AMYOTROPHIC LATERAL SCLEROSIS

This early study tests the safety and function of a brain implant that lets people with severe paralysis control external devices using their thoughts. The implant is placed in the brain by a robot and connects to tiny threads that read brain signals. Up to 15 adults with quadrip…

This study tests whether adding two supplements (NAC and EH-301) to standard ALS medication (riluzole) can slow down the disease or improve symptoms. About 90 people with early-stage ALS will receive either the active combination or a placebo for 6 months, followed by an optional…

This study tests whether a very high-calorie, fatty diet can help people with ALS live longer and slow the disease. About 392 participants with early-stage ALS will either follow the special diet or a placebo. The main goal is to see if the diet improves survival and daily functi…

This early study tests a wireless brain implant from Neuralink that aims to let people with severe paralysis or ALS communicate just by thinking. The device is placed in the brain by a robot. The study will check if it is safe and works for 6 adults who cannot speak or use their …

This early-stage study tests a single injection of INS1202, a gene therapy, given into the spinal fluid of people with ALS. The main goal is to check safety and find the right dose. About 23 adults aged 18 to 79 with either a specific SOD1 gene mutation or no known genetic cause …

This study tests a brain implant called BrainGate2 for people with tetraplegia (paralysis of all four limbs) due to spinal cord injury, ALS, stroke, or similar conditions. The goal is to see if it is safe and if participants can use their thoughts to control a computer cursor or …

This early-stage study tests whether a special helmet that uses sound waves can safely open a temporary window in the brain's protective barrier. This would allow an anti-inflammatory medicine (IVIg) to reach the motor cortex, the area controlling movement that is damaged in ALS.…

This study checks the long-term safety of tofersen (Qalsody) in 12 Chinese adults with a specific genetic type of ALS (SOD1-ALS). Participants receive 13 doses injected into the spine over a year. The main goal is to track side effects and how the drug moves through the body.

This early study tests a brain-computer interface (BCI) called Connexus in 2 people with severe paralysis from conditions like ALS or spinal cord injury. The device is designed to decode imagined speech and allow users to control a computer, helping them communicate. The main goa…

This phase 3 trial tests if the drug pridopidine can slow the progression of ALS, a serious nerve disease. About 500 adults with ALS will take either pridopidine or a placebo daily for 48 weeks, followed by an open-label period where everyone gets the drug. Researchers will measu…

This phase 3 study tests whether adding masitinib to standard riluzole treatment can slow the progression of ALS, a devastating nerve disease. About 495 adults with early-stage ALS will receive either masitinib or a placebo, both alongside riluzole. The main goal is to see if the…

This study tests whether acetyl-L-carnitine, a natural substance, can slow the loss of self-sufficiency in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of the supplement or a placebo, alongside standard care. Researchers will track…

This study tests an experimental drug, dazucorilant, in 279 adults with ALS. The goal is to see if it can slow the disease's progression and improve muscle strength and breathing. Participants will receive either the drug or a placebo, and researchers will monitor their safety an…

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles and makes it hard to move, speak, and breathe. About 1,500 adults with ALS will take part. The main goal is to see if the treatments can slow th…

This study tests a drug called darifenacin, typically used for overactive bladder, in 30 people with ALS. The goal is to see if it can help repair the connection between nerves and muscles, potentially slowing the disease and improving quality of life. Participants will take the …

This early-stage study is testing a new experimental drug called VTx-002 in 12 people with ALS. The main goal is to see if the drug is safe and tolerable when given as a single injection into the fluid around the brain and spinal cord. Researchers will also look for signs that th…

This study aims to see if a device called SleepImage can accurately detect respiratory failure in people with ALS (amyotrophic lateral sclerosis). Researchers will compare SleepImage data with standard overnight sleep tests in 15 adults with ALS. The goal is to find a simpler way…

This study aims to see if a quick, painless measurement of muscle activity can help doctors diagnose ALS earlier and more accurately. Researchers will test this new method on 650 people, including those with ALS symptoms, healthy volunteers, and ALS patients followed over time. T…

This study tests whether immersive virtual reality can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). About 35 adults with ALS and ongoing breathing discomfort will try virtual reality sessions. The goal is…

This study tests whether a video-based home exercise program can improve body control and daily activities in people with ALS. Twenty adults with ALS will follow the program 3 days a week for 8 weeks. Researchers will measure muscle strength, body awareness, and quality of life b…

This study tests whether pairing brain and spinal cord stimulation can improve hand strength and dexterity in people with ALS. Researchers will first customize the stimulation for each participant, then compare two weeks of stimulation with or without hand exercises. The goal is …

This study tests whether ranolazine, a heart medication, can safely reduce muscle cramps and improve quality of life in people with ALS. About 72 adults with ALS who have frequent cramps will receive either ranolazine or a placebo for 28 weeks. Researchers will track side effects…

This study tests a special exercise method using whole-body electrical muscle stimulation (WB-EMS) in adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy. Because these conditions make normal exercise hard, WB-EMS directly triggers muscle contractions without…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help people with ALS who feel depressed. Researchers will check if the treatment is practical and if it improves mood, quality of life, and hopelessness. The study involves 24 adults with ALS and m…

This study tests whether a custom physiotherapy program, designed around each patient's specific muscle weaknesses, can help people with ALS maintain physical function better than standard physiotherapy. 38 adults with ALS will be assigned to either personalized or usual care exe…

