AMYOTROPHIC LATERAL SCLEROSIS

This phase 3 trial is testing whether the drug pridopidine can slow the progression of amyotrophic lateral sclerosis (ALS) in 500 adults. Participants will take either pridopidine or a placebo daily for 48 weeks, followed by an open-label extension where everyone receives the dru…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests the long-term safety of a drug called LY4256984, given via spinal injection, in people with ALS. It includes 32 participants who completed an earlier study and will be followed for about 96 weeks. The main goal is to see how many people have serious side effects …

This study looks at the long-term safety of an experimental drug called LY4256984 for people with ALS. It enrolls up to 32 participants who have completed a prior ALS trial. The study will follow them for at least 96 weeks to see how well the drug is tolerated over time.

This early-stage study tests a new drug called VTx-002 in 12 people with ALS. The main goal is to check if the drug is safe and tolerable when given as a single injection into the fluid around the brain and spinal cord. Researchers will also look for signs that the drug might slo…

This study tests an investigational drug called LTX-002 in people with amyotrophic lateral sclerosis (ALS). The drug is designed to target a specific genetic message linked to the disease. The main goal is to check the drug's safety and tolerability, and to see how it moves throu…

This study tests an experimental drug, dazucorilant, in 279 adults with ALS (Lou Gehrig's disease). The goal is to see if the drug can slow the loss of muscle function and improve quality of life over 24 weeks. Participants will receive either the drug or a placebo, and researche…

This early-stage trial is testing a single injection of a gene therapy called INS1202, given into the spinal fluid, for people with ALS (Lou Gehrig's disease). The study includes 23 adults, some with a specific genetic mutation (SOD1) and some without known genetic causes. The ma…

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles and gets worse over time. About 1,500 adults with early-stage ALS will take part. The goal is to find treatments that help people stay stronger …

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests an experimental drug called TP04HN106 in 60 people with ALS. Half receive the drug, half receive a placebo (saline), and all take riluzole tablets as standard care. The goal is to see if the drug is safe and can slow the decline in physical function measured by t…

This study tests whether an ultra-high-caloric diet made almost entirely of fat can help people with ALS live longer and slow the disease. Researchers will compare the diet to a low-fat placebo in 392 participants. The main goal is to see if the diet extends survival without the …

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This study tests whether taking N-acetylcysteine (NAC) and EH-301 together with the standard drug riluzole can slow down amyotrophic lateral sclerosis (ALS). About 90 people with early-stage ALS will receive either the active combination or a placebo for 6 months. After that, eve…

This study checks the long-term safety of tofersen (Qalsody) in 12 Chinese adults with a specific genetic form of ALS (SOD1-ALS). Participants receive 13 doses of the drug injected into the spine over about a year. The main goal is to track any side effects and how the drug moves…

This early study tests the safety and function of a brain-computer interface (BCI) implanted by a robot in people with severe paralysis. The device aims to let users control external devices like computers or phones using their thoughts. The trial enrolls 15 adults with quadriple…

Neuralink is testing a brain-computer interface called the N1 Implant, placed by a robot, to help people with severe paralysis communicate. The study will enroll 6 adults with conditions like ALS or spinal cord injury who cannot speak or use their hands well. The main goal is to …

This study tests whether acetyl-L-carnitine (ALCAR), a natural supplement, can slow the loss of self-sufficiency in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of ALCAR or a placebo for 48 weeks, alongside standard care. Researche…

This early-stage trial tests whether a special helmet that uses focused ultrasound can safely open the blood-brain barrier to deliver an anti-inflammatory drug (IVIg) directly to the motor cortex in people with ALS. Six participants will receive two doses of IVIg, with the second…

This Phase 3 trial is testing whether adding masitinib to the standard ALS drug riluzole can slow the disease better than riluzole alone. About 495 people with ALS will take either masitinib or a placebo, plus riluzole, and researchers will track changes in muscle function, breat…

This phase 2 trial tests whether darifenacin, a drug currently used for overactive bladder, can help people with ALS. The study will enroll 30 adults aged 18-85 with confirmed ALS. Participants will take either darifenacin or a placebo daily for 24 weeks. The goal is to see if th…

