University Of Pennsylvania

This study tests whether having a patient navigator helps people from historically marginalized groups get surgery for primary hyperparathyroidism (PHPT) more quickly and reliably. PHPT is a gland condition that causes high calcium levels, leading to fatigue, pain, and organ dama…

This study is testing whether a type of dietary fiber called resistant starch can improve heart health and gut bacteria in women with Polycystic Ovary Syndrome (PCOS). 100 women with PCOS will take either the resistant starch or a placebo (inactive substance) for 12 weeks. Resear…

This is a small, early-stage study to see if draining lymph fluid from a chest duct is safe and can help patients with septic shock. Septic shock is a life-threatening condition where the body's own immune response causes severe inflammation and organ failure. Researchers want to…

This study is testing whether a city-run housing support program helps people with HIV manage their health better. The program provides rent help and counseling to people who are homeless or struggling to keep housing. Researchers will compare health and life outcomes for 200 peo…

This early study is testing if a drug called sotagliflozin, already used for diabetes and heart failure, can help adults with a specific type of heart muscle disease where the heart is thickened but not blocked. About 26 participants will take the drug or a placebo for 12-week pe…

This study is testing how well five different standard medications work to control relapsing polychondritis, a rare disease that causes painful inflammation in cartilage. Twenty adults with mild to moderate active disease will try different drug combinations in two stages, starti…

This study is testing whether a combination of two immunotherapy drugs can help control pancreatic cancer after initial chemotherapy. The treatment is given as maintenance therapy to patients whose cancer hasn't gotten worse after 4-6 months of standard chemotherapy. Researchers …

This study is testing whether a weekly injection called abatacept can help control giant cell arteritis, a serious condition that causes inflamed blood vessels in the head. The trial will involve 78 adults with recently active disease, comparing the drug to a placebo injection fo…

This study aims to find which of three existing medications works best for treating isolated skin vasculitis, a condition where blood vessels in the skin become inflamed. Researchers will enroll 90 adults with active skin lesions and randomly assign them to take either colchicine…

This study is testing if a single dose of a nutritional ketone drink can help control alcohol use disorder. Researchers will measure if the drink changes brain activity in response to alcohol cues, reduces cravings, and leads to less drinking in a controlled setting. The study in…

This study aims to find the best thyroid medication dose for people aged 65 and older. Researchers will compare two different dosing strategies over six months to see which provides better quality of life, mood, memory, and physical health. The study involves 228 participants who…

This study is testing if giving a clot-busting drug called tenecteplase directly into a brain artery can improve blood flow in the smallest vessels after a major clot has been surgically removed. It will involve 20 stroke patients who have already had the main blockage cleared. R…

This study is testing a new support program called THRIVE for people leaving the hospital who have opioid use disorder. It aims to see if connecting patients with a trained peer specialist for in-person and text message support can help reduce dangerous overdoses and skin infecti…

This early-stage trial is testing the safety and finding the right dose of a new type of CAR-T cell therapy for adults with certain aggressive B-cell lymphomas that have come back or not responded to other treatments, including prior CAR-T therapy. The therapy involves modifying …

This study is testing whether starting the labor induction process at home with a small balloon catheter is as safe and effective as starting it in the hospital. It involves first-time mothers who need their labor induced at full term. The main goal is to see if the home-start ap…

This early-stage study is testing a new type of personalized immune cell therapy called TmPSMA-02 CAR T cells in men with advanced prostate cancer that has spread and stopped responding to standard hormone treatments. The main goals are to find a safe dose and see if the body can…

This study is testing whether a monthly injection of a medication called naltrexone helps people who drink primarily for pleasure reduce their heavy drinking more than a placebo (inactive) shot. 60 adults with alcohol use disorder will receive either the real medication or a plac…

This study is testing whether a combination of personalized brain stimulation and intensive speech therapy can improve language skills in people with mild aphasia after a stroke. Researchers will compare real brain stimulation to a fake version to see if it helps with conversatio…

This study is testing if giving monthly cash payments to pregnant women with HIV in Botswana helps them manage their health better. It aims to see if the money reduces stress, helps them take their HIV medication consistently, and keeps them in medical care after giving birth. Th…

This early-stage study is testing the safety of a new type of treatment called CAR-T cell therapy for adults with a specific type of recurrent brain cancer (glioblastoma). Doctors will give patients modified versions of their own immune cells, either after chemotherapy or before …

