that can identify the disease years before symptoms appear.…

This study is testing a new blood test called the AD-seeds-detector that looks for specific protein clumps linked to Alzheimer's disease. Researchers will compare the test results from 1,500 people aged 55-75, including those with Alzheimer's, other dementias, and healthy individ…

This study is testing whether a simple voice recording can help detect Alzheimer's disease early. Researchers will analyze speech patterns from 100 volunteers aged 50 and older and compare them to standard Alzheimer's biomarkers. If successful, this could replace painful lumbar p…

This study is testing a new serious game called REALSoCog to see if it can detect social behavior problems in people with Alzheimer's, Lewy body dementia, or frontotemporal degeneration. Researchers will ask 120 patients to play the game on a laptop, which presents 16 social situ…

This study aims to improve early detection of Alzheimer's disease in people aged 60 and older. Researchers will equip general practitioners and specialists with digital cognitive tests and blood-based biomarkers to identify those with early cognitive decline. The goal is to creat…

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other memory disorders. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute scratch-and-sniff test using…

This study tests a new injection called [18F]-APN-1607 that helps a PET scan see harmful tau tangles in the brain, which are linked to Alzheimer's disease. About 316 adults aged 50 and older with normal memory, mild memory problems, or Alzheimer's dementia will get the injection …

This study tests a single injection of AMDX-2011P, a dye that may stick to Alzheimer's-related plaques in the retina. Researchers want to see if it is safe and can detect these plaques using eye imaging. 25 adults with confirmed Alzheimer's will participate. If successful, this c…

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroen…

This study tests an app designed for primary care doctors to quickly screen older adults for early cognitive decline. The app includes risk questions, a symbol matching task, and voice tasks. Researchers will enroll 100 Spanish-speaking adults aged 60 and older to see if the tool…

This study is testing a new, smaller and mobile PET scanner called the Radialis PET Imager (RPI) to see if it can produce brain images as good as standard PET scanners for detecting amyloid plaques—a hallmark of Alzheimer's disease. Researchers will enroll 160 adults with cogniti…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

This study tests whether the drug HT-4253 can lower Alzheimer's risk in people aged 50-75 who carry the APOE4 gene and have high levels of amyloid in their blood. The 112 participants will receive either the drug or a placebo for 48 weeks. The main goal is to see if the drug can …

This phase 3 trial tests whether acoramidis can prevent or delay transthyretin amyloidosis (ATTR) in 587 adults who carry a faulty gene but have no symptoms yet. ATTR causes sticky plaques to build up in the heart and nerves, leading to heart failure and nerve damage. Acoramidis …

This study tests whether specific goal-setting techniques can help adults aged 45 to 65 become more physically active and stick with it. Participants are overweight or obese and currently get little exercise. They will receive a behavioral program designed to boost self-regulatio…

This study tests whether a device that flashes light and plays sound at 40Hz can prevent Alzheimer's disease in people at risk. 200 adults aged 55-90 with a family history of Alzheimer's will use the device at home for 60 minutes daily over 12 months. Researchers will measure cha…

This study tests whether lifestyle changes like diet and exercise can help prevent dementia in adults aged 55 and older. Researchers will track 2,000 participants over three years, measuring memory, thinking skills, and how well people stick to healthy habits. The goal is to find…

This study tests an online educational program called Brain Health PRO in 700 Canadians at risk for dementia. Participants are randomly assigned to start the 6-month program immediately or after a 6-month delay. The program covers lifestyle factors like diet, exercise, sleep, and…

This study is testing whether the Shingrix vaccine, already used to prevent shingles, can also lower the risk of dementia in adults aged 76 and older. Over 33,000 participants in Finland will receive either the vaccine or a placebo. Researchers will track new dementia diagnoses o…

This study explores whether mindfulness training can help prevent cognitive decline in Latino adults aged 65 and older, a group at higher risk for Alzheimer's disease. Researchers will measure brain activity and thinking skills in 60 participants before and after mindfulness prac…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study tests a brief problem-solving therapy to prevent suicide in adults aged 50 and older who have suicidal thoughts. The therapy is delivered in three formats: face-to-face, by phone, or via a smartphone app. 212 participants will be randomly assigned to one of these forma…

This study tests a tailored program called REMINDER4Care for adults aged 65 and older living in residential or daycare facilities. The program focuses on social and cognitive activities to reduce dementia risk. Researchers will compare the program's effects on thinking skills, mo…

This study tests whether regular aerobic exercise can prevent or slow memory decline in older adults (ages 50-80) who have memory complaints but no dementia. Participants will be randomly assigned to either an aerobic exercise program or a stretching and toning group for six mont…

This study tests Exercogs®, a digital game that uses augmented reality to combine mental challenges, physical exercise, and social interaction. Researchers will enroll 150 adults aged 55 and older who have at least one risk factor for dementia. Participants will play the game thr…

This study looks at how lifestyle habits affect memory and thinking in older Singaporeans aged 60-75. Researchers will test a program that promotes brain-healthy behaviors, focusing on common issues in this group. The goal is to see if these changes can slow down cognitive declin…

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This study tests a pressure-sensor exercise mat and software designed to improve memory, balance, and physical fitness in adults 65 and older. Participants stand on the mat and follow on-screen games and exercises led by a coach. Researchers will compare results with a control gr…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests whether an adapted questionnaire, called the Care Partner Hospital Assessment Tool (CHAT-AD), can help care partners of hospitalized people with Alzheimer's disease or related dementias feel more prepared to provide care after discharge. Participants are unpaid f…

This trial tests a short virtual program designed to help older adults with early-stage dementia and their family caregivers work together on medication management. The program includes education about dementia, discussions about beliefs around independence and help, and creating…

This study tests two experimental drugs, EXV-802 and EXV-801, to see if they can safely reduce agitation in people with Alzheimer's dementia. About 300 participants aged 55-90 with moderate to severe agitation will receive either the drug or a placebo twice daily for 6 weeks. The…

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This study tests an experimental oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either a low dose, high dose, or placebo. The main goal is to see if the drug safely decreases agitated behaviors, such as pac…

This study tests a culturally adapted decision aid for Chinese American family caregivers of people with moderate to advanced dementia who face feeding difficulties. The tool, called CMCFODA, provides information on tube feeding versus hand feeding and includes personalized coach…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

This study is developing and testing an online platform called LEND that shares personal stories from people with dementia and their carers. The goal is to see if these relatable narratives can boost wellbeing, confidence, and quality of life for both groups. The trial involves i…