This study tests whether a wearable device called SleepImage can accurately detect respiratory failure in people with ALS (Lou Gehrig's disease). Researchers will compare the device's readings with standard overnight sleep tests in 15 patients. The goal is to find a simpler way t…

This study is testing whether a quick, painless measurement of muscle activity using surface electrodes can help doctors diagnose ALS earlier and more accurately. Researchers will compare this test to current methods in 650 people with muscle symptoms. They will also track how th…

This study tests if ranolazine, a heart medication, can safely reduce muscle cramps and improve quality of life in people with ALS. About 72 adults with ALS who have frequent cramps will receive either the drug or a placebo for 28 weeks. The main goals are to check safety and see…

This pilot study tests a mechanical in-exsufflator (MIE) device that helps ALS patients cough more effectively by pushing air in and then pulling it out. The goal is to see if daily use for four weeks can maintain or improve lung function. The study will enroll 36 adults with ALS…

This study tests whether pairing non-invasive brain and spinal cord stimulation with hand exercises can improve hand strength and dexterity in veterans with ALS. Thirty-two participants will first undergo a personalized optimization period, then receive two weeks of the combined …

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study tests whether immersive virtual reality (IVR) can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). 35 participants will try both a VR session based on medical hypnosis and a music therapy session. …

This study tests whether a personalized physical therapy program, designed based on each patient's specific muscle strengths and weaknesses using a robotic leg press, can help people with ALS maintain physical function better than standard physical therapy. Thirty-eight participa…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help ease depression and improve quality of life in people with ALS. Researchers will enroll 24 adults with ALS and depressed mood to see if the therapy is feasible and reduces symptoms. The goal i…

This study tests whether a video-based home exercise program can improve trunk and limb control and daily activities in 20 people with ALS. Participants will follow the program 3 days a week for 8 weeks. The goal is to see if this approach can ease symptoms and improve quality of…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This study is looking for biological clues in the blood that explain why many people with ALS lose weight. Researchers will follow 1,000 patients in France and Germany, collecting blood samples and questionnaires alongside standard care. The goal is to find markers that could lea…

This study follows 600 adults who are genetically at risk for ALS due to family history. Over three years, researchers collect blood samples, speech recordings, and health data to track early signs of the disease. The goal is to build a rich database that scientists can use to be…

This study is gathering medical information, blood samples, and speech recordings from 2,000 people with ALS and healthy volunteers over two years. The goal is to create a shared resource that scientists can use to better understand ALS and develop new treatments. Participants ca…

This study follows 60 people with ALS to see how swallowing problems change over time and how they affect quality of life. Researchers also want to understand patients' feelings about getting a feeding tube (PEG). The goal is to learn more, not to test a new treatment.

This study gathers information from the medical records of 1,200 people with ALS and similar conditions. Researchers will use this data to better understand the disease and improve future studies. No experimental treatments are given—the goal is simply to learn from real-world pa…

This study looks at how the FDA-approved drug edaravone (Radicava) affects people with different forms of ALS. Researchers will collect blood, urine, and spinal fluid samples from 160 participants to measure markers of oxidative stress. The goal is to identify which ALS patients …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study aims to find genetic causes and risk factors for ALS by analyzing DNA from 1,200 people in Norway with probable or definite ALS. Researchers will look for known disease-causing mutations and search for new genes linked to the disease. The goal is to better understand w…

This study looks at whether changes in smell and taste contribute to poor nutrition in people with ALS. Researchers will measure food preferences in 60 adults with ALS using a computer test. The goal is to find new ways to improve diet and quality of life by personalizing food ad…

This study is for people with ALS and healthy volunteers. It uses brain and spine MRI scans and blood tests to find markers that show how the disease progresses. The goal is to develop better tools to measure ALS over time. About 90 participants will be followed for up to one yea…

This study is building a large registry of people with ALS in the United States. The goal is to count how many people have the disease and learn about possible causes, such as environmental or genetic factors. Anyone 18 or older with ALS can join. The registry does not test a tre…

