University Of Pennsylvania

This phase II trial tests whether combining two immunotherapy drugs (INCAGN1876 and INCMGA00012) with targeted radiation can help people with recurrent glioblastoma, an aggressive brain cancer. The 39 participants receive the drugs before and after surgery to remove the tumor, pl…

This study tests whether combining two drugs, itacitinib and everolimus, can help people with classical Hodgkin lymphoma that has returned or not responded to prior treatments. The trial is open to adults with measurable disease and aims to see how well the combination works in s…

This study looks at two ways to start labor in women who have had one previous C-section and are at least 37 weeks pregnant with a single baby. One method uses a cervical balloon alone, and the other uses the balloon along with the drug oxytocin. The goal is to see if using both …

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study looks at whether a progestin contraceptive implant (Nexplanon) can reduce painful sickle cell crises and improve quality of life in women aged 18-45 with sickle cell disease. Twenty-two participants will use the implant for a period and report their pain episodes. The …

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study tests whether technology and caregiver support can help liver transplant recipients take their medications correctly. Researchers will enroll 360 adults who received a liver transplant within the past 3 months. Participants will use a system called Way to Health, which…

This pilot study tests a new device called OsciPulse that rapidly compresses the calves to improve blood flow and reduce the risk of blood clots in people hospitalized after a stroke. About 40 adults with leg weakness will be randomly assigned to receive either OsciPulse or stand…

This study tests whether sending primary care doctors a monthly report comparing their hypertension control rates to peers can improve patient care. About 93 doctors and their patients with high blood pressure are involved. The goal is to see if this feedback leads to more medica…

This study tests whether ibudilast, an anti-inflammatory drug used in Japan, can help people with alcohol use disorder drink less. Fifty adults will take either ibudilast or a placebo for 6 weeks, plus counseling. The main goal is to see if it reduces the number of heavy drinking…

This study tests whether adding peer recovery support—coaching from someone who has personally overcome opioid addiction—to standard medication treatment (buprenorphine) helps people stay in care longer. Fifteen adults with opioid use disorder will receive peer support for 180 da…

This study compares two breathing support strategies—prone positioning and high-frequency ventilation—against standard care in 600 children with severe acute respiratory distress syndrome. The goal is to see which approach helps children spend more days off a ventilator within 28…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy to buy fruits and vegetables online helps them eat healthier. 214 participants will be split into groups, some getting the subsidy and some not, to see if it increases their produce purchases …

This study tests whether giving estrogen through a vein during kidney transplant surgery can reduce damage to the new kidney. It includes 30 women who need dialysis and are getting a kidney from a deceased donor. The goal is to see if estrogen helps the kidney work better right a…

This early-stage trial tests whether specially engineered immune cells are safe and feasible for people with a recurring type of brain cancer called glioblastoma. The cells are designed to recognize and attack two specific proteins found on the cancer cells. The study involves 67…

This phase II trial tests whether a fecal microbiota transplant (using donor stool) can help eliminate multidrug-resistant organisms (MDROs) from the gut of infected patients. 32 adults with resistant bacterial infections will receive the transplant plus standard antibiotics. The…

This study tests two methods to increase referrals to a centralized pharmacy service for managing statin therapy in patients with or at high risk for heart disease. One method sends reminders to doctors during office visits, and the other sends electronic messages outside of visi…

This study compares two types of implants used in back surgery for people with worn-out discs in the lower spine. About 60 adults will receive either a PEEK cage with bone-growing protein or a CONDUIT cage during a procedure called DLIF. Researchers will check which cage leads to…

This phase 2 trial is testing whether adding the targeted drug belantamab mafodotin before and after a stem cell transplant can help people with multiple myeloma achieve deeper remission. About 41 participants will receive the drug alongside standard treatments. The main goal is …

This phase 2 study tests the drug sirolimus (rapamycin) in 7 people with idiopathic multicentric Castleman disease who have not improved with standard therapy. The goal is to see if sirolimus can improve symptoms like fatigue, fever, and night sweats, and shrink enlarged lymph no…

This early-phase study tests a new type of immunotherapy for men with advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are genetically modified to better recognize and attack prostate cancer cells while …

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This early-phase trial is testing whether a new immune cell therapy called CART123, given together with the drug ruxolitinib, is safe for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The study will enroll 12 adults who have no other c…