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This study tests a device called Neuclare that is placed on the head to see if it can temporarily improve planning and problem-solving skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medic…

This study tests a tool called HART that helps caregivers of people with Alzheimer's or related dementias find health apps suited to their needs. Fifteen family caregivers will use the tool for four weeks and provide feedback on how easy it is to use and whether it improves their…

This study tests a program that teaches family caregivers how to help their loved ones with mild to moderate dementia manage chronic pain. Researchers will work with 60 people (30 patients and their caregivers) to see if the training improves pain coping and quality of life. The …

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests an experimental drug, ITI-1284, to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. About 370 participants will receive either the drug or a placebo, and doctors will track changes in symptom sev…

This study tests an experimental drug called ITI-1284 to see if it can safely reduce agitation in people with Alzheimer's dementia. About 320 participants will receive either the drug or a placebo, and researchers will measure changes in agitated behaviors using a caregiver quest…

This phase 2 trial is testing whether CBD capsules can safely reduce agitation in people with Alzheimer's disease. About 40 participants will receive both CBD and a placebo at different times to compare effects. The study also looks for biological markers that might predict who r…

This Phase 3 trial tests whether the drug KarXT can safely reduce psychosis (hallucinations and delusions) in people with Alzheimer's disease. About 500 participants aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychosis will receive either KarXT or a plac…

This study tests whether a very low dose of levetiracetam, a drug used for epilepsy, can reduce abnormal overactivity in a key memory area of the brain. It includes 40 people who have a parent or sibling with Alzheimer's and have memory concerns but still score normally on thinki…

This randomized trial tests whether a structured, personalized music program (MUSIC CARE©) can reduce care refusal during daily hygiene care in nursing home residents with dementia. Care refusal—resisting bathing, dressing, or medication—is common and stressful for both residents…

This study tests the safety and tolerability of the drug Zunveyl in 150 adults aged 50 and older with mild to moderate Alzheimer's disease. Over 12 weeks, researchers will monitor side effects and whether the drug helps reduce neuropsychiatric symptoms like agitation or mood chan…

This pilot study will test whether a non-invasive brain stimulation device called rTMS can improve cognitive function in adults aged 50 to 90 with mild to moderate memory problems. Eighty participants will receive six sessions of targeted magnetic pulses over three weeks. Researc…

This early-phase trial tests whether propranolol, a drug typically used for high blood pressure, can improve language abilities and reduce anxiety in older adults with primary progressive aphasia (PPA). PPA is a type of dementia that gradually impairs speech and language, and the…

This study tests whether a low-dose extended-release version of levetiracetam (AGB101) can reduce overactivity in the hippocampus, a brain region often overactive in early dementia. Sixty adults aged 50–80 with normal thinking skills will take the drug or a placebo for two weeks …

This study investigates whether complex rhythmic movement training, like dancing with new partners, can improve mobility and learning in people with Parkinson's disease or mild cognitive impairment. Researchers will compare how participants with Parkinson's, those with memory pro…

This study tests a 6-week web-based program designed to help family caregivers of people with dementia manage behavioral and psychological symptoms like agitation, anxiety, and sleep problems. The program includes educational modules, symptom tracking, and online support. Researc…

This study tests whether a safe, non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve working memory in people with dementia. The stimulation is timed to each person's brain waves, measured by EEG, to help brain regions communicate b…

This study tests whether spermidine, a natural substance found in foods like wheat germ, can improve sleep quality and memory in older adults with mild cognitive impairment (MCI), a condition that raises dementia risk. 76 participants aged 55-70 will take spermidine or a placebo …

This study tests a four-week financial counseling and advocacy program for family caregivers of people with Alzheimer's or related dementias who are in early or middle adulthood. Participants receive financial coaching, self-advocacy support, and referrals, and researchers measur…

This Phase 3 trial tests whether the drug combination KarXT + KarX-EC can safely reduce psychosis symptoms (like hallucinations and delusions) in people with Alzheimer's disease. About 325 participants aged 55-90 will receive either the drug or a placebo. The study is currently r…

This study tests a head-mounted far-infrared therapy device in 40 people with mild-to-moderate Alzheimer's disease. The device is placed on specific points on the head and delivers gentle heat. Researchers will check if it is safe and whether it helps improve cognitive function, …

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive procedure using magnetic pulses, can improve short-term memory in people with early Alzheimer's disease. Forty participants will receive either real or sham rTMS over four weeks, then be …

This study tests a behavioral sleep program called Care2Sleep for people with Alzheimer's disease and their caregivers. The program includes sleep hygiene, activity, and light exposure. Researchers will compare it to a sleep education group to see if it improves sleep, health, an…

This study tests whether a virtual reality game can help older adults with mild cognitive disorders improve their inhibitory control—the ability to stop and think before acting. 48 participants will play the game either on a VR headset or a tablet for 20 minutes, twice a week for…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve memory and thinking in people with mild cognitive impairment. Forty participants will receive either real or fake light sessions for 12 weeks. Researchers will measure brain acti…

This study tests a web-based version of cognitive behavioral therapy for insomnia (CBT-I) in 60 family caregivers of people with dementia. Caregivers will complete four online sessions focused on sleep habits, relaxation, and changing unhelpful thoughts. The goal is to improve sl…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can improve cognitive function in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive either real TIS or a sham …

This study tests an educational support group program for people with progressive aphasia (a language disorder caused by Alzheimer's or other dementias) and their carepartners. The program includes group education, support sessions, and communication skills training. Researchers …

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study tests a new drug called EI-1071 in 15 people with mild to severe Alzheimer's disease. The main goal is to see if the drug is safe and tolerable over 4 weeks. Researchers will also check if it reduces brain inflammation using special brain scans. Participants must have …

This study tests a training program for caregivers that helps them identify and address unmet needs of people with dementia living in long-term care facilities. The goal is to reduce behavioral and psychological symptoms like agitation and anxiety. About 120 residents will take p…

This study tests whether combining mental exercises (cognitive stimulation therapy) with physical activities (motor stimulation) can improve thinking and mobility in people with mild-to-moderate dementia. About 421 participants aged 65 and older will attend 14 sessions over 7 wee…

This study tests whether listening to personalized music enhanced with binaural beats (sound patterns that may influence brain waves) or spatialized (3D-like) audio can reduce behavioral and psychological symptoms of dementia, such as agitation and anxiety. Researchers will enrol…