This study is testing a device called the mScan to see if it can track how ALS progresses over time. Researchers will measure electrical signals in muscles and compare them to standard tests. The goal is to find a simple, objective way to monitor the disease that could be used at…

This study follows 100 people with ALS to see how their autonomic and sensory nerves change over time. Researchers will use skin biopsies and other tests to track nerve damage and look for biomarkers that could help predict disease progression. The goal is to better understand AL…

This study takes skin biopsies and blood samples from people with ALS, healthy carriers of ALS-related gene mutations, and control subjects. Researchers will grow skin cells in the lab to study how the disease works at a cellular level. The goal is to better understand ALS, not t…

CAPTURE ALS is a long-term study that collects health data and biological samples from 150 people with ALS and related conditions. The goal is to create a shared resource for researchers worldwide to better understand the disease and develop new treatments. No experimental drugs …

This study looks at the long-term safety of the drug tofersen (Qalsody®) in people with a rare, inherited form of ALS called SOD1-ALS. Researchers will collect health information from about 125 participants in Europe and the US over at least 7 years. The main goal is to see what …

This study looks at how physical abilities impact the quality of life of people with ALS, a disease that weakens muscles over time. About 30 adults with ALS will fill out questionnaires about their daily function and well-being during regular clinic visits for up to two years. Th…

This study, called CRiALS, is a large umbrella protocol that aims to recruit up to 10,000 people. It includes individuals with ALS or related neurodegenerative diseases, their family members, and healthy volunteers. The main goal is to build a pool of participants for a variety o…

This study follows healthy people who have a family history and genetic risk for ALS. Researchers want to find early warning signs and understand what triggers the disease. Participants do not receive any treatment, but their health is tracked over time. The goal is to learn how …

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study looks at immune cells called macrophages in people with ALS, a disease that affects movement. Researchers will compare these cells between ALS patients, healthy people, and those with other motor problems. The goal is to find new targets for future treatments and bette…

This early-stage study tests a new drug called amisodin in 48 healthy adults to see if it is safe and how the body processes it. The study is a first step before testing the drug in people with ALS. Participants receive either the drug or a placebo, and researchers monitor for si…

This study at Penn State University will have 1,300 listeners judge recordings of speech from people with ALS and healthy speakers. The goal is to see how different conversation tasks affect how clearly someone with ALS is understood. No treatment is involved; this is purely obse…

This study uses surveys to learn about the care, needs, and quality of life of people with ALS who have the C9orf72 mutation, as well as their caregivers. Researchers want to find out what support is missing and how to improve daily life for both groups. About 208 participants wi…

This study aims to find biological markers in the blood that can help measure whether a potential ALS therapy is working. Researchers will collect tiny particles shed by brain cells from 30 ALS patients and 30 healthy volunteers. By comparing these particles, they hope to identif…

This study follows 140 adults with ALS for up to 3 years, collecting spinal fluid and blood samples along with clinical and cognitive tests. The goal is to understand how certain biological markers relate to different forms of the disease and its progression. This is an observati…

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders. The samples are stored for future research to find biomarkers that could help understand or diagnose these diseases. Participants include patients and their spouses…

This study is for people with ALS, a disease that weakens muscles over time. Researchers want to see if a small wearable sensor called Actimyo can measure walking and arm movements during daily life. About 20 participants will wear the sensor for one month after each clinic visit…

This study uses powerful MRI scans to find biomarkers—measurable signs of disease—for amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Researchers will compare brain images from patients and healthy volunteers to better understand these diseases and potent…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study is creating a large collection of blood, spinal fluid, and urine samples from 800 ALS patients and 200 healthy volunteers. Researchers will also track clinical changes and at-home measures over time. The goal is to provide a valuable resource for scientists worldwide t…

This study collects tissues and MRI scans from 40 adults with ALS to find markers of disease progression. Researchers will compare imaging and genetic data from spinal cord and brain areas. The goal is to better understand ALS and guide future research.