Can a daily breathing exercise slow ALS lung decline?
NCT ID NCT06119087
First seen Jun 24, 2026 · Last updated Aug 13, 2026 · Updated 3 times
Summary
This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researchers will compare their peak cough flow to a similar group not using the device.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mechanical insufflation using the BiWaze Cough device
- What this could lead to
- If it works, this could point toward a simple daily exercise to help people with early ALS maintain stronger coughs and better breathing for longer.
- What could go wrong
- This is a very small, early study with only 20 participants and no control group, so results may not apply to everyone. The device may be uncomfortable or hard to use daily.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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