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The program is designed to help both partners manage emotional distress after a recent diagnosis. The study will include 24 couples and …

This study tests a 5-week virtual cognitive training program for people aged 65-85 with mild cognitive impairment (MCI). Participants attend weekly two-hour group sessions online, learning memory strategies, mindfulness, and planning skills. Researchers want to see if the shorter…

This pilot study tests whether a device called Cereset Research can help caregivers of people with dementia who feel stressed, anxious, or have trouble sleeping. The device plays tones that echo the brain's own rhythms, aiming to improve heart rate variability and reduce stress. …

This study tests whether a non-invasive brain-computer interface combined with 40Hz audio-visual stimulation can improve cognitive function in people with Alzheimer's disease. 90 participants will be randomly assigned to receive either fixed 40Hz stimulation, personalized closed-…

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study is testing whether a special flickering light therapy can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's disease. About 120 participants will be randomly assigned to one of four light conditions and use the light at home for two …

This small pilot study is testing whether a single infusion of human mesenchymal stem cells can help control agitation, aggression, and other behavioral symptoms in people with moderate to severe Alzheimer's disease. The study involves 8 adults aged 55-90 who are already taking a…

This study tests whether restricting eating to a 10-hour daytime window (fasting 14 hours overnight) can reduce sleep problems and cognitive decline in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try the diet for 3 or 6 …

This study tests an online education program called iSupport-Korea, designed for family caregivers of people with dementia. About 160 caregivers will be randomly assigned to use the program or receive usual support, and researchers will track changes in their well-being and confi…

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study tests a programme called Mentis Plus+ Caregivers, designed to improve mental health for adults who care for a family member with dementia. The programme includes six modules that teach skills like self-control, problem-solving, and building relationships. Researchers w…

This study tests whether adding two check-in calls per week to standard cognitive behavioral therapy (CBT) improves quality of life for adults caring for a family member with dementia in rural Texas. Sixty caregivers will receive either individual CBT for 12-16 weeks or CBT plus …

This study tests whether online (telehealth) programs can reduce pre-death grief, burden, and stress in family caregivers of people with dementia. About 60 adult caregivers who speak English and have a mental health condition like anxiety or depression will take part. The goal is…

This study is testing an app called PancreasPlus for people with pancreatic cancer. The app helps patients track symptoms, get information, and communicate with their care team from home. Researchers want to see if using the app improves quality of life, reduces anxiety, and cuts…

This study tests whether a virtual, home-based exercise program can reduce depression and anxiety in family caregivers of people with Alzheimer's disease. Twenty-five caregivers will be randomly assigned to either the exercise program or a wait-list group. The program includes we…

This study tests a personalized home-based activity program for people with mild-to-moderate dementia who have behavioral and psychological symptoms. About 55 participants will receive either the activity program or routine care after leaving the hospital. The program involves fa…

This study explores whether intensive singing lessons can improve thinking, memory, and mood in people with early-stage Alzheimer's. Over 5 months, participants will take twice-weekly singing lessons with a personal teacher, then switch to once-a-month sessions. Researchers will …

This study tests whether a special light that flickers 40 times per second can help people with mild to moderate Alzheimer's disease. For 6 months, 62 participants will use the light device at home for 1 hour each day. Researchers will measure changes in brain activity, memory, a…

This study tests whether personalized virtual music therapy can boost memory and mood in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive two 30-minute online music therapy sessions each week for 8 weeks, led by a certified thera…

This study tests whether using robots at home can reduce apathy—loss of motivation and interest—in people with mild cognitive impairment or dementia. About 75 adults over 40 with apathy will be randomly assigned to interact with a telepresence robot, a social robot, or receive st…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This study tests whether adding tablet-based cognitive exercises to standard non-drug care (like better sleep and mobility) can reduce delirium in older adults. Sixty people aged 60+ in a subacute care unit will receive either standard care alone or standard care plus twice-daily…

This study tests a web-based program called NiteCAPP designed to improve sleep in people caring for a loved one with dementia, especially those living in rural areas. One hundred caregiver-patient pairs will use the program for 4 weekly sessions plus follow-up boosters. Researche…

This study tests whether exercising to beat-accented music helps older adults (65+) with memory concerns stay active and improve thinking skills. Eighty participants will be randomly assigned to a 6-month exercise program with or without special music. The goal is to see if music…

This study tests whether a device that sends gentle magnetic pulses to specific brain areas can improve thinking and memory in older adults. It includes 20 people aged 65 to 84—half with mild dementia and half without. Participants receive either real or sham stimulation to see i…

This study tests whether a 14-session cognitive stimulation therapy group can improve thinking skills, mood, and quality of life for older adults (60+) with dementia or mild cognitive impairment living in residential homes. About 110 participants will be randomly assigned to eith…

This study tests whether cognitive stimulation therapy (CST) delivered by trained volunteers can improve thinking and quality of life for people with mild to moderate dementia. 520 participants in Hong Kong will either receive 7 weeks of volunteer-led CST sessions or continue wit…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with cognitive training, can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in…

This study tests a culturally adapted program called ACES for Black immigrant caregivers of people with dementia. The goal is to see if it helps reduce depression and caregiver burden, and improve quality of life over 3 months. About 150 care partners and their loved ones with de…

This early-stage study is testing whether a fecal microbiota transplant (FMT) is safe and feasible for people with mild-to-moderate Alzheimer's disease. Ten participants will receive the transplant via colonoscopy, and researchers will monitor side effects, recruitment rates, and…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 adults aged 50 and older will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep the…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests a new drug called NSC001 in 90 people with mild to moderate Alzheimer's disease. The drug is designed to activate a specific receptor in the brain (M1 muscarinic) that may help with memory and thinking. The main goal is to check if the drug is safe and tolerable,…

This study is testing a mobile app called Care Buddy that helps family caregivers of people with dementia find local services, support groups, and health information. About 210 caregivers in Singapore will use the app for two years. The goal is to see if the app reduces caregiver…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests whether exercising before a mild brain stimulation session can improve memory in people with mild cognitive impairment linked to heart or blood vessel problems. 64 adults aged 50 and older will be randomly assigned to receive either real or sham brain stimulation…

This study tests whether Jing Si Herbal Tea, taken twice daily, can improve quality of life and sleep for people with dementia and their caregivers. Researchers will first test the tea's feasibility in 100 people with dementia, then conduct a larger placebo-controlled trial with …