This study is testing whether a gentle, non-invasive brain stimulation technique, when combined with standard thinking-skills therapy, can help improve memory and thinking in people who have had a recent stroke. About 70 participants who are having trouble with thinking after a s…

This study is testing a new community health worker program to help people in Philadelphia better manage their risk for heart disease. The program combines group education sessions with one-on-one support to help participants develop self-management skills and address social need…

This study is testing if sildenafil citrate, the active ingredient in Viagra, can improve blood flow in the brain and help with long-term symptoms after a traumatic brain injury (TBI). Researchers will give 160 adults with chronic TBI either sildenafil or a placebo pill for four …

This study is testing a 6-month remote support program designed to help patients lower their blood pressure and cholesterol. It uses automated messages and a support team to encourage healthy habits and medication use outside of regular doctor visits. The goal is to see if this a…

This study is evaluating a telephone support program called SUSTAIN, designed to help manage depression, anxiety, and chronic pain in older adults. The program provides check-in calls, education, and care coordination for 4,000 seniors in Pennsylvania. Researchers want to see how…

This small, early-stage study is testing whether a low dose of the anti-inflammatory drug colchicine can reduce inflammation in the leg arteries of people with peripheral artery disease. Researchers will compare 24 patients taking colchicine for four weeks to those taking a place…

This study tests whether a newer breathing support technology helps extremely premature babies breathe successfully on their own after coming off a ventilator. Researchers are comparing two non-invasive breathing support methods in babies born between 23 and 28 weeks of pregnancy…

This study aims to help people with psoriatic arthritis who didn't get enough relief from their first biologic medication. Researchers want to know if switching to a different type of drug (guselkumab) works better than switching to another similar drug (golimumab). The trial wil…

This study is testing if a special pill bottle that tracks when it's opened can help adults with depression take their medication more consistently. Researchers will follow 525 participants for 12 weeks to see if better medication habits lead to improved mood and quality of life.…

This study is testing whether a gentle, non-invasive brain stimulation technique can help people with PTSD better manage their fear and physical arousal during therapy. Researchers will give 120 participants either real or fake stimulation to see if it helps them stay calm enough…

This is an early safety study testing a new type of personalized immune cell therapy for people with advanced non-small cell lung cancer that has spread to the lining of the chest. Doctors will collect a patient's own immune cells, modify them in a lab to target a specific protei…

This study is testing whether a fecal microbiota transplant (FMT) can help clear dangerous, antibiotic-resistant bacteria from a patient's gut. Researchers will compare the transplant plus standard antibiotic therapy to antibiotics alone in 150 hospitalized adults. The goal is to…

This study aims to find a safe and effective starting dose of methadone for people addicted to fentanyl. Researchers will test a 'loading dose' method against the standard approach in 24 participants to see if it better controls withdrawal symptoms. The main goal is to identify a…

This early-stage study is testing a drug called dorzagliatin to see if it helps control blood sugar in adults with cystic fibrosis (CF) who also have pancreatic problems. Researchers will compare the drug to a placebo (inactive pill) in 15 participants to measure how the body pro…

This study is testing the drug ruxolitinib for adults with a rare immune system disorder called idiopathic Multicentric Castleman Disease (iMCD) that hasn't improved with standard treatments. The goal is to see if ruxolitinib can help control symptoms like severe fatigue, fever, …

This study aims to improve smoking cessation treatments specifically for people living with HIV, who smoke at higher rates and have more difficulty quitting than the general population. Researchers will test whether personalizing medication choices based on how a person's body pr…

This early-stage study is testing emergency rescue drugs for patients who develop severe, life-threatening immune reactions after receiving CAR-T cell cancer therapy. The study will enroll up to 10 adults already participating in CAR-T cell trials at the University of Pennsylvani…

This study is testing whether a cream called clascoterone can help control pilonidal disease, a common and often painful skin condition near the tailbone. About 75 participants will apply either the study cream or a placebo cream twice daily for 12 weeks. Researchers will check i…

This study is comparing two different mammogram machines to see if a newer model takes better pictures of tiny calcium deposits in the breast, which can be an early sign of cancer. About 100 women who need a follow-up diagnostic mammogram after a suspicious screening will have sc…

This study is testing a new type of CT scanner designed to take clearer pictures while using less radiation. It will involve 250 adults who are already scheduled for routine CT scans of areas like the chest, abdomen, or bones. Doctors will compare the images from this new scanner…