This study tests whether adding a drug called cevostamab after standard CAR T cell therapy can help people with relapsed or refractory multiple myeloma achieve a deeper remission. About 30 adults who have already received CAR T cells will get cevostamab infusions every 3 weeks fo…

This study tests a one-time treatment using the patient's own immune cells, modified to target a protein called CD22 on leukemia cells. It is for children and young adults whose B-cell acute lymphoblastic leukemia has returned or not responded to standard treatments. The main goa…

This study tests whether a gamification program, along with support from a partner and updates to their doctor, can help 84 adults with high blood pressure and high cholesterol take their medications more consistently. Participants who have struggled with adherence will either re…

This early-phase study tests whether giving two immune-boosting drugs (LVGN7409 and a PD-1 inhibitor) before surgery can safely help the body fight HPV-negative head and neck cancer. About 27 adults with resectable tumors will receive the combination, then undergo surgery. The ma…

This early-phase study tests a new cell therapy called huCART19-IL18 for people with CD19-positive blood cancers (like some leukemias and lymphomas) that have relapsed or not responded to standard treatments. The therapy involves modifying a patient's own immune cells to better t…

This early-stage trial tests a new approach for adults with acute lymphoblastic leukemia that has not responded to chemotherapy. Researchers take a patient's own immune cells, modify them in the lab to recognize and attack cancer cells with CD22 and CD19 proteins, and infuse them…

This early-stage study tests a new approach to HIV treatment. Researchers take a person's own T-cells, modify them to better recognize and attack HIV, and infuse them back. The main goal is to check safety in 12 stable HIV patients, while also seeing if the modified cells can hel…

This study tests a small, portable MRI machine for scanning the brains of 100 adults with hydrocephalus or other neurological conditions. Participants get both the portable scan and a standard CT or MRI on the same day. The goal is to see if the portable device can reliably detec…

This study looks at whether a special type of PET scan (FDG-PET) can more accurately detect bone infections (osteomyelitis) in people with diabetic foot disease. Researchers will compare the scan results with MRI and follow patient outcomes to see how well it works. The goal is t…

This study looks at whether a type of PET scan called FDG-PET can tell the difference between an infection and other problems, like loosening, in people with painful joint replacements. About 530 participants will get the scan, and the results will be compared with other tests an…

This study looks at 400 women recently diagnosed with breast cancer to compare four imaging techniques: MRI, digital mammogram, ultrasound, and PET scan. The goal is to see which method, or combination, best determines how far the cancer has spread before surgery. The results cou…

This study uses a machine-learning tool to scan electronic health records and flag patients likely to have familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. Researchers then test a simple referral system that automatically schedules a visit wi…

This study tests whether a new, more powerful 7 Tesla MRI can better detect scarring and swelling in the heart muscle of people with cardiomyopathy. Researchers will scan 13 adults aged 20-70 to see if the higher-resolution images improve diagnosis. The goal is to see if this adv…

This early-stage study tests a new radioactive tracer called [18F]ISO-1 in PET scans for people with breast cancer. The tracer targets sigma-2 receptors, which are linked to how fast cancer cells multiply. Researchers want to see if the scan can measure tumor growth rates and hel…

This study looks at whether a special type of PET/CT scan (called FDG PET/CT) can help doctors see how well hormone therapy is working in breast cancer that has spread to the bones. About 75 adults with estrogen receptor-positive breast cancer and bone metastases will get the sca…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This study tests whether offering lottery-based rewards for saving money can help Kenyan men reduce behaviors that raise their risk for HIV and other STIs. About 1,500 men aged 18-39 who drink alcohol and have paid for sex in the past will be split into two groups. One group gets…

This study looks at ways to help teen drivers stay safe on the road. Car crashes are the top cause of death for teens. Over 2,200 teens and their parents will test new strategies to reduce accidents. The goal is to find clear methods that prevent crashes and save lives.