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This study tests whether a mobile app that plays personalized calming music can improve sleep for people with dementia and reduce stress for their caregivers. The trial will involve 144 participants (72 people with dementia and their caregivers). One group uses the music app at n…

This study tests a 16-week partner exercise program called BUDPA for people with mild dementia and their family caregivers. The program involves group workouts and at-home practice, aiming to improve thinking, mood, and the relationship between the pair. Researchers will track 23…

This study tests a portable device that plays soft sounds during deep sleep to improve memory and slow cognitive decline in older adults. Sixty participants aged 60-85 with mild memory problems will use the device at home for two 4-week periods. The goal is to see if enhancing sl…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study is testing whether a probiotic called L. lactis CKDB001 can safely slow memory and thinking decline in people with early Alzheimer's disease. About 60 adults aged 55–85 with mild symptoms and positive amyloid brain scans will receive either the probiotic or a placebo f…

This study tests whether a non-invasive brain stimulation technique called tACS can safely improve thinking and memory in people with frontotemporal dementia (FTD). Thirty adults with FTD will receive both real and sham (fake) stimulation in a crossover design, so each person act…

This study tests whether adding mental tasks to treadmill walking (dual-task training) improves movement, thinking, and daily living skills more than walking alone. It involves 46 people with early-to-mid stage Alzheimer's who can already walk. The goal is to see if this combined…

This study tests a program called Connect-Home ADRD that helps nursing home staff and caregivers support dementia patients when they move to home, assisted living, or long-term care. About 360 patients and their caregivers will take part. The goal is to see if the program reduces…

This study tests a workshop series designed for people aged 60 and older with early-stage memory loss who live alone. The program provides education and skills training via Zoom to reduce stress, improve well-being, and help with future planning. Researchers will gather feedback …

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

Many older adults who survive an ICU stay with delirium continue to have trouble with memory, attention, and planning. This pilot study tests whether a noninvasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can safely improve these cognitive pr…

This study tests whether the antidepressant vortioxetine can improve mood symptoms and thinking abilities in people with early-stage behavioral variant frontotemporal dementia (bvFTD). Participants will take the medication for 12 weeks and undergo brain scans and memory tests bef…

This study tests whether a computer-based program can reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and also help their care partners feel less burdened. About 388 pairs (patient and care partner) will take part. The program involves …

This study tests whether home-based telerehabilitation therapy—hand and arm exercises prescribed by an occupational therapist and done remotely—is feasible and helpful for stroke survivors with vascular dementia. The main goal is to see if it lessens the burden on family caregive…

This study is testing a tablet-based meditation game called MediTrain to see if it can help older adults improve their thinking skills and manage stress. Researchers will enroll 4,000 people aged 60 and older to find the best amount of game play needed for benefits. The game adap…

This study tests personalized speech therapy delivered online for people with primary progressive aphasia (PPA), a condition that slowly destroys language skills. Researchers will enroll 30 adults with mild PPA and tailor exercises to their specific variant. The goal is to see if…

This study tests whether a learning technique called structured retrieval practice (repeatedly recalling information with feedback) can help dementia caregivers remember caregiving strategies and feel less stressed. About 65 unpaid caregivers aged 50+ will be randomly assigned to…

This study compares two approaches for treating newly diagnosed Alzheimer's disease: the drug donepezil versus a non-drug approach using cognitive stimulation or remediation. Researchers will measure changes in thinking and memory over 6 months in 240 participants aged 50 and old…

This study tests whether a 12-week exercise program, done twice a week, can improve physical function, thinking skills, and reduce fall risk in older adults living in nursing homes. The program includes strength, balance, and aerobic exercises. Researchers will compare it to a st…

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. About 102 participants will use the digital program or standard paper-and-pencil exercises at home for 5 wee…

This study tests whether a non-invasive device that sends a mild electrical current to the brain (tDCS) can improve mood, reduce apathy, and ease irritability in people with Alzheimer's disease. Participants use the device at home for 30-minute sessions. The study involves 24 adu…

This study tests a personalized, non-drug method called CoMBI to reduce troubling behaviors like agitation and anxiety in people with dementia living in nursing homes. Researchers will compare CoMBI to usual care in 60 participants to see if it improves quality of life and reduce…

This study is developing a short, personalized program called PERI-MIND to help menopausal women who are worried about dementia. The program includes education about menopause and dementia risk, plus practical skills to cope with fear. Researchers will first hold focus groups to …

This study looks at language difficulties in people with Lewy body disease (like Parkinson's or dementia with Lewy bodies) who also have mild cognitive impairment. Researchers will first compare sentence understanding between patients and healthy older adults. Then they will test…

This study tests whether nabilone, a synthetic cannabinoid, can safely reduce agitation in people with Alzheimer's disease. Agitation is common and distressing, with few good treatment options. About 112 participants will receive either nabilone or a placebo for 8 weeks, and rese…

This study tests whether a safe, non-invasive brain stimulation technique called tACS can improve cognitive abilities in people with Lewy body dementia. Forty participants will receive either real or sham stimulation over two weeks, and their thinking, memory, and daily function …

This pilot study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely improve memory in people with mild-to-moderate Alzheimer's disease. The treatment targets the precuneus, a brain region important f…

This study tests whether a smartphone app called Safe Haven can help college students feel less depressed, anxious, or stressed. About 68 undergraduates will either use the app plus standard campus care, or just standard care alone. The app includes daily mood tracking, weekly ch…

This study tests a program called COTID, where an occupational therapist visits the homes of older adults with dementia who have recently been hospitalized for a fall. The therapist helps make the home safer and trains the caregiver to support the patient. The goal is to see if t…

This study tests a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease better understand what day, month, or season it is. Twenty participants will use the tool during their hospital stay to see if it improves their time orientation. The goal is…

This study tests whether vestibular therapy—a set of head-movement exercises done with a physical therapist—can reduce falls in people with Alzheimer's disease who also have inner-ear balance problems. About 100 participants aged 60 and older will receive either the therapy or st…

This study tests whether masupirdine, a daily tablet, can safely reduce agitation in people with Alzheimer's dementia. About 375 participants will receive either masupirdine or a placebo. The main goal is to see if the drug improves agitation symptoms, which can include aggressio…

