New study seeks to uncover links between ALS and dementia

NCT ID NCT03225144

Recruiting now Knowledge-focused Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 12 times

Summary

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and differences. The goal is to better understand these diseases and identify people eligible for future research studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify common features and risk factors for these brain diseases, pointing toward better diagnosis or future treatments.
What could go wrong: This is an observational screening study, not a treatment trial. It may not directly lead to new therapies, and results may take years to apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis Corticobasal Degeneration corticobasal syndrome frontotemporal dementia Huntington disease motor neuron disorder primary progressive aphasia progressive bulbar palsy progressive supranuclear palsy semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS FRONTOTEMPORAL DEMENTIA PROGRESSIVE SUPRANUCLEAR PALSY

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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