This study collects information from the medical records of 1,200 people with ALS and related conditions. The goal is to learn more about these diseases and improve future research. Participants must receive care at a clinic that uses Epic electronic health records and speak Engl…

This study follows 100 people with ALS to see how their autonomic and sensory nerves change over time. Researchers will use skin biopsies and other tests to look for signs of nerve damage. The goal is to find markers that could help predict disease progression and be used in futu…

This study enrolls 600 adults who have a close relative with ALS or carry an ALS-related gene. Over three years, researchers will collect blood samples, speech recordings, and health surveys to track early changes. The goal is to build a rich database that helps scientists better…

This study looks at how physical abilities impact the quality of life for people with ALS, a disease that weakens muscles over time. About 30 adults with ALS will fill out questionnaires about their daily function and well-being during regular clinic visits for up to two years. N…

This study looks at the long-term safety of the drug tofersen (Qalsody) in people with a rare, inherited form of ALS called SOD1-ALS. Researchers will collect health information from about 125 participants in Europe and the U.S. over at least 7 years, without changing their medic…

This study is a large research program that invites people with ALS, their family members, and healthy volunteers to take part in various studies. The goal is to help scientists learn more about ALS and related diseases. No treatment is given—this is purely for research and knowl…

This study is testing a wearable sensor called Actimyo to measure walking and arm movement in people with ALS and healthy volunteers. About 20 ALS patients will wear the sensor for one month after each clinic visit, over a year. The goal is to see if the sensor can track disease …

This early-stage study tests the safety of a brain implant (BrainGate system) in up to 3 people with severe paralysis or locked-in syndrome. The goal is to see if participants can use their thoughts to control a computer cursor or other assistive devices. The study focuses on saf…

This study follows healthy people who have a family history of ALS and a known genetic mutation that increases their risk. Researchers want to understand what happens in the body before ALS symptoms start, and what factors might trigger the disease. Participants will travel to Mi…

This study is testing a device called the myolex mScan to see if it can track ALS progression better than current methods. The device uses a gentle electrical current to measure muscle changes over time. Researchers will follow 80 people with ALS for 8 months to compare the scan …

This study is building a large collection of health data and biological samples from 150 people with ALS and related conditions. Researchers will track changes in muscle strength, breathing, speech, and quality of life over time. No new treatments are being tested, but the inform…

This study looks at immune cells (macrophages) from 180 people with ALS, healthy volunteers, and those with other motor problems. Researchers want to find differences in the cells' activity that could lead to new treatments or ways to diagnose ALS earlier. No treatment is given; …

This study looks at how people without any speech disorders understand the speech of individuals with ALS and healthy speakers of the same age. Researchers will record speech during different types of conversations and then have listeners write down what they heard. The goal is t…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen up to 360 adults with these conditions using tests like memory exams, movement assessments, MRI scans, and genetic tes…

This study collects spinal cord and brain tissues, along with MRI scans, from 40 adults with ALS after they pass away. The goal is to find biological markers that show how the disease progresses. By linking imaging data with genetic and tissue changes, researchers hope to better …

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate by simply trying to talk. Two adults with conditions like spinal cord injury or ALS will be enrolled. The goal is to understand how speech is …

This study follows 140 adults with ALS over up to 3 years, collecting spinal fluid and blood samples along with clinical data. The goal is to understand how biological markers relate to different forms of the disease. No new treatment is being tested; the focus is on improving di…

This study aims to find biological markers (biomarkers) in the blood of people with ALS that can show whether a potential new treatment is working. Researchers will collect tiny particles released by nerve cells from blood samples of 30 ALS patients and 30 healthy volunteers. By …

This study is creating a large collection of biological samples—like blood, spinal fluid, and urine—from 800 people with ALS and 200 healthy volunteers. Researchers will also track participants' health over time using clinic visits and at-home tests. The goal is to provide this d…

This study surveys 208 people with ALS who have a specific genetic change (C9orf72 mutation) and their caregivers. The goal is to learn about their care, support, and quality of life to find ways to improve both. No new treatments are tested; instead, the study gathers informatio…

This study aims to understand amyotrophic lateral sclerosis (ALS) by growing skin cells from patients in the lab. Researchers will take small skin samples and blood from 110 adults, including people with ALS, healthy carriers of ALS-related gene changes, and control subjects. By …

This study is creating a large national registry of people with ALS in the United States. Researchers will collect information from up to 30,000 participants to better understand how many people have the disease, who is affected, and what environmental or occupational factors mig…

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders, as well as their spouses or partners. The samples are stored in a biobank for future research to find biomarkers that could help understand or diagnose these diseas…

This study is collecting blood samples, medical history, and other health information from 2,000 people with ALS and healthy volunteers over 2 years. The goal is to build a large database that researchers can use to better understand ALS and related diseases. No new treatments ar…

This study aims to find measurable signs, called biomarkers, of amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) using powerful MRI scans. Researchers will compare brain scans of people with these diseases to those of healthy volunteers. Finding these bioma…

This is an early safety study of a new oral drug called Amisodin, which is being developed for Amyotrophic Lateral Sclerosis (ALS). The trial will enroll 48 healthy adults to test different single and multiple doses to see how safe the drug is and how the body processes it. The m…