This study is testing whether sputum (mucus) samples collected at home and mailed to a lab are as good as samples collected in a clinic for detecting lung infections in adults with cystic fibrosis (CF). It aims to make infection monitoring easier and more accessible, especially a…

This study aims to see if using a special, focused ultrasound of the heart is safe and helpful for guiding treatment of critically ill patients in the emergency room or intensive care unit. It will enroll 1,000 adult patients who are in shock or cardiac arrest and are already sch…

This study is testing a new type of CT scan to see if it can better identify the dangerous materials inside plaque in the neck arteries of people who have had a stroke. Researchers will compare the new scan results to MRI images and, for some participants, actual plaque tissue re…

This study is testing if a simple office procedure called hysteroscopy can be as good as a standard surgery for diagnosing early pregnancy problems when an ultrasound can't find the pregnancy. It aims to see if this method can give a faster, more accurate answer, helping doctors …

This study aims to see if adding a short course of an approved diabetes/heart failure drug (sotagliflozin) to a special low-carb diet helps get clearer pictures of heart inflammation on a PET scan. The goal is to improve the diagnosis of cardiac sarcoidosis, a condition where inf…

This study aims to create a new, easier-to-use tool for detecting early signs of movement problems in babies. Researchers will use special sensors and video recordings of babies' movements, combined with artificial intelligence (AI), to see if they can accurately predict future m…

This study is testing a special fluorescent dye called indocyanine green (TumorGlow™) that is given before surgery. The dye makes cancer cells glow under a special camera, helping surgeons see and remove more of the tumor. The research aims to find the safest and most effective d…

This study tests a new technology called Sense4Safety, designed to help prevent falls in older adults living at home who have mild memory problems. The system uses sensors placed in the home to monitor for signs of increased fall risk and connects participants with a coach to cre…

This study aims to see if simple strategies can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains when shopping for groceries online. Researchers will test two approaches: using marketing nudges (like highlighting whole grain …

This large study is testing if starting low-dose aspirin very early in pregnancy can prevent two serious complications: pregnancy loss and preeclampsia (dangerous high blood pressure). It will enroll 1,150 pregnant women who have risk factors for these conditions. Participants wi…

This study aims to find the best way to support Suicide Intervention Officers in the Connecticut Army National Guard. It will compare two support strategies to see which one helps these officers more effectively reduce suicide risk among the soldiers in their units. The goal is t…

This study is testing whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. The coordinator will work with 520 patients aged 40-75 to better manage cholesterol, blood pressure, weight, and other heart health…

This study aims to see if a combination of policies—like taxes on ultra-processed foods, warning labels, and healthier checkout options—in online grocery and restaurant platforms can help people make better food choices. Researchers will recruit 300 adults with lower incomes to s…

This study is testing whether using a special breathing device can help slow the decline of cough strength in people with early-stage ALS. Twenty participants will use the device twice daily for six months to perform deep breathing exercises. Researchers will compare their cough …

This study is testing if a special wristband can help reduce nausea and vomiting after weight-loss surgery. The device, called the Reletex Reliefband, uses gentle electrical pulses on the wrist. Researchers will compare it to a fake device to see if it helps patients feel better,…

This study compares two methods of giving steroid injections for plantar fasciitis (heel pain). Researchers want to see if using ultrasound guidance to place the injection works better than using standard anatomical landmarks. The study will measure pain relief and quality of lif…

This study is testing whether a targeted nerve block is better than standard pain medicine for people who come to the emergency room with knee pain. About 34 adults with moderate to severe knee pain will be randomly assigned to receive either the nerve block or usual care. Resear…

This study is testing a new mouthpiece designed to make upper endoscopy procedures safer and more comfortable. Researchers want to see if this device reduces dental injuries and improves the experience for both patients and doctors during routine stomach exams. The study will inv…

This study is testing a new therapy that uses real-time brain scans to help people with depression. While inside an MRI machine, participants see their own brain activity and try to change negative thought patterns. Researchers want to see if this high-tech brain training can red…

This study is testing whether a new digital system for tracking symptoms helps people on dialysis feel better. About 2,400 patients at up to 36 clinics will either use the new tablet-based symptom tracker or receive their usual care for a year. The goal is to see if regularly rep…

This study is testing whether a special counseling program can help reduce suicidal thoughts and improve HIV care for teenagers living with HIV in Malawi. Researchers will enroll 60 depressed teens who have had suicidal thoughts and randomly assign them to receive either the new …