This study works with primary care and reproductive health clinics to make it easier for women who inject drugs to get PrEP, a daily pill that prevents HIV. Researchers are testing a program where clinic staff get extra training and support to identify and prescribe PrEP to these…

This study tests whether wearing bright light glasses during dialysis can reduce severe fatigue in people with end-stage kidney disease. Sixty adults on hemodialysis will use the glasses for one hour, three times a week, for four weeks. The goal is to see if this simple, non-drug…

This study compares three proven PTSD treatments—talk therapy (prolonged exposure), antidepressant medication (paroxetine or venlafaxine), and their combination—in 304 veterans. Researchers aim to identify which treatment works best for whom, using personalized algorithms. Partic…

This study compares two common acne pills for women: spironolactone (a hormone blocker) and doxycycline (an antibiotic). About 350 women aged 16-40 with moderate to severe acne will take one of the two medicines for several weeks. Researchers will count how many pimples clear up …

This early-phase study tests whether taking CoQ10 supplements for 8 weeks can ease fatigue in people with Crohn's disease. About 60 adults with stable Crohn's will receive one of two doses, and researchers will track changes in fatigue and quality of life. The goal is to see if a…

This study tested whether a personalized exercise program done 2-4 weeks before knee or hip replacement surgery could improve thinking and reduce delirium in adults aged 55 and older. Participants wore activity trackers and used a smartphone app. The study was suspended, so resul…

This pilot study tests whether offering small financial rewards (up to $50/month) and text reminders can encourage people with first-episode psychosis to attend their therapy and medication appointments. About 145 participants from two specialty clinics will take part over three …

This study tests whether adding a doula to standard pregnancy care can improve mental health and birth outcomes for Black birthing people. 230 participants will be randomly assigned to receive doula support or standard care alone. The main goal is to see if doula care lowers depr…

This pilot study is testing whether providing medically tailored meals to heart failure patients after they leave the hospital is practical and helpful. Researchers will enroll 85 adults who are on Medicaid or Medicare and recovering from a heart failure hospitalization. The meal…

This study compares a home-based, tailored sleep therapy (CBT-I) to a web-based version for 80 caregivers who have insomnia while caring for a child with autism. The goal is to see which approach is more acceptable and feasible for improving sleep and reducing caregiver burden. P…

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This study looks at whether low-resistance exercise (like light strength training) can safely help people with pulmonary arterial hypertension (PAH) feel better and be less frail. About 20 adults with stable PAH will try the program. Researchers will track safety, how well people…

This study is testing a new type of prosthetic leg for children aged 3 to 18 that can be easily adjusted as they grow. The device is designed to be fitted in a single session and adjusted by the wearer. Researchers will measure comfort, socket pressure, walking speed, and quality…

This study tests a program of balance and strength exercises, bladder training, and home safety checks in 375 women aged 70 and older who have urinary incontinence. The goal is to see if this approach reduces falls and improves bladder control compared to just giving them informa…

This study tests an accelerated version of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression. Instead of the usual 6-week course, participants receive 10 sessions per day for 5 days. The goal is to see if this intense schedule can quickly redu…

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study tests whether a simplified behavioral relaxation program can improve sleep in pregnant women with insomnia. Twenty women in their second or third trimester will receive coaching calls and sleep hygiene tips. The goal is to see if this approach helps them fall asleep fa…

This long-term study follows over 5,000 people with chronic kidney disease to learn how the condition affects the heart and blood vessels. Researchers are tracking kidney function, heart events like heart attacks and strokes, and various risk factors. The goal is to find better w…

This study tests whether an AI tool can help doctors quickly and fairly identify prostate cancer patients who might qualify for a clinical trial. Researchers will use AI to rank patient records by how well they match trial criteria, then check the results. The goal is to see if t…

This study looks at whether having close contact with pets can help keep your gut healthy while taking antibiotics and lower the risk of a serious infection called C. difficile. Researchers will follow 200 adults getting dental implants who need antibiotics, checking their gut ba…

This study looks at whether a big investment in Black neighborhoods—like cleaning up vacant lots, fixing abandoned houses, planting trees, and offering financial counseling and cash help—can improve children's health. Researchers are working with 221 families in Philadelphia. The…

This study looks at how SGLT2 inhibitors, a type of diabetes drug also used for heart failure, affect the body's metabolism. About 40 adults with mild to moderate heart failure will have blood tests, walking tests, and calf MRIs before and after starting the medication. The goal …

This study follows 4,000 people who have had a lung transplant to see how their lungs and overall health change over many years. Researchers will collect data from clinic visits, lung function tests, and surveys about daily activities and quality of life. The goal is to better un…

This study follows 300 people who had a traumatic brain injury (TBI) for at least two years after their injury. Researchers want to see how their recovery changes over time and test a blood marker that may show brain damage. The goal is to better understand the long-term effects …

This study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…

This study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…

This study tests a toolkit called PEACE, designed to help early intervention providers coach parents of young children with autism. Researchers will enroll 200 providers and 400 parent-child dyads to see if the toolkit improves how providers support families. The goal is to make …