This study tests whether virtual cycling — pedaling a stationary bike while watching an interactive video — can improve quality of life for older adults with cognitive impairment living in nursing homes. Researchers will compare a group that does virtual cycling with a control gr…

This study tests a new, non-invasive brain stimulation technique that combines magnetic and electrical pulses to target brain networks involved in memory. Researchers will enroll 60 people with mild Alzheimer's to see if this approach can improve thinking and daily function. The …

This pilot study tests whether scrambler therapy, a device that uses mild electrical signals on the skin, can reduce nerve pain in people with corticobasal syndrome (CBS). Twenty-five adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scramble…

This study tests an online program called CAN-DO that teaches dementia caregivers skills to handle healthcare, financial, legal, and family issues. 270 caregivers will take the course either right away or after a wait, and complete surveys over 6 months. The goal is to see if the…

This study tests whether a gentle electrical current applied to the brain, guided by a caregiver at home, can improve memory, thinking, and walking in older adults with mild cognitive impairment or mild dementia. 144 participants will receive either real or sham stimulation over …

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study aims to collect cognitive performance data from 1,000 healthy adults aged 18 to 100 using a fully digital, voice-recognition-based testing platform. Participants complete a one-time, 30-45 minute online assessment covering memory, language, attention, and problem-solvi…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This study follows 600 people aged 55 to 85 with early, middle, or late-stage Alzheimer's disease for 12 months. Researchers will track changes in memory, daily activities, behavior, and traditional Chinese medicine symptom patterns. They will also observe whether those receiving…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This pilot study explores whether adding a digital health platform called Lōvu to standard prenatal care is practical and well-received by pregnant people. Participants use a Bluetooth scale, blood pressure cuff, and fetal Doppler that send data to their care team, alongside ment…

This study tests whether simple reminders—called nudges—sent to doctors and patients can increase the use of genetic testing for people with certain conditions like Parkinson's disease, ALS, or heart problems. The trial will compare different ways of prompting genetic testing, su…

This study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…

This study uses advanced MRI (3T fMRI) to look at brain activity in people who have or will have deep brain stimulation (DBS) implants. DBS is a treatment for conditions like Parkinson's disease, tremor, and obsessive-compulsive disorder. The researchers will scan participants un…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

This study aims to understand why people with Alzheimer's disease differ from each other and from healthy older adults. Researchers will use advanced brain imaging (7T MRI), brain wave recordings (EEG), and blood and stool samples to look for patterns that might reflect different…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study uses a special PET scan to measure amyloid plaques in the brains of 160 people with Alzheimer's disease. Researchers want to see how these plaques relate to race and heart health risks. Participants are already part of a larger Alzheimer's study at the University of Al…

This study uses a special PET scan to measure a harmful protein called tau in the brains of 160 people with Alzheimer's disease. Researchers want to see how tau buildup relates to a person's thinking abilities, race, and heart health risks. Participants are already part of a larg…

This study looks at older adults hospitalized for heart, lung, or orthopedic issues to see how many also have undiagnosed mild cognitive impairment or dementia. Participants take a memory test at admission, and those with possible problems get a full brain evaluation and a follow…

This study is testing whether a special PET imaging tracer, [18F]PI-2620, can detect tau protein buildup in the brains of people with Parkinson's disease, including those with a genetic form linked to the LRRK2 gene. About 60 participants will undergo high-resolution brain scans …

This early-stage study is testing an experimental drug called LY3439539 in 30 people with mild-to-moderate Alzheimer's disease. The main goal is to see if the drug changes certain proteins in the spinal fluid that are linked to Alzheimer's. Participants will receive the drug thro…

This study uses a special PET scan tracer, [18F]MH.MZ, to measure serotonin 2A receptors in the brains of people with neurodegenerative diseases like Parkinson's. Researchers want to see if these receptors differ between patients with psychosis and healthy people of the same age.…

This study looks at whether successfully treating moderate-to-severe sleep apnea can improve memory and reduce biological markers linked to Alzheimer's disease in older adults. About 200 cognitively healthy people aged 55-85 will either receive immediate sleep apnea treatment or …

This study looks at whether the immune system's T-cells react differently in people with Parkinson's disease or Alzheimer's disease compared to healthy older adults. Researchers will collect blood samples from 120 participants—30 with Parkinson's, 30 with Alzheimer's or mild cogn…

This study follows people with several types of spinocerebellar ataxia (SCA) — rare genetic diseases that cause balance, coordination, and speech problems — to learn how these conditions change over time. Researchers will collect blood samples, perform neurological exams, and use…

This study is testing whether a program delivered remotely (by video or phone) that combines exercise and dementia caregiving support is practical and helpful for older adults with Down syndrome and their caregivers. About 40 participants will take part. The goal is to see if the…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This observational study asks whether older patients placed under isolation precautions in the hospital are more likely to develop delirium or experience cognitive decline. Researchers will compare isolated patients aged 70 and older with similar non-isolated patients, tracking d…

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study is testing whether proteins in the blood can accurately diagnose Alzheimer's disease and predict how quickly it will progress. Researchers will follow 2,000 adults with memory complaints for five years, collecting annual blood samples. The goal is to find a less invasi…

This study uses special brain scans (PET imaging) to measure two key proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The study involves 60 adults with typical or atypical Alzh…

This study uses advanced PET scans and blood tests to examine brain inflammation and white matter damage in people with corticobasal syndrome, a rare movement and thinking disorder. Researchers will compare these brain changes across different subtypes of the condition and agains…

This study investigates paradoxical lucidity—brief, unexpected episodes of mental clarity—in people with end-stage dementia. Researchers will use caregiver diaries and video EEG monitoring to capture and analyze these rare events. The goal is to create a standard definition and m…

This study will follow 2,500 elderly people in Hong Kong for 2-3 years to find early signs of Alzheimer's disease. Researchers will use blood tests, brain scans, and memory assessments to see if a simple blood test can detect the disease before symptoms get worse. The goal is to …

This study follows older adults (ages 70-95) who have memory concerns but no dementia, tracking them for up to 5 years to see who develops Alzheimer's. Researchers use brain scans, EEG, eye movement tests, and memory assessments to spot early warning signs. The goal is to better …

This study uses special PET scans to measure brain inflammation and tau protein buildup in people with different forms of Alzheimer's disease, including those with memory, vision, or language problems. Researchers aim to understand how inflammation relates to other brain changes …