This study is testing whether providing extra support from doulas (trained birth companions) and care coordinators helps parents of very premature babies. It focuses on parents in a Philadelphia hospital NICU, aiming to reduce stress, anxiety, and depression after their baby goes…

This study is testing whether adding pregabalin to lofexidine helps people with opioid addiction better manage withdrawal symptoms when trying to stop using opioids. The trial involves 150 adults who want to start a long-acting medication called naltrexone for their addiction. Pa…

This study is testing if a smartphone app that turns daily walking into a game can help people with a specific type of heart failure (HFpEF) become more active. Researchers will compare the game app with social support features to one with competition features, and to a basic con…

This study is testing whether a guided home exercise program, monitored through a smartphone app and a smartwatch, can help people who have recently received a mechanical heart pump. Researchers want to see if this program helps patients walk farther, get stronger, and feel bette…

This study aims to see if a personalized form of magnetic brain stimulation can reduce persistent negative thoughts and emotions in people with depression or anxiety. Researchers will first map each participant's unique brain patterns linked to negative feelings using an MRI scan…

This study is adapting a text-message chatbot named Penny to provide support for pregnant and new mothers who have opioid use disorder. The goal is to see if having a 24/7 text-based companion can help reduce feelings of loneliness and help women stay engaged in their healthcare.…

This study is testing whether a 12-week coping skills training program can help reduce depression and anxiety in people with COPD (chronic obstructive pulmonary disease). It will compare the training program to a simpler COPD education program. The study is enrolling 750 patient-…

This study is testing whether a six-month virtual health coaching program can help family caregivers of hospitalized older adults take better care of themselves and reduce their stress. Researchers will compare the coaching program to providing online health information alone. Th…

This study is testing whether wearing special light therapy glasses during dialysis treatments can help reduce severe fatigue in people with end-stage kidney disease. Researchers will compare bright light to dim light in 60 participants over four weeks. The main goal is to see if…

This study is testing a new therapy program called TUNE In, designed to help adults with autism spectrum disorder improve their social functioning. The program teaches skills for understanding emotions, reducing social anxiety, and navigating social interactions. Researchers will…

This study is testing whether a common injectable birth control medication (Depo-Provera) can reduce the frequency of painful episodes in women with sickle cell disease. Adult women with sickle cell who regularly experience pain will first be observed for 3 months without hormona…

This study is testing whether a ketone supplement drink can help people going through alcohol withdrawal. Researchers will compare the drink to a placebo in 30 adults with moderate to severe alcohol use disorder during a 4-day detox program. The main goal is to see if the ketone …

This study is testing whether a 6-week group program teaching stress management and mindfulness skills can improve quality of life for people with sickle cell disease. 50 adults will be randomly assigned to either start the program right away or wait 6 weeks. The program includes…

This international study aims to gather anonymous medical information from 1,000 people worldwide who have homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol from birth. Doctors from many countries will share patient data …

This research study aims to understand how genetic risk affects blood sugar control in people who don't have diabetes. Researchers will compare people with high and low genetic risk scores for type 2 diabetes by measuring their body's response to sugar. The study involves 100 par…

This study aims to measure and compare lung inflammation in different groups of people using a special imaging scan. Researchers will use an experimental radioactive tracer during a PET/CT scan to see if there are differences in lung inflammation between e-cigarette users, tradit…

This study is creating a global registry to track up to 500 people with CDKL5 Deficiency Disorder (CDD), a rare genetic condition. The goal is to collect information from patients and their doctors over several years to better understand the disease's symptoms, progression, and h…

This study aims to understand how opioid addiction affects brain function and thinking skills, and whether brain scans and thinking tests can predict who will do well in treatment. Researchers will study 192 adults with opioid addiction who are already on stable medication treatm…

This study is testing whether an artificial intelligence (AI) tool can save doctors time and reduce stress when writing patient handoff notes. About 90 hospitalist doctors will be randomly assigned to either use an AI tool that drafts the notes or continue their usual method. Res…

This study aims to find out if pulse oximeters—the clip-on devices that measure oxygen levels—are equally accurate for children of all skin colors. Researchers will observe 650 children under 18 who are already having a heart procedure, comparing the pulse oximeter reading to a m…