This study looks at how noise from airplanes affects people's sleep. About 400 volunteers living near airports will wear a small device that tracks heart rate and movement for 5 nights, while a recorder captures indoor sounds. They will also fill out morning surveys about their s…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This observational study looks at 300 adults with severe traumatic brain injury to see how low brain oxygen levels affect certain proteins in the blood, known as biomarkers. Researchers will measure these proteins to better understand brain damage and recovery. The study does not…

This study is developing and testing a telehealth tool to support community mental health clinicians in using cognitive behavioral therapy (CBT) with their patients. Researchers will work with about 100 clinicians and their patients to design, refine, and evaluate the tool throug…

This early-phase study tests whether a new type of PET scan can measure inflammation in the brains of people with Parkinson's disease. Researchers will compare scans from 11 participants (both with Parkinson's and healthy volunteers) to see if the imaging drug 18F-NOS can help di…

This study uses special electrodes placed inside the brain to directly measure how transcranial magnetic stimulation (TMS) affects neural activity. Ten adult patients who already have these electrodes for medical reasons will receive single TMS pulses. The goal is to see if TMS c…

This study follows 755 children who were in the pediatric intensive care unit (PICU) to learn how they recover physically, mentally, and emotionally. Researchers will track quality of life, fatigue, and sleep over time. The goal is to understand what helps children and families h…

This study tests two different electronic health record alerts to help doctors order palliative care consults for seriously ill patients in the hospital. About 18,000 adults across 9 hospitals will take part. The goal is to see which alert works better at getting patients the ext…

This study aims to find specific gene changes (filaggrin mutations) in 300 Latinx adults with eczema. Researchers will use advanced DNA testing to see how these changes relate to the disease. The goal is to better understand eczema in this group, not to test a new treatment.

This study creates a registry for up to 500 people with CDKL5 Deficiency Disorder (CDD), a rare genetic condition that causes seizures and developmental delays. Patients and their caregivers will provide information about symptoms, treatments, and quality of life over several yea…

This study uses special PET scans to look for signs of inflammation in the brains of people with Alzheimer's disease or mild cognitive impairment, compared to healthy volunteers. Nine participants will receive an investigational radioactive tracer called [18F]NOS, and some may al…

This study uses low-intensity focused ultrasound (LIFU) to gently stimulate the brain while recording responses with implanted electrodes. Researchers aim to map how different brain regions communicate in real time. About 30 adults with epilepsy or other conditions who already ha…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study looks at how being in ketosis (a state from a very low-carb diet) changes the way the body processes alcohol and affects the brain. About 23 healthy adults will follow three different 3-day diets and then drink 4-5 alcoholic beverages. Researchers will use breath tests…

This study tests whether specially designed messages can help young women in South Africa resist false information about a future HIV vaccine. Over 2,000 women aged 18-29 will receive either standard information or enhanced messages that use psychological techniques to build resi…

This pilot study will use special PET scans to measure opioid receptor binding in the brain, spinal cord, and other organs in up to 60 adults, including healthy volunteers and people with opioid use disorder. The goal is to better understand how opioids affect the whole body, not…

This study looks at how a single dose of a ketone ester supplement (DeltaG) changes glucose use in the brain and heart of people with alcohol use disorder compared to healthy volunteers. Twenty participants will receive either the supplement or a placebo, then undergo PET scans. …

This study tests a three-session virtual program designed to help U.S. adults improve their social connections, get more involved in their communities, and feel better physically and mentally. Researchers will enroll 200 people who will attend weekly Zoom meetings with trained fa…

This study tests whether changing how people interact in online social networks can improve their attitudes and intentions toward COVID-19 vaccination. Over 4,400 adults in the US with internet access will be placed into different online groups and answer health questions while s…

This study compares two approaches to palliative care for seriously ill patients with a high risk of dying within a year. Over 78,000 patients across 48 hospitals will be assigned to usual care, care led by their own doctors (generalist), or care from a specialist team. Researche…

This study tests a new PET/CT scan that uses a tracer called 18F-FluorThanatrace to measure PARP-1 activity in breast cancer tumors. About 50 adults with known or suspected breast cancer will get one or two scans. The goal is to see how well the scan detects cancer activity and c…

This study looks at how age, sex, and eating a fatty meal affect the body's internal daily rhythms, known as the chronobiome. Researchers will compare blood samples from 48 healthy adults, half aged 18-30 and half aged 55-75, to see differences in proteins. The goal is to better …