This study investigates how fluid drains from the brain to lymph nodes in the neck, a connection that may be important for clearing waste linked to Alzheimer's disease. Researchers will inject a fluorescent dye into the meningeal space of recently deceased organ donors and track …

This study looks at whether older adults with prediabetes have lower brain energy use and slower thinking compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can improve brain energy and processing speed. Twenty participants will under…

This study aims to enroll 50,000 adults aged 45 and older in France to test for a gene called APOE, which is linked to Alzheimer's risk. Participants provide a saliva sample at home and complete online questionnaires. The goal is to build a large registry of genetic and health da…

This study aims to create a risk score that uses information from electronic medical records to predict the chance of developing dementia within 5, 9, or 13 years in older adults with depression. Researchers will analyze data from 44 participants aged 50 and older who have a depr…

This study examines whether a person's personality traits before they got sick are linked to the thinking and behavior problems seen in certain brain disorders. Researchers will ask caregivers about the patient's personality from the 10 years before the illness started. The goal …

This study looks at how differences in the NOTCH2NLC gene affect the symptoms and course of neuronal intranuclear inclusion disease (NIID), a rare inherited brain disorder. Researchers will follow 12 members of one family, including those with NIID, gene carriers without symptoms…

This study looks at how certain brain cells (cholinergic neurons) change with age in adults with Down syndrome, and how that relates to Alzheimer's disease risk. Researchers will use brain scans and EEGs to measure these changes in 30 adults aged 18-55 who do not have dementia. T…

This study tests a new, non-invasive MRI technique to detect early brain changes linked to Alzheimer's disease. Researchers will compare brain scans from 50 people with mild memory concerns to healthy volunteers. The goal is to find a simple, affordable way to identify those at r…

This study looks at early changes in mitochondria (the energy centers of cells) and metabolic markers in blood cells of people with Alzheimer's or related dementias. Researchers will compare these measures between those with and without Alzheimer's to find clues about how the dis…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia, along with their care partners, reduce medications that may be harmful. Participants receive educational materials and can meet with a pharmacist to review their…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study collects a small sample of tissue from inside the nose to learn how the sense of smell changes in people with Alzheimer's. Researchers will compare samples from healthy volunteers and those with early or mild Alzheimer's. The goal is to understand the biology behind sm…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …

This study uses brain scans (PET and MRI) to find early signs of Alzheimer's disease in 650 adults with normal cognition or early-stage symptoms. Participants receive special tracers that highlight amyloid and tau proteins in the brain. The goal is to understand how these biomark…

This study tests a new radioactive tracer called [11C]-CS1P1 to see if it can detect inflammation in the brains of people with Alzheimer's disease. Researchers will compare brain scans from 80 older adults—some healthy and some with memory problems—to see if the tracer lights up …

The CROWN-I study is an observational research project involving 160 people with Alzheimer's disease or mild cognitive impairment. Participants will provide samples and undergo assessments over time to help researchers understand the molecular and genetic features that distinguis…

This observational study is recruiting 600 participants to improve detection and understanding of dementia with Lewy bodies (DLB). Researchers will collect clinical data, brain scans, and spinal fluid samples from people with early symptoms like hallucinations or movement problem…

This large nationwide study in China will track nearly 10,000 people with Alzheimer's disease to measure the financial and emotional burden on patients and their caregivers. Researchers will collect data on medical expenses, care costs, and lost income. The goal is to fill gaps i…

This study looks at why people with Alzheimer's disease may move more slowly. Researchers will use brain MRI scans and simple reaction time tests in 155 participants with mild cognitive impairment or early dementia. The goal is to link brain lesions to attention-related motor slo…

This study follows 20 people from families with a genetic risk for frontotemporal dementia (FTD), including those already diagnosed and those at risk. Over five years, researchers will track changes in health and brain function to better understand how the disease develops. The g…

This study is creating a new computer-based cognitive assessment to help detect Alzheimer's disease in its earliest stages. Researchers are working with memory nurses and older adults to design the test and a training course for nurses. 120 older adults with memory concerns will …

This study enrolls adults with Down syndrome ages 25-55 into a ready-to-test group. Researchers will track memory, thinking, and brain changes over time to better understand how Alzheimer's disease develops in this population. The goal is to make future clinical trials faster and…

This study looks at whether special brain cells called tanycytes play a role in Alzheimer's disease and frontotemporal dementia. Researchers will measure hormone levels in blood and spinal fluid from 102 participants to see if these cells help control metabolism and hormone signa…

This study aims to find genes that increase the risk of developing Alzheimer's disease. Researchers are recruiting 10,000 people, including those with Alzheimer's and their family members, from all ethnic backgrounds. By analyzing DNA, they hope to discover new genetic clues that…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This early-phase study is testing the safety and how the body handles a new oral drug called AS-S603, which is being developed to treat Alzheimer's disease. The trial involves 88 healthy volunteers, including Korean and Caucasian adults and Korean elderly people. Participants wil…

This study is a national registry for people with adrenoleukodystrophy (ALD), a rare genetic disorder. Researchers will collect medical records and survey data from up to 1,000 patients and their families over time to understand how the disease progresses. The goal is to find bet…

This study looks at 240 adults aged 40-60 to see if being overweight or obese in midlife is linked to early signs of Alzheimer's in the brain. Participants will have metabolic tests and brain scans (MRI and PET) to measure inflammation, brain shrinkage, and protein buildup. The g…

This study uses brain imaging (PET scans) and memory tests to understand why some people with Parkinson's disease develop dementia. Researchers will follow 320 participants over several years, using scans to look for abnormal proteins and track thinking changes. The goal is to id…

This study compares swallowing function in older adults with and without Alzheimer's disease. Researchers will also survey caregivers to understand the burden of swallowing issues. Participants will undergo tests of swallowing, coughing, and muscle strength. The goal is to learn …

This study tests whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Over 30 participants will receive both real and sham (placebo) s…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study looks at whether treating depression with a common antidepressant (escitalopram) can change brain and blood markers linked to Alzheimer's disease. Researchers will compare the drug to a placebo in 60 adults aged 60 and older who have major depression but no memory prob…

This study is testing whether a non-invasive electrical stimulation technique can improve working memory, attention, and thinking skills in healthy older adults and those with mild cognitive impairment. The stimulation targets deep brain structures without surgery, using special …

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study looks at how social and emotional thinking skills relate to everyday behavior in people with Alzheimer's disease and similar conditions. Researchers will give 120 participants tests of social cognition and ask their study partners to complete behavior checklists. They …

