Can a daily breathing exercise slow ALS lung decline?
NCT ID NCT06119087
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researchers will compare their peak cough flow to a similar group not using the device.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mechanical insufflation using the BiWaze Cough device
What this could lead to
If it works, this could point toward a simple daily exercise to help people with early ALS maintain stronger coughs and better breathing for longer.
What could go wrong
This is a very small, early study with only 20 participants and no control group, so results may not apply to everyone. The device may be uncomfortable or hard to use daily.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States