This study aims to better understand burning mouth syndrome by tracking symptoms as they happen. Participants will use a smartphone app to report their pain three times a day for 12 weeks and provide saliva samples. The goal is to see how symptoms change throughout the day and if…

This study aims to collect and store existing tissue samples from people already enrolled in other vasculitis research studies. Researchers will analyze these samples along with health data to better understand what causes these rare inflammatory diseases. The goal is to generate…

This study aims to understand how breathing through the nose versus the mouth affects airway collapse in people with sleep apnea. Researchers will observe 50 adults with sleep apnea during a standard sleep test and an overnight lab study. The goal is to gather information to help…

This study aims to better measure the severity and impact of rare autoimmune blistering skin diseases like pemphigus and bullous pemphigoid. Researchers will enroll 150 adults with these conditions to compare different scoring tools and see how disease severity affects quality of…

This study aims to understand how your immune system remembers past flu exposures when fighting a new infection. Researchers will track 50 adults who test positive for the flu, collecting blood and nasal samples over time. The goal is to see if the body mostly relies on old immun…

This study aims to understand how relapsing polychondritis (RP), a rare disease that causes painful inflammation of cartilage, develops and changes over time. Researchers will follow 100 people diagnosed with RP, collecting health information, blood, and urine samples every 6 to …

This study is testing a new radioactive imaging dye to see how it travels through the body and if it can help doctors better see areas of bacterial infection on a PET/CT scan. Researchers will enroll about 20 adults with known or suspected infections. The main goal is to understa…

This study aims to understand how different types of vasculitis affect pregnancy experiences and outcomes. Researchers are inviting pregnant women with various vasculitis conditions to complete online surveys during their second trimester, third trimester, and after delivery. The…

This study is testing a new imaging tracer to see if it can safely highlight clumps of a specific protein called tau in the brain. Researchers will give the tracer to 90 people, including those with conditions like Progressive Supranuclear Palsy, Alzheimer's, and Parkinson's, as …

This University of Pennsylvania study aims to understand how menstrual cycle hormones affect brain activity in healthy adults. Researchers will use safe, non-invasive brain stimulation techniques on 100 participants to measure differences between men and women, and across differe…

This international registry aims to collect health information from 1,000 Castleman disease patients worldwide. By gathering real-world data about symptoms, treatments, and outcomes, researchers hope to better understand this rare condition. The information will help guide future…

This study is testing whether MRI scans can help doctors see inflammation in the arteries that supply blood to the head, brain, and eyes in people suspected of having giant cell arteritis. It involves 400 adults aged 50+ who are showing new symptoms. Participants will have MRI sc…

This study aims to understand how the first flu virus a person encounters in childhood might influence their immune response to flu vaccines later in life. Researchers will enroll up to 700 healthy adults of different ages, give them the standard seasonal flu shot, and then measu…

This study aims to understand why some people with diabetes lose kidney function very quickly while others decline more slowly. Researchers will collect kidney tissue, blood, and urine from 400 diabetic adults who are already scheduled for a medically necessary kidney biopsy. By …

This research aims to understand if the timing of a common OCD therapy works better during certain phases of a woman's menstrual cycle. The study will use brain scans and hormone tests on 120 adults with OCD to see how hormones affect the brain's response to therapy. The goal is …

This study aims to understand how being in ketosis—through either a ketogenic diet or a ketone supplement drink—affects brain function and alcohol intoxication. Healthy adult participants will try three different 3-day diets, then have an MRI brain scan and drink alcohol to measu…

This study is testing a new type of brain scan to see if it can detect a specific protein called tau, which builds up in some forms of dementia. Researchers will compare scans from people with different types of Alzheimer's disease and frontotemporal dementia to scans from health…

This study aims to find better ways to track disease activity in people with eosinophilic granulomatosis with polyangiitis (EGPA), a rare autoimmune disorder that causes asthma, high white blood cell counts, and blood vessel inflammation. Researchers will follow 700 participants …

This study aims to better understand the detailed anatomy of a common heart valve defect called bicuspid aortic valve. Over 5 years, 60 adult participants will receive annual advanced heart scans and echocardiograms. The goal is to collect detailed measurements to help surgeons i…

This study aims to create a large collection of information to help researchers better understand brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. It will enroll 1000 people, including those diagnosed with these conditions, people with a family history, and …

This study aims to understand why people with cystic fibrosis often develop diabetes. Researchers are testing how the pancreas in CF patients responds to specific hormones that normally help produce insulin. The study involves adults with cystic fibrosis and healthy volunteers to…