This study looks at whether simpler hearing aid settings work better for older adults with Alzheimer's dementia or mild memory problems. Researchers will test two different hearing aid programs in 20 participants to see which one helps them understand speech in noisy settings and…

This study records brain activity from epilepsy patients who already have electrodes implanted for seizure monitoring. While they perform thinking tasks like memory and attention games, researchers watch how different brain areas talk to each other. The goal is to better understa…

This study tests a 4-week training program for assisted living staff (nurses, administrators, and coordinators) to improve palliative care for residents with dementia. The goal is to increase advance care planning discussions and reduce caregiver burnout. About 792 participants f…

This study tests whether a training program for volunteers aged 50 and over can improve their knowledge about dementia, confidence in caregiving, and quality of life. Participants either receive 80-90 hours of BrainLive Coach training or just educational materials. The goal is to…

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or dementia and their healthy family members. The goal is to better understand how gene…

This study tests a new AI-powered conversation tool called LUMEN. It helps caregivers describe changes in a loved one's memory and thinking. The goal is to see if the tool is easy to use and can improve the quality of information doctors receive. Sixty caregivers and doctors will…

This study tests whether improving sleep with a special headband and doing mild exercise twice a week can lower biological markers linked to dementia. Thirty adults with mild memory or thinking problems will use the DREEM 2 headband for sleep therapy and follow a guided exercise …

This study tests whether a special training toolkit helps doctors and nurses have better conversations about future medical care with people living with Alzheimer's or related dementias. The researchers will compare clinics that use the toolkit to those that continue usual care, …

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study looks at slow brain waves during sleep and wakefulness in 90 people: young adults, healthy seniors, and early-stage Alzheimer's patients. Researchers will measure these waves and test memory and attention. They will also play sounds during sleep to see if it boosts mem…

This study compares two online training programs for assisted living staff who care for people with dementia. One program is a self-paced web course called essentiALZ; the other adds a virtual mentoring group called Project ECHO. Researchers will track changes in staff knowledge,…

CAPTURE ALS is a long-term study that collects health data and biological samples from 150 people with ALS and related conditions. The goal is to create a shared resource for researchers worldwide to better understand the disease and develop new treatments. No experimental drugs …

This study follows 500 people with early Alzheimer's who are receiving anti-amyloid antibody therapy (like lecanemab) in routine care. Researchers will compare their cognitive decline to historical data and track side effects. The goal is to learn how well these drugs work in the…

This study looks at how tau protein buildup in the brain may cause psychotic symptoms like delusions in Alzheimer's disease. Researchers will use PET scans and MRI to compare brain changes in Alzheimer's patients with and without psychosis, as well as healthy older adults. The go…

This study is looking for early warning signs of Alzheimer's disease in 800 cognitively healthy adults aged 50 to 80. Researchers will use blood tests, brain scans, and memory assessments over about 4 years to see how Alzheimer's-related changes develop. The goal is to find a way…

This study follows 300 people with a rare genetic movement disorder called SCA27B, along with some family members and healthy volunteers, for up to 2 years. Researchers will use exams, digital devices, and blood tests to measure how the disease changes over time. The goal is to f…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study uses special PET scans to look at two types of brain cells involved in inflammation in Alzheimer's disease. Researchers will give participants two different tracers to see microglia and astrocytes separately. The goal is to develop a method that can tell these cells ap…

This observational study is testing a new model that combines genetic data, blood tests, and digital monitoring (like sleep and activity trackers) to predict early memory decline in adults aged 55 and older who carry the ApoE4 gene variant. Researchers will follow 100 participant…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study is testing whether neighborhood pharmacies can help identify older adults with early memory problems and guide them to the right support. Over 1,000 participants aged 60 and older will take a digital memory test at their pharmacy. If the test shows concerns, the pharma…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study looks at how different exercise intensities affect the brain in people with type 2 diabetes. 75 inactive adults aged 30-75 will do supervised cycling at high or moderate intensity for 6 months, three times a week. Researchers will use brain scans, cognitive tests, and …

This study tests a non-invasive device that uses light and sound at a specific frequency (gamma) to see if it can change brain activity. Researchers will measure effects using brain scans and tests in 150 healthy adults and people with Alzheimer's. The goal is to see if this appr…

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study is for 244 people with early-stage Alzheimer's disease. Researchers want to find new blood markers that show why some people's brains are more resilient to the disease. Participants will give blood samples and take memory tests over time. No new treatment is being test…

This study tests a communication program called COACH-Cog for older adults with both dementia and cancer. It includes a training video for doctors and a coaching session for patients and their care partners. The goal is to see if this helps everyone work together better when maki…

This study is following 100,000 people in China over many years to learn more about dementia and memory loss. Researchers will track who develops these conditions, look for risk factors like genes and lifestyle, and find better ways to diagnose and prevent dementia. The goal is t…

This study is following 40,000 people from families with a strong history of Alzheimer's disease in China. Researchers are collecting genetic, brain imaging, and thinking and memory test data to learn how the disease develops over time. The goal is to find early signs of the dise…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study looks at how Alzheimer's disease is described in novels and how patients actually speak. Researchers will compare the language of 40 people—some with early-stage Alzheimer's and some healthy—to see if fiction matches real-life memory loss. The goal is to create a tool …

This study follows healthy people who have a family history and genetic risk for ALS. Researchers want to find early warning signs and understand what triggers the disease. Participants do not receive any treatment, but their health is tracked over time. The goal is to learn how …

This study aims to better understand how blood flow and sugar use in the brain are altered in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use advanced PET scans to measure these changes in 60 participants across three groups: people w…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study creates a worldwide database for people with DRPLA, a rare genetic brain disorder. Participants or their caregivers fill out questionnaires about symptoms, daily life, and disease impact. The goal is to gather information to help researchers better understand DRPLA and…

This study uses a smartphone app to track how patients feel before and after neurosurgery for conditions like disc disease, spine instability, brain tumors, or aneurysms. Researchers aim to understand normal recovery patterns and how complications affect well-being. 400 adults wh…

This study is testing a new tool called the CHRONOS battery to measure how people with Alzheimer's disease perceive time. Researchers want to see if this quick, 10-minute test can identify specific problems with time perception, like judging durations or remembering when events h…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study looks at how speech changes over time in people at higher risk for Alzheimer's disease. Researchers will have 165 participants complete speech tasks and surveys on an iPad at home for 3 years. The goal is to see if remote speech tracking is a useful and easy way to mon…