This study looks at how HIV might disrupt the body's internal clock, which could lead to health problems like diabetes and heart disease. Researchers will track gene activity at different times of day in 80 people with and without HIV. The goal is to understand why these issues a…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study tests a new payment model for cancer care in Hawaii. Instead of paying for each service separately, doctors get a single payment for an episode of care, with bonuses for meeting quality goals. The study includes 7 oncologists and looks at how this affects care quality,…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study asks 350 critical care doctors and advanced practice providers to review fictional patient cases of sepsis and ARDS. Each case includes treatment recommendations that were either made by a real clinician or generated by an artificial intelligence system. The participan…

This study tests if a package of community improvements—like cleaning vacant lots, fixing abandoned houses, planting trees, and offering financial help—can improve the health of Black residents in Philadelphia. About 571 adults in 60 neighborhoods will be tracked for changes in o…

This study tests a new type of PET scanner that can take pictures of most of the body at once, instead of just a small section. Researchers want to see how well this scanner works in healthy adults and people with memory problems. The goal is to gather information to improve futu…

This study looks at whether custom-made videos can help people who had a stroke 1 to 10 years ago better understand their condition and feel more satisfied with their care. About 100 participants will use a video app and answer surveys after 7 and 90 days. The goal is to see if t…

This study looks at how quickly the body breaks down nicotine and how that affects brain receptors in smokers. Thirteen adult smokers will have PET brain scans after different periods of not smoking, and will receive a tiny amount of nicotine during the scan. The goal is to under…

This study examines stored lymph node samples from 100 people in Botswana who had lymphoma between 2012 and 2017. Researchers want to see how often Epstein-Barr virus (EBV) is found in these samples, and whether HIV infection makes a difference. The goal is to better understand t…

This study looks at how working night shifts changes the bacteria in your gut and how your body handles sugar. Researchers will compare 12 healthy men who work night shifts with those who work during the day. They will track gut bacteria and blood sugar levels at different times …

This study tests a text-messaging program that sends reminders and educational videos to people starting fertility testing. The goal is to see if it helps them complete all the required tests faster. About 160 new female patients at Penn Fertility Care will take part, and half wi…

This study looks at why our internal body clock weakens with age. Researchers will take blood from 20 healthy young adults (ages 20-35) and 20 healthy older adults (ages 70-85) and add it to lab-grown cells to see how it affects their daily rhythms. The goal is to find genes that…

This study looks at how anti-inflammatory drugs change fat molecules in human blood. Researchers will test blood samples from 30 healthy adults in a lab to measure many different fats. The goal is to find new effects or side effects of these drugs, which could lead to better trea…

This study looks at how air pollution and the body's internal clock (circadian rhythm) interact to worsen asthma, especially at night. Researchers will measure tiny molecules called microRNAs in the sputum of 20 adults with and without asthma over 48 hours. The goal is to underst…

This study compares the 24-hour rhythm of blood fats in people with night eating syndrome versus healthy volunteers. Researchers aim to see if unusual eating habits disrupt these rhythms. Only 12 participants are enrolled, and the study is currently suspended.

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study looks at people with high blood pressure whose levels don't drop normally during sleep, a condition linked to worse health outcomes. Researchers will use wearable devices and smartphone apps to monitor blood pressure patterns over 24 hours. The goal is to understand ho…

This study looks at how the immune system behaves in people with chronic hepatitis B. Researchers are measuring different immune cells and signals to understand why some people control the virus better than others. 201 adults already enrolled in a larger hepatitis B study are pro…

This study looks at whether taking a ketone supplement before drinking alcohol changes how drunk people feel or how alcohol shows up in their breath or blood. Ten healthy volunteers will drink alcohol on two separate days, once with the supplement and once with a placebo. The goa…

This study looks at how the immune system responds to chronic hepatitis B infection. Researchers will analyze blood samples from 40 adults already enrolled in larger treatment trials. The goal is to understand why some people respond better to therapy and how the disease progress…

This study is testing whether RNA molecules in the blood can predict if a broken bone will heal normally, slowly, or not at all. Researchers will collect blood samples from 110 people with fractures at several time points after injury and compare the RNA test results to actual he…

This pilot study looks at how the diabetes drug sitagliptin (Januvia) affects people who naturally have lower levels of a protein called DPP4 due to their genes. Researchers will compare 20 adults with and without this genetic trait to see how sitagliptin changes blood sugar and …

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the lymph system versus blood. In MS participants, fluid is also collected before and after treatment with the drug ofatumumab. The goal is to understand how the im…

This study was designed to see if stimulating both sides of a tongue nerve during sleep could improve airway collapse in people with obstructive sleep apnea who already have an Inspire device. It was withdrawn before enrolling anyone, so no results are available.