This study aims to improve surgery for people with drug-resistant epilepsy. Researchers will use advanced MRI brain scans to create detailed maps of a patient's brain network. The goal is to better predict where seizures start and spread, which could help surgeons plan more preci…

This early research aims to understand how temporarily blocking specific neck nerves affects dangerous rapid heart rhythms in patients with ventricular tachycardia. The study involves 20 adults who are already scheduled for a heart procedure to treat their rhythm problem. Researc…

This study is testing whether a simple, one-page conversation guide helps doctors and patients have better discussions about anesthesia options before hip fracture surgery. It involves nearly 1,900 patients aged 50+ across six US hospitals. The goal is to see if this tool, combin…

This study aims to test a new radioactive tracer for brain scans to see if it can detect and measure a specific abnormal protein linked to Multiple System Atrophy (MSA). Researchers will compare brain images from 70 people, including those with MSA, Parkinson's disease, Progressi…

This study is testing a training program called 'Just ASK™' to see if it helps doctors and nurses talk more often with breast cancer patients about joining clinical trials. Researchers will work with four cancer clinics, training their staff at different times and recording patie…

This study aims to understand how well dental implants heal in people who take a specific type of medication called TNF-alpha inhibitors, which are often used for conditions like arthritis. Researchers will compare 15 patients taking these drugs to 15 patients who are not, checki…

This study aims to understand how a specific part of the brain, called the posterior cingulate cortex, helps us control and use our memories to make decisions. Researchers will record brain activity from 130 adults who are already having brain monitoring for epilepsy, while they …

This study is testing whether a specific breathing device, called a supraglottic airway, is practical to use as the first choice for helping premature babies breathe right after birth. It involves about 20 premature infants born between 29 and 34 weeks who need breathing support.…

This study aims to understand how brain activity relates to symptoms in movement disorders like Parkinson's disease, essential tremor, dystonia, and ataxia. Researchers will record brain signals from 100 adult patients, either from the scalp or through a deep brain stimulator if …

This study aims to build a detailed picture of a rare and serious brain disease called central nervous system vasculitis (CNSV). Researchers will follow 40 adult patients for three years, collecting health information and blood samples regularly. The goal is to better understand …

This study aims to understand how variations in a gene called ANGPTL3 affect how the body processes fats (like cholesterol) and sugars. Researchers will compare people who have these specific gene variants with healthy volunteers. Participants will undergo tests like oral fat and…

This study aims to understand how certain diabetes medicines (called SGLT2 inhibitors) affect the kidneys. Researchers will examine stored kidney tissue samples from 200 adults with diabetic kidney disease who are already having a biopsy or surgery as part of their regular care. …

This study aims to test and improve new brain imaging techniques (PET scans) to better detect specific proteins linked to several neurological diseases, including Parkinson's disease and certain dementias. Researchers will enroll about 94 participants, including people with these…

This study aims to understand how daily habits like diet, physical activity, and sleep might help protect children who have a higher genetic risk for obesity. Researchers will follow 242 healthy children, ages 5-7, from mostly minority and low-resource backgrounds for one year. T…

This study aims to find out if two standard antibiotic combinations used to treat serious infections in the hospital carry different risks of kidney injury. Researchers will enroll 750 adult patients and compare kidney health using newer, more sensitive tests over the first five …

This study is testing three different educational approaches to help people with advanced kidney disease prepare for the surgery needed to create vascular access for hemodialysis. Researchers will compare standard education, a video and brochure package, and that same package plu…

This study is creating a detailed database of information from 250 people with Parkinson's disease and related conditions. Researchers will collect health data, biological samples, and brain images over many years to better understand how the disease progresses and what factors i…

This study uses special brain scans to measure tau protein buildup in people with mild memory problems or Alzheimer's disease. Researchers want to understand how tau relates to other brain changes and memory test scores. The study involves 100 participants who will get one brain …

This study aims to test a new brain imaging method to measure and map a protein called tau, which builds up in several neurodegenerative diseases like Alzheimer's and frontotemporal degeneration. Researchers will use a special PET scan on 300 participants, including people with t…

This study aims to find genes that increase the risk of developing vasculitis, a group of rare and severe diseases that cause inflammation of blood vessels. Researchers will collect DNA and health information from 1,000 people diagnosed with one of six specific types of vasculiti…