This study tests a program called DECLARE that helps caregivers of people with dementia who receive home health care. Caregivers will answer a short assessment and get faster access to a social worker trained in dementia care. Researchers want to see if this improves caregiver co…

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…

This study looks at whether a common vitamin, niacin (nicotinic acid), can get into the brain fluid of people with Alzheimer's disease. Researchers will give 30 adults aged 60-85 with mild-to-moderate Alzheimer's a single 500 mg dose of extended-release niacin or a placebo. The m…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can temporarily improve language processing in people with mild cognitive impairment due to Parkinson's disease, Lewy body disease, or amnestic MCI. Seventy particip…

This study at Johns Hopkins University will follow 50 people who have had a stroke and have risk factors like high blood pressure, high cholesterol, or diabetes. Researchers will use repeated MRI scans over about 15 months to track changes in the brain's white matter. The goal is…

This study follows 500 people with primary progressive aphasia, a condition that slowly damages the brain's language areas. Researchers will use brain scans and language tests to map how the disease progresses over time. The goal is to better understand the disease, not to test a…

This study aims to see if blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors, including those with neurological issues or dementia. The goal is to develop a tool that u…

This study is a large national registry that will collect health data, questionnaires, and test results from 5,000 people with early dementia or memory problems. No new treatments are given; instead, researchers will track how dementia progresses and how it is currently diagnosed…

This long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…

This study looks at whether a 6-month cardio-dance fitness program can improve brain health and lower Alzheimer's risk in 280 older African Americans (age 60+). Participants will do either dance fitness or strength/flexibility exercises three times a week. Researchers will measur…

This study looks at whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain connections in healthy older adults and people with very early Alzheimer's disease. About 80 participants aged 40-99 will receive daily stimulation…

This study uses virtual reality and eye-tracking to measure how pupils react during memory tasks. Researchers hope to find a simple, non-invasive way to detect early cognitive decline in Alzheimer's disease, mild cognitive impairment, and depression. 140 adults will be tested at …

This study aims to create simple screening tools to identify financial hardship in people with Alzheimer's and their caregivers. Researchers will interview patients and caregivers, then survey large groups to develop and test the measures. The goal is to help healthcare providers…

The TRIAD study is testing whether combining biological markers, psychological tests, and social factors can help diagnose Alzheimer's disease earlier and more accurately. Researchers will follow 80 patients with cognitive decline and their caregivers, collecting data through mem…

This study is following 1,200 people from two memory clinics in Paris to see how sleep patterns, daily routines, and other personal factors relate to different types and stages of dementia. Participants will wear an activity tracker, answer questionnaires, and have cognitive test…

This study looks at how the help provided by family caregivers changes as Alzheimer's disease gets worse. Researchers will track 312 people with Alzheimer's and their caregivers to measure the time and cost of informal care. The goal is to understand what factors—like memory loss…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild cognitive impairment. Researchers will compare scan results with memory tests and brain activity patterns to understand how tau affects thinking. The goal is…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…

This observational study looks at 300 adults with new-onset cognitive impairment to see how often certain immune system markers (neuronal synaptic antibodies) are present. Researchers aim to develop a scoring system to help diagnose autoimmune dementia more accurately. The study …

This study follows 1500 people with rare genetic brain disorders to learn how these diseases progress. Researchers measure thinking, movement, and daily living skills over time, and also look at brain scans and body fluids. The goal is to better understand the diseases and how tr…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study looks at people with cerebral small vessel disease, a common condition in older adults that can lead to stroke and dementia. Researchers will measure brain activity using EEG and test whether home-based cognitive training or mild brain stimulation can improve thinking …

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study tests a new PET scan tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 healthy volunteers and patients to see if…

This study looks at how stress hormones and genes linked to Alzheimer's affect memory and thinking in older adults with mild cognitive impairment. Participants undergo a stress test and provide blood and saliva samples, then return after 2 years for follow-up. The goal is to unde…

This study explores whether taking practice tests helps dementia caregivers remember and apply what they learn about managing difficult symptoms. Researchers will compare caregivers who use structured practice tests with those who don't. The goal is to see if this simple learning…

This study uses special PET scans to look for brain inflammation in people with multiple sclerosis (MS) and Alzheimer's disease. Researchers will compare two radioactive tracers, [F-18]PBR06 and [C-11]PBR28, to see which works better. Up to 250 participants, including healthy vol…

This study is tracking 5,000 people with early Alzheimer's who are taking the drug lecanemab in regular medical practice. The goal is to see how often brain changes called ARIA occur and how doctors manage treatment when they do. Researchers will also look at infusion reactions. …

This study looks at why some people's thinking and memory get worse as they get older. Researchers will use brain scans and memory tests in 300 healthy adults aged 60 and older to find early signs of Alzheimer's disease. The goal is to better understand how the brain changes over…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study collects information and samples from 1,000 people with or at risk for brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. Researchers will track changes in thinking, language, and brain scans over time. The goal is to build a resource for future stu…

This study follows 1,260 women 3 to 6 years after their first pregnancy to see how pregnancy complications like preeclampsia affect heart health. Researchers will check blood pressure, heart function, and artery health, and also look at lifestyle and environment. The goal is to c…

This study follows 600 volunteers aged 65 and older over several years to track changes in memory, thinking, and biological markers like amyloid proteins. Researchers hope to identify early warning signs of Alzheimer's disease before obvious symptoms appear. The goal is to improv…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…

This study looks at whether certain substances in blood and spinal fluid can help detect Alzheimer's disease early. Researchers will measure specific molecules linked to brain cell communication problems seen in early Alzheimer's. They will study 40 older adults with Alzheimer's …

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study follows 660 adults with CADASIL, a genetic condition that causes strokes and dementia, for up to 5 years. Researchers will use brain scans, memory tests, and blood samples to track how the disease progresses from its earliest stages. The goal is to identify factors tha…

This pilot study is testing whether taking curcumin (the active ingredient in turmeric) for two weeks can cross into the brain and attach to amyloid beta proteins, which are linked to Alzheimer's disease. Researchers will use eye imaging to detect these proteins and also check ho…

This study looks at how flexible brain activity is in people with Lewy body disease, a condition that causes thinking and behavior problems and is often hard to diagnose. Researchers will analyze past EEG recordings from 40 adults to see if certain brain patterns are linked to th…