This study uses a special brain scan called Tau PET to look at a protein linked to Alzheimer's disease in healthy older African Americans. Researchers want to learn how this protein builds up and relates to memory changes over time. The goal is to better understand early signs of…

This early-phase study is testing a new PET scan tracer called [18F]NOS to see if it can detect inflammation in the brain and body of people with alcohol use disorder (AUD). Researchers will compare up to 60 people with AUD and up to 30 healthy volunteers. Each person gets one PE…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study follows 1,000 mothers and their newborns in Botswana to learn how antibiotic-resistant bacteria pass from mother to child around the time of birth. Researchers will track these bacteria over time to understand how they spread. The goal is to find better ways to prevent…

This study looks at how the antibiotic TMP-SMX changes the bacteria and fungi living in the noses of people with granulomatosis with polyangiitis (GPA), a rare autoimmune disease. Researchers want to understand why this antibiotic helps prevent disease flare-ups. Eight adults wit…

This observational study follows 10 adults with obstructive sleep apnea who are already receiving a cryotherapy treatment (the Cryosa Procedure). Researchers will use MRI and ultrasound before and after treatment to measure fat in the throat and nerve activity. The goal is to fin…

This study from the University of Pennsylvania looks at whether simply asking people about their intentions to do a health behavior—like getting a flu shot—makes them more likely to actually do it. Researchers are tracking 350 participants to see if measuring intention changes be…

This study follows 196 women aged 11-35 who are receiving chemotherapy for cancer. Researchers measure hormone levels and ovarian follicles before, during, and after treatment to see how the ovaries are affected. The goal is to better understand the risk of early menopause and fe…

This study uses a special PET scan to measure tau protein buildup in the brains of 106 older adults, some with normal aging and some with mild cognitive impairment (MCI). The goal is to understand how tau relates to memory and brain structure changes, which could help tell apart …

This study looks at how spending 2, 6, or 12 months on the International Space Station changes astronauts' brain structure and thinking skills, including memory and spatial awareness. Researchers will use brain scans and cognitive tests to track these changes over time. The goal …

This study looks at a program that helps caregivers of people with dementia. It offers support, education, and referrals to community services. Researchers will review past data and interview some caregivers to see if the program reduces stress and improves satisfaction. About 35…

This study tests whether group virtual preconception care can improve pregnancy and health outcomes for people with infertility. About 140 patients from Penn Fertility Care will either join biweekly group sessions or receive usual care. Researchers will track blood pressure, weig…

This study looks at whether using a cesarean risk calculator during labor can lower the number of C-sections and reduce complications for mothers and newborns. Researchers will track 20,000 women giving birth at full term to see if the tool helps guide decisions. The goal is to i…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …

This study tracks infections that people get while in the hospital and monitors how germs become resistant to antibiotics. Researchers will collect swabs from 1,500 patients to test for resistant bacteria and build a national network to spot outbreaks early. The goal is to streng…

This study aims to understand how the brain uses both hearing and vision to understand speech. Researchers will record brain activity from 100 people who already have electrodes implanted for medical reasons. Participants will watch and listen to videos of people speaking while t…

This study tests whether an augmented reality virtual ruler can help doctors place PICC lines more accurately and with less radiation. Twenty adults scheduled for non-emergency PICC placement will have the virtual ruler used during their procedure. The main goal is to see if the …

This study looks at how a high-fat, high-carb meal affects inflammation and stress responses in women with migraine compared to healthy women. Thirty women aged 18-35, with and without migraine, will have blood tests and pain tests after eating a test meal. The goal is to underst…

This study is looking at how a protein called tau builds up in the brains of older adults with mild cognitive impairment (MCI) or who are cognitively normal. Researchers will use a special PET scan with a tracer called [18F]PI-2620 to take detailed pictures of the brain's memory …

This early-phase study tests whether a special PET scan using a tracer called FLT can show how breast cancer tumors respond to a combination of two drugs, ribociclib and paclitaxel. The study involves 20 people with metastatic breast cancer that has spread beyond the liver and bo…