AMYOTROPHIC LATERAL SCLEROSIS

This was an early, small study to see how safe a single dose of a new drug called QRL-101 is for people with ALS and to measure how the body absorbs and processes it. Twelve participants with ALS received either the drug or a placebo. The main goal was to gather initial safety da…

This study tested an investigational drug called DNL343 to see if it could slow the progression of ALS and improve survival. It involved 249 people with ALS who were randomly assigned to receive either the active drug or a placebo for 24 weeks. The main goals were to measure chan…

This study tested whether deferiprone, a drug that removes excess iron from the body, could slow the progression of amyotrophic lateral sclerosis (ALS). Researchers enrolled 372 people with early-stage ALS and randomly assigned them to receive either deferiprone or a placebo for …

This study tested whether adding a low-dose immune drug called Interleukin-2 to standard ALS medication (riluzole) is safe and affects the immune system. It involved 36 adults with ALS who received either the drug or a placebo in three short courses over 12 weeks. The main goal w…

This study tested whether adding a new drug called IFB-088 to the standard medication riluzole could help people with a specific, rapidly progressing form of ALS that starts with speech and swallowing problems. 51 participants were randomly assigned to receive either IFB-088 or a…

This study tested whether a drug called PrimeC is safe and can help slow down ALS. For six months, 69 people with ALS took either PrimeC or a placebo pill twice daily, while continuing their standard ALS medications. Researchers checked for side effects and measured changes in ph…

This small study tested whether injections of an experimental drug called Engensis are safe for people with ALS (Lou Gehrig's disease). Eighteen participants received either the drug or a placebo injection into their muscles over several months. Researchers primarily checked for …

This study tested whether a low-dose immune drug (IL-2) could slow the progression of ALS by boosting helpful immune cells that may calm inflammation in the nervous system. It involved 304 newly diagnosed ALS patients who received either the drug or a placebo for 18 months. The m…

This trial tested whether the drug ABBV-CLS-7262 could slow the progression of ALS (amyotrophic lateral sclerosis) and improve survival. It involved 310 people with ALS who were randomly assigned to receive either the drug or a placebo for 24 weeks. Researchers measured changes i…

This study tested whether a combination of two natural antioxidants (curcumin and resveratrol) delivered in a special form, plus a repurposed drug, could help control Amyotrophic Lateral Sclerosis (ALS). It involved 90 adults with ALS who were randomly assigned to receive either …

This early-stage study aimed to check if an experimental injection called VM202 is safe for people with ALS (Lou Gehrig's disease). It involved 18 adults recently diagnosed with ALS to see what side effects might occur. The main goal was to understand safety, not to prove if the …

This study followed 8 people with ALS (amyotrophic lateral sclerosis) for an extra 6 months to check the long-term safety of an experimental drug called Engensis. All participants had already received the drug or a placebo in a previous trial. The main goal was to monitor for any…

This small study tested if a simple technique called remote ischemic conditioning (RIC) could help improve hand function. RIC involves briefly restricting blood flow to an arm with a blood pressure cuff, which may trigger the body's natural healing and learning responses. Researc…

This study aimed to find new ways to diagnose and track Amyotrophic Lateral Sclerosis (ALS) by analyzing chemicals in tears and cells from the eye's surface. Researchers compared 55 people with ALS to people without the disease to see if the chemical makeup of tears could serve a…

This study aimed to understand the pain and discomfort that people with ALS (amyotrophic lateral sclerosis) experience during procedures in clinical trials. Researchers interviewed 15 patients to learn what specific parts of trials are most difficult. The goal is to use this info…

This small study tested whether focused ultrasound could safely and temporarily open the blood-brain barrier in people with ALS. The blood-brain barrier normally protects the brain but can block potential treatments. Researchers wanted to see if this technique was feasible and sa…

This study aimed to find biological markers (biomarkers) in muscle and blood to help diagnose ALS faster and understand the disease better. Researchers analyzed samples from 37 people, comparing those with ALS to healthy volunteers. The goal was to identify unique chemical patter…

This study aimed to understand the metabolic changes in Amyotrophic Lateral Sclerosis (ALS) by comparing skin cells from patients and healthy volunteers. Researchers took small skin samples from 9 participants to grow cells and analyze their chemical makeup. The goal was to find …

This study aimed to understand if differences in genes related to how the body processes vitamin D are linked to ALS. Researchers compared the genetic makeup of 400 people with ALS to 400 people without the disease. The goal was to gather knowledge, not to test a treatment.

This study aimed to find new markers in MRI brain, spinal cord, and muscle scans that could help doctors diagnose ALS earlier and measure how the disease progresses over time. It involved 22 adults with ALS and healthy volunteers who underwent multiple advanced MRI scans over six…

This study aimed to understand why people with ALS have trouble starting to walk and maintaining balance. Researchers compared 59 people with and without ALS, using brain scans (fMRI) and detailed movement tests. The goal was to map how the brain controls movement in ALS to guide…

This early-stage study tested whether baricitinib, a drug approved for rheumatoid arthritis, can get into the spinal fluid and reduce signs of brain inflammation in people with Alzheimer's disease, ALS, or early memory concerns. Seventeen participants took the pill daily for 24 w…

This study aimed to understand how symptoms develop and change over time in people with a specific genetic mutation (C9ORF72) that causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Researchers followed 50 adults with this mutation for up to three years…

This completed observational study looked at the connection between gut health and ALS. Researchers measured substances produced by gut bacteria in 44 people with ALS and healthy volunteers. They also explored whether following a Mediterranean diet for six months changed these su…

This study aimed to understand the origin of subtle sensory changes in people with Amyotrophic Lateral Sclerosis (ALS). Researchers used brain imaging and electrical activity recordings to see how ALS affects brain function related to touch and sensation. The goal was to gather k…